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Protein

Epiplakin

Gene

EPPK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed:15671067, PubMed:27206504, PubMed:23398049). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed:27206504, PubMed:23398049). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization (By similarity).By similarity3 Publications

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.Curated

GO - Molecular functioni

  • cytoskeletal protein binding Source: InterPro
  • intermediate filament binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • intermediate filament organization Source: UniProtKB
  • negative regulation of cell migration Source: UniProtKB
  • negative regulation of epithelial cell proliferation Source: UniProtKB
  • negative regulation of keratinocyte migration Source: UniProtKB
  • negative regulation of keratinocyte proliferation Source: UniProtKB
  • negative regulation of wound healing Source: UniProtKB
  • regulation of epithelium regeneration Source: UniProtKB
  • wound healing Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Epiplakin1 Publication
Alternative name(s):
450 kDa epidermal antigen
Gene namesi
Name:EPPK11 PublicationImported
Synonyms:EPIPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000261150.2
HGNCiHGNC:15577 EPPK1
MIMi607553 gene
neXtProtiNX_P58107

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi83481
OpenTargetsiENSG00000261150
PharmGKBiPA27835

Polymorphism and mutation databases

DMDMi300669637

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000781451 – 5088EpiplakinAdd BLAST5088

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphothreonineCombined sources1
Modified residuei1529PhosphoserineBy similarity1
Modified residuei1543PhosphothreonineCombined sources1
Modified residuei2282PhosphoserineBy similarity1
Modified residuei2422PhosphoserineCombined sources1
Modified residuei2508PhosphoserineCombined sources1
Modified residuei2718PhosphoserineCombined sources1
Modified residuei2818PhosphoserineBy similarity1
Modified residuei2958PhosphoserineCombined sources1
Modified residuei3044PhosphoserineCombined sources1
Modified residuei3249PhosphoserineCombined sources1
Modified residuei3349PhosphoserineBy similarity1
Modified residuei3489PhosphoserineCombined sources1
Modified residuei3575PhosphoserineCombined sources1
Modified residuei3783PhosphoserineCombined sources1
Modified residuei3883PhosphoserineBy similarity1
Modified residuei4023PhosphoserineCombined sources1
Modified residuei4109PhosphoserineCombined sources1
Modified residuei4317PhosphoserineCombined sources1
Modified residuei4417PhosphoserineBy similarity1
Modified residuei4557PhosphoserineCombined sources1
Modified residuei4645PhosphoserineCombined sources1
Modified residuei4850PhosphoserineCombined sources1
Modified residuei4950PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP58107
MaxQBiP58107
PaxDbiP58107
PeptideAtlasiP58107
PRIDEiP58107

PTM databases

iPTMnetiP58107
PhosphoSitePlusiP58107
SwissPalmiP58107

Expressioni

Tissue specificityi

Expressed in epithelial cells of liver, small intestine, colon, salivary glands, stomach and appendix.1 Publication

Inductioni

Up-regulated upon calcium-mediated keratinocyte differentiation.1 Publication

Gene expression databases

BgeeiENSG00000261150
CleanExiHS_EPPK1
ExpressionAtlasiA0A087X1U6 baseline and differential

Organism-specific databases

HPAiHPA066808
HPA067357
HPA069333

Interactioni

Subunit structurei

Interacts with KRT5, KRT14 and KRT5/KRT14 heterotetramer; interacts preferentially with assembled filaments rather than keratin monomers (PubMed:15671067). Interacts with KRT8 and KRT18 and KRT8/KRT18 heterotetramer; interacts preferentially with assembled filaments rather than keratin monomers (PubMed:15671067). Interacts with KRT1, VIM and DES; interaction is stronger with KRT1 than with VIM or DES; interaction is dependent of higher-order structure of intermediate filament (PubMed:16923132).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123666, 60 interactors
IntActiP58107, 39 interactors
MINTiP58107
STRINGi9606.ENSP00000436337

Structurei

3D structure databases

ProteinModelPortaliP58107
SMRiP58107
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 71Plectin 1Add BLAST38
Repeati72 – 109Plectin 2Add BLAST38
Repeati110 – 147Plectin 3Add BLAST38
Repeati148 – 185Plectin 4Add BLAST38
Repeati192 – 225Plectin 5Add BLAST34
Repeati278 – 315Plectin 6Add BLAST38
Repeati316 – 353Plectin 7Add BLAST38
Repeati355 – 391Plectin 8Add BLAST37
Repeati392 – 429Plectin 9Add BLAST38
Repeati546 – 583Plectin 10Add BLAST38
Repeati603 – 640Plectin 11Add BLAST38
Repeati641 – 678Plectin 12Add BLAST38
Repeati679 – 716Plectin 13Add BLAST38
Repeati717 – 754Plectin 14Add BLAST38
Repeati758 – 792Plectin 15Add BLAST35
Repeati865 – 903Plectin 16Add BLAST39
Repeati923 – 960Plectin 17Add BLAST38
Repeati961 – 998Plectin 18Add BLAST38
Repeati999 – 1036Plectin 19Add BLAST38
Repeati1037 – 1074Plectin 20Add BLAST38
Repeati1239 – 1276Plectin 21Add BLAST38
Repeati1277 – 1314Plectin 22Add BLAST38
Repeati1315 – 1352Plectin 23Add BLAST38
Repeati1353 – 1390Plectin 24Add BLAST38
Repeati1391 – 1428Plectin 25Add BLAST38
Repeati1564 – 1601Plectin 26Add BLAST38
Repeati1602 – 1639Plectin 27Add BLAST38
Repeati1640 – 1677Plectin 28Add BLAST38
Repeati1678 – 1715Plectin 29Add BLAST38
Repeati1719 – 1753Plectin 30Add BLAST35
Repeati1890 – 1927Plectin 31Add BLAST38
Repeati1928 – 1965Plectin 32Add BLAST38
Repeati1966 – 2003Plectin 33Add BLAST38
Repeati2004 – 2041Plectin 34Add BLAST38
Repeati2042 – 2079Plectin 35Add BLAST38
Repeati2217 – 2259Plectin 36Add BLAST43
Repeati2260 – 2297Plectin 37Add BLAST38
Repeati2298 – 2335Plectin 38Add BLAST38
Repeati2336 – 2373Plectin 39Add BLAST38
Repeati2377 – 2411Plectin 40Add BLAST35
Repeati2753 – 2795Plectin 41Add BLAST43
Repeati2796 – 2833Plectin 42Add BLAST38
Repeati2834 – 2871Plectin 43Add BLAST38
Repeati2872 – 2908Plectin 44Add BLAST37
Repeati2913 – 2947Plectin 45Add BLAST35
Repeati3284 – 3326Plectin 46Add BLAST43
Repeati3327 – 3364Plectin 47Add BLAST38
Repeati3365 – 3402Plectin 48Add BLAST38
Repeati3403 – 3440Plectin 49Add BLAST38
Repeati3444 – 3478Plectin 50Add BLAST35
Repeati3818 – 3860Plectin 51Add BLAST43
Repeati3861 – 3898Plectin 52Add BLAST38
Repeati3899 – 3936Plectin 53Add BLAST38
Repeati3937 – 3974Plectin 54Add BLAST38
Repeati3978 – 4012Plectin 55Add BLAST35
Repeati4352 – 4394Plectin 56Add BLAST43
Repeati4395 – 4432Plectin 57Add BLAST38
Repeati4433 – 4470Plectin 58Add BLAST38
Repeati4471 – 4508Plectin 59Add BLAST38
Repeati4512 – 4546Plectin 60Add BLAST35
Repeati4885 – 4927Plectin 61Add BLAST43
Repeati4928 – 4965Plectin 62Add BLAST38
Repeati4966 – 5003Plectin 63Add BLAST38
Repeati5004 – 5041Plectin 64Add BLAST38
Repeati5045 – 5079Plectin 65Add BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni42 – 1115Interaction with KRT5By similarityAdd BLAST1074
Regioni1572 – 5085Interaction with KRT5By similarityAdd BLAST3514
Regioni2761 – 2953Interaction with KRT14By similarityAdd BLAST193

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili3687 – 3714Sequence analysisAdd BLAST28
Coiled coili4221 – 4248Sequence analysisAdd BLAST28

Domaini

Plectin repeats are important for the binding to keratin and VIM and controls intermediate filament networks organization.2 Publications

Sequence similaritiesi

Belongs to the plakin or cytolinker family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0516 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000119163
HOVERGENiHBG051491
InParanoidiP58107
OMAiRAATMEV
OrthoDBiEOG091G00AR

Family and domain databases

Gene3Di3.90.1290.10, 13 hits
InterProiView protein in InterPro
IPR035915 Plakin_repeat_sf
IPR030269 Plectin
IPR001101 Plectin_repeat
PANTHERiPTHR44968:SF2 PTHR44968:SF2, 21 hits
PfamiView protein in Pfam
PF00681 Plectin, 36 hits
SMARTiView protein in SMART
SM00250 PLEC, 65 hits
SUPFAMiSSF75399 SSF75399, 13 hits

Sequencei

Sequence statusi: Complete.

P58107-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGHTLPPLP VPGTNSTEQA SVPRAMAATL GAGTPPRPQA RSIAGVYVEA
60 70 80 90 100
SGQAQSVYAA MEQGLLPAGL GQALLEAQAA TGGLVDLARG QLLPVSKALQ
110 120 130 140 150
QGLVGLELKE KLLAAERATT GYPDPYGGEK LALFQAIGKE VVDRALGQSW
160 170 180 190 200
LEVQLATGGL VDPAQGVLVA PEPACHQGLL DRETWHKLSE LEPGTGDLRF
210 220 230 240 250
LDPNTLERLT YHQLLERCVR APGSGLALLP LKITFRSMGG AVSAAELLEV
260 270 280 290 300
GILDEQAVQG LREGRLAAVD VSARAEVRRY LEGTGSVAGV VLLPEGHKKS
310 320 330 340 350
FFQAATEHLL PMGTALPLLE AQAATHTLVD PITGQRLWVD EAVRAGLVSP
360 370 380 390 400
ELHEQLLVAE QAVTGHHDPF SGSQIPLFQA MKKGLVDRPL ALRLLDAQLA
410 420 430 440 450
TGGLVCPARR LRLPLEAALR CGCLDEDTQR QLSQAGSFSD GTHGGLRYEQ
460 470 480 490 500
LLALCVTDPE TGLAFLPLSG GPRGGEPQGP PFIKYSTRQA LSTATATVSV
510 520 530 540 550
GKFRGRPVSL WELLFSEAIS SEQRAMLAQQ YQEGTLSVEK LAAKLSATLE
560 570 580 590 600
QAAATARVTF SGLRDTVTPG ELLKAEIIDQ DLYERLEHGQ ATAKDVGSLA
610 620 630 640 650
SVQRYLQGTG CIAGLLLPGS QERLSIYEAR CKGLLRPGTA LILLEAQAAT
660 670 680 690 700
GFIIDPKANK GHSVEEALRA AVIGPDVFAK LLSAERAVTG YTDPYTGQQI
710 720 730 740 750
SLFQAMQKGL IVREHGIRLL EAQIATGGVI DPVHSHRVPV DVAYRRGYFD
760 770 780 790 800
QMLNLILLDP SDDTKGFFDP NTHENLTYLQ LLERCVRDPE TGLYLLPLSS
810 820 830 840 850
TQSPLVDSAT QQAFQNLLLS VKYGRFQGQR VSAWELINSE YFSEGRRRQL
860 870 880 890 900
LRRYRQREVT LGQVAKLLEA ETQRQADIML PALRSRVTVH QLLEAGIIDQ
910 920 930 940 950
QLLDQVLAGT ISPEALLLMD GVRRYLCGLG AVGGVRLLPS GQRLSLYQAM
960 970 980 990 1000
RQKLLGPRVA LALLEAQAAT GTIMDPHSPE SLSVDEAVRR GVVGPELYGR
1010 1020 1030 1040 1050
LKRAEGAIAG FRDPFSGKQV SVFQAMKKGL IPWEQAARLL EAQVATGGII
1060 1070 1080 1090 1100
DPTSHHHLPM PVAIQRGYVD QEMETALSSS SETFPTPDGQ GRTSYAQLLE
1110 1120 1130 1140 1150
ECPRDETSGL HLLPLPESAP ALPTEEQVQR SLQAVPGAKD GTSLWDLLSS
1160 1170 1180 1190 1200
CHFTEEQRRG LLEDVQEGRT TVPQLLASVQ RWVQETKLLA QARVMVPGPR
1210 1220 1230 1240 1250
GEVPAVWLLD AGIITQETLE ALAQGTQSPA QVAEQPAVKA CLWGTGCVAG
1260 1270 1280 1290 1300
VLLQPSGAKA SIAQAVRDGL LPTGLGQRLL EAQVASGFLV DPLNNQRLSV
1310 1320 1330 1340 1350
EDAVKVGLVG RELSEQLGQA ERAAAGYPDP YSRASLSLWQ AMEKGLVPQN
1360 1370 1380 1390 1400
EGLPLLQVQL ATGGVVDPVH GVHLPQAAAC RLGLLDTQTS QVLTAVDKDN
1410 1420 1430 1440 1450
KFFFDPSARD QVTYQQLRER CVCDSETGLL LLPLPSDTVL EVDDHTAVAL
1460 1470 1480 1490 1500
RAMKVPVSTG RFKGCSVSLW DLLLSEYVGA DKRRELVALC RSGRAAALRQ
1510 1520 1530 1540 1550
VVSAVTTLVE AAERQPLQAT FRGLRKQVSA RDLFRAQLIS RKTLDELSQG
1560 1570 1580 1590 1600
TTTVKEVAEM DSVKRSLEGG NFIAGVLIQG TQERMSIPEA LRRHILRPGT
1610 1620 1630 1640 1650
ALVLLEAQAA TGFIIDPVEN RKLTVEEAFK AGMFGKETYV KLLSAERAVT
1660 1670 1680 1690 1700
GYTDPYTGQQ ISLFQAMQKD LIVREHGIRL LEAQIATGGI IDPVHSHRVP
1710 1720 1730 1740 1750
VDVAYRCGYF DEEMNRILAD PSDDTKGFFD PNTHENLTYL QLLERCVEDP
1760 1770 1780 1790 1800
ETGLYLLQII KKGENYVYIN EATRHVLQSR TAKMRVGRFA DQVVSFWDLL
1810 1820 1830 1840 1850
SSPYFTEDRK RELIQEYGAQ SGGLEKLLEI ITTTIEETET QNQGIKVAAI
1860 1870 1880 1890 1900
RGEVTAADLF NSRVIDQKTL HTLRVGRTGG QALSTLECVK PYLEGSGCIA
1910 1920 1930 1940 1950
GVTVPSTREV MSLHEASRKE LIPAAFATWL LEAQAATGFL LDPCTRQKLS
1960 1970 1980 1990 2000
VDEAVDVGLV NEELRERLLK AERAATGYRD PATGDTIPLF QAMQKQLIEK
2010 2020 2030 2040 2050
AEALRLLEVQ VATGGVIDPQ HHHRLPLETA YRRGCLHKDI YALISDQKHM
2060 2070 2080 2090 2100
RKRFVDPNTQ EKVSYRELQE RCRPQEDTGW LLFPVNKAAR DSEHIDDETR
2110 2120 2130 2140 2150
RALEAEQVEI TVGRFRGQKP TLWALLNSEY VTEEKKLQLV RMYRTHTRRA
2160 2170 2180 2190 2200
LQTVAQLILE LIEKQETSNK HLWFQGIRRQ ITASELLSSA IITEEMLQDL
2210 2220 2230 2240 2250
ETGRSTTQEL MEDDRVKRYL EGTSCIAGVL VPAKDQPGRQ EKMSIYQAMW
2260 2270 2280 2290 2300
KGVLRPGTAL VLLEAQAATG FVIDPVRNLR LSVEEAVAAG VVGGEIQEKL
2310 2320 2330 2340 2350
LSAERAVTGY TDPYTGQQIS LFQAMQKDLI VREHGIRLLE AQIATGGVID
2360 2370 2380 2390 2400
PVHSHRVPVD VAYRRGYFDE EMNRVLADPS DDTKGFFDPN THENLTYVQL
2410 2420 2430 2440 2450
LRRCVPDPDT GLYMLQLAGR GSAVHQLSEE LRCALRDARV TPGSGALQGQ
2460 2470 2480 2490 2500
SVSVWELLFY REVSEDRRQD LLSRYRAGTL TVEELGATLT SLLAQAQAQA
2510 2520 2530 2540 2550
RAEAEAGSPR PDPREALRAA TMEVKVGRLR GRAVPVWDVL ASGYVSRAAR
2560 2570 2580 2590 2600
EELLAEFGSG TLDLPALTRR LTAIIEEAEE APGARPQLQD AWRGPREPGP
2610 2620 2630 2640 2650
AGRGDGDSGR SQREGQGEGE TQEAAAAAAA AAARRQEQTL RDATMEVQRG
2660 2670 2680 2690 2700
QFQGRPVSVW DVLFSSYLSE ARRDELLAQH AAGALGLPDL VAVLTRVIEE
2710 2720 2730 2740 2750
TEERLSKVSF RGLRRQVSAS ELHTSGILGP ETLRDLAQGT KTLQEVTEMD
2760 2770 2780 2790 2800
SVKRYLEGTS CIAGVLVPAK DQPGRQEKMS IYQAMWKGVL RPGTALVLLE
2810 2820 2830 2840 2850
AQAATGFVID PVRNLRLSVE EAVAAGVVGG EIQEKLLSAE RAVTGYTDPY
2860 2870 2880 2890 2900
TGQQISLFQA MQKDLIVREH GIRLLEAQIA TGGVIDPVHS HRVPVDVAYQ
2910 2920 2930 2940 2950
RGYFDEEMNR VLADPSDDTK GFFDPNTHEN LTYVQLLRRC VPDPDTGLYM
2960 2970 2980 2990 3000
LQLAGRGSAV HQLSEELRCA LRDARVTPGS GALQGQSVSV WELLFYREVS
3010 3020 3030 3040 3050
EDRRQDLLSR YRAGTLTVEE LGATLTSLLA QAQAQARAEA EAGSPRPDPR
3060 3070 3080 3090 3100
EALRAATMEV KVGRLRGRAV PVWDVLASGY VSRAAREELL AEFGSGTLDL
3110 3120 3130 3140 3150
PALTRRLTAI IEEAEEAPGA RPQLQDAWRG PREPGPAGRG DGDSGRSQRE
3160 3170 3180 3190 3200
GQGEGETQEA AAAARRQEQT LRDATMEVQR GQFQGRPVSV WDVLFSSYLS
3210 3220 3230 3240 3250
EARRDELLAQ HAAGALGLPD LVAVLTRVIE ETEERLSKVS FRGLRCQVSA
3260 3270 3280 3290 3300
SELHTSGILG PETLRDLAQG TKTLQEVTEM DSVKRYLEGT SCIAGVLVPA
3310 3320 3330 3340 3350
KDQPGRQEKM SIYQAMWKGV LRPGTALVLL EAQAATGFVI DPVRNLRLSV
3360 3370 3380 3390 3400
EEAVAAGVVG GEIQEKLLSA ERAVTGYTDP YTGQQISLFQ AMQKDLIVRE
3410 3420 3430 3440 3450
HGIRLLEAQI ATGGVIDPVH SHRVPVDVAY RRGYFDEEMN RVLADPSDDT
3460 3470 3480 3490 3500
KGFFDPNTHE NLTYVQLLRR CVPDPDTGLY MLQLAGRGSA VHQLSEELRC
3510 3520 3530 3540 3550
ALRDARVTPG SGALQGQSVS VWELLFYREV SEDRRQDLLS RYRAGTLTVE
3560 3570 3580 3590 3600
ELGATLTSLL AQAQAQARAE AEAGSPRPDP REALRAATME VKVGRLRGRA
3610 3620 3630 3640 3650
VPVWDVLASG YVSRAAREEL LAEFGSGTLD LPALTRRLTA IIEEAEEAPG
3660 3670 3680 3690 3700
ARPQLQDAWR GPREPGPAGR GDGDSGRSQR EGQGEGETQE AAAATAAARR
3710 3720 3730 3740 3750
QEQTLRDATM EVQRGQFQGR PVSVWDVLFS SYLSEARRDE LLAQHAAGAL
3760 3770 3780 3790 3800
GLPDLVAVLT RVIEETEERL SKVSFRGLRR QVSASELHTS GILGPETLRD
3810 3820 3830 3840 3850
LAQGTKTLQE VTEMDSVKRY LEGTSCIAGV LVPAKDQPGR QEKMSIYQAM
3860 3870 3880 3890 3900
WKGVLRPGTA LVLLEAQAAT GFVIDPVRNL RLSVEEAVAA GVVGGEIQEK
3910 3920 3930 3940 3950
LLSAERAVTG YTDPYTGQQI SLFQAMQKDL IVREHGIRLL EAQIATGGVI
3960 3970 3980 3990 4000
DPVHSHRVPV DVAYRRGYFD EEMNRVLADP SDDTKGFFDP NTHENLTYVQ
4010 4020 4030 4040 4050
LLRRCVPDPD TGLYMLQLAG RGSAVHQLSE ELRCALRDAR VTPGSGALQG
4060 4070 4080 4090 4100
QSVSVWELLF YREVSEDRRQ DLLSRYRAGT LTVEELGATL TSLLAQAQAQ
4110 4120 4130 4140 4150
ARAEAEAGSP RPDPREALRA ATMEVKVGRL RGRAVPVWDV LASGYVSRAA
4160 4170 4180 4190 4200
REELLAEFGS GTLDLPALTR RLTAIIEEAE EAPGARPQLQ DAWRGPREPG
4210 4220 4230 4240 4250
PAGRGDGDSG RSQREGQGEG ETQEAAAATA AARRQEQTLR DATMEVQRGQ
4260 4270 4280 4290 4300
FQGRPVSVWD VLFSSYLSEA RRDELLAQHA AGALGLPDLV AVLTRVIEET
4310 4320 4330 4340 4350
EERLSKVSFR GLRRQVSASE LHTSGILGPE TLRDLAQGTK TLQEVTEMDS
4360 4370 4380 4390 4400
VKRYLEGTSC IAGVLVPAKD QPGHQEKMSI YQAMWKGVLR PGTALVLLEA
4410 4420 4430 4440 4450
QAATGFVIDP VRNLRLSVEE AVAAGVVGGE IQEKLLSAER AVTGYTDPYT
4460 4470 4480 4490 4500
GQQISLFQAM QKDLIVREHG IRLLEAQIAT GGVIDPVHSH RVPVDVAYRR
4510 4520 4530 4540 4550
GYFDEEMNRV LAHPSDDTKG FFDPNTHENL TYVQLLRRCV PDPDTGLYML
4560 4570 4580 4590 4600
QLAGRGSAVH QLSEELRCAL RDARVMPGSG ALQGQSVSVW ELLFYREVSE
4610 4620 4630 4640 4650
DRRQDLLSRY RAGTLTVEEL GATLTSLLAQ AQAQARAEAE AEAGSPRPDP
4660 4670 4680 4690 4700
REALRAATME VKVGRLRGRA VPVWDVLASG YVSGAAREEL LAEFGSGTLD
4710 4720 4730 4740 4750
LPALTRRLTA IIEEAEEAPG ARPQLQDAWR GPREPGPAGR GDGDSGRSQR
4760 4770 4780 4790 4800
EGQGEGETQE AAAAARRQEQ TLRDATMEVQ RGQFQGRPVS VWDVLFSSYL
4810 4820 4830 4840 4850
SEAHRDELLA QHAAGALGLP DLVAVLTRVI EETEERLSKV SFRGLRRQVS
4860 4870 4880 4890 4900
ASELHTSGIL GPETLRDLAQ GTKTLQEVTE MDSVKRYLEG TSCIAGVLVP
4910 4920 4930 4940 4950
AKDQPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFV IDPVRNLRLS
4960 4970 4980 4990 5000
VEEAVAAGVV GGEIQEKLLS AERAVTGYTD PYTGQQISLF QAMQKDLIVR
5010 5020 5030 5040 5050
EHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YRRGYFDEEM NRVLADPSDD
5060 5070 5080
TKGFFDPNTH ENLTYLQLLQ RATLDPETGL LFLSLSLQ
Length:5,088
Mass (Da):555,658
Last modified:March 28, 2018 - v3
Checksum:iED7799C641FA8FC5
GO

Sequence cautioni

The sequence BAB40803 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC92750 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202D → N in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti544K → E in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti602V → A in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti1507T → A in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti1507T → A in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti1618V → A in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti1897G → D in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti2081L → V in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti2081L → V in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti2286 – 2288AVA → PVP in BAB40803 (PubMed:11278896).Curated3
Sequence conflicti2286 – 2288AVA → PVP in BAC92750 (PubMed:14708632).Curated3
Sequence conflicti2294G → S in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti2294G → S in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti2592W → R in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti2592W → R in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti2624 – 2628Missing in BAC92750 (PubMed:14708632).5
Sequence conflicti2624 – 2625Missing in BAB40803 (PubMed:11278896).Curated2
Sequence conflicti2715R → C in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti2900Q → R in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti2900Q → R in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti2977T → M in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3083R → G in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti3083R → G in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3159E → EAAA in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti3161A → AAAT in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3246C → R in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti3246C → R in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3445D → H in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3614R → G in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti3614R → G in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3695T → A in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti3840R → H in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3979D → H in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4042T → M in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4079G → S in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti4119R → RPS in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4148R → G in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4227 – 4229Missing in BAC92750 (PubMed:14708632).Curated3
Sequence conflicti4374H → R in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti4374H → R in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4513H → D in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti4513H → D in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4576M → T in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti4576M → T in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4637 – 4638Missing in BAB40803 (PubMed:11278896).Curated2
Sequence conflicti4637 – 4638Missing in BAC92750 (PubMed:14708632).Curated2
Sequence conflicti4760E → EAAA in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti4760E → EAAA in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4804H → R in BAB40803 (PubMed:11278896).Curated1
Sequence conflicti4804H → R in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti5066L → V in BAC92750 (PubMed:14708632).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051895 mRNA Translation: BAB40803.1 Different initiation.
AB107036 Genomic DNA Translation: BAC92750.1 Different initiation.
AC109322 Genomic DNA No translation available.
AC234917 Genomic DNA No translation available.
AL137725 mRNA Translation: CAB70895.1
RefSeqiNP_112598.3, NM_031308.3
XP_016869379.1, XM_017013890.1
UniGeneiHs.200412
Hs.743673

Genome annotation databases

EnsembliENST00000615648; ENSP00000484472; ENSG00000261150
GeneIDi83481
KEGGihsa:83481

Similar proteinsi

Entry informationi

Entry nameiEPIPL_HUMAN
AccessioniPrimary (citable) accession number: P58107
Secondary accession number(s): A0A087X1U6, Q76E58, Q9NSU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 28, 2018
Last modified: April 25, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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