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P58107

- EPIPL_HUMAN

UniProt

P58107 - EPIPL_HUMAN

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Protein

Epiplakin

Gene
EPPK1, EPIPL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Epiplakin
Alternative name(s):
450 kDa epidermal antigen
Gene namesi
Name:EPPK1
Synonyms:EPIPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:15577. EPPK1.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27835.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 50905090EpiplakinPRO_0000078145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1529 – 15291Phosphoserine By similarity
Modified residuei2422 – 24221Phosphoserine1 Publication
Modified residuei2508 – 25081Phosphoserine2 Publications
Modified residuei2716 – 27161Phosphoserine3 Publications
Modified residuei2718 – 27181Phosphoserine1 Publication
Modified residuei2956 – 29561Phosphoserine1 Publication
Modified residuei3042 – 30421Phosphoserine2 Publications
Modified residuei3250 – 32501Phosphoserine3 Publications
Modified residuei3252 – 32521Phosphoserine1 Publication
Modified residuei3490 – 34901Phosphoserine1 Publication
Modified residuei3576 – 35761Phosphoserine2 Publications
Modified residuei3784 – 37841Phosphoserine3 Publications
Modified residuei3786 – 37861Phosphoserine1 Publication
Modified residuei4024 – 40241Phosphoserine1 Publication
Modified residuei4110 – 41101Phosphoserine2 Publications
Modified residuei4318 – 43181Phosphoserine3 Publications
Modified residuei4320 – 43201Phosphoserine1 Publication
Modified residuei4558 – 45581Phosphoserine1 Publication
Modified residuei4644 – 46441Phosphoserine2 Publications
Modified residuei4852 – 48521Phosphoserine3 Publications
Modified residuei4854 – 48541Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP58107.
PeptideAtlasiP58107.
PRIDEiP58107.

PTM databases

PhosphoSiteiP58107.

Expressioni

Tissue specificityi

Widely expressed with highest levels in liver, small intestine, colon, salivary glands, stomach and appendix.

Gene expression databases

CleanExiHS_EPPK1.
GenevestigatoriP58107.

Interactioni

Protein-protein interaction databases

BioGridi123666. 26 interactions.
IntActiP58107. 8 interactions.
MINTiMINT-4998630.

Structurei

3D structure databases

ProteinModelPortaliP58107.
SMRiP58107. Positions 43-232, 234-468, 559-798, 882-1165, 1198-1434, 1520-1759, 1849-2087, 2174-2417, 2775-2956, 3309-3490, 3843-4024, 4377-4558, 4911-5085.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati34 – 7138Plectin 1Add
BLAST
Repeati72 – 10938Plectin 2Add
BLAST
Repeati110 – 14738Plectin 3Add
BLAST
Repeati148 – 18538Plectin 4Add
BLAST
Repeati192 – 22534Plectin 5Add
BLAST
Repeati278 – 31538Plectin 6Add
BLAST
Repeati316 – 35338Plectin 7Add
BLAST
Repeati355 – 39137Plectin 8Add
BLAST
Repeati392 – 42938Plectin 9Add
BLAST
Repeati546 – 58338Plectin 10Add
BLAST
Repeati603 – 64038Plectin 11Add
BLAST
Repeati641 – 67838Plectin 12Add
BLAST
Repeati679 – 71638Plectin 13Add
BLAST
Repeati717 – 75438Plectin 14Add
BLAST
Repeati758 – 79235Plectin 15Add
BLAST
Repeati865 – 90339Plectin 16Add
BLAST
Repeati923 – 96038Plectin 17Add
BLAST
Repeati961 – 99838Plectin 18Add
BLAST
Repeati999 – 103638Plectin 19Add
BLAST
Repeati1037 – 107438Plectin 20Add
BLAST
Repeati1239 – 127638Plectin 21Add
BLAST
Repeati1277 – 131438Plectin 22Add
BLAST
Repeati1315 – 135238Plectin 23Add
BLAST
Repeati1353 – 139038Plectin 24Add
BLAST
Repeati1391 – 142838Plectin 25Add
BLAST
Repeati1564 – 160138Plectin 26Add
BLAST
Repeati1602 – 163938Plectin 27Add
BLAST
Repeati1640 – 167738Plectin 28Add
BLAST
Repeati1678 – 171538Plectin 29Add
BLAST
Repeati1719 – 175335Plectin 30Add
BLAST
Repeati1890 – 192738Plectin 31Add
BLAST
Repeati1928 – 196538Plectin 32Add
BLAST
Repeati1966 – 200338Plectin 33Add
BLAST
Repeati2004 – 204138Plectin 34Add
BLAST
Repeati2042 – 207938Plectin 35Add
BLAST
Repeati2217 – 225943Plectin 36Add
BLAST
Repeati2260 – 229738Plectin 37Add
BLAST
Repeati2298 – 233538Plectin 38Add
BLAST
Repeati2336 – 237338Plectin 39Add
BLAST
Repeati2377 – 241135Plectin 40Add
BLAST
Repeati2751 – 279343Plectin 41Add
BLAST
Repeati2794 – 283138Plectin 42Add
BLAST
Repeati2832 – 286938Plectin 43Add
BLAST
Repeati2870 – 290738Plectin 44Add
BLAST
Repeati2911 – 294535Plectin 45Add
BLAST
Repeati3285 – 332743Plectin 46Add
BLAST
Repeati3328 – 336538Plectin 47Add
BLAST
Repeati3366 – 340338Plectin 48Add
BLAST
Repeati3404 – 344138Plectin 49Add
BLAST
Repeati3445 – 347935Plectin 50Add
BLAST
Repeati3819 – 386143Plectin 51Add
BLAST
Repeati3862 – 389938Plectin 52Add
BLAST
Repeati3900 – 393738Plectin 53Add
BLAST
Repeati3938 – 397538Plectin 54Add
BLAST
Repeati3979 – 401335Plectin 55Add
BLAST
Repeati4353 – 439543Plectin 56Add
BLAST
Repeati4396 – 443338Plectin 57Add
BLAST
Repeati4434 – 447138Plectin 58Add
BLAST
Repeati4472 – 450938Plectin 59Add
BLAST
Repeati4513 – 454735Plectin 60Add
BLAST
Repeati4887 – 492943Plectin 61Add
BLAST
Repeati4930 – 496738Plectin 62Add
BLAST
Repeati4968 – 500538Plectin 63Add
BLAST
Repeati5006 – 504338Plectin 64Add
BLAST
Repeati5047 – 508135Plectin 65Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1960 – 197617 Reviewed predictionAdd
BLAST
Coiled coili2618 – 264932 Reviewed predictionAdd
BLAST
Coiled coili3152 – 318332 Reviewed predictionAdd
BLAST
Coiled coili3686 – 371732 Reviewed predictionAdd
BLAST
Coiled coili4220 – 425132 Reviewed predictionAdd
BLAST
Coiled coili4754 – 478532 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 65 plectin repeats.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

HOVERGENiHBG051491.

Family and domain databases

Gene3Di3.90.1290.10. 13 hits.
InterProiIPR001101. Plectin_repeat.
[Graphical view]
PfamiPF00681. Plectin. 30 hits.
[Graphical view]
SMARTiSM00250. PLEC. 65 hits.
[Graphical view]
SUPFAMiSSF75399. SSF75399. 13 hits.

Sequencei

Sequence statusi: Complete.

P58107-1 [UniParc]FASTAAdd to Basket

« Hide

MSGHTLPPLP VPGTNSTEQA SVPRAMAATL GAGTPPRPQA RSIAGVYVEA     50
SGQAQSVYAA MEQGLLPAGL GQALLEAQAA TGGLVDLARG QLLPVSKALQ 100
QGLVGLELKE KLLAAERATT GYPDPYGGEK LALFQAIGKE VVDRALGQSW 150
LEVQLATGGL VDPAQGVLVA PEPACHQGLL DRETWHKLSE LEPGTGDLRF 200
LNPNTLERLT YHQLLERCVR APGSGLALLP LKITFRSMGG AVSAAELLEV 250
GILDEQAVQG LREGRLAAVD VSARAEVRRY LEGTGSVAGV VLLPEGHKKS 300
FFQAATEHLL PMGTALPLLE AQAATHTLVD PITGQRLWVD EAVRAGLVSP 350
ELHEQLLVAE QAVTGHHDPF SGSQIPLFQA MKKGLVDRPL ALRLLDAQLA 400
TGGLVCPARR LRLPLEAALR CGCLDEDTQR QLSQAGSFSD GTHGGLRYEQ 450
LLALCVTDPE TGLAFLPLSG GPRGGEPQGP PFIKYSTRQA LSTATATVSV 500
GKFRGRPVSL WELLFSEAIS SEQRAMLAQQ YQEGTLSVEK LAAELSATLE 550
QAAATARVTF SGLRDTVTPG ELLKAEIIDQ DLYERLEHGQ ATAKDVGSLA 600
SAQRYLQGTG CIAGLLLPGS QERLSIYEAR CKGLLRPGTA LILLEAQAAT 650
GFIIDPKANK GHSVEEALRA AVIGPDVFAK LLSAERAVTG YTDPYTGQQI 700
SLFQAMQKGL IVREHGIRLL EAQIATGGVI DPVHSHRVPV DVAYRRGYFD 750
QMLNLILLDP SDDTKGFFDP NTHENLTYLQ LLERCVRDPE TGLYLLPLSS 800
TQSPLVDSAT QQAFQNLLLS VKYGRFQGQR VSAWELINSE YFSEGRRRQL 850
LRRYRQREVT LGQVAKLLEA ETQRQADIML PALRSRVTVH QLLEAGIIDQ 900
QLLDQVLAGT ISPEALLLMD GVRRYLCGLG AVGGVRLLPS GQRLSLYQAM 950
RQKLLGPRVA LALLEAQAAT GTIMDPHSPE SLSVDEAVRR GVVGPELYGR 1000
LKRAEGAIAG FRDPFSGKQV SVFQAMKKGL IPWEQAARLL EAQVATGGII 1050
DPTSHHHLPM PVAIQRGYVD QEMETALSSS SETFPTPDGQ GRTSYAQLLE 1100
ECPRDETSGL HLLPLPESAP ALPTEEQVQR SLQAVPGAKD GTSLWDLLSS 1150
CHFTEEQRRG LLEDVQEGRT TVPQLLASVQ RWVQETKLLA QARVMVPGPR 1200
GEVPAVWLLD AGIITQETLE ALAQGTQSPA QVAEQPAVKA CLWGTGCVAG 1250
VLLQPSGAKA SIAQAVRDGL LPTGLGQRLL EAQVASGFLV DPLNNQRLSV 1300
EDAVKVGLVG RELSEQLGQA ERAAAGYPDP YSRASLSLWQ AMEKGLVPQN 1350
EGLPLLQVQL ATGGVVDPVH GVHLPQAAAC RLGLLDTQTS QVLTAVDKDN 1400
KFFFDPSARD QVTYQQLRER CVCDSETGLL LLPLPSDTVL EVDDHTAVAL 1450
RAMKVPVSTG RFKGCSVSLW DLLLSEYVGA DKRRELVALC RSGRAAALRQ 1500
VVSAVTALVE AAERQPLQAT FRGLRKQVSA RDLFRAQLIS RKTLDELSQG 1550
TTTVKEVAEM DSVKRSLEGG NFIAGVLIQG TQERMSIPEA LRRHILRPGT 1600
ALVLLEAQAA TGFIIDPAEN RKLTVEEAFK AGMFGKETYV KLLSAERAVT 1650
GYTDPYTGQQ ISLFQAMQKD LIVREHGIRL LEAQIATGGI IDPVHSHRVP 1700
VDVAYRCGYF DEEMNRILAD PSDDTKGFFD PNTHENLTYL QLLERCVEDP 1750
ETGLYLLQII KKGENYVYIN EATRHVLQSR TAKMRVGRFA DQVVSFWDLL 1800
SSPYFTEDRK RELIQEYGAQ SGGLEKLLEI ITTTIEETET QNQGIKVAAI 1850
RGEVTAADLF NSRVIDQKTL HTLRVGRTGG QALSTLECVK PYLEGSDCIA 1900
GVTVPSTREV MSLHEASRKE LIPAAFATWL LEAQAATGFL LDPCTRQKLS 1950
VDEAVDVGLV NEELRERLLK AERAATGYRD PATGDTIPLF QAMQKQLIEK 2000
AEALRLLEVQ VATGGVIDPQ HHHRLPLETA YRRGCLHKDI YALISDQKHM 2050
RKRFVDPNTQ EKVSYRELQE RCRPQEDTGW VLFPVNKAAR DSEHIDDETR 2100
RALEAEQVEI TVGRFRGQKP TLWALLNSEY VTEEKKLQLV RMYRTHTRRA 2150
LQTVAQLILE LIEKQETSNK HLWFQGIRRQ ITASELLSSA IITEEMLQDL 2200
ETGRSTTQEL MEDDRVKRYL EGTSCIAGVL VPAKDQPGRQ EKMSIYQAMW 2250
KGVLRPGTAL VLLEAQAATG FVIDPVRNLR LSVEEPVPAG VVGSEIQEKL 2300
LSAERAVTGY TDPYTGQQIS LFQAMQKDLI VREHGIRLLE AQIATGGVID 2350
PVHSHRVPVD VAYRRGYFDE EMNRVLADPS DDTKGFFDPN THENLTYVQL 2400
LRRCVPDPDT GLYMLQLAGR GSAVHQLSEE LRCALRDARV TPGSGALQGQ 2450
SVSVWELLFY REVSEDRRQD LLSRYRAGTL TVEELGATLT SLLAQAQAQA 2500
RAEAEAGSPR PDPREALRAA TMEVKVGRLR GRAVPVWDVL ASGYVSRAAR 2550
EELLAEFGSG TLDLPALTRR LTAIIEEAEE APGARPQLQD ARRGPREPGP 2600
AGRGDGDSGR SQREGQGEGE TQEAAAAAAA ARRQEQTLRD ATMEVQRGQF 2650
QGRPVSVWDV LFSSYLSEAR RDELLAQHAA GALGLPDLVA VLTRVIEETE 2700
ERLSKVSFRG LRRQVSASEL HTSGILGPET LRDLAQGTKT LQEVTEMDSV 2750
KRYLEGTSCI AGVLVPAKDQ PGRQEKMSIY QAMWKGVLRP GTALVLLEAQ 2800
AATGFVIDPV RNLRLSVEEA VAAGVVGGEI QEKLLSAERA VTGYTDPYTG 2850
QQISLFQAMQ KDLIVREHGI RLLEAQIATG GVIDPVHSHR VPVDVAYRRG 2900
YFDEEMNRVL ADPSDDTKGF FDPNTHENLT YVQLLRRCVP DPDTGLYMLQ 2950
LAGRGSAVHQ LSEELRCALR DARVTPGSGA LQGQSVSVWE LLFYREVSED 3000
RRQDLLSRYR AGTLTVEELG ATLTSLLAQA QAQARAEAEA GSPRPDPREA 3050
LRAATMEVKV GRLRGRAVPV WDVLASGYVS GAAREELLAE FGSGTLDLPA 3100
LTRRLTAIIE EAEEAPGARP QLQDAWRGPR EPGPAGRGDG DSGRSQREGQ 3150
GEGETQEAAA AAAAARRQEQ TLRDATMEVQ RGQFQGRPVS VWDVLFSSYL 3200
SEARRDELLA QHAAGALGLP DLVAVLTRVI EETEERLSKV SFRGLRRQVS 3250
ASELHTSGIL GPETLRDLAQ GTKTLQEVTE MDSVKRYLEG TSCIAGVLVP 3300
AKDQPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFV IDPVRNLRLS 3350
VEEAVAAGVV GGEIQEKLLS AERAVTGYTD PYTGQQISLF QAMQKDLIVR 3400
EHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YRRGYFDEEM NRVLADPSDD 3450
TKGFFDPNTH ENLTYVQLLR RCVPDPDTGL YMLQLAGRGS AVHQLSEELR 3500
CALRDARVTP GSGALQGQSV SVWELLFYRE VSEDRRQDLL SRYRAGTLTV 3550
EELGATLTSL LAQAQAQARA EAEAGSPRPD PREALRAATM EVKVGRLRGR 3600
AVPVWDVLAS GYVSGAAREE LLAEFGSGTL DLPALTRRLT AIIEEAEEAP 3650
GARPQLQDAW RGPREPGPAG RGDGDSGRSQ REGQGEGETQ EAAAAAAAAR 3700
RQEQTLRDAT MEVQRGQFQG RPVSVWDVLF SSYLSEARRD ELLAQHAAGA 3750
LGLPDLVAVL TRVIEETEER LSKVSFRGLR RQVSASELHT SGILGPETLR 3800
DLAQGTKTLQ EVTEMDSVKR YLEGTSCIAG VLVPAKDQPG RQEKMSIYQA 3850
MWKGVLRPGT ALVLLEAQAA TGFVIDPVRN LRLSVEEAVA AGVVGGEIQE 3900
KLLSAERAVT GYTDPYTGQQ ISLFQAMQKD LIVREHGIRL LEAQIATGGV 3950
IDPVHSHRVP VDVAYRRGYF DEEMNRVLAD PSDDTKGFFD PNTHENLTYV 4000
QLLRRCVPDP DTGLYMLQLA GRGSAVHQLS EELRCALRDA RVTPGSGALQ 4050
GQSVSVWELL FYREVSEDRR QDLLSRYRAS TLTVEELGAT LTSLLAQAQA 4100
QARAEAEAGS PRPDPREALR AATMEVKVGR LRGRAVPVWD VLASGYVSRA 4150
AREELLAEFG SGTLDLPALT RRLTAIIEEA EEAPGARPQL QDAWRGPREP 4200
GPAGRGDGDS GRSQREGQGE GETQEAAAAT AAARRQEQTL RDATMEVQRG 4250
QFQGRPVSVW DVLFSSYLSE ARRDELLAQH AAGALGLPDL VAVLTRVIEE 4300
TEERLSKVSF RGLRRQVSAS ELHTSGILGP ETLRDLAQGT KTLQEVTEMD 4350
SVKRYLEGTS CIAGVLVPAK DQPGRQEKMS IYQAMWKGVL RPGTALVLLE 4400
AQAATGFVID PVRNLRLSVE EAVAAGVVGG EIQEKLLSAE RAVTGYTDPY 4450
TGQQISLFQA MQKDLIVREH GIRLLEAQIA TGGVIDPVHS HRVPVDVAYR 4500
RGYFDEEMNR VLADPSDDTK GFFDPNTHEN LTYVQLLRRC VPDPDTGLYM 4550
LQLAGRGSAV HQLSEELRCA LRDARVTPGS GALQGQSVSV WELLFYREVS 4600
EDRRQDLLSR YRAGTLTVEE LGATLTSLLA QAQAQARAEA EAGSPRPDPR 4650
EALRAATMEV KVGRLRGRAV PVWDVLASGY VSGAAREELL AEFGSGTLDL 4700
PALTRRLTAI IEEAEEAPGA RPQLQDAWRG PREPGPAGRG DGDSGRSQRE 4750
GQGEGETQEA AAAAAAARRQ EQTLRDATME VQRGQFQGRP VSVWDVLFSS 4800
YLSEARRDEL LAQHAAGALG LPDLVAVLTR VIEETEERLS KVSFRGLRRQ 4850
VSASELHTSG ILGPETLRDL AQGTKTLQEV TEMDSVKRYL EGTSCIAGVL 4900
VPAKDQPGRQ EKMSIYQAMW KGVLRPGTAL VLLEAQAATG FVIDPVRNLR 4950
LSVEEAVAAG VVGGEIQEKL LSAERAVTGY TDPYTGQQIS LFQAMQKDLI 5000
VREHGIRLLE AQIATGGVID PVHSHRVPVD VAYRRGYFDE EMNRVLADPS 5050
DDTKGFFDPN THENLTYLQL LQRATLDPET GLLFLSLSLQ 5090
Length:5,090
Mass (Da):555,621
Last modified:July 13, 2010 - v2
Checksum:i3A9A74F3C7E167F5
GO

Sequence cautioni

The sequence BAB40803.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC92750.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti202 – 2021N → D in BAC92750. 1 Publication
Sequence conflicti544 – 5441E → K in BAC92750. 1 Publication
Sequence conflicti602 – 6021A → V in BAC92750. 1 Publication
Sequence conflicti1618 – 16181A → V in BAC92750. 1 Publication
Sequence conflicti1897 – 18971D → G in BAC92750. 1 Publication
Sequence conflicti2624 – 26263Missing in BAC92750. 1 Publication
Sequence conflicti2713 – 27131R → C in BAC92750. 1 Publication
Sequence conflicti2975 – 29751T → M in BAC92750. 1 Publication
Sequence conflicti3162 – 31621A → T in BAC92750. 1 Publication
Sequence conflicti3446 – 34461D → H in BAC92750. 1 Publication
Sequence conflicti3696 – 36961A → T in BAC92750. 1 Publication
Sequence conflicti3841 – 38411R → H in BAC92750. 1 Publication
Sequence conflicti3980 – 39801D → H in BAC92750. 1 Publication
Sequence conflicti4043 – 40431T → M in BAC92750. 1 Publication
Sequence conflicti4080 – 40801S → G in BAC92750. 1 Publication
Sequence conflicti4120 – 41201R → RPS in BAC92750. 1 Publication
Sequence conflicti4149 – 41491R → G in BAC92750. 1 Publication
Sequence conflicti4228 – 42303Missing in BAC92750. 1 Publication
Sequence conflicti4760 – 47623Missing in CAB70895. 1 Publication
Sequence conflicti4806 – 48061R → U in CAB70895. 1 Publication
Sequence conflicti5068 – 50681L → V in BAC92750. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB051895 mRNA. Translation: BAB40803.1. Different initiation.
AB107036 Genomic DNA. Translation: BAC92750.1. Different initiation.
AL137725 mRNA. Translation: CAB70895.1.
RefSeqiNP_112598.3. NM_031308.3.
UniGeneiHs.200412.
Hs.743673.

Genome annotation databases

GeneIDi83481.
UCSCiuc003zaa.1. human.

Polymorphism databases

DMDMi300669637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB051895 mRNA. Translation: BAB40803.1 . Different initiation.
AB107036 Genomic DNA. Translation: BAC92750.1 . Different initiation.
AL137725 mRNA. Translation: CAB70895.1 .
RefSeqi NP_112598.3. NM_031308.3.
UniGenei Hs.200412.
Hs.743673.

3D structure databases

ProteinModelPortali P58107.
SMRi P58107. Positions 43-232, 234-468, 559-798, 882-1165, 1198-1434, 1520-1759, 1849-2087, 2174-2417, 2775-2956, 3309-3490, 3843-4024, 4377-4558, 4911-5085.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123666. 26 interactions.
IntActi P58107. 8 interactions.
MINTi MINT-4998630.

PTM databases

PhosphoSitei P58107.

Polymorphism databases

DMDMi 300669637.

Proteomic databases

MaxQBi P58107.
PeptideAtlasi P58107.
PRIDEi P58107.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 83481.
UCSCi uc003zaa.1. human.

Organism-specific databases

GeneCardsi GC08M144935.
HGNCi HGNC:15577. EPPK1.
MIMi 607553. gene.
neXtProti NX_P58107.
PharmGKBi PA27835.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG051491.

Miscellaneous databases

GeneWikii Epiplakin_1.
NextBioi 72429.
PROi P58107.
SOURCEi Search...

Gene expression databases

CleanExi HS_EPPK1.
Genevestigatori P58107.

Family and domain databases

Gene3Di 3.90.1290.10. 13 hits.
InterProi IPR001101. Plectin_repeat.
[Graphical view ]
Pfami PF00681. Plectin. 30 hits.
[Graphical view ]
SMARTi SM00250. PLEC. 65 hits.
[Graphical view ]
SUPFAMi SSF75399. SSF75399. 13 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Epiplakin, a novel member of the plakin family originally identified as a 450-kDa human epidermal autoantigen: structure and tissue localization."
    Fujiwara S., Takeo N., Otani Y., Parry D.A.D., Kunimatsu M., Lu R., Sasaki M., Matsuo N., Khaleduzzaman M., Yoshioka H.
    J. Biol. Chem. 276:13340-13347(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cervix carcinoma.
  2. "Structure and heterogeneity of the human gene for epiplakin (EPPK1)."
    Takeo N., Wang W., Matsuo N., Sumiyoshi H., Yoshioka H., Fujiwara S.
    J. Invest. Dermatol. 121:1224-1226(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 266-274.
    Tissue: Platelet.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4713-5090.
    Tissue: Testis.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2508; SER-3042; SER-3576; SER-4110 AND SER-4644, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2716; SER-3250; SER-3784; SER-4318 AND SER-4852, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2422; SER-2508; SER-2716; SER-2956; SER-3042; SER-3250; SER-3490; SER-3576; SER-3784; SER-4024; SER-4110; SER-4318; SER-4558; SER-4644 AND SER-4852, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2716; SER-2718; SER-3250; SER-3252; SER-3784; SER-3786; SER-4318; SER-4320; SER-4852 AND SER-4854, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEPIPL_HUMAN
AccessioniPrimary (citable) accession number: P58107
Secondary accession number(s): Q76E58, Q9NSU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 13, 2010
Last modified: September 3, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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