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P58160

- CITX_STRP1

UniProt

P58160 - CITX_STRP1

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Protein
Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
Gene
citX, SPy_1190, M5005_Spy0908
Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein By similarity.UniRule annotation

Catalytic activityi

2'-(5-triphosphoribosyl)-3'-dephospho-CoA + citrate lyase apo-[acyl-carrier-protein] = citrate lyase holo-[acyl-carrier-protein] + diphosphate.UniRule annotation

GO - Molecular functioni

  1. holo-citrate lyase synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. prosthetic group biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-986-MONOMER.
SPYO293653:GHFC-967-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (EC:2.7.7.61)
Alternative name(s):
Apo-ACP nucleodityltransferase
Holo-ACP synthase
Holo-citrate lyase synthase
Gene namesi
Name:citX
Ordered Locus Names:SPy_1190, M5005_Spy0908
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferaseUniRule annotation
PRO_0000214688Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_1190.

Structurei

3D structure databases

ProteinModelPortaliP58160.

Family & Domainsi

Sequence similaritiesi

Belongs to the CitX family.

Phylogenomic databases

eggNOGiCOG3697.
HOGENOMiHOG000130710.
KOiK05964.
OMAiCENFYVL.
OrthoDBiEOG6T7NCD.

Family and domain databases

HAMAPiMF_00398. CitX.
InterProiIPR005551. CitX.
[Graphical view]
PfamiPF03802. CitX. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03124. citrate_citX. 1 hit.

Sequencei

Sequence statusi: Complete.

P58160-1 [UniParc]FASTAAdd to Basket

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MCKDTYFSGE AIQLSDMLRA REERALRQLH LLKEYPEGSL LSVTMNIPGP    50
IKTSPKLLEA FDIVIKAIQT ALADDKICYQ LRLLPTTGYE YYLITSLPSR 100
DLKLKMIALE TELPIGRLMD LDVLVLQNDL PHSISRTVLG GSPRQCFICS 150
KEAKVCGRLR KHSVEEMQTA ISKLLHSFFN KDNQSSSSDK TG 192
Length:192
Mass (Da):21,618
Last modified:June 1, 2001 - v1
Checksum:i5F315E4A2593CFE4
GO

Sequence cautioni

The sequence AAZ51526.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34054.1.
CP000017 Genomic DNA. Translation: AAZ51526.1. Different initiation.
RefSeqiNP_269333.1. NC_002737.1.
YP_282271.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK34054; AAK34054; SPy_1190.
AAZ51526; AAZ51526; M5005_Spy0908.
GeneIDi3572000.
901299.
KEGGispy:SPy_1190.
spz:M5005_Spy_0908.
PATRICi19715951. VBIStrPyo79812_1040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34054.1 .
CP000017 Genomic DNA. Translation: AAZ51526.1 . Different initiation.
RefSeqi NP_269333.1. NC_002737.1.
YP_282271.1. NC_007297.1.

3D structure databases

ProteinModelPortali P58160.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160490.SPy_1190.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK34054 ; AAK34054 ; SPy_1190 .
AAZ51526 ; AAZ51526 ; M5005_Spy0908 .
GeneIDi 3572000.
901299.
KEGGi spy:SPy_1190.
spz:M5005_Spy_0908.
PATRICi 19715951. VBIStrPyo79812_1040.

Phylogenomic databases

eggNOGi COG3697.
HOGENOMi HOG000130710.
KOi K05964.
OMAi CENFYVL.
OrthoDBi EOG6T7NCD.

Enzyme and pathway databases

BioCyci SPYO160490:GJ81-986-MONOMER.
SPYO293653:GHFC-967-MONOMER.

Family and domain databases

HAMAPi MF_00398. CitX.
InterProi IPR005551. CitX.
[Graphical view ]
Pfami PF03802. CitX. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03124. citrate_citX. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiCITX_STRP1
AccessioniPrimary (citable) accession number: P58160
Secondary accession number(s): Q48YP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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