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P58160

- CITX_STRP1

UniProt

P58160 - CITX_STRP1

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Protein

Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase

Gene

citX

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein.By similarity

Catalytic activityi

2'-(5-triphosphoribosyl)-3'-dephospho-CoA + citrate lyase apo-[acyl-carrier protein] = citrate lyase holo-[acyl-carrier protein] + diphosphate.

GO - Molecular functioni

  1. holo-citrate lyase synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. prosthetic group biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-986-MONOMER.
SPYO293653:GHFC-967-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (EC:2.7.7.61)
Alternative name(s):
Apo-ACP nucleodityltransferase
Holo-ACP synthase
Holo-citrate lyase synthase
Gene namesi
Name:citX
Ordered Locus Names:SPy_1190, M5005_Spy0908
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferasePRO_0000214688Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_1190.

Structurei

3D structure databases

ProteinModelPortaliP58160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CitX family.Curated

Phylogenomic databases

eggNOGiCOG3697.
HOGENOMiHOG000130710.
KOiK05964.
OMAiCENFYVL.
OrthoDBiEOG6T7NCD.

Family and domain databases

HAMAPiMF_00398. CitX.
InterProiIPR005551. CitX.
[Graphical view]
PfamiPF03802. CitX. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03124. citrate_citX. 1 hit.

Sequencei

Sequence statusi: Complete.

P58160-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCKDTYFSGE AIQLSDMLRA REERALRQLH LLKEYPEGSL LSVTMNIPGP
60 70 80 90 100
IKTSPKLLEA FDIVIKAIQT ALADDKICYQ LRLLPTTGYE YYLITSLPSR
110 120 130 140 150
DLKLKMIALE TELPIGRLMD LDVLVLQNDL PHSISRTVLG GSPRQCFICS
160 170 180 190
KEAKVCGRLR KHSVEEMQTA ISKLLHSFFN KDNQSSSSDK TG
Length:192
Mass (Da):21,618
Last modified:June 1, 2001 - v1
Checksum:i5F315E4A2593CFE4
GO

Sequence cautioni

The sequence AAZ51526.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34054.1.
CP000017 Genomic DNA. Translation: AAZ51526.1. Different initiation.
RefSeqiNP_269333.1. NC_002737.1.
YP_282271.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK34054; AAK34054; SPy_1190.
AAZ51526; AAZ51526; M5005_Spy0908.
GeneIDi3572000.
901299.
KEGGispy:SPy_1190.
spz:M5005_Spy_0908.
PATRICi19715951. VBIStrPyo79812_1040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34054.1 .
CP000017 Genomic DNA. Translation: AAZ51526.1 . Different initiation.
RefSeqi NP_269333.1. NC_002737.1.
YP_282271.1. NC_007297.1.

3D structure databases

ProteinModelPortali P58160.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160490.SPy_1190.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK34054 ; AAK34054 ; SPy_1190 .
AAZ51526 ; AAZ51526 ; M5005_Spy0908 .
GeneIDi 3572000.
901299.
KEGGi spy:SPy_1190.
spz:M5005_Spy_0908.
PATRICi 19715951. VBIStrPyo79812_1040.

Phylogenomic databases

eggNOGi COG3697.
HOGENOMi HOG000130710.
KOi K05964.
OMAi CENFYVL.
OrthoDBi EOG6T7NCD.

Enzyme and pathway databases

BioCyci SPYO160490:GJ81-986-MONOMER.
SPYO293653:GHFC-967-MONOMER.

Family and domain databases

HAMAPi MF_00398. CitX.
InterProi IPR005551. CitX.
[Graphical view ]
Pfami PF03802. CitX. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03124. citrate_citX. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiCITX_STRP1
AccessioniPrimary (citable) accession number: P58160
Secondary accession number(s): Q48YP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3