Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Antitoxin ParD1

Gene

parD1

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Antitoxin component of a toxin-antitoxin (TA) module. Neutralizes the effect of cognate toxin ParE1, but no other RelE or ParE toxin. May act as a DNA gyrase inhibitor (By similarity).By similarity1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • protein heterotetramerization Source: UniProtKB
  • regulation of transcription, DNA-templated Source: InterPro

Enzyme and pathway databases

BioCyciCAULO:CC0874-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Antitoxin ParD1
Gene namesi
Name:parD1
Ordered Locus Names:CC_0874
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

Cannot be disrupted, suggesting it is a functional antitoxin. No visible phenotype when the parDE1 operon is deleted.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002163511 – 88Antitoxin ParD1Add BLAST88

Interactioni

Subunit structurei

Homodimer in solution, forms a ParD12-ParE12 heterotetramer.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

STRINGi190650.CC_0874.

Structurei

Secondary structure

188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 8Combined sources3
Helixi12 – 22Combined sources11
Turni23 – 25Combined sources3
Helixi30 – 60Combined sources31
Beta strandi63 – 66Combined sources4
Helixi69 – 78Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KXEX-ray2.60C/D1-88[»]
ProteinModelPortaliP58091.
SMRiP58091.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58091.

Family & Domainsi

Sequence similaritiesi

Belongs to the ParD antitoxin family.Curated

Phylogenomic databases

eggNOGiENOG4105X54. Bacteria.
COG3609. LUCA.
HOGENOMiHOG000260299.
KOiK07746.
OMAiAGEQSGF.

Family and domain databases

Gene3Di1.10.1220.10. 1 hit.
InterProiView protein in InterPro
IPR013321. Arc_rbn_hlx_hlx.
IPR022789. ParD.
IPR010985. Ribbon_hlx_hlx.
PfamiView protein in Pfam
PF03693. ParD_antitoxin. 1 hit.
SUPFAMiSSF47598. SSF47598. 1 hit.
TIGRFAMsiTIGR02606. antidote_CC2985. 1 hit.

Sequencei

Sequence statusi: Complete.

P58091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKNTSVVL GDHFQAFIDS QVADGRYGSA SEVIRAGLRL LEENEAKLAA
60 70 80
LRAALIEGEE SGFIEDFDFD AFIEERSRAS APQGFHEE
Length:88
Mass (Da):9,636
Last modified:June 1, 2001 - v1
Checksum:i571769967C364F77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22859.1.
PIRiG87357.
RefSeqiNP_419691.1. NC_002696.2.
WP_010918759.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK22859; AAK22859; CC_0874.
GeneIDi941170.
KEGGiccr:CC_0874.
PATRICifig|190650.5.peg.887.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPARD1_CAUCR
AccessioniPrimary (citable) accession number: P58091
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 7, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries