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Protein

Parathyroid hormone-related protein

Gene

PTHLH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity).By similarity
Osteostatin is a potent inhibitor of osteoclastic bone resorption.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_330097. G alpha (s) signalling events.
REACT_344063. Class B/2 (Secretin family receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone-related protein
Short name:
PTH-rP
Short name:
PTHrP
Cleaved into the following chain:
Gene namesi
Name:PTHLH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Propeptidei25 – 3410By similarityPRO_0000023217
Chaini37 – 177141Parathyroid hormone-related proteinPRO_0000023218Add
BLAST
Peptidei143 – 17533OsteostatinBy similarityPRO_0000023219Add
BLAST

Post-translational modificationi

There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PRIDEiP58073.

Expressioni

Tissue specificityi

Expressed in the mammary gland.

Interactioni

Subunit structurei

PTHrP interacts with PTH1R (via N-terminal extracellular domain).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040744.

Structurei

3D structure databases

ProteinModelPortaliP58073.
SMRiP58073. Positions 37-70, 103-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 6812Important for receptor bindingBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi108 – 12922Nuclear localization signalBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the parathyroid hormone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40343.
GeneTreeiENSGT00390000004933.
HOGENOMiHOG000115765.
HOVERGENiHBG003236.
InParanoidiP58073.
OMAiPATNTKN.
OrthoDBiEOG7FBRK8.
TreeFamiTF332953.

Family and domain databases

InterProiIPR003626. PTH-rel.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR17223. PTHR17223. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWRLVQQWS VAVFLLSYSV PSCGRSVEEL GRRLKRAVSE HQLLHDKGKS
60 70 80 90 100
IQDLRRRFFL HHLIAEIHTA EIRATSEVSP NSKPAPNTKN HPVRFGSDDE
110 120 130 140 150
GKYLTQETNK VETYKEQPLK TPGKKKKSKP GKRKEQEKKK RRTRSAWLTS
160 170
YVAGTGLEED YLSDISATSL ELNSRRH
Length:177
Mass (Da):20,408
Last modified:June 1, 2001 - v1
Checksum:i6A5B48ECB219EF08
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261S → L in BAC44840 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097837 mRNA. Translation: BAC44840.1.
BC149411 mRNA. Translation: AAI49412.1.
RefSeqiNP_777178.1. NM_174753.1.
XP_005206971.1. XM_005206914.2.
XP_010803682.1. XM_010805380.1.
XP_010803683.1. XM_010805381.1.
UniGeneiBt.12848.

Genome annotation databases

EnsembliENSBTAT00000008581; ENSBTAP00000008581; ENSBTAG00000006538.
ENSBTAT00000043154; ENSBTAP00000040744; ENSBTAG00000006538.
GeneIDi286767.
KEGGibta:286767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097837 mRNA. Translation: BAC44840.1.
BC149411 mRNA. Translation: AAI49412.1.
RefSeqiNP_777178.1. NM_174753.1.
XP_005206971.1. XM_005206914.2.
XP_010803682.1. XM_010805380.1.
XP_010803683.1. XM_010805381.1.
UniGeneiBt.12848.

3D structure databases

ProteinModelPortaliP58073.
SMRiP58073. Positions 37-70, 103-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040744.

Proteomic databases

PRIDEiP58073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000008581; ENSBTAP00000008581; ENSBTAG00000006538.
ENSBTAT00000043154; ENSBTAP00000040744; ENSBTAG00000006538.
GeneIDi286767.
KEGGibta:286767.

Organism-specific databases

CTDi5744.

Phylogenomic databases

eggNOGiNOG40343.
GeneTreeiENSGT00390000004933.
HOGENOMiHOG000115765.
HOVERGENiHBG003236.
InParanoidiP58073.
OMAiPATNTKN.
OrthoDBiEOG7FBRK8.
TreeFamiTF332953.

Enzyme and pathway databases

ReactomeiREACT_330097. G alpha (s) signalling events.
REACT_344063. Class B/2 (Secretin family receptors).

Miscellaneous databases

NextBioi20806428.

Family and domain databases

InterProiIPR003626. PTH-rel.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR17223. PTHR17223. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of bovine parathyroid hormone-related protein (PTHrP) cDNA and expression of PTHrP mRNA in the bovine mammary gland."
    Wojcik S.F., Schanbacher F.L., McCauley L.K., Zhou H., Kartsogiannis V., Capen C.C., Rosol T.J.
    J. Mol. Endocrinol. 20:271-280(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Molecular cloning of bovine parathyroid hormone-related protein cDNA."
    Onda K., Inaba M., Ono K.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Holstein-Friesian.
    Tissue: Mammary gland.
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal spinal cord.

Entry informationi

Entry nameiPTHR_BOVIN
AccessioniPrimary (citable) accession number: P58073
Secondary accession number(s): A6QPN9, Q8HYS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 27, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.