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Protein

Prophage outer membrane lipoprotein RzoD

Gene

rzoD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the spanin complex that disrupts the outer membrane and causes cell lysis during virus exit. The spanin complex conducts the final step in cell lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cytolysis, Host cell lysis by virus, Virus exit from host cell

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-2658.
ECOL316407:JW5080-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Prophage outer membrane lipoprotein RzoDCurated
Short name:
o-spanin
Alternative name(s):
Outer membrane lipoprotein Rz1 from lambdoid prophage DLP12
Spanin from lambdoid prophage DLP12, outer membrane subunit
Gene namesi
Name:rzoD
Ordered Locus Names:b4510, JW5080
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14380. rzoD.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19PROSITE-ProRule annotationAdd BLAST19
ChainiPRO_000000336520 – 60Prophage outer membrane lipoprotein RzoDAdd BLAST41

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi20N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi20S-diacylglycerol cysteinePROSITE-ProRule annotation1
Disulfide bondi29InterchainBy similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP58041.
PRIDEiP58041.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts (via C-terminus) with RZ (via C-terminus). Part of the spanin complex which spans the entire periplasmic space. The spanin complex is composed of spanin, inner membrane subunit and spanin, outer membrane subunit (By similarity).By similarity

Protein-protein interaction databases

BioGridi4259886. 8 interactors.
STRINGi511145.b4510.

Structurei

3D structure databases

ProteinModelPortaliP58041.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lambdalikevirus o-spanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000054872.
OMAiPVQVPCV.

Family and domain databases

InterProiIPR010346. o-spanin.
[Graphical view]
PfamiPF06085. Rz1. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKLKMMLCV MMLPLVVVGC TSKQSVSQCV KPPRPPAWIM QPPPDWQTPL
60
NGIISPSERG
Length:60
Mass (Da):6,690
Last modified:April 27, 2001 - v1
Checksum:i30E5AF0DC674AA6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: ABD18640.1.
AP009048 Genomic DNA. Translation: BAE76332.1.
RefSeqiYP_588440.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiABD18640; ABD18640; b4510.
BAE76332; BAE76332; BAE76332.
GeneIDi1450242.
KEGGiecj:JW5080.
eco:b4510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: ABD18640.1.
AP009048 Genomic DNA. Translation: BAE76332.1.
RefSeqiYP_588440.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP58041.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259886. 8 interactors.
STRINGi511145.b4510.

Proteomic databases

PaxDbiP58041.
PRIDEiP58041.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD18640; ABD18640; b4510.
BAE76332; BAE76332; BAE76332.
GeneIDi1450242.
KEGGiecj:JW5080.
eco:b4510.

Organism-specific databases

EcoGeneiEG14380. rzoD.

Phylogenomic databases

HOGENOMiHOG000054872.
OMAiPVQVPCV.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-2658.
ECOL316407:JW5080-MONOMER.

Miscellaneous databases

PROiP58041.

Family and domain databases

InterProiIPR010346. o-spanin.
[Graphical view]
PfamiPF06085. Rz1. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRZOD_ECOLI
AccessioniPrimary (citable) accession number: P58041
Secondary accession number(s): Q2EEQ5, Q2MBM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Encoded by the cryptic lambdoid prophage DLP12.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.