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P58028

- AOFB_CAVPO

UniProt

P58028 - AOFB_CAVPO

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Protein

Amine oxidase [flavin-containing] B

Gene
MAOB
Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine By similarity.

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FAD.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei156 – 1561Important for catalytic activity By similarity
Sitei365 – 3651Important for catalytic activity By similarity
Sitei382 – 3821Important for catalytic activity By similarity

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] B (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type B
Short name:
MAO-B
Gene namesi
Name:MAOB
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 489488Cytoplasmic By similarityAdd
BLAST
Transmembranei490 – 51627Helical; Anchor for type IV membrane protein; By similarityAdd
BLAST
Topological domaini517 – 5204Mitochondrial intermembrane By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 520519Amine oxidase [flavin-containing] BPRO_0000099858Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521N6-acetyllysine By similarity
Modified residuei397 – 3971S-8alpha-FAD cysteine By similarity

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000000879.

Structurei

3D structure databases

ProteinModelPortaliP58028.
SMRiP58028. Positions 4-496.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi36 – 5217Arg/Lys-rich (basic)Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1231.
HOGENOMiHOG000221615.
HOVERGENiHBG004255.
InParanoidiP58028.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58028-1 [UniParc]FASTAAdd to Basket

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MNSKCDVVVV GGGISGLAAA KLLHDSGLNV VVLEARDCVG GRTYTLRNQN    50
VKYVDLGGAY VGPTQNRILR LAKELGLETY RVNDVERQIH HVKGKSYPFR 100
GPFPPAWNPI SYLDHNNLWR TMDDMGKEIP SDAPWKAPLA EEWDHMTMKE 150
LLNKICWTNC PRQFGTLFVN LCFTAETHEV SALWFLWYVK QCGGTTRIIS 200
TTNGGQERKF VGGSGQISER IMNLLGDRVK LQRPVVYIDQ TGESVLVETL 250
NHEIYEAKYV ISAIPPALGM KIHFKPPLPM MKNQLVSRVP LGSVIKCIVY 300
YKDPFWRKKD FCGTMVIEGE EAPVLYTMDD TKPDGSYAAI IGFIAAHKAR 350
KLARLTKEER LKKLCELYAK VLGSKEALKP VHYEEKNWCE EQYSGGCYTA 400
YFPPGIMTQY GRFLRQPVGR IFFAGTETAT HWSGYMEGAV EAGERAAREV 450
LNAIGKIPED EIWQPEPESV DVPAQPITTT FLERHLPSVP GLLRLIRLTT 500
VVSAVALGFL AQKRGLLLRI 520
Length:520
Mass (Da):58,410
Last modified:January 23, 2007 - v2
Checksum:i0AEBAE99A48BC206
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB047271 mRNA. Translation: BAB40418.1.
RefSeqiNP_001166452.1. NM_001172981.1.

Genome annotation databases

GeneIDi100135573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB047271 mRNA. Translation: BAB40418.1 .
RefSeqi NP_001166452.1. NM_001172981.1.

3D structure databases

ProteinModelPortali P58028.
SMRi P58028. Positions 4-496.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000000879.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100135573.

Organism-specific databases

CTDi 4129.

Phylogenomic databases

eggNOGi COG1231.
HOGENOMi HOG000221615.
HOVERGENi HBG004255.
InParanoidi P58028.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequences of putative cDNAs for guinea-pig monoamine oxidase."
    Yaekashiwa N., Tamate H.B., Takeuchi T., Sugimoto H., Shibata K., Kinemuchi H.
    Inflammopharmacology 11:145-154(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain and Liver.

Entry informationi

Entry nameiAOFB_CAVPO
AccessioniPrimary (citable) accession number: P58028
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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