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Protein

Epiplakin

Gene

EPPK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed:15671067, PubMed:27206504, PubMed:23398049). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed:27206504, PubMed:23398049). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization (By similarity).By similarity3 Publications

GO - Molecular functioni

  • intermediate filament binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • intermediate filament organization Source: UniProtKB
  • negative regulation of cell migration Source: UniProtKB
  • negative regulation of epithelial cell proliferation Source: UniProtKB
  • negative regulation of keratinocyte migration Source: UniProtKB
  • negative regulation of keratinocyte proliferation Source: UniProtKB
  • negative regulation of wound healing Source: UniProtKB
  • regulation of epithelium regeneration Source: UniProtKB
  • wound healing Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31434-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Epiplakin1 Publication
Alternative name(s):
450 kDa epidermal antigen
Gene namesi
Name:EPPK11 PublicationImported
Synonyms:EPIPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:15577. EPPK1.

Subcellular locationi

GO - Cellular componenti

  • bicellular tight junction Source: UniProtKB
  • cell periphery Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB
  • hemidesmosome Source: UniProtKB
  • keratin filament Source: UniProtKB
  • perinucleolar compartment Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi83481.
PharmGKBiPA27835.

Polymorphism and mutation databases

DMDMi300669637.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000781451 – 5090EpiplakinAdd BLAST5090

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphothreonineCombined sources1
Modified residuei1529PhosphoserineBy similarity1
Modified residuei1543PhosphothreonineCombined sources1
Modified residuei2282PhosphoserineBy similarity1
Modified residuei2422PhosphoserineCombined sources1
Modified residuei2508PhosphoserineCombined sources1
Modified residuei2716PhosphoserineCombined sources1
Modified residuei2816PhosphoserineBy similarity1
Modified residuei2956PhosphoserineCombined sources1
Modified residuei3042PhosphoserineCombined sources1
Modified residuei3250PhosphoserineCombined sources1
Modified residuei3350PhosphoserineBy similarity1
Modified residuei3490PhosphoserineCombined sources1
Modified residuei3576PhosphoserineCombined sources1
Modified residuei3784PhosphoserineCombined sources1
Modified residuei3884PhosphoserineBy similarity1
Modified residuei4024PhosphoserineCombined sources1
Modified residuei4110PhosphoserineCombined sources1
Modified residuei4318PhosphoserineCombined sources1
Modified residuei4418PhosphoserineBy similarity1
Modified residuei4558PhosphoserineCombined sources1
Modified residuei4644PhosphoserineCombined sources1
Modified residuei4852PhosphoserineCombined sources1
Modified residuei4952PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP58107.
MaxQBiP58107.
PaxDbiP58107.
PeptideAtlasiP58107.
PRIDEiP58107.

PTM databases

iPTMnetiP58107.
PhosphoSitePlusiP58107.
SwissPalmiP58107.

Expressioni

Tissue specificityi

Expressed in epithelial cells of liver, small intestine, colon, salivary glands, stomach and appendix.1 Publication

Inductioni

Up-regulated upon calcium-mediated keratinocyte differentiation.1 Publication

Gene expression databases

BgeeiENSG00000261150.
CleanExiHS_EPPK1.

Organism-specific databases

HPAiHPA069333.

Interactioni

Subunit structurei

Interacts with KRT5, KRT14 and KRT5/KRT14 heterotetramer; interacts preferentially with assembled filaments rather than keratin monomers (PubMed:15671067). Interacts with KRT8 and KRT18 and KRT8/KRT18 heterotetramer; interacts preferentially with assembled filaments rather than keratin monomers (PubMed:15671067). Interacts with KRT1, VIM and DES; interaction is stronger with KRT1 than with VIM or DES; interaction is dependent of higher-order structure of intermediate filament (PubMed:16923132).2 Publications

GO - Molecular functioni

  • intermediate filament binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123666. 53 interactors.
IntActiP58107. 17 interactors.
MINTiMINT-4998630.
STRINGi9606.ENSP00000436337.

Structurei

3D structure databases

ProteinModelPortaliP58107.
SMRiP58107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 71Plectin 1Add BLAST38
Repeati72 – 109Plectin 2Add BLAST38
Repeati110 – 147Plectin 3Add BLAST38
Repeati148 – 185Plectin 4Add BLAST38
Repeati192 – 225Plectin 5Add BLAST34
Repeati278 – 315Plectin 6Add BLAST38
Repeati316 – 353Plectin 7Add BLAST38
Repeati355 – 391Plectin 8Add BLAST37
Repeati392 – 429Plectin 9Add BLAST38
Repeati546 – 583Plectin 10Add BLAST38
Repeati603 – 640Plectin 11Add BLAST38
Repeati641 – 678Plectin 12Add BLAST38
Repeati679 – 716Plectin 13Add BLAST38
Repeati717 – 754Plectin 14Add BLAST38
Repeati758 – 792Plectin 15Add BLAST35
Repeati865 – 903Plectin 16Add BLAST39
Repeati923 – 960Plectin 17Add BLAST38
Repeati961 – 998Plectin 18Add BLAST38
Repeati999 – 1036Plectin 19Add BLAST38
Repeati1037 – 1074Plectin 20Add BLAST38
Repeati1239 – 1276Plectin 21Add BLAST38
Repeati1277 – 1314Plectin 22Add BLAST38
Repeati1315 – 1352Plectin 23Add BLAST38
Repeati1353 – 1390Plectin 24Add BLAST38
Repeati1391 – 1428Plectin 25Add BLAST38
Repeati1564 – 1601Plectin 26Add BLAST38
Repeati1602 – 1639Plectin 27Add BLAST38
Repeati1640 – 1677Plectin 28Add BLAST38
Repeati1678 – 1715Plectin 29Add BLAST38
Repeati1719 – 1753Plectin 30Add BLAST35
Repeati1890 – 1927Plectin 31Add BLAST38
Repeati1928 – 1965Plectin 32Add BLAST38
Repeati1966 – 2003Plectin 33Add BLAST38
Repeati2004 – 2041Plectin 34Add BLAST38
Repeati2042 – 2079Plectin 35Add BLAST38
Repeati2217 – 2259Plectin 36Add BLAST43
Repeati2260 – 2297Plectin 37Add BLAST38
Repeati2298 – 2335Plectin 38Add BLAST38
Repeati2336 – 2373Plectin 39Add BLAST38
Repeati2377 – 2411Plectin 40Add BLAST35
Repeati2751 – 2793Plectin 41Add BLAST43
Repeati2794 – 2831Plectin 42Add BLAST38
Repeati2832 – 2869Plectin 43Add BLAST38
Repeati2870 – 2907Plectin 44Add BLAST38
Repeati2911 – 2945Plectin 45Add BLAST35
Repeati3285 – 3327Plectin 46Add BLAST43
Repeati3328 – 3365Plectin 47Add BLAST38
Repeati3366 – 3403Plectin 48Add BLAST38
Repeati3404 – 3441Plectin 49Add BLAST38
Repeati3445 – 3479Plectin 50Add BLAST35
Repeati3819 – 3861Plectin 51Add BLAST43
Repeati3862 – 3899Plectin 52Add BLAST38
Repeati3900 – 3937Plectin 53Add BLAST38
Repeati3938 – 3975Plectin 54Add BLAST38
Repeati3979 – 4013Plectin 55Add BLAST35
Repeati4353 – 4395Plectin 56Add BLAST43
Repeati4396 – 4433Plectin 57Add BLAST38
Repeati4434 – 4471Plectin 58Add BLAST38
Repeati4472 – 4509Plectin 59Add BLAST38
Repeati4513 – 4547Plectin 60Add BLAST35
Repeati4887 – 4929Plectin 61Add BLAST43
Repeati4930 – 4967Plectin 62Add BLAST38
Repeati4968 – 5005Plectin 63Add BLAST38
Repeati5006 – 5043Plectin 64Add BLAST38
Repeati5047 – 5081Plectin 65Add BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni42 – 1115Interaction with KRT5By similarityAdd BLAST1074
Regioni1572 – 5087Interaction with KRT5By similarityAdd BLAST3516
Regioni2759 – 2951Interaction with KRT14By similarityAdd BLAST193

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1960 – 1976Sequence analysisAdd BLAST17
Coiled coili2618 – 2649Sequence analysisAdd BLAST32
Coiled coili3152 – 3183Sequence analysisAdd BLAST32
Coiled coili3686 – 3717Sequence analysisAdd BLAST32
Coiled coili4220 – 4251Sequence analysisAdd BLAST32
Coiled coili4754 – 4785Sequence analysisAdd BLAST32

Domaini

Plectin repeats are important for the binding to keratin and VIM and controls intermediate filament networks organization.2 Publications

Sequence similaritiesi

Belongs to the plakin or cytolinker family.Curated
Contains 65 plectin repeats.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0516. Eukaryota.
COG5069. LUCA.
HOVERGENiHBG051491.
InParanoidiP58107.

Family and domain databases

Gene3Di3.90.1290.10. 13 hits.
InterProiIPR001101. Plectin_repeat.
[Graphical view]
PfamiPF00681. Plectin. 36 hits.
[Graphical view]
SMARTiSM00250. PLEC. 65 hits.
[Graphical view]
SUPFAMiSSF75399. SSF75399. 13 hits.

Sequencei

Sequence statusi: Complete.

P58107-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGHTLPPLP VPGTNSTEQA SVPRAMAATL GAGTPPRPQA RSIAGVYVEA
60 70 80 90 100
SGQAQSVYAA MEQGLLPAGL GQALLEAQAA TGGLVDLARG QLLPVSKALQ
110 120 130 140 150
QGLVGLELKE KLLAAERATT GYPDPYGGEK LALFQAIGKE VVDRALGQSW
160 170 180 190 200
LEVQLATGGL VDPAQGVLVA PEPACHQGLL DRETWHKLSE LEPGTGDLRF
210 220 230 240 250
LNPNTLERLT YHQLLERCVR APGSGLALLP LKITFRSMGG AVSAAELLEV
260 270 280 290 300
GILDEQAVQG LREGRLAAVD VSARAEVRRY LEGTGSVAGV VLLPEGHKKS
310 320 330 340 350
FFQAATEHLL PMGTALPLLE AQAATHTLVD PITGQRLWVD EAVRAGLVSP
360 370 380 390 400
ELHEQLLVAE QAVTGHHDPF SGSQIPLFQA MKKGLVDRPL ALRLLDAQLA
410 420 430 440 450
TGGLVCPARR LRLPLEAALR CGCLDEDTQR QLSQAGSFSD GTHGGLRYEQ
460 470 480 490 500
LLALCVTDPE TGLAFLPLSG GPRGGEPQGP PFIKYSTRQA LSTATATVSV
510 520 530 540 550
GKFRGRPVSL WELLFSEAIS SEQRAMLAQQ YQEGTLSVEK LAAELSATLE
560 570 580 590 600
QAAATARVTF SGLRDTVTPG ELLKAEIIDQ DLYERLEHGQ ATAKDVGSLA
610 620 630 640 650
SAQRYLQGTG CIAGLLLPGS QERLSIYEAR CKGLLRPGTA LILLEAQAAT
660 670 680 690 700
GFIIDPKANK GHSVEEALRA AVIGPDVFAK LLSAERAVTG YTDPYTGQQI
710 720 730 740 750
SLFQAMQKGL IVREHGIRLL EAQIATGGVI DPVHSHRVPV DVAYRRGYFD
760 770 780 790 800
QMLNLILLDP SDDTKGFFDP NTHENLTYLQ LLERCVRDPE TGLYLLPLSS
810 820 830 840 850
TQSPLVDSAT QQAFQNLLLS VKYGRFQGQR VSAWELINSE YFSEGRRRQL
860 870 880 890 900
LRRYRQREVT LGQVAKLLEA ETQRQADIML PALRSRVTVH QLLEAGIIDQ
910 920 930 940 950
QLLDQVLAGT ISPEALLLMD GVRRYLCGLG AVGGVRLLPS GQRLSLYQAM
960 970 980 990 1000
RQKLLGPRVA LALLEAQAAT GTIMDPHSPE SLSVDEAVRR GVVGPELYGR
1010 1020 1030 1040 1050
LKRAEGAIAG FRDPFSGKQV SVFQAMKKGL IPWEQAARLL EAQVATGGII
1060 1070 1080 1090 1100
DPTSHHHLPM PVAIQRGYVD QEMETALSSS SETFPTPDGQ GRTSYAQLLE
1110 1120 1130 1140 1150
ECPRDETSGL HLLPLPESAP ALPTEEQVQR SLQAVPGAKD GTSLWDLLSS
1160 1170 1180 1190 1200
CHFTEEQRRG LLEDVQEGRT TVPQLLASVQ RWVQETKLLA QARVMVPGPR
1210 1220 1230 1240 1250
GEVPAVWLLD AGIITQETLE ALAQGTQSPA QVAEQPAVKA CLWGTGCVAG
1260 1270 1280 1290 1300
VLLQPSGAKA SIAQAVRDGL LPTGLGQRLL EAQVASGFLV DPLNNQRLSV
1310 1320 1330 1340 1350
EDAVKVGLVG RELSEQLGQA ERAAAGYPDP YSRASLSLWQ AMEKGLVPQN
1360 1370 1380 1390 1400
EGLPLLQVQL ATGGVVDPVH GVHLPQAAAC RLGLLDTQTS QVLTAVDKDN
1410 1420 1430 1440 1450
KFFFDPSARD QVTYQQLRER CVCDSETGLL LLPLPSDTVL EVDDHTAVAL
1460 1470 1480 1490 1500
RAMKVPVSTG RFKGCSVSLW DLLLSEYVGA DKRRELVALC RSGRAAALRQ
1510 1520 1530 1540 1550
VVSAVTALVE AAERQPLQAT FRGLRKQVSA RDLFRAQLIS RKTLDELSQG
1560 1570 1580 1590 1600
TTTVKEVAEM DSVKRSLEGG NFIAGVLIQG TQERMSIPEA LRRHILRPGT
1610 1620 1630 1640 1650
ALVLLEAQAA TGFIIDPAEN RKLTVEEAFK AGMFGKETYV KLLSAERAVT
1660 1670 1680 1690 1700
GYTDPYTGQQ ISLFQAMQKD LIVREHGIRL LEAQIATGGI IDPVHSHRVP
1710 1720 1730 1740 1750
VDVAYRCGYF DEEMNRILAD PSDDTKGFFD PNTHENLTYL QLLERCVEDP
1760 1770 1780 1790 1800
ETGLYLLQII KKGENYVYIN EATRHVLQSR TAKMRVGRFA DQVVSFWDLL
1810 1820 1830 1840 1850
SSPYFTEDRK RELIQEYGAQ SGGLEKLLEI ITTTIEETET QNQGIKVAAI
1860 1870 1880 1890 1900
RGEVTAADLF NSRVIDQKTL HTLRVGRTGG QALSTLECVK PYLEGSDCIA
1910 1920 1930 1940 1950
GVTVPSTREV MSLHEASRKE LIPAAFATWL LEAQAATGFL LDPCTRQKLS
1960 1970 1980 1990 2000
VDEAVDVGLV NEELRERLLK AERAATGYRD PATGDTIPLF QAMQKQLIEK
2010 2020 2030 2040 2050
AEALRLLEVQ VATGGVIDPQ HHHRLPLETA YRRGCLHKDI YALISDQKHM
2060 2070 2080 2090 2100
RKRFVDPNTQ EKVSYRELQE RCRPQEDTGW VLFPVNKAAR DSEHIDDETR
2110 2120 2130 2140 2150
RALEAEQVEI TVGRFRGQKP TLWALLNSEY VTEEKKLQLV RMYRTHTRRA
2160 2170 2180 2190 2200
LQTVAQLILE LIEKQETSNK HLWFQGIRRQ ITASELLSSA IITEEMLQDL
2210 2220 2230 2240 2250
ETGRSTTQEL MEDDRVKRYL EGTSCIAGVL VPAKDQPGRQ EKMSIYQAMW
2260 2270 2280 2290 2300
KGVLRPGTAL VLLEAQAATG FVIDPVRNLR LSVEEPVPAG VVGSEIQEKL
2310 2320 2330 2340 2350
LSAERAVTGY TDPYTGQQIS LFQAMQKDLI VREHGIRLLE AQIATGGVID
2360 2370 2380 2390 2400
PVHSHRVPVD VAYRRGYFDE EMNRVLADPS DDTKGFFDPN THENLTYVQL
2410 2420 2430 2440 2450
LRRCVPDPDT GLYMLQLAGR GSAVHQLSEE LRCALRDARV TPGSGALQGQ
2460 2470 2480 2490 2500
SVSVWELLFY REVSEDRRQD LLSRYRAGTL TVEELGATLT SLLAQAQAQA
2510 2520 2530 2540 2550
RAEAEAGSPR PDPREALRAA TMEVKVGRLR GRAVPVWDVL ASGYVSRAAR
2560 2570 2580 2590 2600
EELLAEFGSG TLDLPALTRR LTAIIEEAEE APGARPQLQD ARRGPREPGP
2610 2620 2630 2640 2650
AGRGDGDSGR SQREGQGEGE TQEAAAAAAA ARRQEQTLRD ATMEVQRGQF
2660 2670 2680 2690 2700
QGRPVSVWDV LFSSYLSEAR RDELLAQHAA GALGLPDLVA VLTRVIEETE
2710 2720 2730 2740 2750
ERLSKVSFRG LRRQVSASEL HTSGILGPET LRDLAQGTKT LQEVTEMDSV
2760 2770 2780 2790 2800
KRYLEGTSCI AGVLVPAKDQ PGRQEKMSIY QAMWKGVLRP GTALVLLEAQ
2810 2820 2830 2840 2850
AATGFVIDPV RNLRLSVEEA VAAGVVGGEI QEKLLSAERA VTGYTDPYTG
2860 2870 2880 2890 2900
QQISLFQAMQ KDLIVREHGI RLLEAQIATG GVIDPVHSHR VPVDVAYRRG
2910 2920 2930 2940 2950
YFDEEMNRVL ADPSDDTKGF FDPNTHENLT YVQLLRRCVP DPDTGLYMLQ
2960 2970 2980 2990 3000
LAGRGSAVHQ LSEELRCALR DARVTPGSGA LQGQSVSVWE LLFYREVSED
3010 3020 3030 3040 3050
RRQDLLSRYR AGTLTVEELG ATLTSLLAQA QAQARAEAEA GSPRPDPREA
3060 3070 3080 3090 3100
LRAATMEVKV GRLRGRAVPV WDVLASGYVS GAAREELLAE FGSGTLDLPA
3110 3120 3130 3140 3150
LTRRLTAIIE EAEEAPGARP QLQDAWRGPR EPGPAGRGDG DSGRSQREGQ
3160 3170 3180 3190 3200
GEGETQEAAA AAAAARRQEQ TLRDATMEVQ RGQFQGRPVS VWDVLFSSYL
3210 3220 3230 3240 3250
SEARRDELLA QHAAGALGLP DLVAVLTRVI EETEERLSKV SFRGLRRQVS
3260 3270 3280 3290 3300
ASELHTSGIL GPETLRDLAQ GTKTLQEVTE MDSVKRYLEG TSCIAGVLVP
3310 3320 3330 3340 3350
AKDQPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFV IDPVRNLRLS
3360 3370 3380 3390 3400
VEEAVAAGVV GGEIQEKLLS AERAVTGYTD PYTGQQISLF QAMQKDLIVR
3410 3420 3430 3440 3450
EHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YRRGYFDEEM NRVLADPSDD
3460 3470 3480 3490 3500
TKGFFDPNTH ENLTYVQLLR RCVPDPDTGL YMLQLAGRGS AVHQLSEELR
3510 3520 3530 3540 3550
CALRDARVTP GSGALQGQSV SVWELLFYRE VSEDRRQDLL SRYRAGTLTV
3560 3570 3580 3590 3600
EELGATLTSL LAQAQAQARA EAEAGSPRPD PREALRAATM EVKVGRLRGR
3610 3620 3630 3640 3650
AVPVWDVLAS GYVSGAAREE LLAEFGSGTL DLPALTRRLT AIIEEAEEAP
3660 3670 3680 3690 3700
GARPQLQDAW RGPREPGPAG RGDGDSGRSQ REGQGEGETQ EAAAAAAAAR
3710 3720 3730 3740 3750
RQEQTLRDAT MEVQRGQFQG RPVSVWDVLF SSYLSEARRD ELLAQHAAGA
3760 3770 3780 3790 3800
LGLPDLVAVL TRVIEETEER LSKVSFRGLR RQVSASELHT SGILGPETLR
3810 3820 3830 3840 3850
DLAQGTKTLQ EVTEMDSVKR YLEGTSCIAG VLVPAKDQPG RQEKMSIYQA
3860 3870 3880 3890 3900
MWKGVLRPGT ALVLLEAQAA TGFVIDPVRN LRLSVEEAVA AGVVGGEIQE
3910 3920 3930 3940 3950
KLLSAERAVT GYTDPYTGQQ ISLFQAMQKD LIVREHGIRL LEAQIATGGV
3960 3970 3980 3990 4000
IDPVHSHRVP VDVAYRRGYF DEEMNRVLAD PSDDTKGFFD PNTHENLTYV
4010 4020 4030 4040 4050
QLLRRCVPDP DTGLYMLQLA GRGSAVHQLS EELRCALRDA RVTPGSGALQ
4060 4070 4080 4090 4100
GQSVSVWELL FYREVSEDRR QDLLSRYRAS TLTVEELGAT LTSLLAQAQA
4110 4120 4130 4140 4150
QARAEAEAGS PRPDPREALR AATMEVKVGR LRGRAVPVWD VLASGYVSRA
4160 4170 4180 4190 4200
AREELLAEFG SGTLDLPALT RRLTAIIEEA EEAPGARPQL QDAWRGPREP
4210 4220 4230 4240 4250
GPAGRGDGDS GRSQREGQGE GETQEAAAAT AAARRQEQTL RDATMEVQRG
4260 4270 4280 4290 4300
QFQGRPVSVW DVLFSSYLSE ARRDELLAQH AAGALGLPDL VAVLTRVIEE
4310 4320 4330 4340 4350
TEERLSKVSF RGLRRQVSAS ELHTSGILGP ETLRDLAQGT KTLQEVTEMD
4360 4370 4380 4390 4400
SVKRYLEGTS CIAGVLVPAK DQPGRQEKMS IYQAMWKGVL RPGTALVLLE
4410 4420 4430 4440 4450
AQAATGFVID PVRNLRLSVE EAVAAGVVGG EIQEKLLSAE RAVTGYTDPY
4460 4470 4480 4490 4500
TGQQISLFQA MQKDLIVREH GIRLLEAQIA TGGVIDPVHS HRVPVDVAYR
4510 4520 4530 4540 4550
RGYFDEEMNR VLADPSDDTK GFFDPNTHEN LTYVQLLRRC VPDPDTGLYM
4560 4570 4580 4590 4600
LQLAGRGSAV HQLSEELRCA LRDARVTPGS GALQGQSVSV WELLFYREVS
4610 4620 4630 4640 4650
EDRRQDLLSR YRAGTLTVEE LGATLTSLLA QAQAQARAEA EAGSPRPDPR
4660 4670 4680 4690 4700
EALRAATMEV KVGRLRGRAV PVWDVLASGY VSGAAREELL AEFGSGTLDL
4710 4720 4730 4740 4750
PALTRRLTAI IEEAEEAPGA RPQLQDAWRG PREPGPAGRG DGDSGRSQRE
4760 4770 4780 4790 4800
GQGEGETQEA AAAAAAARRQ EQTLRDATME VQRGQFQGRP VSVWDVLFSS
4810 4820 4830 4840 4850
YLSEARRDEL LAQHAAGALG LPDLVAVLTR VIEETEERLS KVSFRGLRRQ
4860 4870 4880 4890 4900
VSASELHTSG ILGPETLRDL AQGTKTLQEV TEMDSVKRYL EGTSCIAGVL
4910 4920 4930 4940 4950
VPAKDQPGRQ EKMSIYQAMW KGVLRPGTAL VLLEAQAATG FVIDPVRNLR
4960 4970 4980 4990 5000
LSVEEAVAAG VVGGEIQEKL LSAERAVTGY TDPYTGQQIS LFQAMQKDLI
5010 5020 5030 5040 5050
VREHGIRLLE AQIATGGVID PVHSHRVPVD VAYRRGYFDE EMNRVLADPS
5060 5070 5080 5090
DDTKGFFDPN THENLTYLQL LQRATLDPET GLLFLSLSLQ
Length:5,090
Mass (Da):555,621
Last modified:July 13, 2010 - v2
Checksum:i3A9A74F3C7E167F5
GO

Sequence cautioni

The sequence BAB40803 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC92750 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202N → D in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti544E → K in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti602A → V in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti1618A → V in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti1897D → G in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti2624 – 2626Missing in BAC92750 (PubMed:14708632).Curated3
Sequence conflicti2713R → C in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti2975T → M in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3162A → T in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3446D → H in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3696A → T in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3841R → H in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti3980D → H in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4043T → M in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4080S → G in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4120R → RPS in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4149R → G in BAC92750 (PubMed:14708632).Curated1
Sequence conflicti4228 – 4230Missing in BAC92750 (PubMed:14708632).Curated3
Sequence conflicti4760 – 4762Missing in CAB70895 (PubMed:17974005).Curated3
Sequence conflicti4806R → U in CAB70895 (PubMed:17974005).Curated1
Sequence conflicti5068L → V in BAC92750 (PubMed:14708632).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051895 mRNA. Translation: BAB40803.1. Different initiation.
AB107036 Genomic DNA. Translation: BAC92750.1. Different initiation.
AL137725 mRNA. Translation: CAB70895.1.
RefSeqiNP_112598.3. NM_031308.3.
UniGeneiHs.200412.
Hs.743673.

Genome annotation databases

GeneIDi83481.
KEGGihsa:83481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051895 mRNA. Translation: BAB40803.1. Different initiation.
AB107036 Genomic DNA. Translation: BAC92750.1. Different initiation.
AL137725 mRNA. Translation: CAB70895.1.
RefSeqiNP_112598.3. NM_031308.3.
UniGeneiHs.200412.
Hs.743673.

3D structure databases

ProteinModelPortaliP58107.
SMRiP58107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123666. 53 interactors.
IntActiP58107. 17 interactors.
MINTiMINT-4998630.
STRINGi9606.ENSP00000436337.

PTM databases

iPTMnetiP58107.
PhosphoSitePlusiP58107.
SwissPalmiP58107.

Polymorphism and mutation databases

DMDMi300669637.

Proteomic databases

EPDiP58107.
MaxQBiP58107.
PaxDbiP58107.
PeptideAtlasiP58107.
PRIDEiP58107.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi83481.
KEGGihsa:83481.

Organism-specific databases

CTDi83481.
DisGeNETi83481.
GeneCardsiEPPK1.
HGNCiHGNC:15577. EPPK1.
HPAiHPA069333.
MIMi607553. gene.
neXtProtiNX_P58107.
PharmGKBiPA27835.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0516. Eukaryota.
COG5069. LUCA.
HOVERGENiHBG051491.
InParanoidiP58107.

Enzyme and pathway databases

BioCyciZFISH:G66-31434-MONOMER.

Miscellaneous databases

GeneWikiiEpiplakin_1.
GenomeRNAii83481.
PROiP58107.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000261150.
CleanExiHS_EPPK1.

Family and domain databases

Gene3Di3.90.1290.10. 13 hits.
InterProiIPR001101. Plectin_repeat.
[Graphical view]
PfamiPF00681. Plectin. 36 hits.
[Graphical view]
SMARTiSM00250. PLEC. 65 hits.
[Graphical view]
SUPFAMiSSF75399. SSF75399. 13 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiEPIPL_HUMAN
AccessioniPrimary (citable) accession number: P58107
Secondary accession number(s): Q76E58, Q9NSU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 13, 2010
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.