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Protein

NAD kinase

Gene

Nadk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + NAD+ = ADP + NADP+.

Cofactori

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. NAD+ kinase activity Source: UniProtKB

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_209575. Nicotinate metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
Poly(P)/ATP NAD kinase
Gene namesi
Name:Nadk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2183149. Nadk.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439NAD kinasePRO_0000120714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461PhosphoserineBy similarity
Modified residuei48 – 481PhosphoserineBy similarity
Modified residuei50 – 501PhosphoserineBy similarity
Modified residuei64 – 641PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP58058.
PaxDbiP58058.
PRIDEiP58058.

PTM databases

PhosphoSiteiP58058.

Expressioni

Gene expression databases

BgeeiP58058.
CleanExiMM_NADK.
ExpressionAtlasiP58058. baseline and differential.
GenevestigatoriP58058.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030939.

Structurei

3D structure databases

ProteinModelPortaliP58058.
SMRiP58058. Positions 72-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi322 – 3298Poly-Ala

Sequence similaritiesi

Belongs to the NAD kinase family.Curated

Phylogenomic databases

eggNOGiCOG0061.
GeneTreeiENSGT00390000013792.
HOGENOMiHOG000176769.
HOVERGENiHBG008249.
InParanoidiP58058.
KOiK00858.
OMAiQTIMHIQ.
OrthoDBiEOG7ZPNJT.
TreeFamiTF324076.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

P58058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMEQEKMNL SQELSADSAS YNCSACHGDE TWSYNHPIRG RAKSRSLSAS
60 70 80 90 100
PALGSTKEFR RTRSLHGPCP VTTFGPKACV LQNPQTIMHI QDPASQRLTW
110 120 130 140 150
NKSPKSVLVI KKIRDASLLQ PFKELCIYLM EENNMIVYVE KKVLEDPAIV
160 170 180 190 200
SDENFGPVKK KFCTFREDYD DISNQIDFII CLGGDGTLLY ASSLFQGSVP
210 220 230 240 250
PVMAFHLGSL GFLTPFNFEN FQSQVNQVIE GNAAVILRSR LKVRVVKEPR
260 270 280 290 300
DKKTAIHNGL SENGLDTEGG KQAMQYQVLN EVVIDRGPSS YLSNVDVYLD
310 320 330 340 350
GHLITTVQGD GVIVSTPTGS TAYAAAAGAS MVHPNVPAIM VTPICPHSLS
360 370 380 390 400
FRPIVVPAGV ELKIMLSPEA RNTAWVSFDG RKRQEIRHGD SISITTSCYP
410 420 430
LPSICVCDPV SDWFESLAQC LHWNVRKKQA HFPEDEEDS
Length:439
Mass (Da):48,597
Last modified:July 27, 2011 - v2
Checksum:iC3AFA7CDC3F0BF9C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti430 – 4301A → V in AAH04012 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK170095 mRNA. Translation: BAE41560.1.
AK170608 mRNA. Translation: BAE41908.1.
AK170960 mRNA. Translation: BAE42141.1.
BC004012 mRNA. Translation: AAH04012.1.
AL627405 Genomic DNA. Translation: CAM16741.1.
CH466594 Genomic DNA. Translation: EDL15013.1.
CCDSiCCDS19031.1.
RefSeqiNP_001153109.1. NM_001159637.1.
NP_619612.2. NM_138671.2.
XP_006538725.1. XM_006538662.1.
XP_006538726.1. XM_006538663.1.
UniGeneiMm.28347.

Genome annotation databases

EnsembliENSMUST00000030939; ENSMUSP00000030939; ENSMUSG00000029063.
ENSMUST00000105613; ENSMUSP00000101238; ENSMUSG00000029063.
GeneIDi192185.
KEGGimmu:192185.
UCSCiuc008wdt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK170095 mRNA. Translation: BAE41560.1.
AK170608 mRNA. Translation: BAE41908.1.
AK170960 mRNA. Translation: BAE42141.1.
BC004012 mRNA. Translation: AAH04012.1.
AL627405 Genomic DNA. Translation: CAM16741.1.
CH466594 Genomic DNA. Translation: EDL15013.1.
CCDSiCCDS19031.1.
RefSeqiNP_001153109.1. NM_001159637.1.
NP_619612.2. NM_138671.2.
XP_006538725.1. XM_006538662.1.
XP_006538726.1. XM_006538663.1.
UniGeneiMm.28347.

3D structure databases

ProteinModelPortaliP58058.
SMRiP58058. Positions 72-422.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030939.

PTM databases

PhosphoSiteiP58058.

Proteomic databases

MaxQBiP58058.
PaxDbiP58058.
PRIDEiP58058.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030939; ENSMUSP00000030939; ENSMUSG00000029063.
ENSMUST00000105613; ENSMUSP00000101238; ENSMUSG00000029063.
GeneIDi192185.
KEGGimmu:192185.
UCSCiuc008wdt.2. mouse.

Organism-specific databases

CTDi65220.
MGIiMGI:2183149. Nadk.

Phylogenomic databases

eggNOGiCOG0061.
GeneTreeiENSGT00390000013792.
HOGENOMiHOG000176769.
HOVERGENiHBG008249.
InParanoidiP58058.
KOiK00858.
OMAiQTIMHIQ.
OrthoDBiEOG7ZPNJT.
TreeFamiTF324076.

Enzyme and pathway databases

ReactomeiREACT_209575. Nicotinate metabolism.

Miscellaneous databases

ChiTaRSiNadk. mouse.
NextBioi371192.
PROiP58058.
SOURCEiSearch...

Gene expression databases

BgeeiP58058.
CleanExiMM_NADK.
ExpressionAtlasiP58058. baseline and differential.
GenevestigatoriP58058.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiNADK_MOUSE
AccessioniPrimary (citable) accession number: P58058
Secondary accession number(s): Q3TCP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: July 27, 2011
Last modified: March 4, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.