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Protein

NAD kinase

Gene

Nadk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + NAD+ = ADP + NADP+.

Cofactori

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • NAD+ kinase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Metal-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-196807 Nicotinate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
Poly(P)/ATP NAD kinase
Gene namesi
Name:Nadk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2183149 Nadk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207141 – 439NAD kinaseAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46PhosphoserineBy similarity1
Modified residuei48PhosphoserineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Modified residuei55PhosphoserineBy similarity1
Modified residuei64PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP58058
MaxQBiP58058
PaxDbiP58058
PeptideAtlasiP58058
PRIDEiP58058

PTM databases

iPTMnetiP58058
PhosphoSitePlusiP58058

Expressioni

Gene expression databases

BgeeiENSMUSG00000029063
CleanExiMM_NADK
ExpressionAtlasiP58058 baseline and differential
GenevisibleiP58058 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030939

Structurei

3D structure databases

ProteinModelPortaliP58058
SMRiP58058
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi322 – 329Poly-Ala8

Sequence similaritiesi

Belongs to the NAD kinase family.Curated

Phylogenomic databases

eggNOGiKOG2178 Eukaryota
COG0061 LUCA
GeneTreeiENSGT00390000013792
HOGENOMiHOG000176769
HOVERGENiHBG008249
InParanoidiP58058
KOiK00858
OMAiQTIMHIQ
OrthoDBiEOG091G09US
TreeFamiTF324076

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

P58058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMEQEKMNL SQELSADSAS YNCSACHGDE TWSYNHPIRG RAKSRSLSAS
60 70 80 90 100
PALGSTKEFR RTRSLHGPCP VTTFGPKACV LQNPQTIMHI QDPASQRLTW
110 120 130 140 150
NKSPKSVLVI KKIRDASLLQ PFKELCIYLM EENNMIVYVE KKVLEDPAIV
160 170 180 190 200
SDENFGPVKK KFCTFREDYD DISNQIDFII CLGGDGTLLY ASSLFQGSVP
210 220 230 240 250
PVMAFHLGSL GFLTPFNFEN FQSQVNQVIE GNAAVILRSR LKVRVVKEPR
260 270 280 290 300
DKKTAIHNGL SENGLDTEGG KQAMQYQVLN EVVIDRGPSS YLSNVDVYLD
310 320 330 340 350
GHLITTVQGD GVIVSTPTGS TAYAAAAGAS MVHPNVPAIM VTPICPHSLS
360 370 380 390 400
FRPIVVPAGV ELKIMLSPEA RNTAWVSFDG RKRQEIRHGD SISITTSCYP
410 420 430
LPSICVCDPV SDWFESLAQC LHWNVRKKQA HFPEDEEDS
Length:439
Mass (Da):48,597
Last modified:July 27, 2011 - v2
Checksum:iC3AFA7CDC3F0BF9C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti430A → V in AAH04012 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK170095 mRNA Translation: BAE41560.1
AK170608 mRNA Translation: BAE41908.1
AK170960 mRNA Translation: BAE42141.1
BC004012 mRNA Translation: AAH04012.1
AL627405 Genomic DNA Translation: CAM16741.1
CH466594 Genomic DNA Translation: EDL15013.1
CCDSiCCDS19031.1
RefSeqiNP_001153109.1, NM_001159637.1
NP_619612.2, NM_138671.2
XP_006538725.1, XM_006538662.3
XP_006538726.1, XM_006538663.3
UniGeneiMm.28347

Genome annotation databases

EnsembliENSMUST00000030939; ENSMUSP00000030939; ENSMUSG00000029063
ENSMUST00000105613; ENSMUSP00000101238; ENSMUSG00000029063
GeneIDi192185
KEGGimmu:192185
UCSCiuc008wdt.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNADK_MOUSE
AccessioniPrimary (citable) accession number: P58058
Secondary accession number(s): Q3TCP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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