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Protein

Serine protease inhibitor Kazal-type 7

Gene

SPINK7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable serine protease inhibitor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei47 – 48Reactive bondPROSITE-ProRule annotation2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145879-MONOMER.

Protein family/group databases

MEROPSiI01.057.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor Kazal-type 7
Alternative name(s):
Esophagus cancer-related gene 2 protein
Short name:
ECRG-2
Gene namesi
Name:SPINK7
Synonyms:ECG2
ORF Names:UNQ745/PRO1474
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:24643. SPINK7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi84651.
OpenTargetsiENSG00000145879.
PharmGKBiPA143485620.

Polymorphism and mutation databases

BioMutaiSPINK7.
DMDMi13959341.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001656520 – 85Serine protease inhibitor Kazal-type 7Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 67PROSITE-ProRule annotation1 Publication
Disulfide bondi45 ↔ 64PROSITE-ProRule annotation1 Publication
Disulfide bondi53 ↔ 85PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP58062.
PeptideAtlasiP58062.
PRIDEiP58062.

Expressioni

Gene expression databases

BgeeiENSG00000145879.
CleanExiHS_SPINK7.
ExpressionAtlasiP58062. baseline and differential.
GenevisibleiP58062. HS.

Organism-specific databases

HPAiHPA036294.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q8IZW43EBI-1182445,EBI-1182458
EPB42P164523EBI-1182445,EBI-1182496
MRPS12O152353EBI-1182445,EBI-712205
MT1GP136403EBI-1182445,EBI-1182473
MT1HP802943EBI-1182445,EBI-296567
MT2AP027957EBI-1182445,EBI-996616
RABL6Q3YEC73EBI-1182445,EBI-742029

Protein-protein interaction databases

BioGridi124174. 16 interactors.
IntActiP58062. 7 interactors.
STRINGi9606.ENSP00000274565.

Structurei

Secondary structure

185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi33 – 36Combined sources4
Beta strandi52 – 54Combined sources3
Beta strandi59 – 62Combined sources4
Helixi63 – 72Combined sources10
Beta strandi75 – 77Combined sources3
Beta strandi79 – 83Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LEONMR-A20-85[»]
ProteinModelPortaliP58062.
SMRiP58062.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 85Kazal-likePROSITE-ProRule annotationAdd BLAST60

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3649. Eukaryota.
ENOG410YC3T. LUCA.
GeneTreeiENSGT00860000133862.
HOGENOMiHOG000090244.
HOVERGENiHBG006182.
InParanoidiP58062.
OMAiTVDCSIY.
OrthoDBiEOG091G1BGL.
PhylomeDBiP58062.

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF00050. Kazal_1. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITGGLLLL CTVVYFCSSS EAASLSPKKV DCSIYKKYPV VAIPCPITYL
60 70 80
PVCGSDYITY GNECHLCTES LKSNGRVQFL HDGSC
Length:85
Mass (Da):9,232
Last modified:May 4, 2001 - v1
Checksum:iAE861AC8E1EA07D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268198 mRNA. Translation: AAK27795.1.
AY359072 mRNA. Translation: AAQ89431.1.
BC109385 mRNA. Translation: AAI09386.1.
BC110067 mRNA. Translation: AAI10068.1.
CCDSiCCDS4289.1.
RefSeqiNP_115955.1. NM_032566.2.
UniGeneiHs.244569.

Genome annotation databases

EnsembliENST00000274565; ENSP00000274565; ENSG00000145879.
GeneIDi84651.
KEGGihsa:84651.
UCSCiuc003lpd.4. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268198 mRNA. Translation: AAK27795.1.
AY359072 mRNA. Translation: AAQ89431.1.
BC109385 mRNA. Translation: AAI09386.1.
BC110067 mRNA. Translation: AAI10068.1.
CCDSiCCDS4289.1.
RefSeqiNP_115955.1. NM_032566.2.
UniGeneiHs.244569.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LEONMR-A20-85[»]
ProteinModelPortaliP58062.
SMRiP58062.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124174. 16 interactors.
IntActiP58062. 7 interactors.
STRINGi9606.ENSP00000274565.

Protein family/group databases

MEROPSiI01.057.

Polymorphism and mutation databases

BioMutaiSPINK7.
DMDMi13959341.

Proteomic databases

PaxDbiP58062.
PeptideAtlasiP58062.
PRIDEiP58062.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274565; ENSP00000274565; ENSG00000145879.
GeneIDi84651.
KEGGihsa:84651.
UCSCiuc003lpd.4. human.

Organism-specific databases

CTDi84651.
DisGeNETi84651.
GeneCardsiSPINK7.
HGNCiHGNC:24643. SPINK7.
HPAiHPA036294.
neXtProtiNX_P58062.
OpenTargetsiENSG00000145879.
PharmGKBiPA143485620.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3649. Eukaryota.
ENOG410YC3T. LUCA.
GeneTreeiENSGT00860000133862.
HOGENOMiHOG000090244.
HOVERGENiHBG006182.
InParanoidiP58062.
OMAiTVDCSIY.
OrthoDBiEOG091G1BGL.
PhylomeDBiP58062.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145879-MONOMER.

Miscellaneous databases

GenomeRNAii84651.
PROiP58062.

Gene expression databases

BgeeiENSG00000145879.
CleanExiHS_SPINK7.
ExpressionAtlasiP58062. baseline and differential.
GenevisibleiP58062. HS.

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF00050. Kazal_1. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiISK7_HUMAN
AccessioniPrimary (citable) accession number: P58062
Secondary accession number(s): Q32LY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 4, 2001
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.