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P58107

- EPIPL_HUMAN

UniProt

P58107 - EPIPL_HUMAN

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Protein

Epiplakin

Gene

EPPK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Epiplakin
Alternative name(s):
450 kDa epidermal antigen
Gene namesi
Name:EPPK1
Synonyms:EPIPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:15577. EPPK1.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27835.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 50905090EpiplakinPRO_0000078145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1529 – 15291PhosphoserineBy similarity
Modified residuei2422 – 24221Phosphoserine1 Publication
Modified residuei2508 – 25081Phosphoserine2 Publications
Modified residuei2716 – 27161Phosphoserine3 Publications
Modified residuei2718 – 27181Phosphoserine1 Publication
Modified residuei2956 – 29561Phosphoserine1 Publication
Modified residuei3042 – 30421Phosphoserine2 Publications
Modified residuei3250 – 32501Phosphoserine3 Publications
Modified residuei3252 – 32521Phosphoserine1 Publication
Modified residuei3490 – 34901Phosphoserine1 Publication
Modified residuei3576 – 35761Phosphoserine2 Publications
Modified residuei3784 – 37841Phosphoserine3 Publications
Modified residuei3786 – 37861Phosphoserine1 Publication
Modified residuei4024 – 40241Phosphoserine1 Publication
Modified residuei4110 – 41101Phosphoserine2 Publications
Modified residuei4318 – 43181Phosphoserine3 Publications
Modified residuei4320 – 43201Phosphoserine1 Publication
Modified residuei4558 – 45581Phosphoserine1 Publication
Modified residuei4644 – 46441Phosphoserine2 Publications
Modified residuei4852 – 48521Phosphoserine3 Publications
Modified residuei4854 – 48541Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP58107.
PeptideAtlasiP58107.
PRIDEiP58107.

PTM databases

PhosphoSiteiP58107.

Expressioni

Tissue specificityi

Widely expressed with highest levels in liver, small intestine, colon, salivary glands, stomach and appendix.

Gene expression databases

CleanExiHS_EPPK1.
GenevestigatoriP58107.

Interactioni

Protein-protein interaction databases

BioGridi123666. 34 interactions.
IntActiP58107. 8 interactions.
MINTiMINT-4998630.

Structurei

3D structure databases

ProteinModelPortaliP58107.
SMRiP58107. Positions 43-232, 234-468, 559-798, 882-1165, 1198-1434, 1520-1759, 1849-2087, 2174-2417, 2775-2956, 3309-3490, 3843-4024, 4377-4558, 4911-5085.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati34 – 7138Plectin 1Add
BLAST
Repeati72 – 10938Plectin 2Add
BLAST
Repeati110 – 14738Plectin 3Add
BLAST
Repeati148 – 18538Plectin 4Add
BLAST
Repeati192 – 22534Plectin 5Add
BLAST
Repeati278 – 31538Plectin 6Add
BLAST
Repeati316 – 35338Plectin 7Add
BLAST
Repeati355 – 39137Plectin 8Add
BLAST
Repeati392 – 42938Plectin 9Add
BLAST
Repeati546 – 58338Plectin 10Add
BLAST
Repeati603 – 64038Plectin 11Add
BLAST
Repeati641 – 67838Plectin 12Add
BLAST
Repeati679 – 71638Plectin 13Add
BLAST
Repeati717 – 75438Plectin 14Add
BLAST
Repeati758 – 79235Plectin 15Add
BLAST
Repeati865 – 90339Plectin 16Add
BLAST
Repeati923 – 96038Plectin 17Add
BLAST
Repeati961 – 99838Plectin 18Add
BLAST
Repeati999 – 103638Plectin 19Add
BLAST
Repeati1037 – 107438Plectin 20Add
BLAST
Repeati1239 – 127638Plectin 21Add
BLAST
Repeati1277 – 131438Plectin 22Add
BLAST
Repeati1315 – 135238Plectin 23Add
BLAST
Repeati1353 – 139038Plectin 24Add
BLAST
Repeati1391 – 142838Plectin 25Add
BLAST
Repeati1564 – 160138Plectin 26Add
BLAST
Repeati1602 – 163938Plectin 27Add
BLAST
Repeati1640 – 167738Plectin 28Add
BLAST
Repeati1678 – 171538Plectin 29Add
BLAST
Repeati1719 – 175335Plectin 30Add
BLAST
Repeati1890 – 192738Plectin 31Add
BLAST
Repeati1928 – 196538Plectin 32Add
BLAST
Repeati1966 – 200338Plectin 33Add
BLAST
Repeati2004 – 204138Plectin 34Add
BLAST
Repeati2042 – 207938Plectin 35Add
BLAST
Repeati2217 – 225943Plectin 36Add
BLAST
Repeati2260 – 229738Plectin 37Add
BLAST
Repeati2298 – 233538Plectin 38Add
BLAST
Repeati2336 – 237338Plectin 39Add
BLAST
Repeati2377 – 241135Plectin 40Add
BLAST
Repeati2751 – 279343Plectin 41Add
BLAST
Repeati2794 – 283138Plectin 42Add
BLAST
Repeati2832 – 286938Plectin 43Add
BLAST
Repeati2870 – 290738Plectin 44Add
BLAST
Repeati2911 – 294535Plectin 45Add
BLAST
Repeati3285 – 332743Plectin 46Add
BLAST
Repeati3328 – 336538Plectin 47Add
BLAST
Repeati3366 – 340338Plectin 48Add
BLAST
Repeati3404 – 344138Plectin 49Add
BLAST
Repeati3445 – 347935Plectin 50Add
BLAST
Repeati3819 – 386143Plectin 51Add
BLAST
Repeati3862 – 389938Plectin 52Add
BLAST
Repeati3900 – 393738Plectin 53Add
BLAST
Repeati3938 – 397538Plectin 54Add
BLAST
Repeati3979 – 401335Plectin 55Add
BLAST
Repeati4353 – 439543Plectin 56Add
BLAST
Repeati4396 – 443338Plectin 57Add
BLAST
Repeati4434 – 447138Plectin 58Add
BLAST
Repeati4472 – 450938Plectin 59Add
BLAST
Repeati4513 – 454735Plectin 60Add
BLAST
Repeati4887 – 492943Plectin 61Add
BLAST
Repeati4930 – 496738Plectin 62Add
BLAST
Repeati4968 – 500538Plectin 63Add
BLAST
Repeati5006 – 504338Plectin 64Add
BLAST
Repeati5047 – 508135Plectin 65Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1960 – 197617Sequence AnalysisAdd
BLAST
Coiled coili2618 – 264932Sequence AnalysisAdd
BLAST
Coiled coili3152 – 318332Sequence AnalysisAdd
BLAST
Coiled coili3686 – 371732Sequence AnalysisAdd
BLAST
Coiled coili4220 – 425132Sequence AnalysisAdd
BLAST
Coiled coili4754 – 478532Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the plakin or cytolinker family.Curated
Contains 65 plectin repeats.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

HOVERGENiHBG051491.
InParanoidiP58107.

Family and domain databases

Gene3Di3.90.1290.10. 13 hits.
InterProiIPR001101. Plectin_repeat.
[Graphical view]
PfamiPF00681. Plectin. 30 hits.
[Graphical view]
SMARTiSM00250. PLEC. 65 hits.
[Graphical view]
SUPFAMiSSF75399. SSF75399. 13 hits.

Sequencei

Sequence statusi: Complete.

P58107-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSGHTLPPLP VPGTNSTEQA SVPRAMAATL GAGTPPRPQA RSIAGVYVEA
60 70 80 90 100
SGQAQSVYAA MEQGLLPAGL GQALLEAQAA TGGLVDLARG QLLPVSKALQ
110 120 130 140 150
QGLVGLELKE KLLAAERATT GYPDPYGGEK LALFQAIGKE VVDRALGQSW
160 170 180 190 200
LEVQLATGGL VDPAQGVLVA PEPACHQGLL DRETWHKLSE LEPGTGDLRF
210 220 230 240 250
LNPNTLERLT YHQLLERCVR APGSGLALLP LKITFRSMGG AVSAAELLEV
260 270 280 290 300
GILDEQAVQG LREGRLAAVD VSARAEVRRY LEGTGSVAGV VLLPEGHKKS
310 320 330 340 350
FFQAATEHLL PMGTALPLLE AQAATHTLVD PITGQRLWVD EAVRAGLVSP
360 370 380 390 400
ELHEQLLVAE QAVTGHHDPF SGSQIPLFQA MKKGLVDRPL ALRLLDAQLA
410 420 430 440 450
TGGLVCPARR LRLPLEAALR CGCLDEDTQR QLSQAGSFSD GTHGGLRYEQ
460 470 480 490 500
LLALCVTDPE TGLAFLPLSG GPRGGEPQGP PFIKYSTRQA LSTATATVSV
510 520 530 540 550
GKFRGRPVSL WELLFSEAIS SEQRAMLAQQ YQEGTLSVEK LAAELSATLE
560 570 580 590 600
QAAATARVTF SGLRDTVTPG ELLKAEIIDQ DLYERLEHGQ ATAKDVGSLA
610 620 630 640 650
SAQRYLQGTG CIAGLLLPGS QERLSIYEAR CKGLLRPGTA LILLEAQAAT
660 670 680 690 700
GFIIDPKANK GHSVEEALRA AVIGPDVFAK LLSAERAVTG YTDPYTGQQI
710 720 730 740 750
SLFQAMQKGL IVREHGIRLL EAQIATGGVI DPVHSHRVPV DVAYRRGYFD
760 770 780 790 800
QMLNLILLDP SDDTKGFFDP NTHENLTYLQ LLERCVRDPE TGLYLLPLSS
810 820 830 840 850
TQSPLVDSAT QQAFQNLLLS VKYGRFQGQR VSAWELINSE YFSEGRRRQL
860 870 880 890 900
LRRYRQREVT LGQVAKLLEA ETQRQADIML PALRSRVTVH QLLEAGIIDQ
910 920 930 940 950
QLLDQVLAGT ISPEALLLMD GVRRYLCGLG AVGGVRLLPS GQRLSLYQAM
960 970 980 990 1000
RQKLLGPRVA LALLEAQAAT GTIMDPHSPE SLSVDEAVRR GVVGPELYGR
1010 1020 1030 1040 1050
LKRAEGAIAG FRDPFSGKQV SVFQAMKKGL IPWEQAARLL EAQVATGGII
1060 1070 1080 1090 1100
DPTSHHHLPM PVAIQRGYVD QEMETALSSS SETFPTPDGQ GRTSYAQLLE
1110 1120 1130 1140 1150
ECPRDETSGL HLLPLPESAP ALPTEEQVQR SLQAVPGAKD GTSLWDLLSS
1160 1170 1180 1190 1200
CHFTEEQRRG LLEDVQEGRT TVPQLLASVQ RWVQETKLLA QARVMVPGPR
1210 1220 1230 1240 1250
GEVPAVWLLD AGIITQETLE ALAQGTQSPA QVAEQPAVKA CLWGTGCVAG
1260 1270 1280 1290 1300
VLLQPSGAKA SIAQAVRDGL LPTGLGQRLL EAQVASGFLV DPLNNQRLSV
1310 1320 1330 1340 1350
EDAVKVGLVG RELSEQLGQA ERAAAGYPDP YSRASLSLWQ AMEKGLVPQN
1360 1370 1380 1390 1400
EGLPLLQVQL ATGGVVDPVH GVHLPQAAAC RLGLLDTQTS QVLTAVDKDN
1410 1420 1430 1440 1450
KFFFDPSARD QVTYQQLRER CVCDSETGLL LLPLPSDTVL EVDDHTAVAL
1460 1470 1480 1490 1500
RAMKVPVSTG RFKGCSVSLW DLLLSEYVGA DKRRELVALC RSGRAAALRQ
1510 1520 1530 1540 1550
VVSAVTALVE AAERQPLQAT FRGLRKQVSA RDLFRAQLIS RKTLDELSQG
1560 1570 1580 1590 1600
TTTVKEVAEM DSVKRSLEGG NFIAGVLIQG TQERMSIPEA LRRHILRPGT
1610 1620 1630 1640 1650
ALVLLEAQAA TGFIIDPAEN RKLTVEEAFK AGMFGKETYV KLLSAERAVT
1660 1670 1680 1690 1700
GYTDPYTGQQ ISLFQAMQKD LIVREHGIRL LEAQIATGGI IDPVHSHRVP
1710 1720 1730 1740 1750
VDVAYRCGYF DEEMNRILAD PSDDTKGFFD PNTHENLTYL QLLERCVEDP
1760 1770 1780 1790 1800
ETGLYLLQII KKGENYVYIN EATRHVLQSR TAKMRVGRFA DQVVSFWDLL
1810 1820 1830 1840 1850
SSPYFTEDRK RELIQEYGAQ SGGLEKLLEI ITTTIEETET QNQGIKVAAI
1860 1870 1880 1890 1900
RGEVTAADLF NSRVIDQKTL HTLRVGRTGG QALSTLECVK PYLEGSDCIA
1910 1920 1930 1940 1950
GVTVPSTREV MSLHEASRKE LIPAAFATWL LEAQAATGFL LDPCTRQKLS
1960 1970 1980 1990 2000
VDEAVDVGLV NEELRERLLK AERAATGYRD PATGDTIPLF QAMQKQLIEK
2010 2020 2030 2040 2050
AEALRLLEVQ VATGGVIDPQ HHHRLPLETA YRRGCLHKDI YALISDQKHM
2060 2070 2080 2090 2100
RKRFVDPNTQ EKVSYRELQE RCRPQEDTGW VLFPVNKAAR DSEHIDDETR
2110 2120 2130 2140 2150
RALEAEQVEI TVGRFRGQKP TLWALLNSEY VTEEKKLQLV RMYRTHTRRA
2160 2170 2180 2190 2200
LQTVAQLILE LIEKQETSNK HLWFQGIRRQ ITASELLSSA IITEEMLQDL
2210 2220 2230 2240 2250
ETGRSTTQEL MEDDRVKRYL EGTSCIAGVL VPAKDQPGRQ EKMSIYQAMW
2260 2270 2280 2290 2300
KGVLRPGTAL VLLEAQAATG FVIDPVRNLR LSVEEPVPAG VVGSEIQEKL
2310 2320 2330 2340 2350
LSAERAVTGY TDPYTGQQIS LFQAMQKDLI VREHGIRLLE AQIATGGVID
2360 2370 2380 2390 2400
PVHSHRVPVD VAYRRGYFDE EMNRVLADPS DDTKGFFDPN THENLTYVQL
2410 2420 2430 2440 2450
LRRCVPDPDT GLYMLQLAGR GSAVHQLSEE LRCALRDARV TPGSGALQGQ
2460 2470 2480 2490 2500
SVSVWELLFY REVSEDRRQD LLSRYRAGTL TVEELGATLT SLLAQAQAQA
2510 2520 2530 2540 2550
RAEAEAGSPR PDPREALRAA TMEVKVGRLR GRAVPVWDVL ASGYVSRAAR
2560 2570 2580 2590 2600
EELLAEFGSG TLDLPALTRR LTAIIEEAEE APGARPQLQD ARRGPREPGP
2610 2620 2630 2640 2650
AGRGDGDSGR SQREGQGEGE TQEAAAAAAA ARRQEQTLRD ATMEVQRGQF
2660 2670 2680 2690 2700
QGRPVSVWDV LFSSYLSEAR RDELLAQHAA GALGLPDLVA VLTRVIEETE
2710 2720 2730 2740 2750
ERLSKVSFRG LRRQVSASEL HTSGILGPET LRDLAQGTKT LQEVTEMDSV
2760 2770 2780 2790 2800
KRYLEGTSCI AGVLVPAKDQ PGRQEKMSIY QAMWKGVLRP GTALVLLEAQ
2810 2820 2830 2840 2850
AATGFVIDPV RNLRLSVEEA VAAGVVGGEI QEKLLSAERA VTGYTDPYTG
2860 2870 2880 2890 2900
QQISLFQAMQ KDLIVREHGI RLLEAQIATG GVIDPVHSHR VPVDVAYRRG
2910 2920 2930 2940 2950
YFDEEMNRVL ADPSDDTKGF FDPNTHENLT YVQLLRRCVP DPDTGLYMLQ
2960 2970 2980 2990 3000
LAGRGSAVHQ LSEELRCALR DARVTPGSGA LQGQSVSVWE LLFYREVSED
3010 3020 3030 3040 3050
RRQDLLSRYR AGTLTVEELG ATLTSLLAQA QAQARAEAEA GSPRPDPREA
3060 3070 3080 3090 3100
LRAATMEVKV GRLRGRAVPV WDVLASGYVS GAAREELLAE FGSGTLDLPA
3110 3120 3130 3140 3150
LTRRLTAIIE EAEEAPGARP QLQDAWRGPR EPGPAGRGDG DSGRSQREGQ
3160 3170 3180 3190 3200
GEGETQEAAA AAAAARRQEQ TLRDATMEVQ RGQFQGRPVS VWDVLFSSYL
3210 3220 3230 3240 3250
SEARRDELLA QHAAGALGLP DLVAVLTRVI EETEERLSKV SFRGLRRQVS
3260 3270 3280 3290 3300
ASELHTSGIL GPETLRDLAQ GTKTLQEVTE MDSVKRYLEG TSCIAGVLVP
3310 3320 3330 3340 3350
AKDQPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFV IDPVRNLRLS
3360 3370 3380 3390 3400
VEEAVAAGVV GGEIQEKLLS AERAVTGYTD PYTGQQISLF QAMQKDLIVR
3410 3420 3430 3440 3450
EHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YRRGYFDEEM NRVLADPSDD
3460 3470 3480 3490 3500
TKGFFDPNTH ENLTYVQLLR RCVPDPDTGL YMLQLAGRGS AVHQLSEELR
3510 3520 3530 3540 3550
CALRDARVTP GSGALQGQSV SVWELLFYRE VSEDRRQDLL SRYRAGTLTV
3560 3570 3580 3590 3600
EELGATLTSL LAQAQAQARA EAEAGSPRPD PREALRAATM EVKVGRLRGR
3610 3620 3630 3640 3650
AVPVWDVLAS GYVSGAAREE LLAEFGSGTL DLPALTRRLT AIIEEAEEAP
3660 3670 3680 3690 3700
GARPQLQDAW RGPREPGPAG RGDGDSGRSQ REGQGEGETQ EAAAAAAAAR
3710 3720 3730 3740 3750
RQEQTLRDAT MEVQRGQFQG RPVSVWDVLF SSYLSEARRD ELLAQHAAGA
3760 3770 3780 3790 3800
LGLPDLVAVL TRVIEETEER LSKVSFRGLR RQVSASELHT SGILGPETLR
3810 3820 3830 3840 3850
DLAQGTKTLQ EVTEMDSVKR YLEGTSCIAG VLVPAKDQPG RQEKMSIYQA
3860 3870 3880 3890 3900
MWKGVLRPGT ALVLLEAQAA TGFVIDPVRN LRLSVEEAVA AGVVGGEIQE
3910 3920 3930 3940 3950
KLLSAERAVT GYTDPYTGQQ ISLFQAMQKD LIVREHGIRL LEAQIATGGV
3960 3970 3980 3990 4000
IDPVHSHRVP VDVAYRRGYF DEEMNRVLAD PSDDTKGFFD PNTHENLTYV
4010 4020 4030 4040 4050
QLLRRCVPDP DTGLYMLQLA GRGSAVHQLS EELRCALRDA RVTPGSGALQ
4060 4070 4080 4090 4100
GQSVSVWELL FYREVSEDRR QDLLSRYRAS TLTVEELGAT LTSLLAQAQA
4110 4120 4130 4140 4150
QARAEAEAGS PRPDPREALR AATMEVKVGR LRGRAVPVWD VLASGYVSRA
4160 4170 4180 4190 4200
AREELLAEFG SGTLDLPALT RRLTAIIEEA EEAPGARPQL QDAWRGPREP
4210 4220 4230 4240 4250
GPAGRGDGDS GRSQREGQGE GETQEAAAAT AAARRQEQTL RDATMEVQRG
4260 4270 4280 4290 4300
QFQGRPVSVW DVLFSSYLSE ARRDELLAQH AAGALGLPDL VAVLTRVIEE
4310 4320 4330 4340 4350
TEERLSKVSF RGLRRQVSAS ELHTSGILGP ETLRDLAQGT KTLQEVTEMD
4360 4370 4380 4390 4400
SVKRYLEGTS CIAGVLVPAK DQPGRQEKMS IYQAMWKGVL RPGTALVLLE
4410 4420 4430 4440 4450
AQAATGFVID PVRNLRLSVE EAVAAGVVGG EIQEKLLSAE RAVTGYTDPY
4460 4470 4480 4490 4500
TGQQISLFQA MQKDLIVREH GIRLLEAQIA TGGVIDPVHS HRVPVDVAYR
4510 4520 4530 4540 4550
RGYFDEEMNR VLADPSDDTK GFFDPNTHEN LTYVQLLRRC VPDPDTGLYM
4560 4570 4580 4590 4600
LQLAGRGSAV HQLSEELRCA LRDARVTPGS GALQGQSVSV WELLFYREVS
4610 4620 4630 4640 4650
EDRRQDLLSR YRAGTLTVEE LGATLTSLLA QAQAQARAEA EAGSPRPDPR
4660 4670 4680 4690 4700
EALRAATMEV KVGRLRGRAV PVWDVLASGY VSGAAREELL AEFGSGTLDL
4710 4720 4730 4740 4750
PALTRRLTAI IEEAEEAPGA RPQLQDAWRG PREPGPAGRG DGDSGRSQRE
4760 4770 4780 4790 4800
GQGEGETQEA AAAAAAARRQ EQTLRDATME VQRGQFQGRP VSVWDVLFSS
4810 4820 4830 4840 4850
YLSEARRDEL LAQHAAGALG LPDLVAVLTR VIEETEERLS KVSFRGLRRQ
4860 4870 4880 4890 4900
VSASELHTSG ILGPETLRDL AQGTKTLQEV TEMDSVKRYL EGTSCIAGVL
4910 4920 4930 4940 4950
VPAKDQPGRQ EKMSIYQAMW KGVLRPGTAL VLLEAQAATG FVIDPVRNLR
4960 4970 4980 4990 5000
LSVEEAVAAG VVGGEIQEKL LSAERAVTGY TDPYTGQQIS LFQAMQKDLI
5010 5020 5030 5040 5050
VREHGIRLLE AQIATGGVID PVHSHRVPVD VAYRRGYFDE EMNRVLADPS
5060 5070 5080 5090
DDTKGFFDPN THENLTYLQL LQRATLDPET GLLFLSLSLQ
Length:5,090
Mass (Da):555,621
Last modified:July 13, 2010 - v2
Checksum:i3A9A74F3C7E167F5
GO

Sequence cautioni

The sequence BAB40803.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC92750.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti202 – 2021N → D in BAC92750. (PubMed:14708632)Curated
Sequence conflicti544 – 5441E → K in BAC92750. (PubMed:14708632)Curated
Sequence conflicti602 – 6021A → V in BAC92750. (PubMed:14708632)Curated
Sequence conflicti1618 – 16181A → V in BAC92750. (PubMed:14708632)Curated
Sequence conflicti1897 – 18971D → G in BAC92750. (PubMed:14708632)Curated
Sequence conflicti2624 – 26263Missing in BAC92750. (PubMed:14708632)Curated
Sequence conflicti2713 – 27131R → C in BAC92750. (PubMed:14708632)Curated
Sequence conflicti2975 – 29751T → M in BAC92750. (PubMed:14708632)Curated
Sequence conflicti3162 – 31621A → T in BAC92750. (PubMed:14708632)Curated
Sequence conflicti3446 – 34461D → H in BAC92750. (PubMed:14708632)Curated
Sequence conflicti3696 – 36961A → T in BAC92750. (PubMed:14708632)Curated
Sequence conflicti3841 – 38411R → H in BAC92750. (PubMed:14708632)Curated
Sequence conflicti3980 – 39801D → H in BAC92750. (PubMed:14708632)Curated
Sequence conflicti4043 – 40431T → M in BAC92750. (PubMed:14708632)Curated
Sequence conflicti4080 – 40801S → G in BAC92750. (PubMed:14708632)Curated
Sequence conflicti4120 – 41201R → RPS in BAC92750. (PubMed:14708632)Curated
Sequence conflicti4149 – 41491R → G in BAC92750. (PubMed:14708632)Curated
Sequence conflicti4228 – 42303Missing in BAC92750. (PubMed:14708632)Curated
Sequence conflicti4760 – 47623Missing in CAB70895. (PubMed:17974005)Curated
Sequence conflicti4806 – 48061R → U in CAB70895. (PubMed:17974005)Curated
Sequence conflicti5068 – 50681L → V in BAC92750. (PubMed:14708632)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051895 mRNA. Translation: BAB40803.1. Different initiation.
AB107036 Genomic DNA. Translation: BAC92750.1. Different initiation.
AL137725 mRNA. Translation: CAB70895.1.
RefSeqiNP_112598.3. NM_031308.3.
UniGeneiHs.200412.
Hs.743673.

Genome annotation databases

GeneIDi83481.
KEGGihsa:83481.
UCSCiuc003zaa.1. human.

Polymorphism databases

DMDMi300669637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051895 mRNA. Translation: BAB40803.1 . Different initiation.
AB107036 Genomic DNA. Translation: BAC92750.1 . Different initiation.
AL137725 mRNA. Translation: CAB70895.1 .
RefSeqi NP_112598.3. NM_031308.3.
UniGenei Hs.200412.
Hs.743673.

3D structure databases

ProteinModelPortali P58107.
SMRi P58107. Positions 43-232, 234-468, 559-798, 882-1165, 1198-1434, 1520-1759, 1849-2087, 2174-2417, 2775-2956, 3309-3490, 3843-4024, 4377-4558, 4911-5085.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123666. 34 interactions.
IntActi P58107. 8 interactions.
MINTi MINT-4998630.

PTM databases

PhosphoSitei P58107.

Polymorphism databases

DMDMi 300669637.

Proteomic databases

MaxQBi P58107.
PeptideAtlasi P58107.
PRIDEi P58107.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 83481.
KEGGi hsa:83481.
UCSCi uc003zaa.1. human.

Organism-specific databases

CTDi 83481.
GeneCardsi GC08M144935.
HGNCi HGNC:15577. EPPK1.
MIMi 607553. gene.
neXtProti NX_P58107.
PharmGKBi PA27835.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG051491.
InParanoidi P58107.

Miscellaneous databases

GeneWikii Epiplakin_1.
NextBioi 72429.
PROi P58107.
SOURCEi Search...

Gene expression databases

CleanExi HS_EPPK1.
Genevestigatori P58107.

Family and domain databases

Gene3Di 3.90.1290.10. 13 hits.
InterProi IPR001101. Plectin_repeat.
[Graphical view ]
Pfami PF00681. Plectin. 30 hits.
[Graphical view ]
SMARTi SM00250. PLEC. 65 hits.
[Graphical view ]
SUPFAMi SSF75399. SSF75399. 13 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Epiplakin, a novel member of the plakin family originally identified as a 450-kDa human epidermal autoantigen: structure and tissue localization."
    Fujiwara S., Takeo N., Otani Y., Parry D.A.D., Kunimatsu M., Lu R., Sasaki M., Matsuo N., Khaleduzzaman M., Yoshioka H.
    J. Biol. Chem. 276:13340-13347(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cervix carcinoma.
  2. "Structure and heterogeneity of the human gene for epiplakin (EPPK1)."
    Takeo N., Wang W., Matsuo N., Sumiyoshi H., Yoshioka H., Fujiwara S.
    J. Invest. Dermatol. 121:1224-1226(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 266-274.
    Tissue: Platelet.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4713-5090.
    Tissue: Testis.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2508; SER-3042; SER-3576; SER-4110 AND SER-4644, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2716; SER-3250; SER-3784; SER-4318 AND SER-4852, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2422; SER-2508; SER-2716; SER-2956; SER-3042; SER-3250; SER-3490; SER-3576; SER-3784; SER-4024; SER-4110; SER-4318; SER-4558; SER-4644 AND SER-4852, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2716; SER-2718; SER-3250; SER-3252; SER-3784; SER-3786; SER-4318; SER-4320; SER-4852 AND SER-4854, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEPIPL_HUMAN
AccessioniPrimary (citable) accession number: P58107
Secondary accession number(s): Q76E58, Q9NSU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 13, 2010
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3