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P58062

- ISK7_HUMAN

UniProt

P58062 - ISK7_HUMAN

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Protein
Serine protease inhibitor Kazal-type 7
Gene
SPINK7, ECG2, UNQ745/PRO1474
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Probable serine protease inhibitor.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei47 – 482Reactive bond Reviewed prediction

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI01.057.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine protease inhibitor Kazal-type 7
    Alternative name(s):
    Esophagus cancer-related gene 2 protein
    Short name:
    ECRG-2
    Gene namesi
    Name:SPINK7
    Synonyms:ECG2
    ORF Names:UNQ745/PRO1474
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:24643. SPINK7.

    Subcellular locationi

    Secreted Reviewed prediction

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485620.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919 Reviewed prediction
    Add
    BLAST
    Chaini20 – 8566Serine protease inhibitor Kazal-type 7
    PRO_0000016565Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 671 Publication
    Disulfide bondi45 ↔ 641 Publication
    Disulfide bondi53 ↔ 851 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP58062.
    PeptideAtlasiP58062.
    PRIDEiP58062.

    Expressioni

    Gene expression databases

    ArrayExpressiP58062.
    BgeeiP58062.
    CleanExiHS_SPINK7.
    GenevestigatoriP58062.

    Organism-specific databases

    HPAiHPA036294.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Q8IZW43EBI-1182445,EBI-1182458
    EPB42P164523EBI-1182445,EBI-1182496
    MRPS12O152353EBI-1182445,EBI-712205
    MT1GP136403EBI-1182445,EBI-1182473
    MT1HP802943EBI-1182445,EBI-296567
    MT2AP027957EBI-1182445,EBI-996616
    RABL6Q3YEC73EBI-1182445,EBI-742029

    Protein-protein interaction databases

    BioGridi124174. 8 interactions.
    IntActiP58062. 7 interactions.
    STRINGi9606.ENSP00000274565.

    Structurei

    Secondary structure

    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi33 – 364
    Beta strandi52 – 543
    Beta strandi59 – 624
    Helixi63 – 7210
    Beta strandi75 – 773
    Beta strandi79 – 835

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LEONMR-A20-85[»]
    ProteinModelPortaliP58062.
    SMRiP58062. Positions 20-85.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 8560Kazal-like
    Add
    BLAST

    Sequence similaritiesi

    Contains 1 Kazal-like domain.

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG247304.
    HOGENOMiHOG000090244.
    HOVERGENiHBG006182.
    InParanoidiP58062.
    OMAiTHFCSSS.
    OrthoDBiEOG7BW0M2.
    PhylomeDBiP58062.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    [Graphical view]
    PfamiPF00050. Kazal_1. 1 hit.
    [Graphical view]
    SMARTiSM00280. KAZAL. 1 hit.
    [Graphical view]
    PROSITEiPS00282. KAZAL_1. 1 hit.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P58062-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKITGGLLLL CTVVYFCSSS EAASLSPKKV DCSIYKKYPV VAIPCPITYL   50
    PVCGSDYITY GNECHLCTES LKSNGRVQFL HDGSC 85
    Length:85
    Mass (Da):9,232
    Last modified:May 4, 2001 - v1
    Checksum:iAE861AC8E1EA07D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF268198 mRNA. Translation: AAK27795.1.
    AY359072 mRNA. Translation: AAQ89431.1.
    BC109385 mRNA. Translation: AAI09386.1.
    BC110067 mRNA. Translation: AAI10068.1.
    CCDSiCCDS4289.1.
    RefSeqiNP_115955.1. NM_032566.2.
    UniGeneiHs.244569.

    Genome annotation databases

    EnsembliENST00000274565; ENSP00000274565; ENSG00000145879.
    GeneIDi84651.
    KEGGihsa:84651.
    UCSCiuc003lpd.3. human.

    Polymorphism databases

    DMDMi13959341.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF268198 mRNA. Translation: AAK27795.1 .
    AY359072 mRNA. Translation: AAQ89431.1 .
    BC109385 mRNA. Translation: AAI09386.1 .
    BC110067 mRNA. Translation: AAI10068.1 .
    CCDSi CCDS4289.1.
    RefSeqi NP_115955.1. NM_032566.2.
    UniGenei Hs.244569.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LEO NMR - A 20-85 [» ]
    ProteinModelPortali P58062.
    SMRi P58062. Positions 20-85.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 124174. 8 interactions.
    IntActi P58062. 7 interactions.
    STRINGi 9606.ENSP00000274565.

    Protein family/group databases

    MEROPSi I01.057.

    Polymorphism databases

    DMDMi 13959341.

    Proteomic databases

    PaxDbi P58062.
    PeptideAtlasi P58062.
    PRIDEi P58062.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274565 ; ENSP00000274565 ; ENSG00000145879 .
    GeneIDi 84651.
    KEGGi hsa:84651.
    UCSCi uc003lpd.3. human.

    Organism-specific databases

    CTDi 84651.
    GeneCardsi GC05P147691.
    HGNCi HGNC:24643. SPINK7.
    HPAi HPA036294.
    neXtProti NX_P58062.
    PharmGKBi PA143485620.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG247304.
    HOGENOMi HOG000090244.
    HOVERGENi HBG006182.
    InParanoidi P58062.
    OMAi THFCSSS.
    OrthoDBi EOG7BW0M2.
    PhylomeDBi P58062.

    Miscellaneous databases

    GenomeRNAii 84651.
    NextBioi 74610.
    PROi P58062.

    Gene expression databases

    ArrayExpressi P58062.
    Bgeei P58062.
    CleanExi HS_SPINK7.
    Genevestigatori P58062.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    [Graphical view ]
    Pfami PF00050. Kazal_1. 1 hit.
    [Graphical view ]
    SMARTi SM00280. KAZAL. 1 hit.
    [Graphical view ]
    PROSITEi PS00282. KAZAL_1. 1 hit.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Cloning and function research of the esophagus cancer related gene-2 (ECRG-2)."
      Bi M., Lu S.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Esophagus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "NMR structure note: human esophageal cancer-related gene 2."
      Feng Y., Geng Y., Zhou T., Wang J.
      J. Biomol. NMR 53:65-70(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 20-85, DISULFIDE BONDS.

    Entry informationi

    Entry nameiISK7_HUMAN
    AccessioniPrimary (citable) accession number: P58062
    Secondary accession number(s): Q32LY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 4, 2001
    Last sequence update: May 4, 2001
    Last modified: July 9, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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