Reviewed, UniProtKB/Swiss-Prot P58062 (ISK7_HUMAN)

Names and origin

Protein names

Recommended name:
    Serine protease inhibitor Kazal-type 7
Alternative name(s):
    Esophagus cancer-related gene 2 protein
      Short name=ECRG-2

Gene names

Name:	SPINK7
Synonyms:	ECG2
ORF Names:	UNQ745/PRO1474

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	85 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Probable serine protease inhibitor.
Subcellular location	SecretedPotential.
Sequence similarities	Contains 1 Kazal-like domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Protease inhibitor Serine protease inhibitor
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct serine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q8IZW4	3	EBI-1182445,EBI-1182458
EPB42	P16452	3	EBI-1182445,EBI-1182496
MRPS12	O15235	3	EBI-1182445,EBI-712205
MT1G	P13640	3	EBI-1182445,EBI-1182473
MT1H	P80294	3	EBI-1182445,EBI-296567
MT2A	P02795	5	EBI-1182445,EBI-996616
PARF	Q3YEC7	3	EBI-1182445,EBI-742029

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 85	66	Serine protease inhibitor Kazal-type 7		PRO_0000016565
Regions
	Domain	30 – 85	56	Kazal-like
Sites
	Site	47 – 48	2	Reactive bond Potential
Amino acid modifications
	Disulfide bond	32 ↔ 67		By similarity
	Disulfide bond	45 ↔ 64		By similarity
	Disulfide bond	53 ↔ 85		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P58062-1 [UniParc]. Last modified May 4, 2001. Version 1. Checksum: AE861AC8E1EA07D3	FASTA	85	9,232
	10 20 30 40 50 60 MKITGGLLLL CTVVYFCSSS EAASLSPKKV DCSIYKKYPV VAIPCPITYL PVCGSDYITY 70 80 GNECHLCTES LKSNGRVQFL HDGSC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and function research of the esophagus cancer related gene-2 (ECRG-2)." Bi M., Lu S. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Oesophagus.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF268198 mRNA. Translation: AAK27795.1. AY359072 mRNA. Translation: AAQ89431.1. BC109385 mRNA. Translation: AAI09386.1. BC110067 mRNA. Translation: AAI10068.1.
RefSeq	NP_115955.1.
UniGene	Hs.244569
3D structure databases
HSSP	HSSP built from PDB template 1CSO based on UniProtKB P01004.
ModBase	Search...
Protein-protein interaction databases
IntAct	P58062.
Protein family/group databases
MEROPS	I01.971.
Proteomic databases
PeptideAtlas	P58062.
Genome annotation databases
Ensembl	ENSG00000145879. Homo sapiens. [Contig view]
GeneID	84651.
KEGG	hsa:84651.
Organism-specific databases
H-InvDB	HIX0031993.
HGNC	HGNC:24643. SPINK7.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P58062.
HOVERGEN	P58062.
Gene expression databases
ArrayExpress	P58062.
CleanEx	HS_SPINK7.
GermOnline	ENSG00000145879. Homo sapiens.
Family and domain databases
InterPro	IPR002350. Prot_inh_Kazal. IPR001239. Prot_inh_Kazal-m. [Graphical view]
Pfam	PF00050. Kazal_1. 1 hit. [Graphical view]
PRINTS	PR00290. KAZALINHBTR.
SMART	SM00280. KAZAL. 1 hit. [Graphical view]
PROSITE	PS00282. KAZAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	74610.

Entry information

Entry name

ISK7_HUMAN

Accession

Primary (citable) accession number: P58062
Secondary accession number(s): Q32LY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 4, 2001
Last sequence update:	May 4, 2001
Last modified:	November 25, 2008
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)