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P58107 (EPIPL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Epiplakin
Alternative name(s):
450 kDa epidermal antigen
Gene names
Name:EPPK1
Synonyms:EPIPL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length5090 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasmcytoskeleton By similarity.

Tissue specificity

Widely expressed with highest levels in liver, small intestine, colon, salivary glands, stomach and appendix.

Sequence similarities

Belongs to the plakin or cytolinker family.

Contains 65 plectin repeats.

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.

Sequence caution

The sequence BAB40803.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC92750.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   DomainCoiled coil
Repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 50905090Epiplakin
PRO_0000078145

Regions

Repeat34 – 7138Plectin 1
Repeat72 – 10938Plectin 2
Repeat110 – 14738Plectin 3
Repeat148 – 18538Plectin 4
Repeat192 – 22534Plectin 5
Repeat278 – 31538Plectin 6
Repeat316 – 35338Plectin 7
Repeat355 – 39137Plectin 8
Repeat392 – 42938Plectin 9
Repeat546 – 58338Plectin 10
Repeat603 – 64038Plectin 11
Repeat641 – 67838Plectin 12
Repeat679 – 71638Plectin 13
Repeat717 – 75438Plectin 14
Repeat758 – 79235Plectin 15
Repeat865 – 90339Plectin 16
Repeat923 – 96038Plectin 17
Repeat961 – 99838Plectin 18
Repeat999 – 103638Plectin 19
Repeat1037 – 107438Plectin 20
Repeat1239 – 127638Plectin 21
Repeat1277 – 131438Plectin 22
Repeat1315 – 135238Plectin 23
Repeat1353 – 139038Plectin 24
Repeat1391 – 142838Plectin 25
Repeat1564 – 160138Plectin 26
Repeat1602 – 163938Plectin 27
Repeat1640 – 167738Plectin 28
Repeat1678 – 171538Plectin 29
Repeat1719 – 175335Plectin 30
Repeat1890 – 192738Plectin 31
Repeat1928 – 196538Plectin 32
Repeat1966 – 200338Plectin 33
Repeat2004 – 204138Plectin 34
Repeat2042 – 207938Plectin 35
Repeat2217 – 225943Plectin 36
Repeat2260 – 229738Plectin 37
Repeat2298 – 233538Plectin 38
Repeat2336 – 237338Plectin 39
Repeat2377 – 241135Plectin 40
Repeat2751 – 279343Plectin 41
Repeat2794 – 283138Plectin 42
Repeat2832 – 286938Plectin 43
Repeat2870 – 290738Plectin 44
Repeat2911 – 294535Plectin 45
Repeat3285 – 332743Plectin 46
Repeat3328 – 336538Plectin 47
Repeat3366 – 340338Plectin 48
Repeat3404 – 344138Plectin 49
Repeat3445 – 347935Plectin 50
Repeat3819 – 386143Plectin 51
Repeat3862 – 389938Plectin 52
Repeat3900 – 393738Plectin 53
Repeat3938 – 397538Plectin 54
Repeat3979 – 401335Plectin 55
Repeat4353 – 439543Plectin 56
Repeat4396 – 443338Plectin 57
Repeat4434 – 447138Plectin 58
Repeat4472 – 450938Plectin 59
Repeat4513 – 454735Plectin 60
Repeat4887 – 492943Plectin 61
Repeat4930 – 496738Plectin 62
Repeat4968 – 500538Plectin 63
Repeat5006 – 504338Plectin 64
Repeat5047 – 508135Plectin 65
Coiled coil1960 – 197617 Potential
Coiled coil2618 – 264932 Potential
Coiled coil3152 – 318332 Potential
Coiled coil3686 – 371732 Potential
Coiled coil4220 – 425132 Potential
Coiled coil4754 – 478532 Potential

Amino acid modifications

Modified residue15291Phosphoserine By similarity
Modified residue24221Phosphoserine Ref.8
Modified residue25081Phosphoserine Ref.5 Ref.8
Modified residue27161Phosphoserine Ref.6 Ref.8 Ref.10
Modified residue27181Phosphoserine Ref.10
Modified residue29561Phosphoserine Ref.8
Modified residue30421Phosphoserine Ref.5 Ref.8
Modified residue32501Phosphoserine Ref.6 Ref.8 Ref.10
Modified residue32521Phosphoserine Ref.10
Modified residue34901Phosphoserine Ref.8
Modified residue35761Phosphoserine Ref.5 Ref.8
Modified residue37841Phosphoserine Ref.6 Ref.8 Ref.10
Modified residue37861Phosphoserine Ref.10
Modified residue40241Phosphoserine Ref.8
Modified residue41101Phosphoserine Ref.5 Ref.8
Modified residue43181Phosphoserine Ref.6 Ref.8 Ref.10
Modified residue43201Phosphoserine Ref.10
Modified residue45581Phosphoserine Ref.8
Modified residue46441Phosphoserine Ref.5 Ref.8
Modified residue48521Phosphoserine Ref.6 Ref.8 Ref.10
Modified residue48541Phosphoserine Ref.10

Experimental info

Sequence conflict2021N → D in BAC92750. Ref.2
Sequence conflict5441E → K in BAC92750. Ref.2
Sequence conflict6021A → V in BAC92750. Ref.2
Sequence conflict16181A → V in BAC92750. Ref.2
Sequence conflict18971D → G in BAC92750. Ref.2
Sequence conflict2624 – 26263Missing in BAC92750. Ref.2
Sequence conflict27131R → C in BAC92750. Ref.2
Sequence conflict29751T → M in BAC92750. Ref.2
Sequence conflict31621A → T in BAC92750. Ref.2
Sequence conflict34461D → H in BAC92750. Ref.2
Sequence conflict36961A → T in BAC92750. Ref.2
Sequence conflict38411R → H in BAC92750. Ref.2
Sequence conflict39801D → H in BAC92750. Ref.2
Sequence conflict40431T → M in BAC92750. Ref.2
Sequence conflict40801S → G in BAC92750. Ref.2
Sequence conflict41201R → RPS in BAC92750. Ref.2
Sequence conflict41491R → G in BAC92750. Ref.2
Sequence conflict4228 – 42303Missing in BAC92750. Ref.2
Sequence conflict4760 – 47623Missing in CAB70895. Ref.4
Sequence conflict48061R → U in CAB70895. Ref.4
Sequence conflict50681L → V in BAC92750. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P58107 [UniParc].

Last modified July 13, 2010. Version 2.
Checksum: 3A9A74F3C7E167F5

FASTA5,090555,621
        10         20         30         40         50         60 
MSGHTLPPLP VPGTNSTEQA SVPRAMAATL GAGTPPRPQA RSIAGVYVEA SGQAQSVYAA 

        70         80         90        100        110        120 
MEQGLLPAGL GQALLEAQAA TGGLVDLARG QLLPVSKALQ QGLVGLELKE KLLAAERATT 

       130        140        150        160        170        180 
GYPDPYGGEK LALFQAIGKE VVDRALGQSW LEVQLATGGL VDPAQGVLVA PEPACHQGLL 

       190        200        210        220        230        240 
DRETWHKLSE LEPGTGDLRF LNPNTLERLT YHQLLERCVR APGSGLALLP LKITFRSMGG 

       250        260        270        280        290        300 
AVSAAELLEV GILDEQAVQG LREGRLAAVD VSARAEVRRY LEGTGSVAGV VLLPEGHKKS 

       310        320        330        340        350        360 
FFQAATEHLL PMGTALPLLE AQAATHTLVD PITGQRLWVD EAVRAGLVSP ELHEQLLVAE 

       370        380        390        400        410        420 
QAVTGHHDPF SGSQIPLFQA MKKGLVDRPL ALRLLDAQLA TGGLVCPARR LRLPLEAALR 

       430        440        450        460        470        480 
CGCLDEDTQR QLSQAGSFSD GTHGGLRYEQ LLALCVTDPE TGLAFLPLSG GPRGGEPQGP 

       490        500        510        520        530        540 
PFIKYSTRQA LSTATATVSV GKFRGRPVSL WELLFSEAIS SEQRAMLAQQ YQEGTLSVEK 

       550        560        570        580        590        600 
LAAELSATLE QAAATARVTF SGLRDTVTPG ELLKAEIIDQ DLYERLEHGQ ATAKDVGSLA 

       610        620        630        640        650        660 
SAQRYLQGTG CIAGLLLPGS QERLSIYEAR CKGLLRPGTA LILLEAQAAT GFIIDPKANK 

       670        680        690        700        710        720 
GHSVEEALRA AVIGPDVFAK LLSAERAVTG YTDPYTGQQI SLFQAMQKGL IVREHGIRLL 

       730        740        750        760        770        780 
EAQIATGGVI DPVHSHRVPV DVAYRRGYFD QMLNLILLDP SDDTKGFFDP NTHENLTYLQ 

       790        800        810        820        830        840 
LLERCVRDPE TGLYLLPLSS TQSPLVDSAT QQAFQNLLLS VKYGRFQGQR VSAWELINSE 

       850        860        870        880        890        900 
YFSEGRRRQL LRRYRQREVT LGQVAKLLEA ETQRQADIML PALRSRVTVH QLLEAGIIDQ 

       910        920        930        940        950        960 
QLLDQVLAGT ISPEALLLMD GVRRYLCGLG AVGGVRLLPS GQRLSLYQAM RQKLLGPRVA 

       970        980        990       1000       1010       1020 
LALLEAQAAT GTIMDPHSPE SLSVDEAVRR GVVGPELYGR LKRAEGAIAG FRDPFSGKQV 

      1030       1040       1050       1060       1070       1080 
SVFQAMKKGL IPWEQAARLL EAQVATGGII DPTSHHHLPM PVAIQRGYVD QEMETALSSS 

      1090       1100       1110       1120       1130       1140 
SETFPTPDGQ GRTSYAQLLE ECPRDETSGL HLLPLPESAP ALPTEEQVQR SLQAVPGAKD 

      1150       1160       1170       1180       1190       1200 
GTSLWDLLSS CHFTEEQRRG LLEDVQEGRT TVPQLLASVQ RWVQETKLLA QARVMVPGPR 

      1210       1220       1230       1240       1250       1260 
GEVPAVWLLD AGIITQETLE ALAQGTQSPA QVAEQPAVKA CLWGTGCVAG VLLQPSGAKA 

      1270       1280       1290       1300       1310       1320 
SIAQAVRDGL LPTGLGQRLL EAQVASGFLV DPLNNQRLSV EDAVKVGLVG RELSEQLGQA 

      1330       1340       1350       1360       1370       1380 
ERAAAGYPDP YSRASLSLWQ AMEKGLVPQN EGLPLLQVQL ATGGVVDPVH GVHLPQAAAC 

      1390       1400       1410       1420       1430       1440 
RLGLLDTQTS QVLTAVDKDN KFFFDPSARD QVTYQQLRER CVCDSETGLL LLPLPSDTVL 

      1450       1460       1470       1480       1490       1500 
EVDDHTAVAL RAMKVPVSTG RFKGCSVSLW DLLLSEYVGA DKRRELVALC RSGRAAALRQ 

      1510       1520       1530       1540       1550       1560 
VVSAVTALVE AAERQPLQAT FRGLRKQVSA RDLFRAQLIS RKTLDELSQG TTTVKEVAEM 

      1570       1580       1590       1600       1610       1620 
DSVKRSLEGG NFIAGVLIQG TQERMSIPEA LRRHILRPGT ALVLLEAQAA TGFIIDPAEN 

      1630       1640       1650       1660       1670       1680 
RKLTVEEAFK AGMFGKETYV KLLSAERAVT GYTDPYTGQQ ISLFQAMQKD LIVREHGIRL 

      1690       1700       1710       1720       1730       1740 
LEAQIATGGI IDPVHSHRVP VDVAYRCGYF DEEMNRILAD PSDDTKGFFD PNTHENLTYL 

      1750       1760       1770       1780       1790       1800 
QLLERCVEDP ETGLYLLQII KKGENYVYIN EATRHVLQSR TAKMRVGRFA DQVVSFWDLL 

      1810       1820       1830       1840       1850       1860 
SSPYFTEDRK RELIQEYGAQ SGGLEKLLEI ITTTIEETET QNQGIKVAAI RGEVTAADLF 

      1870       1880       1890       1900       1910       1920 
NSRVIDQKTL HTLRVGRTGG QALSTLECVK PYLEGSDCIA GVTVPSTREV MSLHEASRKE 

      1930       1940       1950       1960       1970       1980 
LIPAAFATWL LEAQAATGFL LDPCTRQKLS VDEAVDVGLV NEELRERLLK AERAATGYRD 

      1990       2000       2010       2020       2030       2040 
PATGDTIPLF QAMQKQLIEK AEALRLLEVQ VATGGVIDPQ HHHRLPLETA YRRGCLHKDI 

      2050       2060       2070       2080       2090       2100 
YALISDQKHM RKRFVDPNTQ EKVSYRELQE RCRPQEDTGW VLFPVNKAAR DSEHIDDETR 

      2110       2120       2130       2140       2150       2160 
RALEAEQVEI TVGRFRGQKP TLWALLNSEY VTEEKKLQLV RMYRTHTRRA LQTVAQLILE 

      2170       2180       2190       2200       2210       2220 
LIEKQETSNK HLWFQGIRRQ ITASELLSSA IITEEMLQDL ETGRSTTQEL MEDDRVKRYL 

      2230       2240       2250       2260       2270       2280 
EGTSCIAGVL VPAKDQPGRQ EKMSIYQAMW KGVLRPGTAL VLLEAQAATG FVIDPVRNLR 

      2290       2300       2310       2320       2330       2340 
LSVEEPVPAG VVGSEIQEKL LSAERAVTGY TDPYTGQQIS LFQAMQKDLI VREHGIRLLE 

      2350       2360       2370       2380       2390       2400 
AQIATGGVID PVHSHRVPVD VAYRRGYFDE EMNRVLADPS DDTKGFFDPN THENLTYVQL 

      2410       2420       2430       2440       2450       2460 
LRRCVPDPDT GLYMLQLAGR GSAVHQLSEE LRCALRDARV TPGSGALQGQ SVSVWELLFY 

      2470       2480       2490       2500       2510       2520 
REVSEDRRQD LLSRYRAGTL TVEELGATLT SLLAQAQAQA RAEAEAGSPR PDPREALRAA 

      2530       2540       2550       2560       2570       2580 
TMEVKVGRLR GRAVPVWDVL ASGYVSRAAR EELLAEFGSG TLDLPALTRR LTAIIEEAEE 

      2590       2600       2610       2620       2630       2640 
APGARPQLQD ARRGPREPGP AGRGDGDSGR SQREGQGEGE TQEAAAAAAA ARRQEQTLRD 

      2650       2660       2670       2680       2690       2700 
ATMEVQRGQF QGRPVSVWDV LFSSYLSEAR RDELLAQHAA GALGLPDLVA VLTRVIEETE 

      2710       2720       2730       2740       2750       2760 
ERLSKVSFRG LRRQVSASEL HTSGILGPET LRDLAQGTKT LQEVTEMDSV KRYLEGTSCI 

      2770       2780       2790       2800       2810       2820 
AGVLVPAKDQ PGRQEKMSIY QAMWKGVLRP GTALVLLEAQ AATGFVIDPV RNLRLSVEEA 

      2830       2840       2850       2860       2870       2880 
VAAGVVGGEI QEKLLSAERA VTGYTDPYTG QQISLFQAMQ KDLIVREHGI RLLEAQIATG 

      2890       2900       2910       2920       2930       2940 
GVIDPVHSHR VPVDVAYRRG YFDEEMNRVL ADPSDDTKGF FDPNTHENLT YVQLLRRCVP 

      2950       2960       2970       2980       2990       3000 
DPDTGLYMLQ LAGRGSAVHQ LSEELRCALR DARVTPGSGA LQGQSVSVWE LLFYREVSED 

      3010       3020       3030       3040       3050       3060 
RRQDLLSRYR AGTLTVEELG ATLTSLLAQA QAQARAEAEA GSPRPDPREA LRAATMEVKV 

      3070       3080       3090       3100       3110       3120 
GRLRGRAVPV WDVLASGYVS GAAREELLAE FGSGTLDLPA LTRRLTAIIE EAEEAPGARP 

      3130       3140       3150       3160       3170       3180 
QLQDAWRGPR EPGPAGRGDG DSGRSQREGQ GEGETQEAAA AAAAARRQEQ TLRDATMEVQ 

      3190       3200       3210       3220       3230       3240 
RGQFQGRPVS VWDVLFSSYL SEARRDELLA QHAAGALGLP DLVAVLTRVI EETEERLSKV 

      3250       3260       3270       3280       3290       3300 
SFRGLRRQVS ASELHTSGIL GPETLRDLAQ GTKTLQEVTE MDSVKRYLEG TSCIAGVLVP 

      3310       3320       3330       3340       3350       3360 
AKDQPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFV IDPVRNLRLS VEEAVAAGVV 

      3370       3380       3390       3400       3410       3420 
GGEIQEKLLS AERAVTGYTD PYTGQQISLF QAMQKDLIVR EHGIRLLEAQ IATGGVIDPV 

      3430       3440       3450       3460       3470       3480 
HSHRVPVDVA YRRGYFDEEM NRVLADPSDD TKGFFDPNTH ENLTYVQLLR RCVPDPDTGL 

      3490       3500       3510       3520       3530       3540 
YMLQLAGRGS AVHQLSEELR CALRDARVTP GSGALQGQSV SVWELLFYRE VSEDRRQDLL 

      3550       3560       3570       3580       3590       3600 
SRYRAGTLTV EELGATLTSL LAQAQAQARA EAEAGSPRPD PREALRAATM EVKVGRLRGR 

      3610       3620       3630       3640       3650       3660 
AVPVWDVLAS GYVSGAAREE LLAEFGSGTL DLPALTRRLT AIIEEAEEAP GARPQLQDAW 

      3670       3680       3690       3700       3710       3720 
RGPREPGPAG RGDGDSGRSQ REGQGEGETQ EAAAAAAAAR RQEQTLRDAT MEVQRGQFQG 

      3730       3740       3750       3760       3770       3780 
RPVSVWDVLF SSYLSEARRD ELLAQHAAGA LGLPDLVAVL TRVIEETEER LSKVSFRGLR 

      3790       3800       3810       3820       3830       3840 
RQVSASELHT SGILGPETLR DLAQGTKTLQ EVTEMDSVKR YLEGTSCIAG VLVPAKDQPG 

      3850       3860       3870       3880       3890       3900 
RQEKMSIYQA MWKGVLRPGT ALVLLEAQAA TGFVIDPVRN LRLSVEEAVA AGVVGGEIQE 

      3910       3920       3930       3940       3950       3960 
KLLSAERAVT GYTDPYTGQQ ISLFQAMQKD LIVREHGIRL LEAQIATGGV IDPVHSHRVP 

      3970       3980       3990       4000       4010       4020 
VDVAYRRGYF DEEMNRVLAD PSDDTKGFFD PNTHENLTYV QLLRRCVPDP DTGLYMLQLA 

      4030       4040       4050       4060       4070       4080 
GRGSAVHQLS EELRCALRDA RVTPGSGALQ GQSVSVWELL FYREVSEDRR QDLLSRYRAS 

      4090       4100       4110       4120       4130       4140 
TLTVEELGAT LTSLLAQAQA QARAEAEAGS PRPDPREALR AATMEVKVGR LRGRAVPVWD 

      4150       4160       4170       4180       4190       4200 
VLASGYVSRA AREELLAEFG SGTLDLPALT RRLTAIIEEA EEAPGARPQL QDAWRGPREP 

      4210       4220       4230       4240       4250       4260 
GPAGRGDGDS GRSQREGQGE GETQEAAAAT AAARRQEQTL RDATMEVQRG QFQGRPVSVW 

      4270       4280       4290       4300       4310       4320 
DVLFSSYLSE ARRDELLAQH AAGALGLPDL VAVLTRVIEE TEERLSKVSF RGLRRQVSAS 

      4330       4340       4350       4360       4370       4380 
ELHTSGILGP ETLRDLAQGT KTLQEVTEMD SVKRYLEGTS CIAGVLVPAK DQPGRQEKMS 

      4390       4400       4410       4420       4430       4440 
IYQAMWKGVL RPGTALVLLE AQAATGFVID PVRNLRLSVE EAVAAGVVGG EIQEKLLSAE 

      4450       4460       4470       4480       4490       4500 
RAVTGYTDPY TGQQISLFQA MQKDLIVREH GIRLLEAQIA TGGVIDPVHS HRVPVDVAYR 

      4510       4520       4530       4540       4550       4560 
RGYFDEEMNR VLADPSDDTK GFFDPNTHEN LTYVQLLRRC VPDPDTGLYM LQLAGRGSAV 

      4570       4580       4590       4600       4610       4620 
HQLSEELRCA LRDARVTPGS GALQGQSVSV WELLFYREVS EDRRQDLLSR YRAGTLTVEE 

      4630       4640       4650       4660       4670       4680 
LGATLTSLLA QAQAQARAEA EAGSPRPDPR EALRAATMEV KVGRLRGRAV PVWDVLASGY 

      4690       4700       4710       4720       4730       4740 
VSGAAREELL AEFGSGTLDL PALTRRLTAI IEEAEEAPGA RPQLQDAWRG PREPGPAGRG 

      4750       4760       4770       4780       4790       4800 
DGDSGRSQRE GQGEGETQEA AAAAAAARRQ EQTLRDATME VQRGQFQGRP VSVWDVLFSS 

      4810       4820       4830       4840       4850       4860 
YLSEARRDEL LAQHAAGALG LPDLVAVLTR VIEETEERLS KVSFRGLRRQ VSASELHTSG 

      4870       4880       4890       4900       4910       4920 
ILGPETLRDL AQGTKTLQEV TEMDSVKRYL EGTSCIAGVL VPAKDQPGRQ EKMSIYQAMW 

      4930       4940       4950       4960       4970       4980 
KGVLRPGTAL VLLEAQAATG FVIDPVRNLR LSVEEAVAAG VVGGEIQEKL LSAERAVTGY 

      4990       5000       5010       5020       5030       5040 
TDPYTGQQIS LFQAMQKDLI VREHGIRLLE AQIATGGVID PVHSHRVPVD VAYRRGYFDE 

      5050       5060       5070       5080       5090 
EMNRVLADPS DDTKGFFDPN THENLTYLQL LQRATLDPET GLLFLSLSLQ 

« Hide

References

« Hide 'large scale' references
[1]"Epiplakin, a novel member of the plakin family originally identified as a 450-kDa human epidermal autoantigen: structure and tissue localization."
Fujiwara S., Takeo N., Otani Y., Parry D.A.D., Kunimatsu M., Lu R., Sasaki M., Matsuo N., Khaleduzzaman M., Yoshioka H.
J. Biol. Chem. 276:13340-13347(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Cervix carcinoma.
[2]"Structure and heterogeneity of the human gene for epiplakin (EPPK1)."
Takeo N., Wang W., Matsuo N., Sumiyoshi H., Yoshioka H., Fujiwara S.
J. Invest. Dermatol. 121:1224-1226(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 266-274.
Tissue: Platelet.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4713-5090.
Tissue: Testis.
[5]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2508; SER-3042; SER-3576; SER-4110 AND SER-4644, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2716; SER-3250; SER-3784; SER-4318 AND SER-4852, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2422; SER-2508; SER-2716; SER-2956; SER-3042; SER-3250; SER-3490; SER-3576; SER-3784; SER-4024; SER-4110; SER-4318; SER-4558; SER-4644 AND SER-4852, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2716; SER-2718; SER-3250; SER-3252; SER-3784; SER-3786; SER-4318; SER-4320; SER-4852 AND SER-4854, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB051895 mRNA. Translation: BAB40803.1. Different initiation.
AB107036 Genomic DNA. Translation: BAC92750.1. Different initiation.
AL137725 mRNA. Translation: CAB70895.1.
RefSeqNP_112598.3. NM_031308.3.
UniGeneHs.200412.
Hs.743673.

3D structure databases

ProteinModelPortalP58107.
SMRP58107. Positions 43-232, 234-468, 559-798, 882-1165, 1198-1434, 1520-1759, 1849-2087, 2174-2417, 2775-2956, 3309-3490, 3843-4024, 4377-4558, 4911-5085.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123666. 25 interactions.
IntActP58107. 8 interactions.
MINTMINT-4998630.

PTM databases

PhosphoSiteP58107.

Polymorphism databases

DMDM300669637.

Proteomic databases

MaxQBP58107.
PeptideAtlasP58107.
PRIDEP58107.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID83481.
KEGGhsa:83481.
UCSCuc003zaa.1. human.

Organism-specific databases

CTD83481.
GeneCardsGC08M144935.
HGNCHGNC:15577. EPPK1.
MIM607553. gene.
neXtProtNX_P58107.
PharmGKBPA27835.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG051491.

Gene expression databases

CleanExHS_EPPK1.
GenevestigatorP58107.

Family and domain databases

Gene3D3.90.1290.10. 13 hits.
InterProIPR001101. Plectin_repeat.
[Graphical view]
PfamPF00681. Plectin. 30 hits.
[Graphical view]
SMARTSM00250. PLEC. 65 hits.
[Graphical view]
SUPFAMSSF75399. SSF75399. 13 hits.
ProtoNetSearch...

Other

NextBio72429.
PROP58107.
SOURCESearch...

Entry information

Entry nameEPIPL_HUMAN
AccessionPrimary (citable) accession number: P58107
Secondary accession number(s): Q76E58, Q9NSU9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 13, 2010
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM