Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P58107

- EPIPL_HUMAN

UniProt

P58107 - EPIPL_HUMAN

Protein

Epiplakin

Gene

EPPK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (13 Jul 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epiplakin
    Alternative name(s):
    450 kDa epidermal antigen
    Gene namesi
    Name:EPPK1
    Synonyms:EPIPL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:15577. EPPK1.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27835.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 50905090EpiplakinPRO_0000078145Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1529 – 15291PhosphoserineBy similarity
    Modified residuei2422 – 24221Phosphoserine1 Publication
    Modified residuei2508 – 25081Phosphoserine2 Publications
    Modified residuei2716 – 27161Phosphoserine3 Publications
    Modified residuei2718 – 27181Phosphoserine1 Publication
    Modified residuei2956 – 29561Phosphoserine1 Publication
    Modified residuei3042 – 30421Phosphoserine2 Publications
    Modified residuei3250 – 32501Phosphoserine3 Publications
    Modified residuei3252 – 32521Phosphoserine1 Publication
    Modified residuei3490 – 34901Phosphoserine1 Publication
    Modified residuei3576 – 35761Phosphoserine2 Publications
    Modified residuei3784 – 37841Phosphoserine3 Publications
    Modified residuei3786 – 37861Phosphoserine1 Publication
    Modified residuei4024 – 40241Phosphoserine1 Publication
    Modified residuei4110 – 41101Phosphoserine2 Publications
    Modified residuei4318 – 43181Phosphoserine3 Publications
    Modified residuei4320 – 43201Phosphoserine1 Publication
    Modified residuei4558 – 45581Phosphoserine1 Publication
    Modified residuei4644 – 46441Phosphoserine2 Publications
    Modified residuei4852 – 48521Phosphoserine3 Publications
    Modified residuei4854 – 48541Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP58107.
    PeptideAtlasiP58107.
    PRIDEiP58107.

    PTM databases

    PhosphoSiteiP58107.

    Expressioni

    Tissue specificityi

    Widely expressed with highest levels in liver, small intestine, colon, salivary glands, stomach and appendix.

    Gene expression databases

    CleanExiHS_EPPK1.
    GenevestigatoriP58107.

    Interactioni

    Protein-protein interaction databases

    BioGridi123666. 26 interactions.
    IntActiP58107. 8 interactions.
    MINTiMINT-4998630.

    Structurei

    3D structure databases

    ProteinModelPortaliP58107.
    SMRiP58107. Positions 43-232, 234-468, 559-798, 882-1165, 1198-1434, 1520-1759, 1849-2087, 2174-2417, 2775-2956, 3309-3490, 3843-4024, 4377-4558, 4911-5085.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati34 – 7138Plectin 1Add
    BLAST
    Repeati72 – 10938Plectin 2Add
    BLAST
    Repeati110 – 14738Plectin 3Add
    BLAST
    Repeati148 – 18538Plectin 4Add
    BLAST
    Repeati192 – 22534Plectin 5Add
    BLAST
    Repeati278 – 31538Plectin 6Add
    BLAST
    Repeati316 – 35338Plectin 7Add
    BLAST
    Repeati355 – 39137Plectin 8Add
    BLAST
    Repeati392 – 42938Plectin 9Add
    BLAST
    Repeati546 – 58338Plectin 10Add
    BLAST
    Repeati603 – 64038Plectin 11Add
    BLAST
    Repeati641 – 67838Plectin 12Add
    BLAST
    Repeati679 – 71638Plectin 13Add
    BLAST
    Repeati717 – 75438Plectin 14Add
    BLAST
    Repeati758 – 79235Plectin 15Add
    BLAST
    Repeati865 – 90339Plectin 16Add
    BLAST
    Repeati923 – 96038Plectin 17Add
    BLAST
    Repeati961 – 99838Plectin 18Add
    BLAST
    Repeati999 – 103638Plectin 19Add
    BLAST
    Repeati1037 – 107438Plectin 20Add
    BLAST
    Repeati1239 – 127638Plectin 21Add
    BLAST
    Repeati1277 – 131438Plectin 22Add
    BLAST
    Repeati1315 – 135238Plectin 23Add
    BLAST
    Repeati1353 – 139038Plectin 24Add
    BLAST
    Repeati1391 – 142838Plectin 25Add
    BLAST
    Repeati1564 – 160138Plectin 26Add
    BLAST
    Repeati1602 – 163938Plectin 27Add
    BLAST
    Repeati1640 – 167738Plectin 28Add
    BLAST
    Repeati1678 – 171538Plectin 29Add
    BLAST
    Repeati1719 – 175335Plectin 30Add
    BLAST
    Repeati1890 – 192738Plectin 31Add
    BLAST
    Repeati1928 – 196538Plectin 32Add
    BLAST
    Repeati1966 – 200338Plectin 33Add
    BLAST
    Repeati2004 – 204138Plectin 34Add
    BLAST
    Repeati2042 – 207938Plectin 35Add
    BLAST
    Repeati2217 – 225943Plectin 36Add
    BLAST
    Repeati2260 – 229738Plectin 37Add
    BLAST
    Repeati2298 – 233538Plectin 38Add
    BLAST
    Repeati2336 – 237338Plectin 39Add
    BLAST
    Repeati2377 – 241135Plectin 40Add
    BLAST
    Repeati2751 – 279343Plectin 41Add
    BLAST
    Repeati2794 – 283138Plectin 42Add
    BLAST
    Repeati2832 – 286938Plectin 43Add
    BLAST
    Repeati2870 – 290738Plectin 44Add
    BLAST
    Repeati2911 – 294535Plectin 45Add
    BLAST
    Repeati3285 – 332743Plectin 46Add
    BLAST
    Repeati3328 – 336538Plectin 47Add
    BLAST
    Repeati3366 – 340338Plectin 48Add
    BLAST
    Repeati3404 – 344138Plectin 49Add
    BLAST
    Repeati3445 – 347935Plectin 50Add
    BLAST
    Repeati3819 – 386143Plectin 51Add
    BLAST
    Repeati3862 – 389938Plectin 52Add
    BLAST
    Repeati3900 – 393738Plectin 53Add
    BLAST
    Repeati3938 – 397538Plectin 54Add
    BLAST
    Repeati3979 – 401335Plectin 55Add
    BLAST
    Repeati4353 – 439543Plectin 56Add
    BLAST
    Repeati4396 – 443338Plectin 57Add
    BLAST
    Repeati4434 – 447138Plectin 58Add
    BLAST
    Repeati4472 – 450938Plectin 59Add
    BLAST
    Repeati4513 – 454735Plectin 60Add
    BLAST
    Repeati4887 – 492943Plectin 61Add
    BLAST
    Repeati4930 – 496738Plectin 62Add
    BLAST
    Repeati4968 – 500538Plectin 63Add
    BLAST
    Repeati5006 – 504338Plectin 64Add
    BLAST
    Repeati5047 – 508135Plectin 65Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1960 – 197617Sequence AnalysisAdd
    BLAST
    Coiled coili2618 – 264932Sequence AnalysisAdd
    BLAST
    Coiled coili3152 – 318332Sequence AnalysisAdd
    BLAST
    Coiled coili3686 – 371732Sequence AnalysisAdd
    BLAST
    Coiled coili4220 – 425132Sequence AnalysisAdd
    BLAST
    Coiled coili4754 – 478532Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the plakin or cytolinker family.Curated
    Contains 65 plectin repeats.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    HOVERGENiHBG051491.

    Family and domain databases

    Gene3Di3.90.1290.10. 13 hits.
    InterProiIPR001101. Plectin_repeat.
    [Graphical view]
    PfamiPF00681. Plectin. 30 hits.
    [Graphical view]
    SMARTiSM00250. PLEC. 65 hits.
    [Graphical view]
    SUPFAMiSSF75399. SSF75399. 13 hits.

    Sequencei

    Sequence statusi: Complete.

    P58107-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGHTLPPLP VPGTNSTEQA SVPRAMAATL GAGTPPRPQA RSIAGVYVEA     50
    SGQAQSVYAA MEQGLLPAGL GQALLEAQAA TGGLVDLARG QLLPVSKALQ 100
    QGLVGLELKE KLLAAERATT GYPDPYGGEK LALFQAIGKE VVDRALGQSW 150
    LEVQLATGGL VDPAQGVLVA PEPACHQGLL DRETWHKLSE LEPGTGDLRF 200
    LNPNTLERLT YHQLLERCVR APGSGLALLP LKITFRSMGG AVSAAELLEV 250
    GILDEQAVQG LREGRLAAVD VSARAEVRRY LEGTGSVAGV VLLPEGHKKS 300
    FFQAATEHLL PMGTALPLLE AQAATHTLVD PITGQRLWVD EAVRAGLVSP 350
    ELHEQLLVAE QAVTGHHDPF SGSQIPLFQA MKKGLVDRPL ALRLLDAQLA 400
    TGGLVCPARR LRLPLEAALR CGCLDEDTQR QLSQAGSFSD GTHGGLRYEQ 450
    LLALCVTDPE TGLAFLPLSG GPRGGEPQGP PFIKYSTRQA LSTATATVSV 500
    GKFRGRPVSL WELLFSEAIS SEQRAMLAQQ YQEGTLSVEK LAAELSATLE 550
    QAAATARVTF SGLRDTVTPG ELLKAEIIDQ DLYERLEHGQ ATAKDVGSLA 600
    SAQRYLQGTG CIAGLLLPGS QERLSIYEAR CKGLLRPGTA LILLEAQAAT 650
    GFIIDPKANK GHSVEEALRA AVIGPDVFAK LLSAERAVTG YTDPYTGQQI 700
    SLFQAMQKGL IVREHGIRLL EAQIATGGVI DPVHSHRVPV DVAYRRGYFD 750
    QMLNLILLDP SDDTKGFFDP NTHENLTYLQ LLERCVRDPE TGLYLLPLSS 800
    TQSPLVDSAT QQAFQNLLLS VKYGRFQGQR VSAWELINSE YFSEGRRRQL 850
    LRRYRQREVT LGQVAKLLEA ETQRQADIML PALRSRVTVH QLLEAGIIDQ 900
    QLLDQVLAGT ISPEALLLMD GVRRYLCGLG AVGGVRLLPS GQRLSLYQAM 950
    RQKLLGPRVA LALLEAQAAT GTIMDPHSPE SLSVDEAVRR GVVGPELYGR 1000
    LKRAEGAIAG FRDPFSGKQV SVFQAMKKGL IPWEQAARLL EAQVATGGII 1050
    DPTSHHHLPM PVAIQRGYVD QEMETALSSS SETFPTPDGQ GRTSYAQLLE 1100
    ECPRDETSGL HLLPLPESAP ALPTEEQVQR SLQAVPGAKD GTSLWDLLSS 1150
    CHFTEEQRRG LLEDVQEGRT TVPQLLASVQ RWVQETKLLA QARVMVPGPR 1200
    GEVPAVWLLD AGIITQETLE ALAQGTQSPA QVAEQPAVKA CLWGTGCVAG 1250
    VLLQPSGAKA SIAQAVRDGL LPTGLGQRLL EAQVASGFLV DPLNNQRLSV 1300
    EDAVKVGLVG RELSEQLGQA ERAAAGYPDP YSRASLSLWQ AMEKGLVPQN 1350
    EGLPLLQVQL ATGGVVDPVH GVHLPQAAAC RLGLLDTQTS QVLTAVDKDN 1400
    KFFFDPSARD QVTYQQLRER CVCDSETGLL LLPLPSDTVL EVDDHTAVAL 1450
    RAMKVPVSTG RFKGCSVSLW DLLLSEYVGA DKRRELVALC RSGRAAALRQ 1500
    VVSAVTALVE AAERQPLQAT FRGLRKQVSA RDLFRAQLIS RKTLDELSQG 1550
    TTTVKEVAEM DSVKRSLEGG NFIAGVLIQG TQERMSIPEA LRRHILRPGT 1600
    ALVLLEAQAA TGFIIDPAEN RKLTVEEAFK AGMFGKETYV KLLSAERAVT 1650
    GYTDPYTGQQ ISLFQAMQKD LIVREHGIRL LEAQIATGGI IDPVHSHRVP 1700
    VDVAYRCGYF DEEMNRILAD PSDDTKGFFD PNTHENLTYL QLLERCVEDP 1750
    ETGLYLLQII KKGENYVYIN EATRHVLQSR TAKMRVGRFA DQVVSFWDLL 1800
    SSPYFTEDRK RELIQEYGAQ SGGLEKLLEI ITTTIEETET QNQGIKVAAI 1850
    RGEVTAADLF NSRVIDQKTL HTLRVGRTGG QALSTLECVK PYLEGSDCIA 1900
    GVTVPSTREV MSLHEASRKE LIPAAFATWL LEAQAATGFL LDPCTRQKLS 1950
    VDEAVDVGLV NEELRERLLK AERAATGYRD PATGDTIPLF QAMQKQLIEK 2000
    AEALRLLEVQ VATGGVIDPQ HHHRLPLETA YRRGCLHKDI YALISDQKHM 2050
    RKRFVDPNTQ EKVSYRELQE RCRPQEDTGW VLFPVNKAAR DSEHIDDETR 2100
    RALEAEQVEI TVGRFRGQKP TLWALLNSEY VTEEKKLQLV RMYRTHTRRA 2150
    LQTVAQLILE LIEKQETSNK HLWFQGIRRQ ITASELLSSA IITEEMLQDL 2200
    ETGRSTTQEL MEDDRVKRYL EGTSCIAGVL VPAKDQPGRQ EKMSIYQAMW 2250
    KGVLRPGTAL VLLEAQAATG FVIDPVRNLR LSVEEPVPAG VVGSEIQEKL 2300
    LSAERAVTGY TDPYTGQQIS LFQAMQKDLI VREHGIRLLE AQIATGGVID 2350
    PVHSHRVPVD VAYRRGYFDE EMNRVLADPS DDTKGFFDPN THENLTYVQL 2400
    LRRCVPDPDT GLYMLQLAGR GSAVHQLSEE LRCALRDARV TPGSGALQGQ 2450
    SVSVWELLFY REVSEDRRQD LLSRYRAGTL TVEELGATLT SLLAQAQAQA 2500
    RAEAEAGSPR PDPREALRAA TMEVKVGRLR GRAVPVWDVL ASGYVSRAAR 2550
    EELLAEFGSG TLDLPALTRR LTAIIEEAEE APGARPQLQD ARRGPREPGP 2600
    AGRGDGDSGR SQREGQGEGE TQEAAAAAAA ARRQEQTLRD ATMEVQRGQF 2650
    QGRPVSVWDV LFSSYLSEAR RDELLAQHAA GALGLPDLVA VLTRVIEETE 2700
    ERLSKVSFRG LRRQVSASEL HTSGILGPET LRDLAQGTKT LQEVTEMDSV 2750
    KRYLEGTSCI AGVLVPAKDQ PGRQEKMSIY QAMWKGVLRP GTALVLLEAQ 2800
    AATGFVIDPV RNLRLSVEEA VAAGVVGGEI QEKLLSAERA VTGYTDPYTG 2850
    QQISLFQAMQ KDLIVREHGI RLLEAQIATG GVIDPVHSHR VPVDVAYRRG 2900
    YFDEEMNRVL ADPSDDTKGF FDPNTHENLT YVQLLRRCVP DPDTGLYMLQ 2950
    LAGRGSAVHQ LSEELRCALR DARVTPGSGA LQGQSVSVWE LLFYREVSED 3000
    RRQDLLSRYR AGTLTVEELG ATLTSLLAQA QAQARAEAEA GSPRPDPREA 3050
    LRAATMEVKV GRLRGRAVPV WDVLASGYVS GAAREELLAE FGSGTLDLPA 3100
    LTRRLTAIIE EAEEAPGARP QLQDAWRGPR EPGPAGRGDG DSGRSQREGQ 3150
    GEGETQEAAA AAAAARRQEQ TLRDATMEVQ RGQFQGRPVS VWDVLFSSYL 3200
    SEARRDELLA QHAAGALGLP DLVAVLTRVI EETEERLSKV SFRGLRRQVS 3250
    ASELHTSGIL GPETLRDLAQ GTKTLQEVTE MDSVKRYLEG TSCIAGVLVP 3300
    AKDQPGRQEK MSIYQAMWKG VLRPGTALVL LEAQAATGFV IDPVRNLRLS 3350
    VEEAVAAGVV GGEIQEKLLS AERAVTGYTD PYTGQQISLF QAMQKDLIVR 3400
    EHGIRLLEAQ IATGGVIDPV HSHRVPVDVA YRRGYFDEEM NRVLADPSDD 3450
    TKGFFDPNTH ENLTYVQLLR RCVPDPDTGL YMLQLAGRGS AVHQLSEELR 3500
    CALRDARVTP GSGALQGQSV SVWELLFYRE VSEDRRQDLL SRYRAGTLTV 3550
    EELGATLTSL LAQAQAQARA EAEAGSPRPD PREALRAATM EVKVGRLRGR 3600
    AVPVWDVLAS GYVSGAAREE LLAEFGSGTL DLPALTRRLT AIIEEAEEAP 3650
    GARPQLQDAW RGPREPGPAG RGDGDSGRSQ REGQGEGETQ EAAAAAAAAR 3700
    RQEQTLRDAT MEVQRGQFQG RPVSVWDVLF SSYLSEARRD ELLAQHAAGA 3750
    LGLPDLVAVL TRVIEETEER LSKVSFRGLR RQVSASELHT SGILGPETLR 3800
    DLAQGTKTLQ EVTEMDSVKR YLEGTSCIAG VLVPAKDQPG RQEKMSIYQA 3850
    MWKGVLRPGT ALVLLEAQAA TGFVIDPVRN LRLSVEEAVA AGVVGGEIQE 3900
    KLLSAERAVT GYTDPYTGQQ ISLFQAMQKD LIVREHGIRL LEAQIATGGV 3950
    IDPVHSHRVP VDVAYRRGYF DEEMNRVLAD PSDDTKGFFD PNTHENLTYV 4000
    QLLRRCVPDP DTGLYMLQLA GRGSAVHQLS EELRCALRDA RVTPGSGALQ 4050
    GQSVSVWELL FYREVSEDRR QDLLSRYRAS TLTVEELGAT LTSLLAQAQA 4100
    QARAEAEAGS PRPDPREALR AATMEVKVGR LRGRAVPVWD VLASGYVSRA 4150
    AREELLAEFG SGTLDLPALT RRLTAIIEEA EEAPGARPQL QDAWRGPREP 4200
    GPAGRGDGDS GRSQREGQGE GETQEAAAAT AAARRQEQTL RDATMEVQRG 4250
    QFQGRPVSVW DVLFSSYLSE ARRDELLAQH AAGALGLPDL VAVLTRVIEE 4300
    TEERLSKVSF RGLRRQVSAS ELHTSGILGP ETLRDLAQGT KTLQEVTEMD 4350
    SVKRYLEGTS CIAGVLVPAK DQPGRQEKMS IYQAMWKGVL RPGTALVLLE 4400
    AQAATGFVID PVRNLRLSVE EAVAAGVVGG EIQEKLLSAE RAVTGYTDPY 4450
    TGQQISLFQA MQKDLIVREH GIRLLEAQIA TGGVIDPVHS HRVPVDVAYR 4500
    RGYFDEEMNR VLADPSDDTK GFFDPNTHEN LTYVQLLRRC VPDPDTGLYM 4550
    LQLAGRGSAV HQLSEELRCA LRDARVTPGS GALQGQSVSV WELLFYREVS 4600
    EDRRQDLLSR YRAGTLTVEE LGATLTSLLA QAQAQARAEA EAGSPRPDPR 4650
    EALRAATMEV KVGRLRGRAV PVWDVLASGY VSGAAREELL AEFGSGTLDL 4700
    PALTRRLTAI IEEAEEAPGA RPQLQDAWRG PREPGPAGRG DGDSGRSQRE 4750
    GQGEGETQEA AAAAAAARRQ EQTLRDATME VQRGQFQGRP VSVWDVLFSS 4800
    YLSEARRDEL LAQHAAGALG LPDLVAVLTR VIEETEERLS KVSFRGLRRQ 4850
    VSASELHTSG ILGPETLRDL AQGTKTLQEV TEMDSVKRYL EGTSCIAGVL 4900
    VPAKDQPGRQ EKMSIYQAMW KGVLRPGTAL VLLEAQAATG FVIDPVRNLR 4950
    LSVEEAVAAG VVGGEIQEKL LSAERAVTGY TDPYTGQQIS LFQAMQKDLI 5000
    VREHGIRLLE AQIATGGVID PVHSHRVPVD VAYRRGYFDE EMNRVLADPS 5050
    DDTKGFFDPN THENLTYLQL LQRATLDPET GLLFLSLSLQ 5090
    Length:5,090
    Mass (Da):555,621
    Last modified:July 13, 2010 - v2
    Checksum:i3A9A74F3C7E167F5
    GO

    Sequence cautioni

    The sequence BAB40803.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC92750.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti202 – 2021N → D in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti544 – 5441E → K in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti602 – 6021A → V in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti1618 – 16181A → V in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti1897 – 18971D → G in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti2624 – 26263Missing in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti2713 – 27131R → C in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti2975 – 29751T → M in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti3162 – 31621A → T in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti3446 – 34461D → H in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti3696 – 36961A → T in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti3841 – 38411R → H in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti3980 – 39801D → H in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti4043 – 40431T → M in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti4080 – 40801S → G in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti4120 – 41201R → RPS in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti4149 – 41491R → G in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti4228 – 42303Missing in BAC92750. (PubMed:14708632)Curated
    Sequence conflicti4760 – 47623Missing in CAB70895. (PubMed:17974005)Curated
    Sequence conflicti4806 – 48061R → U in CAB70895. (PubMed:17974005)Curated
    Sequence conflicti5068 – 50681L → V in BAC92750. (PubMed:14708632)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051895 mRNA. Translation: BAB40803.1. Different initiation.
    AB107036 Genomic DNA. Translation: BAC92750.1. Different initiation.
    AL137725 mRNA. Translation: CAB70895.1.
    RefSeqiNP_112598.3. NM_031308.3.
    UniGeneiHs.200412.
    Hs.743673.

    Genome annotation databases

    GeneIDi83481.
    UCSCiuc003zaa.1. human.

    Polymorphism databases

    DMDMi300669637.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051895 mRNA. Translation: BAB40803.1 . Different initiation.
    AB107036 Genomic DNA. Translation: BAC92750.1 . Different initiation.
    AL137725 mRNA. Translation: CAB70895.1 .
    RefSeqi NP_112598.3. NM_031308.3.
    UniGenei Hs.200412.
    Hs.743673.

    3D structure databases

    ProteinModelPortali P58107.
    SMRi P58107. Positions 43-232, 234-468, 559-798, 882-1165, 1198-1434, 1520-1759, 1849-2087, 2174-2417, 2775-2956, 3309-3490, 3843-4024, 4377-4558, 4911-5085.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123666. 26 interactions.
    IntActi P58107. 8 interactions.
    MINTi MINT-4998630.

    PTM databases

    PhosphoSitei P58107.

    Polymorphism databases

    DMDMi 300669637.

    Proteomic databases

    MaxQBi P58107.
    PeptideAtlasi P58107.
    PRIDEi P58107.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 83481.
    UCSCi uc003zaa.1. human.

    Organism-specific databases

    CTDi 83481.
    GeneCardsi GC08M144935.
    HGNCi HGNC:15577. EPPK1.
    MIMi 607553. gene.
    neXtProti NX_P58107.
    PharmGKBi PA27835.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG051491.

    Miscellaneous databases

    GeneWikii Epiplakin_1.
    NextBioi 72429.
    PROi P58107.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_EPPK1.
    Genevestigatori P58107.

    Family and domain databases

    Gene3Di 3.90.1290.10. 13 hits.
    InterProi IPR001101. Plectin_repeat.
    [Graphical view ]
    Pfami PF00681. Plectin. 30 hits.
    [Graphical view ]
    SMARTi SM00250. PLEC. 65 hits.
    [Graphical view ]
    SUPFAMi SSF75399. SSF75399. 13 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Epiplakin, a novel member of the plakin family originally identified as a 450-kDa human epidermal autoantigen: structure and tissue localization."
      Fujiwara S., Takeo N., Otani Y., Parry D.A.D., Kunimatsu M., Lu R., Sasaki M., Matsuo N., Khaleduzzaman M., Yoshioka H.
      J. Biol. Chem. 276:13340-13347(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Cervix carcinoma.
    2. "Structure and heterogeneity of the human gene for epiplakin (EPPK1)."
      Takeo N., Wang W., Matsuo N., Sumiyoshi H., Yoshioka H., Fujiwara S.
      J. Invest. Dermatol. 121:1224-1226(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 266-274.
      Tissue: Platelet.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4713-5090.
      Tissue: Testis.
    5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2508; SER-3042; SER-3576; SER-4110 AND SER-4644, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2716; SER-3250; SER-3784; SER-4318 AND SER-4852, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2422; SER-2508; SER-2716; SER-2956; SER-3042; SER-3250; SER-3490; SER-3576; SER-3784; SER-4024; SER-4110; SER-4318; SER-4558; SER-4644 AND SER-4852, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2716; SER-2718; SER-3250; SER-3252; SER-3784; SER-3786; SER-4318; SER-4320; SER-4852 AND SER-4854, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiEPIPL_HUMAN
    AccessioniPrimary (citable) accession number: P58107
    Secondary accession number(s): Q76E58, Q9NSU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-26 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3