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Protein

Putative phosphotransferase enzyme IIB component SgcB

Gene

sgcB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.By similarity

Catalytic activityi

Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei8 – 81Phosphocysteine intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-2121.
ECOL316407:JW5967-MONOMER.

Protein family/group databases

TCDBi4.A.5.1.3. the pts galactitol (gat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phosphotransferase enzyme IIB component SgcB (EC:2.7.1.-)
Alternative name(s):
Putative PTS system EIIB component
Gene namesi
Name:sgcB
Ordered Locus Names:b4565, JW5967
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14343. sgcB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9292Putative phosphotransferase enzyme IIB component SgcBPRO_0000186690Add
BLAST

Proteomic databases

PaxDbiP58035.

Interactioni

Protein-protein interaction databases

BioGridi4262742. 7 interactions.
STRINGi511145.b4565.

Structurei

3D structure databases

ProteinModelPortaliP58035.
SMRiP58035. Positions 2-90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9292PTS EIIB type-2PROSITE-ProRule annotationAdd
BLAST

Domaini

The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.

Sequence similaritiesi

Contains 1 PTS EIIB type-2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105K18. Bacteria.
COG3414. LUCA.
HOGENOMiHOG000230475.
KOiK02774.
OMAiPVINARS.
OrthoDBiEOG66QM4V.
PhylomeDBiP58035.

Family and domain databases

InterProiIPR013011. PTS_EIIB_2.
IPR003501. PTS_EIIB_2/3.
[Graphical view]
PfamiPF02302. PTS_IIB. 1 hit.
[Graphical view]
SUPFAMiSSF52794. SSF52794. 1 hit.
PROSITEiPS51099. PTS_EIIB_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58035-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKILVACGT GMSTSTMIAH KLQEFLTEQG ISATTAQCCL NEIPLNCNGM
60 70 80 90
DLIVTSMRTN SDYGIPTLNG AALLTGINDD ALKQQIKALL TQ
Length:92
Mass (Da):9,803
Last modified:April 27, 2001 - v1
Checksum:i371BC568AF1F0862
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: ABD18717.1.
AP009048 Genomic DNA. Translation: BAE78296.1.
RefSeqiWP_024165496.1. NZ_LN832404.1.
YP_588476.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiABD18717; ABD18717; b4565.
BAE78296; BAE78296; BAE78296.
GeneIDi1450295.
KEGGiecj:JW5967.
eco:b4565.
PATRICi32124196. VBIEscCol129921_4441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: ABD18717.1.
AP009048 Genomic DNA. Translation: BAE78296.1.
RefSeqiWP_024165496.1. NZ_LN832404.1.
YP_588476.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP58035.
SMRiP58035. Positions 2-90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262742. 7 interactions.
STRINGi511145.b4565.

Protein family/group databases

TCDBi4.A.5.1.3. the pts galactitol (gat) family.

Proteomic databases

PaxDbiP58035.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD18717; ABD18717; b4565.
BAE78296; BAE78296; BAE78296.
GeneIDi1450295.
KEGGiecj:JW5967.
eco:b4565.
PATRICi32124196. VBIEscCol129921_4441.

Organism-specific databases

EcoGeneiEG14343. sgcB.

Phylogenomic databases

eggNOGiENOG4105K18. Bacteria.
COG3414. LUCA.
HOGENOMiHOG000230475.
KOiK02774.
OMAiPVINARS.
OrthoDBiEOG66QM4V.
PhylomeDBiP58035.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-2121.
ECOL316407:JW5967-MONOMER.

Miscellaneous databases

PROiP58035.

Family and domain databases

InterProiIPR013011. PTS_EIIB_2.
IPR003501. PTS_EIIB_2/3.
[Graphical view]
PfamiPF02302. PTS_IIB. 1 hit.
[Graphical view]
SUPFAMiSSF52794. SSF52794. 1 hit.
PROSITEiPS51099. PTS_EIIB_TYPE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Novel phosphotransferases system genes revealed by bacterial genome analysis: operons encoding homologues of sugar-specific permease domains of the phosphotransferase system and pentose catabolic enzymes."
    Reizer J., Charbit A., Reizer A., Saier M.H. Jr.
    Genome Sci. Technol. 1:53-75(1996)
    Cited for: DISCUSSION OF SEQUENCE.

Entry informationi

Entry nameiSGCB_ECOLI
AccessioniPrimary (citable) accession number: P58035
Secondary accession number(s): Q2EEU3, Q2M610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.