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P58056 (NADK_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:CC_1221
OrganismCaulobacter crescentus (strain ATCC 19089 / CB15) [Reference proteome] [HAMAP]
Taxonomic identifier190650 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260NAD kinase HAMAP-Rule MF_00361
PRO_0000120609

Regions

Nucleotide binding49 – 502NAD By similarity
Nucleotide binding119 – 1202NAD By similarity
Nucleotide binding160 – 1656NAD By similarity

Sites

Active site491Proton acceptor By similarity
Binding site1491NAD By similarity
Binding site1571NAD; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
P58056 [UniParc].

Last modified May 4, 2001. Version 1.
Checksum: 509682501D77ED8E

FASTA26028,525
        10         20         30         40         50         60 
MYQPQPFVTR LAFKCSDRPE AQEARERLAA RYGDVGPENA QVIVALGGDG FMLESLHEAI 

        70         80         90        100        110        120 
ASQTPIYGMN RGSVGFLMNE YSEDGLLERI NAAERAVIHP LAMVAIDARR TQHRALAINE 

       130        140        150        160        170        180 
VSLLRQTRQT AKLRISIDGK VRMGELVCDG ALLATPAGST AYNLSAHGPI IPIDGRVLAL 

       190        200        210        220        230        240 
TPISAFRPRR WRGALLPQSA RVTFEILEAD KRPVSAVADN FEVRDAMEVH ISEDRGTSLA 

       250        260 
MLFDAGRSLE ERVLAEQFSA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005673 Genomic DNA. Translation: AAK23203.1.
PIRG87400.
RefSeqNP_420035.1. NC_002696.2.

3D structure databases

ProteinModelPortalP58056.
SMRP58056. Positions 36-235.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK23203; AAK23203; CC_1221.
GeneID941625.
KEGGccr:CC_1221.
PATRIC21299440. VBICauCre124313_1246.

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000139847.
KOK00858.
OMAMNGYAED.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycCAULO:CC1221-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_CAUCR
AccessionPrimary (citable) accession number: P58056
Entry history
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 4, 2001
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families