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P58062 (ISK7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine protease inhibitor Kazal-type 7
Alternative name(s):
Esophagus cancer-related gene 2 protein
Short name=ECRG-2
Gene names
Name:SPINK7
Synonyms:ECG2
ORF Names:UNQ745/PRO1474
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length85 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable serine protease inhibitor.

Subcellular location

Secreted Potential.

Sequence similarities

Contains 1 Kazal-like domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionProtease inhibitor
Serine protease inhibitor
   PTMDisulfide bond
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 8566Serine protease inhibitor Kazal-type 7
PRO_0000016565

Regions

Domain26 – 8560Kazal-like

Sites

Site47 – 482Reactive bond Potential

Amino acid modifications

Disulfide bond32 ↔ 67 Ref.4
Disulfide bond45 ↔ 64 Ref.4
Disulfide bond53 ↔ 85 Ref.4

Secondary structure

............ 85
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P58062 [UniParc].

Last modified May 4, 2001. Version 1.
Checksum: AE861AC8E1EA07D3

FASTA859,232
        10         20         30         40         50         60 
MKITGGLLLL CTVVYFCSSS EAASLSPKKV DCSIYKKYPV VAIPCPITYL PVCGSDYITY 

        70         80 
GNECHLCTES LKSNGRVQFL HDGSC 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and function research of the esophagus cancer related gene-2 (ECRG-2)."
Bi M., Lu S.
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Esophagus.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"NMR structure note: human esophageal cancer-related gene 2."
Feng Y., Geng Y., Zhou T., Wang J.
J. Biomol. NMR 53:65-70(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 20-85, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF268198 mRNA. Translation: AAK27795.1.
AY359072 mRNA. Translation: AAQ89431.1.
BC109385 mRNA. Translation: AAI09386.1.
BC110067 mRNA. Translation: AAI10068.1.
RefSeqNP_115955.1. NM_032566.2.
UniGeneHs.244569.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2LEONMR-A20-85[»]
ProteinModelPortalP58062.
SMRP58062. Positions 20-85.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124174. 8 interactions.
IntActP58062. 7 interactions.
STRING9606.ENSP00000274565.

Protein family/group databases

MEROPSI01.057.

Polymorphism databases

DMDM13959341.

Proteomic databases

PaxDbP58062.
PeptideAtlasP58062.
PRIDEP58062.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000274565; ENSP00000274565; ENSG00000145879.
GeneID84651.
KEGGhsa:84651.
UCSCuc003lpd.3. human.

Organism-specific databases

CTD84651.
GeneCardsGC05P147691.
HGNCHGNC:24643. SPINK7.
HPAHPA036294.
neXtProtNX_P58062.
PharmGKBPA143485620.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG247304.
HOGENOMHOG000090244.
HOVERGENHBG006182.
InParanoidP58062.
OMACHLCIEN.
OrthoDBEOG7BW0M2.
PhylomeDBP58062.

Gene expression databases

ArrayExpressP58062.
BgeeP58062.
CleanExHS_SPINK7.
GenevestigatorP58062.

Family and domain databases

InterProIPR002350. Kazal_dom.
[Graphical view]
PfamPF00050. Kazal_1. 1 hit.
[Graphical view]
SMARTSM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEPS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi84651.
NextBio74610.
PROP58062.

Entry information

Entry nameISK7_HUMAN
AccessionPrimary (citable) accession number: P58062
Secondary accession number(s): Q32LY0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 4, 2001
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM