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Protein

Prophage outer membrane lipoprotein RzoR

Gene

rzoR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the spanin complex that disrupts the outer membrane and causes cell lysis during virus exit. The spanin complex conducts the final step in cell lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCytolysis, Host cell lysis by virus, Viral release from host cell

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-2671

Names & Taxonomyi

Protein namesi
Recommended name:
Prophage outer membrane lipoprotein RzoRCurated
Short name:
o-spanin
Alternative name(s):
Outer membrane lipoprotein Rz1 from lambdoid prophage Rac
Spanin from lambdoid prophage Rac, outer membrane subunit
Gene namesi
Name:rzoR
Ordered Locus Names:b4528, JW5213
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14381 rzoR

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19PROSITE-ProRule annotationAdd BLAST19
ChainiPRO_000000336620 – 61Prophage outer membrane lipoprotein RzoRAdd BLAST42

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi20N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi20S-diacylglycerol cysteinePROSITE-ProRule annotation1
Disulfide bondi29InterchainBy similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP58042
PRIDEiP58042

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts (via C-terminus) with RZ (via C-terminus). Part of the spanin complex which spans the entire periplasmic space. The spanin complex is composed of spanin, inner membrane subunit and spanin, outer membrane subunit (By similarity).By similarity

Protein-protein interaction databases

BioGridi4260160, 14 interactors
STRINGi316385.ECDH10B_1485

Structurei

3D structure databases

ProteinModelPortaliP58042
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 36Poly-Pro5

Sequence similaritiesi

Belongs to the lambdalikevirus o-spanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000054872
OMAiKLKMMFC

Family and domain databases

InterProiView protein in InterPro
IPR010346 o-spanin
PfamiView protein in Pfam
PF06085 Rz1, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKLKMMLCV MMLPLVVVGC TSKQSVSQCV KPPPPPAWIM QPPPDWQTPL
60
NGIISPSGND W
Length:61
Mass (Da):6,761
Last modified:April 27, 2001 - v1
Checksum:i226225EE4DE474AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: ABD18660.1
AP009048 Genomic DNA Translation: BAE76416.1
RefSeqiWP_001228696.1, NZ_CP014272.1
YP_588452.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiABD18660; ABD18660; b4528
BAE76416; BAE76416; BAE76416
GeneIDi1450262
KEGGiecj:JW5213
eco:b4528

Similar proteinsi

Entry informationi

Entry nameiRZOR_ECOLI
AccessioniPrimary (citable) accession number: P58042
Secondary accession number(s): Q2EER8, Q2MBE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health