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Protein

Sestrin-2

Gene

Sesn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the reduction of peroxiredoxins.By similarity

GO - Biological processi

  • autophagy Source: MGI
  • fatty acid beta-oxidation Source: MGI
  • glucose homeostasis Source: MGI
  • glucose import Source: MGI
  • mitochondrial DNA metabolic process Source: MGI
  • mitochondrion organization Source: MGI
  • protein kinase B signaling Source: MGI
  • regulation of cAMP-dependent protein kinase activity Source: MGI
  • regulation of gluconeogenesis involved in cellular glucose homeostasis Source: MGI
  • regulation of protein phosphorylation Source: MGI
  • regulation of response to reactive oxygen species Source: InterPro
  • response to glucose Source: MGI
  • response to insulin Source: MGI
  • triglyceride homeostasis Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-5628897. TP53 Regulates Metabolic Genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Sestrin-2
Gene namesi
Name:Sesn2
Synonyms:Sest2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2651874. Sesn2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • mitochondrion Source: GOC
  • nucleus Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Sestrin-2PRO_0000221182Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei249 – 2491PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP58043.
MaxQBiP58043.
PaxDbiP58043.
PRIDEiP58043.

PTM databases

iPTMnetiP58043.
PhosphoSiteiP58043.

Expressioni

Gene expression databases

BgeeiP58043.
CleanExiMM_SESN2.
GenevisibleiP58043. MM.

Interactioni

Protein-protein interaction databases

BioGridi231026. 38 interactions.
IntActiP58043. 38 interactions.
STRINGi10090.ENSMUSP00000030724.

Structurei

3D structure databases

ProteinModelPortaliP58043.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sestrin family.Curated

Phylogenomic databases

eggNOGiKOG3746. Eukaryota.
ENOG410XP7Z. LUCA.
GeneTreeiENSGT00440000040103.
HOGENOMiHOG000232949.
HOVERGENiHBG054648.
InParanoidiP58043.
KOiK10141.
OMAiASSWRHY.
OrthoDBiEOG7SBNNF.
PhylomeDBiP58043.
TreeFamiTF314230.

Family and domain databases

Gene3Di1.20.1290.10. 1 hit.
InterProiIPR029032. AhpD-like.
IPR006730. Sestrin.
[Graphical view]
PfamiPF04636. PA26. 1 hit.
[Graphical view]
SUPFAMiSSF69118. SSF69118. 1 hit.

Sequencei

Sequence statusi: Complete.

P58043-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVADSECHS EIKGYLPFTR GGVAGPETRE EHREGQARRG SRGPSAFIPV
60 70 80 90 100
EEILREGAES LEQHLGLEAL MSSGRVDNLA VVMGLHPDYL SSFWRLHYLL
110 120 130 140 150
LHTDGPLASS WRHYIAIMAA ARHQCSYLVG SHMTEFLQTG GDPEWLLGLH
160 170 180 190 200
RAPEKLRKLS EVNKLLAHRP WLITKEHIQA LLKTGEHSWS LAELIQALVL
210 220 230 240 250
LTHCHSLASF VFGCGILPEG DAEGSPASQA PSPPSEQGTP PSGDPLNNSG
260 270 280 290 300
GFEAARDVEA LMERMRQLQE SLLRDEGASQ EEMENRFELE KSESLLVTPS
310 320 330 340 350
ADILEPSPHP DILCFVEDPA FGYEDFTRRG TQAPPTFRAQ DYTWEDHGYS
360 370 380 390 400
LIQRLYPEGG QLLDEKFQVA CSLTYNTIAM HSGVDTSMLR RAIWNYIHCV
410 420 430 440 450
FGIRYDDYDY GEVNQLLERN LKIYIKTVAC YPEKTTRRMY NLFWRHFRHS
460 470 480
EKVHVNLLLL EARMQAALLY ALRAITRYMT
Length:480
Mass (Da):54,377
Last modified:April 27, 2001 - v1
Checksum:i11B1FF352E75C90F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005672 mRNA. Translation: AAH05672.1.
CCDSiCCDS18726.1.
RefSeqiNP_659156.1. NM_144907.1.
UniGeneiMm.23608.

Genome annotation databases

EnsembliENSMUST00000030724; ENSMUSP00000030724; ENSMUSG00000028893.
GeneIDi230784.
KEGGimmu:230784.
UCSCiuc008vbj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005672 mRNA. Translation: AAH05672.1.
CCDSiCCDS18726.1.
RefSeqiNP_659156.1. NM_144907.1.
UniGeneiMm.23608.

3D structure databases

ProteinModelPortaliP58043.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231026. 38 interactions.
IntActiP58043. 38 interactions.
STRINGi10090.ENSMUSP00000030724.

PTM databases

iPTMnetiP58043.
PhosphoSiteiP58043.

Proteomic databases

EPDiP58043.
MaxQBiP58043.
PaxDbiP58043.
PRIDEiP58043.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030724; ENSMUSP00000030724; ENSMUSG00000028893.
GeneIDi230784.
KEGGimmu:230784.
UCSCiuc008vbj.1. mouse.

Organism-specific databases

CTDi83667.
MGIiMGI:2651874. Sesn2.

Phylogenomic databases

eggNOGiKOG3746. Eukaryota.
ENOG410XP7Z. LUCA.
GeneTreeiENSGT00440000040103.
HOGENOMiHOG000232949.
HOVERGENiHBG054648.
InParanoidiP58043.
KOiK10141.
OMAiASSWRHY.
OrthoDBiEOG7SBNNF.
PhylomeDBiP58043.
TreeFamiTF314230.

Enzyme and pathway databases

ReactomeiR-MMU-5628897. TP53 Regulates Metabolic Genes.

Miscellaneous databases

PROiP58043.
SOURCEiSearch...

Gene expression databases

BgeeiP58043.
CleanExiMM_SESN2.
GenevisibleiP58043. MM.

Family and domain databases

Gene3Di1.20.1290.10. 1 hit.
InterProiIPR029032. AhpD-like.
IPR006730. Sestrin.
[Graphical view]
PfamiPF04636. PA26. 1 hit.
[Graphical view]
SUPFAMiSSF69118. SSF69118. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: DH10B.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiSESN2_MOUSE
AccessioniPrimary (citable) accession number: P58043
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.