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P58160

- CITX_STRP1

UniProt

P58160 - CITX_STRP1

Protein

Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase

Gene

citX

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein.By similarity

    Catalytic activityi

    2'-(5-triphosphoribosyl)-3'-dephospho-CoA + citrate lyase apo-[acyl-carrier-protein] = citrate lyase holo-[acyl-carrier-protein] + diphosphate.

    GO - Molecular functioni

    1. holo-citrate lyase synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. prosthetic group biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciSPYO160490:GJ81-986-MONOMER.
    SPYO293653:GHFC-967-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (EC:2.7.7.61)
    Alternative name(s):
    Apo-ACP nucleodityltransferase
    Holo-ACP synthase
    Holo-citrate lyase synthase
    Gene namesi
    Name:citX
    Ordered Locus Names:SPy_1190, M5005_Spy0908
    OrganismiStreptococcus pyogenes serotype M1
    Taxonomic identifieri301447 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 192192Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferasePRO_0000214688Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi160490.SPy_1190.

    Structurei

    3D structure databases

    ProteinModelPortaliP58160.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CitX family.Curated

    Phylogenomic databases

    eggNOGiCOG3697.
    HOGENOMiHOG000130710.
    KOiK05964.
    OMAiCENFYVL.
    OrthoDBiEOG6T7NCD.

    Family and domain databases

    HAMAPiMF_00398. CitX.
    InterProiIPR005551. CitX.
    [Graphical view]
    PfamiPF03802. CitX. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03124. citrate_citX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P58160-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCKDTYFSGE AIQLSDMLRA REERALRQLH LLKEYPEGSL LSVTMNIPGP    50
    IKTSPKLLEA FDIVIKAIQT ALADDKICYQ LRLLPTTGYE YYLITSLPSR 100
    DLKLKMIALE TELPIGRLMD LDVLVLQNDL PHSISRTVLG GSPRQCFICS 150
    KEAKVCGRLR KHSVEEMQTA ISKLLHSFFN KDNQSSSSDK TG 192
    Length:192
    Mass (Da):21,618
    Last modified:June 1, 2001 - v1
    Checksum:i5F315E4A2593CFE4
    GO

    Sequence cautioni

    The sequence AAZ51526.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK34054.1.
    CP000017 Genomic DNA. Translation: AAZ51526.1. Different initiation.
    RefSeqiNP_269333.1. NC_002737.1.
    YP_282271.1. NC_007297.1.

    Genome annotation databases

    EnsemblBacteriaiAAK34054; AAK34054; SPy_1190.
    AAZ51526; AAZ51526; M5005_Spy0908.
    GeneIDi3572000.
    901299.
    KEGGispy:SPy_1190.
    spz:M5005_Spy_0908.
    PATRICi19715951. VBIStrPyo79812_1040.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK34054.1 .
    CP000017 Genomic DNA. Translation: AAZ51526.1 . Different initiation.
    RefSeqi NP_269333.1. NC_002737.1.
    YP_282271.1. NC_007297.1.

    3D structure databases

    ProteinModelPortali P58160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160490.SPy_1190.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK34054 ; AAK34054 ; SPy_1190 .
    AAZ51526 ; AAZ51526 ; M5005_Spy0908 .
    GeneIDi 3572000.
    901299.
    KEGGi spy:SPy_1190.
    spz:M5005_Spy_0908.
    PATRICi 19715951. VBIStrPyo79812_1040.

    Phylogenomic databases

    eggNOGi COG3697.
    HOGENOMi HOG000130710.
    KOi K05964.
    OMAi CENFYVL.
    OrthoDBi EOG6T7NCD.

    Enzyme and pathway databases

    BioCyci SPYO160490:GJ81-986-MONOMER.
    SPYO293653:GHFC-967-MONOMER.

    Family and domain databases

    HAMAPi MF_00398. CitX.
    InterProi IPR005551. CitX.
    [Graphical view ]
    Pfami PF03802. CitX. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03124. citrate_citX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700294 / SF370 / Serotype M1.
    2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
      Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
      J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

    Entry informationi

    Entry nameiCITX_STRP1
    AccessioniPrimary (citable) accession number: P58160
    Secondary accession number(s): Q48YP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3