Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase

Gene

citX

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein.By similarity

Catalytic activityi

2'-(5-triphosphoribosyl)-3'-dephospho-CoA + citrate lyase apo-[acyl-carrier protein] = citrate lyase holo-[acyl-carrier protein] + diphosphate.

GO - Molecular functioni

  1. holo-citrate lyase synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. prosthetic group biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-986-MONOMER.
SPYO293653:GHFC-967-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (EC:2.7.7.61)
Alternative name(s):
Apo-ACP nucleodityltransferase
Holo-ACP synthase
Holo-citrate lyase synthase
Gene namesi
Name:citX
Ordered Locus Names:SPy_1190, M5005_Spy0908
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750 Componenti: Chromosome UP000002702 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferasePRO_0000214688Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_1190.

Structurei

3D structure databases

ProteinModelPortaliP58160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CitX family.Curated

Phylogenomic databases

eggNOGiCOG3697.
HOGENOMiHOG000130710.
KOiK05964.
OMAiAFDIVIK.
OrthoDBiEOG6T7NCD.

Family and domain databases

HAMAPiMF_00398. CitX.
InterProiIPR005551. CitX.
[Graphical view]
PfamiPF03802. CitX. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03124. citrate_citX. 1 hit.

Sequencei

Sequence statusi: Complete.

P58160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCKDTYFSGE AIQLSDMLRA REERALRQLH LLKEYPEGSL LSVTMNIPGP
60 70 80 90 100
IKTSPKLLEA FDIVIKAIQT ALADDKICYQ LRLLPTTGYE YYLITSLPSR
110 120 130 140 150
DLKLKMIALE TELPIGRLMD LDVLVLQNDL PHSISRTVLG GSPRQCFICS
160 170 180 190
KEAKVCGRLR KHSVEEMQTA ISKLLHSFFN KDNQSSSSDK TG
Length:192
Mass (Da):21,618
Last modified:June 1, 2001 - v1
Checksum:i5F315E4A2593CFE4
GO

Sequence cautioni

The sequence AAZ51526.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK34054.1.
CP000017 Genomic DNA. Translation: AAZ51526.1. Different initiation.
RefSeqiNP_269333.1. NC_002737.1.
YP_282271.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK34054; AAK34054; SPy_1190.
AAZ51526; AAZ51526; M5005_Spy0908.
GeneIDi3572000.
901299.
KEGGispy:SPy_1190.
spz:M5005_Spy_0908.
PATRICi19715951. VBIStrPyo79812_1040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK34054.1.
CP000017 Genomic DNA. Translation: AAZ51526.1. Different initiation.
RefSeqiNP_269333.1. NC_002737.1.
YP_282271.1. NC_007297.1.

3D structure databases

ProteinModelPortaliP58160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi160490.SPy_1190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK34054; AAK34054; SPy_1190.
AAZ51526; AAZ51526; M5005_Spy0908.
GeneIDi3572000.
901299.
KEGGispy:SPy_1190.
spz:M5005_Spy_0908.
PATRICi19715951. VBIStrPyo79812_1040.

Phylogenomic databases

eggNOGiCOG3697.
HOGENOMiHOG000130710.
KOiK05964.
OMAiAFDIVIK.
OrthoDBiEOG6T7NCD.

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-986-MONOMER.
SPYO293653:GHFC-967-MONOMER.

Family and domain databases

HAMAPiMF_00398. CitX.
InterProiIPR005551. CitX.
[Graphical view]
PfamiPF03802. CitX. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03124. citrate_citX. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiCITX_STRP1
AccessioniPrimary (citable) accession number: P58160
Secondary accession number(s): Q48YP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.