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Protein

Antitoxin ParD1

Gene

parD1

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Antitoxin component of a toxin-antitoxin (TA) module. Neutralizes the effect of cognate toxin ParE1, but no other RelE or ParE toxin. May act as a DNA gyrase inhibitor (By similarity).By similarity1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • protein heterotetramerization Source: UniProtKB
  • regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciCAULO:CC0874-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Antitoxin ParD1
Gene namesi
Name:parD1
Ordered Locus Names:CC_0874
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001816 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

Cannot be disrupted, suggesting it is a functional antitoxin. No visible phenotype when the parDE1 operon is deleted.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8888Antitoxin ParD1PRO_0000216351Add
BLAST

Interactioni

Subunit structurei

Homodimer in solution, forms a ParD12-ParE12 heterotetramer.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

STRINGi190650.CC_0874.

Structurei

Secondary structure

1
88
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 83Combined sources
Helixi12 – 2211Combined sources
Turni23 – 253Combined sources
Helixi30 – 6031Combined sources
Beta strandi63 – 664Combined sources
Helixi69 – 7810Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KXEX-ray2.60C/D1-88[»]
ProteinModelPortaliP58091.
SMRiP58091. Positions 5-79.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58091.

Family & Domainsi

Sequence similaritiesi

Belongs to the ParD antitoxin family.Curated

Phylogenomic databases

eggNOGiENOG4105X54. Bacteria.
COG3609. LUCA.
HOGENOMiHOG000260299.
KOiK07746.
OMAiYFEAFIR.
OrthoDBiEOG6PP9RV.

Family and domain databases

InterProiIPR022789. ParD.
IPR010985. Ribbon_hlx_hlx.
[Graphical view]
PfamiPF03693. ParD_antitoxin. 1 hit.
[Graphical view]
SUPFAMiSSF47598. SSF47598. 1 hit.
TIGRFAMsiTIGR02606. antidote_CC2985. 1 hit.

Sequencei

Sequence statusi: Complete.

P58091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKNTSVVL GDHFQAFIDS QVADGRYGSA SEVIRAGLRL LEENEAKLAA
60 70 80
LRAALIEGEE SGFIEDFDFD AFIEERSRAS APQGFHEE
Length:88
Mass (Da):9,636
Last modified:June 1, 2001 - v1
Checksum:i571769967C364F77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22859.1.
PIRiG87357.
RefSeqiNP_419691.1. NC_002696.2.
WP_010918759.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK22859; AAK22859; CC_0874.
GeneIDi941170.
KEGGiccr:CC_0874.
PATRICi21298706. VBICauCre124313_0887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK22859.1.
PIRiG87357.
RefSeqiNP_419691.1. NC_002696.2.
WP_010918759.1. NC_002696.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KXEX-ray2.60C/D1-88[»]
ProteinModelPortaliP58091.
SMRiP58091. Positions 5-79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190650.CC_0874.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK22859; AAK22859; CC_0874.
GeneIDi941170.
KEGGiccr:CC_0874.
PATRICi21298706. VBICauCre124313_0887.

Phylogenomic databases

eggNOGiENOG4105X54. Bacteria.
COG3609. LUCA.
HOGENOMiHOG000260299.
KOiK07746.
OMAiYFEAFIR.
OrthoDBiEOG6PP9RV.

Enzyme and pathway databases

BioCyciCAULO:CC0874-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP58091.

Family and domain databases

InterProiIPR022789. ParD.
IPR010985. Ribbon_hlx_hlx.
[Graphical view]
PfamiPF03693. ParD_antitoxin. 1 hit.
[Graphical view]
SUPFAMiSSF47598. SSF47598. 1 hit.
TIGRFAMsiTIGR02606. antidote_CC2985. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19089 / CB15.
  2. "Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes."
    Pandey D.P., Gerdes K.
    Nucleic Acids Res. 33:966-976(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION.
    Strain: ATCC 19089 / CB15.
  3. "Interaction specificity, toxicity and regulation of a paralogous set of ParE/RelE-family toxin-antitoxin systems."
    Fiebig A., Castro Rojas C.M., Siegal-Gaskins D., Crosson S.
    Mol. Microbiol. 77:236-251(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AN ANTITOXIN, DISRUPTION PHENOTYPE.
    Strain: ATCC 19089 / CB15.
  4. "A conserved mode of protein recognition and binding in a ParD-ParE toxin-antitoxin complex."
    Dalton K.M., Crosson S.
    Biochemistry 49:2205-2215(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS), SUBUNIT.
    Strain: ATCC 19089 / CB15.

Entry informationi

Entry nameiPARD1_CAUCR
AccessioniPrimary (citable) accession number: P58091
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: December 9, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.