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P58062

- ISK7_HUMAN

UniProt

P58062 - ISK7_HUMAN

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Protein

Serine protease inhibitor Kazal-type 7

Gene

SPINK7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Probable serine protease inhibitor.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei47 – 482Reactive bondPROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.057.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor Kazal-type 7
Alternative name(s):
Esophagus cancer-related gene 2 protein
Short name:
ECRG-2
Gene namesi
Name:SPINK7
Synonyms:ECG2
ORF Names:UNQ745/PRO1474
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:24643. SPINK7.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485620.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 8566Serine protease inhibitor Kazal-type 7PRO_0000016565Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 671 PublicationPROSITE-ProRule annotation
Disulfide bondi45 ↔ 641 PublicationPROSITE-ProRule annotation
Disulfide bondi53 ↔ 851 PublicationPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP58062.
PeptideAtlasiP58062.
PRIDEiP58062.

Expressioni

Gene expression databases

BgeeiP58062.
CleanExiHS_SPINK7.
ExpressionAtlasiP58062. baseline and differential.
GenevestigatoriP58062.

Organism-specific databases

HPAiHPA036294.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q8IZW43EBI-1182445,EBI-1182458
EPB42P164523EBI-1182445,EBI-1182496
MRPS12O152353EBI-1182445,EBI-712205
MT1GP136403EBI-1182445,EBI-1182473
MT1HP802943EBI-1182445,EBI-296567
MT2AP027957EBI-1182445,EBI-996616
RABL6Q3YEC73EBI-1182445,EBI-742029

Protein-protein interaction databases

BioGridi124174. 8 interactions.
IntActiP58062. 7 interactions.
STRINGi9606.ENSP00000274565.

Structurei

Secondary structure

1
85
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi33 – 364Combined sources
Beta strandi52 – 543Combined sources
Beta strandi59 – 624Combined sources
Helixi63 – 7210Combined sources
Beta strandi75 – 773Combined sources
Beta strandi79 – 835Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LEONMR-A20-85[»]
ProteinModelPortaliP58062.
SMRiP58062. Positions 20-85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 8560Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG247304.
GeneTreeiENSGT00730000111393.
HOGENOMiHOG000090244.
HOVERGENiHBG006182.
InParanoidiP58062.
OMAiTHFCSSS.
OrthoDBiEOG7BW0M2.
PhylomeDBiP58062.

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF00050. Kazal_1. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58062-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKITGGLLLL CTVVYFCSSS EAASLSPKKV DCSIYKKYPV VAIPCPITYL
60 70 80
PVCGSDYITY GNECHLCTES LKSNGRVQFL HDGSC
Length:85
Mass (Da):9,232
Last modified:May 4, 2001 - v1
Checksum:iAE861AC8E1EA07D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268198 mRNA. Translation: AAK27795.1.
AY359072 mRNA. Translation: AAQ89431.1.
BC109385 mRNA. Translation: AAI09386.1.
BC110067 mRNA. Translation: AAI10068.1.
CCDSiCCDS4289.1.
RefSeqiNP_115955.1. NM_032566.2.
UniGeneiHs.244569.

Genome annotation databases

EnsembliENST00000274565; ENSP00000274565; ENSG00000145879.
GeneIDi84651.
KEGGihsa:84651.
UCSCiuc003lpd.3. human.

Polymorphism databases

DMDMi13959341.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268198 mRNA. Translation: AAK27795.1 .
AY359072 mRNA. Translation: AAQ89431.1 .
BC109385 mRNA. Translation: AAI09386.1 .
BC110067 mRNA. Translation: AAI10068.1 .
CCDSi CCDS4289.1.
RefSeqi NP_115955.1. NM_032566.2.
UniGenei Hs.244569.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LEO NMR - A 20-85 [» ]
ProteinModelPortali P58062.
SMRi P58062. Positions 20-85.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124174. 8 interactions.
IntActi P58062. 7 interactions.
STRINGi 9606.ENSP00000274565.

Protein family/group databases

MEROPSi I01.057.

Polymorphism databases

DMDMi 13959341.

Proteomic databases

PaxDbi P58062.
PeptideAtlasi P58062.
PRIDEi P58062.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274565 ; ENSP00000274565 ; ENSG00000145879 .
GeneIDi 84651.
KEGGi hsa:84651.
UCSCi uc003lpd.3. human.

Organism-specific databases

CTDi 84651.
GeneCardsi GC05P147691.
HGNCi HGNC:24643. SPINK7.
HPAi HPA036294.
neXtProti NX_P58062.
PharmGKBi PA143485620.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG247304.
GeneTreei ENSGT00730000111393.
HOGENOMi HOG000090244.
HOVERGENi HBG006182.
InParanoidi P58062.
OMAi THFCSSS.
OrthoDBi EOG7BW0M2.
PhylomeDBi P58062.

Miscellaneous databases

GenomeRNAii 84651.
NextBioi 74610.
PROi P58062.

Gene expression databases

Bgeei P58062.
CleanExi HS_SPINK7.
ExpressionAtlasi P58062. baseline and differential.
Genevestigatori P58062.

Family and domain databases

InterProi IPR002350. Kazal_dom.
[Graphical view ]
Pfami PF00050. Kazal_1. 1 hit.
[Graphical view ]
SMARTi SM00280. KAZAL. 1 hit.
[Graphical view ]
PROSITEi PS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and function research of the esophagus cancer related gene-2 (ECRG-2)."
    Bi M., Lu S.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Esophagus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "NMR structure note: human esophageal cancer-related gene 2."
    Feng Y., Geng Y., Zhou T., Wang J.
    J. Biomol. NMR 53:65-70(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 20-85, DISULFIDE BONDS.

Entry informationi

Entry nameiISK7_HUMAN
AccessioniPrimary (citable) accession number: P58062
Secondary accession number(s): Q32LY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 4, 2001
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3