P58062 (ISK7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine protease inhibitor Kazal-type 7

Alternative name(s):
Esophagus cancer-related gene 2 protein
Short name=ECRG-2

Gene names

Name:	SPINK7
Synonyms:	ECG2
ORF Names:	UNQ745/PRO1474

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	85 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable serine protease inhibitor.
Subcellular location	Secreted Potential.
Sequence similarities	Contains 1 Kazal-like domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct serine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q8IZW4	3	EBI-1182445,EBI-1182458
EPB42	P16452	3	EBI-1182445,EBI-1182496
MRPS12	O15235	3	EBI-1182445,EBI-712205
MT1G	P13640	3	EBI-1182445,EBI-1182473
MT1H	P80294	3	EBI-1182445,EBI-296567
MT2A	P02795	7	EBI-1182445,EBI-996616
PARF	Q3YEC7	3	EBI-1182445,EBI-742029

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 85	66	Serine protease inhibitor Kazal-type 7		PRO_0000016565
Regions
	Domain	26 – 85	60	Kazal-like
Sites
	Site	47 – 48	2	Reactive bond Potential
Amino acid modifications
	Disulfide bond	32 ↔ 67		By similarity
	Disulfide bond	45 ↔ 64		By similarity
	Disulfide bond	53 ↔ 85		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P58062 [UniParc]. Last modified May 4, 2001. Version 1. Checksum: AE861AC8E1EA07D3	FASTA	85	9,232
	10 20 30 40 50 60 MKITGGLLLL CTVVYFCSSS EAASLSPKKV DCSIYKKYPV VAIPCPITYL PVCGSDYITY 70 80 GNECHLCTES LKSNGRVQFL HDGSC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and function research of the esophagus cancer related gene-2 (ECRG-2)." Bi M., Lu S. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Oesophagus.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF268198 mRNA. Translation: AAK27795.1. AY359072 mRNA. Translation: AAQ89431.1. BC109385 mRNA. Translation: AAI09386.1. BC110067 mRNA. Translation: AAI10068.1.
IPI	IPI00010630.
RefSeq	NP_115955.1. NM_032566.2.
UniGene	Hs.244569.
3D structure databases
ProteinModelPortal	P58062.
SMR	P58062. Positions 45-73.
ModBase	Search...
Protein-protein interaction databases
IntAct	P58062. 7 interactions.
STRING	P58062.
Protein family/group databases
MEROPS	I01.971.
Polymorphism databases
DMDM	13959341.
Proteomic databases
PeptideAtlas	P58062.
PRIDE	P58062.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000274565; ENSP00000274565; ENSG00000145879.
GeneID	84651.
KEGG	hsa:84651.
UCSC	uc003lpd.1. human.
Organism-specific databases
CTD	84651.
GeneCards	GC05P147691.
H-InvDB	HIX0031993.
HGNC	HGNC:24643. SPINK7.
HPA	HPA036294.
neXtProt	NX_P58062.
PharmGKB	PA143485620.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21155.
GeneTree	ENSGT00570000079206.
HOGENOM	HBG282636.
HOVERGEN	HBG006182.
InParanoid	P58062.
OMA	KVQFLHE.
OrthoDB	EOG4M91T4.
PhylomeDB	P58062.
Gene expression databases
ArrayExpress	P58062.
Bgee	P58062.
CleanEx	HS_SPINK7.
Genevestigator	P58062.
GermOnline	ENSG00000145879. Homo sapiens.
Family and domain databases
InterPro	IPR002350. Prot_inh_Kazal. [Graphical view]
Pfam	PF00050. Kazal_1. 1 hit. [Graphical view]
SMART	SM00280. KAZAL. 1 hit. [Graphical view]
PROSITE	PS00282. KAZAL_1. 1 hit. PS51465. KAZAL_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	74610.

Entry information

Entry name

ISK7_HUMAN

Accession

Primary (citable) accession number: P58062
Secondary accession number(s): Q32LY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 4, 2001
Last sequence update:	May 4, 2001
Last modified:	January 25, 2012
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.