Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P58073 (PTHR_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Parathyroid hormone-related protein

Short name=PTH-rP
Short name=PTHrP

Cleaved into the following chain:

  1. Osteostatin
Gene names
Name:PTHLH
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length177 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath By similarity.

Osteostatin is a potent inhibitor of osteoclastic bone resorption By similarity.

Subunit structure

PTHrP interacts with PTH1R (via N-terminal extracellular domain) By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Secreted By similarity.

Tissue specificity

Expressed in the mammary gland.

Post-translational modification

There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions By similarity.

Sequence similarities

Belongs to the parathyroid hormone family.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
Secreted
   DomainSignal
   LigandCalcium
   Molecular functionHormone
   PTMCleavage on pair of basic residues
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadenylate cyclase-activating G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

endochondral ossification

Inferred from electronic annotation. Source: Ensembl

endoderm development

Inferred from electronic annotation. Source: Ensembl

epithelial cell differentiation

Inferred from electronic annotation. Source: Ensembl

lung alveolus development

Inferred from electronic annotation. Source: Ensembl

mammary gland bud elongation

Inferred from electronic annotation. Source: Ensembl

negative regulation of chondrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

nipple sheath formation

Inferred from electronic annotation. Source: Ensembl

osteoblast development

Inferred from electronic annotation. Source: Ensembl

positive regulation of cAMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

protein processing

Inferred from electronic annotation. Source: Ensembl

surfactant homeostasis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpeptide hormone receptor binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Propeptide25 – 3410 By similarity
PRO_0000023217
Chain37 – 177141Parathyroid hormone-related protein
PRO_0000023218
Peptide143 – 17533Osteostatin By similarity
PRO_0000023219

Regions

Region57 – 6812Important for receptor binding By similarity
Motif108 – 12922Nuclear localization signal By similarity

Experimental info

Sequence conflict261S → L in BAC44840. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P58073 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 6A5B48ECB219EF08

FASTA17720,408
        10         20         30         40         50         60 
MLWRLVQQWS VAVFLLSYSV PSCGRSVEEL GRRLKRAVSE HQLLHDKGKS IQDLRRRFFL 

        70         80         90        100        110        120 
HHLIAEIHTA EIRATSEVSP NSKPAPNTKN HPVRFGSDDE GKYLTQETNK VETYKEQPLK 

       130        140        150        160        170 
TPGKKKKSKP GKRKEQEKKK RRTRSAWLTS YVAGTGLEED YLSDISATSL ELNSRRH 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of bovine parathyroid hormone-related protein (PTHrP) cDNA and expression of PTHrP mRNA in the bovine mammary gland."
Wojcik S.F., Schanbacher F.L., McCauley L.K., Zhou H., Kartsogiannis V., Capen C.C., Rosol T.J.
J. Mol. Endocrinol. 20:271-280(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Molecular cloning of bovine parathyroid hormone-related protein cDNA."
Onda K., Inaba M., Ono K.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Holstein-Friesian.
Tissue: Mammary gland.
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal spinal cord.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB097837 mRNA. Translation: BAC44840.1.
BC149411 mRNA. Translation: AAI49412.1.
RefSeqNP_777178.1. NM_174753.1.
XP_005206971.1. XM_005206914.1.
UniGeneBt.12848.

3D structure databases

ProteinModelPortalP58073.
SMRP58073. Positions 37-70, 103-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000040744.

Proteomic databases

PRIDEP58073.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000008581; ENSBTAP00000008581; ENSBTAG00000006538.
ENSBTAT00000043154; ENSBTAP00000040744; ENSBTAG00000006538.
GeneID286767.
KEGGbta:286767.

Organism-specific databases

CTD5744.

Phylogenomic databases

eggNOGNOG40343.
GeneTreeENSGT00390000004933.
HOGENOMHOG000115765.
HOVERGENHBG003236.
InParanoidP58073.
OMAPATNTKN.
OrthoDBEOG7FBRK8.
TreeFamTF332953.

Family and domain databases

InterProIPR003626. PTH-rel.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERPTHR17223. PTHR17223. 1 hit.
PfamPF01279. Parathyroid. 1 hit.
[Graphical view]
SMARTSM00087. PTH. 1 hit.
[Graphical view]
PROSITEPS00335. PARATHYROID. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806428.

Entry information

Entry namePTHR_BOVIN
AccessionPrimary (citable) accession number: P58073
Secondary accession number(s): A6QPN9, Q8HYS1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families