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P58056

- NADK_CAUCR

UniProt

P58056 - NADK_CAUCR

Protein

NAD kinase

Gene

nadK

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (04 May 2001)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei49 – 491Proton acceptorUniRule annotation
    Binding sitei149 – 1491NADUniRule annotation
    Binding sitei157 – 1571NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi49 – 502NADUniRule annotation
    Nucleotide bindingi119 – 1202NADUniRule annotation
    Nucleotide bindingi160 – 1656NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCAULO:CC1221-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:CC_1221
    OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
    Taxonomic identifieri190650 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
    ProteomesiUP000001816: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260NAD kinasePRO_0000120609Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP58056.
    SMRiP58056. Positions 36-235.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000139847.
    KOiK00858.
    OMAiMNGYAED.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P58056-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYQPQPFVTR LAFKCSDRPE AQEARERLAA RYGDVGPENA QVIVALGGDG    50
    FMLESLHEAI ASQTPIYGMN RGSVGFLMNE YSEDGLLERI NAAERAVIHP 100
    LAMVAIDARR TQHRALAINE VSLLRQTRQT AKLRISIDGK VRMGELVCDG 150
    ALLATPAGST AYNLSAHGPI IPIDGRVLAL TPISAFRPRR WRGALLPQSA 200
    RVTFEILEAD KRPVSAVADN FEVRDAMEVH ISEDRGTSLA MLFDAGRSLE 250
    ERVLAEQFSA 260
    Length:260
    Mass (Da):28,525
    Last modified:May 4, 2001 - v1
    Checksum:i509682501D77ED8E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005673 Genomic DNA. Translation: AAK23203.1.
    PIRiG87400.
    RefSeqiNP_420035.1. NC_002696.2.

    Genome annotation databases

    EnsemblBacteriaiAAK23203; AAK23203; CC_1221.
    GeneIDi941625.
    KEGGiccr:CC_1221.
    PATRICi21299440. VBICauCre124313_1246.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005673 Genomic DNA. Translation: AAK23203.1 .
    PIRi G87400.
    RefSeqi NP_420035.1. NC_002696.2.

    3D structure databases

    ProteinModelPortali P58056.
    SMRi P58056. Positions 36-235.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK23203 ; AAK23203 ; CC_1221 .
    GeneIDi 941625.
    KEGGi ccr:CC_1221.
    PATRICi 21299440. VBICauCre124313_1246.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000139847.
    KOi K00858.
    OMAi MNGYAED.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci CAULO:CC1221-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19089 / CB15.

    Entry informationi

    Entry nameiNADK_CAUCR
    AccessioniPrimary (citable) accession number: P58056
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 4, 2001
    Last sequence update: May 4, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3