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Protein

Antitoxin ParD1

Gene

parD1

Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the effect of cognate toxin ParE1, but no other RelE or ParE toxin. May act as a DNA gyrase inhibitor (By similarity).By similarity1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • protein heterotetramerization Source: UniProtKB
  • regulation of transcription, DNA-templated Source: InterPro

Keywordsi

Biological processToxin-antitoxin system

Enzyme and pathway databases

BioCyciCAULO:CC0874-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Antitoxin ParD1
Gene namesi
Name:parD1
Ordered Locus Names:CC_0874
OrganismiCaulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

Cannot be disrupted, suggesting it is a functional antitoxin. No visible phenotype when the parDE1 operon is deleted.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002163511 – 88Antitoxin ParD1Add BLAST88

Interactioni

Subunit structurei

Homodimer in solution, forms a ParD12-ParE12 heterotetramer.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

STRINGi190650.CC_0874

Structurei

Secondary structure

188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 8Combined sources3
Helixi12 – 22Combined sources11
Turni23 – 25Combined sources3
Helixi30 – 60Combined sources31
Beta strandi63 – 66Combined sources4
Helixi69 – 78Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KXEX-ray2.60C/D1-88[»]
ProteinModelPortaliP58091
SMRiP58091
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58091

Family & Domainsi

Sequence similaritiesi

Belongs to the ParD antitoxin family.Curated

Phylogenomic databases

eggNOGiENOG4105X54 Bacteria
COG3609 LUCA
HOGENOMiHOG000260299
KOiK07746
OMAiAGEQSGF

Family and domain databases

Gene3Di1.10.8.1250, 1 hit
InterProiView protein in InterPro
IPR022789 ParD
IPR038296 ParD_sf
IPR010985 Ribbon_hlx_hlx
PANTHERiPTHR36582 PTHR36582, 1 hit
PfamiView protein in Pfam
PF03693 ParD_antitoxin, 1 hit
SUPFAMiSSF47598 SSF47598, 1 hit
TIGRFAMsiTIGR02606 antidote_CC2985, 1 hit

Sequencei

Sequence statusi: Complete.

P58091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKNTSVVL GDHFQAFIDS QVADGRYGSA SEVIRAGLRL LEENEAKLAA
60 70 80
LRAALIEGEE SGFIEDFDFD AFIEERSRAS APQGFHEE
Length:88
Mass (Da):9,636
Last modified:June 1, 2001 - v1
Checksum:i571769967C364F77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA Translation: AAK22859.1
PIRiG87357
RefSeqiNP_419691.1, NC_002696.2
WP_010918759.1, NC_002696.2

Genome annotation databases

EnsemblBacteriaiAAK22859; AAK22859; CC_0874
GeneIDi941170
KEGGiccr:CC_0874
PATRICifig|190650.5.peg.887

Similar proteinsi

Entry informationi

Entry nameiPARD1_CAUVC
AccessioniPrimary (citable) accession number: P58091
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health