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P58073

- PTHR_BOVIN

UniProt

P58073 - PTHR_BOVIN

Protein

Parathyroid hormone-related protein

Gene

PTHLH

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath By similarity.By similarity
    Osteostatin is a potent inhibitor of osteoclastic bone resorption.By similarity

    GO - Molecular functioni

    1. peptide hormone receptor binding Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
    2. endochondral ossification Source: Ensembl
    3. endoderm development Source: Ensembl
    4. epithelial cell differentiation Source: Ensembl
    5. lung alveolus development Source: Ensembl
    6. mammary gland bud elongation Source: Ensembl
    7. negative regulation of chondrocyte differentiation Source: Ensembl
    8. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    9. nipple sheath formation Source: Ensembl
    10. osteoblast development Source: Ensembl
    11. positive regulation of cAMP biosynthetic process Source: Ensembl
    12. positive regulation of cell proliferation Source: Ensembl
    13. protein processing Source: Ensembl
    14. surfactant homeostasis Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_204109. Class B/2 (Secretin family receptors).
    REACT_206547. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Parathyroid hormone-related protein
    Short name:
    PTH-rP
    Short name:
    PTHrP
    Cleaved into the following chain:
    Gene namesi
    Name:PTHLH
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 5

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. Golgi apparatus Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Propeptidei25 – 3410By similarityPRO_0000023217
    Chaini37 – 177141Parathyroid hormone-related proteinPRO_0000023218Add
    BLAST
    Peptidei143 – 17533OsteostatinBy similarityPRO_0000023219Add
    BLAST

    Post-translational modificationi

    There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions By similarity.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues

    Proteomic databases

    PRIDEiP58073.

    Expressioni

    Tissue specificityi

    Expressed in the mammary gland.

    Interactioni

    Subunit structurei

    PTHrP interacts with PTH1R (via N-terminal extracellular domain).By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000040744.

    Structurei

    3D structure databases

    ProteinModelPortaliP58073.
    SMRiP58073. Positions 37-70, 103-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni57 – 6812Important for receptor bindingBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi108 – 12922Nuclear localization signalBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the parathyroid hormone family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40343.
    GeneTreeiENSGT00390000004933.
    HOGENOMiHOG000115765.
    HOVERGENiHBG003236.
    InParanoidiP58073.
    OMAiPATNTKN.
    OrthoDBiEOG7FBRK8.
    TreeFamiTF332953.

    Family and domain databases

    InterProiIPR003626. PTH-rel.
    IPR001415. PTH/PTH-rel.
    [Graphical view]
    PANTHERiPTHR17223. PTHR17223. 1 hit.
    PfamiPF01279. Parathyroid. 1 hit.
    [Graphical view]
    SMARTiSM00087. PTH. 1 hit.
    [Graphical view]
    PROSITEiPS00335. PARATHYROID. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P58073-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLWRLVQQWS VAVFLLSYSV PSCGRSVEEL GRRLKRAVSE HQLLHDKGKS    50
    IQDLRRRFFL HHLIAEIHTA EIRATSEVSP NSKPAPNTKN HPVRFGSDDE 100
    GKYLTQETNK VETYKEQPLK TPGKKKKSKP GKRKEQEKKK RRTRSAWLTS 150
    YVAGTGLEED YLSDISATSL ELNSRRH 177
    Length:177
    Mass (Da):20,408
    Last modified:June 1, 2001 - v1
    Checksum:i6A5B48ECB219EF08
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261S → L in BAC44840. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB097837 mRNA. Translation: BAC44840.1.
    BC149411 mRNA. Translation: AAI49412.1.
    RefSeqiNP_777178.1. NM_174753.1.
    XP_005206971.1. XM_005206914.1.
    UniGeneiBt.12848.

    Genome annotation databases

    EnsembliENSBTAT00000008581; ENSBTAP00000008581; ENSBTAG00000006538.
    ENSBTAT00000043154; ENSBTAP00000040744; ENSBTAG00000006538.
    GeneIDi286767.
    KEGGibta:286767.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB097837 mRNA. Translation: BAC44840.1 .
    BC149411 mRNA. Translation: AAI49412.1 .
    RefSeqi NP_777178.1. NM_174753.1.
    XP_005206971.1. XM_005206914.1.
    UniGenei Bt.12848.

    3D structure databases

    ProteinModelPortali P58073.
    SMRi P58073. Positions 37-70, 103-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000040744.

    Proteomic databases

    PRIDEi P58073.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000008581 ; ENSBTAP00000008581 ; ENSBTAG00000006538 .
    ENSBTAT00000043154 ; ENSBTAP00000040744 ; ENSBTAG00000006538 .
    GeneIDi 286767.
    KEGGi bta:286767.

    Organism-specific databases

    CTDi 5744.

    Phylogenomic databases

    eggNOGi NOG40343.
    GeneTreei ENSGT00390000004933.
    HOGENOMi HOG000115765.
    HOVERGENi HBG003236.
    InParanoidi P58073.
    OMAi PATNTKN.
    OrthoDBi EOG7FBRK8.
    TreeFami TF332953.

    Enzyme and pathway databases

    Reactomei REACT_204109. Class B/2 (Secretin family receptors).
    REACT_206547. G alpha (s) signalling events.

    Miscellaneous databases

    NextBioi 20806428.

    Family and domain databases

    InterProi IPR003626. PTH-rel.
    IPR001415. PTH/PTH-rel.
    [Graphical view ]
    PANTHERi PTHR17223. PTHR17223. 1 hit.
    Pfami PF01279. Parathyroid. 1 hit.
    [Graphical view ]
    SMARTi SM00087. PTH. 1 hit.
    [Graphical view ]
    PROSITEi PS00335. PARATHYROID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of bovine parathyroid hormone-related protein (PTHrP) cDNA and expression of PTHrP mRNA in the bovine mammary gland."
      Wojcik S.F., Schanbacher F.L., McCauley L.K., Zhou H., Kartsogiannis V., Capen C.C., Rosol T.J.
      J. Mol. Endocrinol. 20:271-280(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Molecular cloning of bovine parathyroid hormone-related protein cDNA."
      Onda K., Inaba M., Ono K.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Holstein-Friesian.
      Tissue: Mammary gland.
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal spinal cord.

    Entry informationi

    Entry nameiPTHR_BOVIN
    AccessioniPrimary (citable) accession number: P58073
    Secondary accession number(s): A6QPN9, Q8HYS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3