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P58028

- AOFB_CAVPO

UniProt

P58028 - AOFB_CAVPO

Protein

Amine oxidase [flavin-containing] B

Gene

MAOB

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine By similarity.By similarity

    Catalytic activityi

    RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

    Cofactori

    FAD.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei156 – 1561Important for catalytic activityBy similarity
    Sitei365 – 3651Important for catalytic activityBy similarity
    Sitei382 – 3821Important for catalytic activityBy similarity

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Amine oxidase [flavin-containing] B (EC:1.4.3.4)
    Alternative name(s):
    Monoamine oxidase type B
    Short name:
    MAO-B
    Gene namesi
    Name:MAOB
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 520519Amine oxidase [flavin-containing] BPRO_0000099858Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei52 – 521N6-acetyllysineBy similarity
    Modified residuei397 – 3971S-8alpha-FAD cysteineBy similarity

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000000879.

    Structurei

    3D structure databases

    ProteinModelPortaliP58028.
    SMRiP58028. Positions 4-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 489488CytoplasmicBy similarityAdd
    BLAST
    Topological domaini517 – 5204Mitochondrial intermembraneBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei490 – 51627Helical; Anchor for type IV membrane proteinBy similarityAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi36 – 5217Arg/Lys-rich (basic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the flavin monoamine oxidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1231.
    HOGENOMiHOG000221615.
    HOVERGENiHBG004255.
    InParanoidiP58028.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002937. Amino_oxidase.
    IPR001613. Flavin_amine_oxidase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01593. Amino_oxidase. 1 hit.
    [Graphical view]
    PRINTSiPR00757. AMINEOXDASEF.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P58028-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSKCDVVVV GGGISGLAAA KLLHDSGLNV VVLEARDCVG GRTYTLRNQN    50
    VKYVDLGGAY VGPTQNRILR LAKELGLETY RVNDVERQIH HVKGKSYPFR 100
    GPFPPAWNPI SYLDHNNLWR TMDDMGKEIP SDAPWKAPLA EEWDHMTMKE 150
    LLNKICWTNC PRQFGTLFVN LCFTAETHEV SALWFLWYVK QCGGTTRIIS 200
    TTNGGQERKF VGGSGQISER IMNLLGDRVK LQRPVVYIDQ TGESVLVETL 250
    NHEIYEAKYV ISAIPPALGM KIHFKPPLPM MKNQLVSRVP LGSVIKCIVY 300
    YKDPFWRKKD FCGTMVIEGE EAPVLYTMDD TKPDGSYAAI IGFIAAHKAR 350
    KLARLTKEER LKKLCELYAK VLGSKEALKP VHYEEKNWCE EQYSGGCYTA 400
    YFPPGIMTQY GRFLRQPVGR IFFAGTETAT HWSGYMEGAV EAGERAAREV 450
    LNAIGKIPED EIWQPEPESV DVPAQPITTT FLERHLPSVP GLLRLIRLTT 500
    VVSAVALGFL AQKRGLLLRI 520
    Length:520
    Mass (Da):58,410
    Last modified:January 23, 2007 - v2
    Checksum:i0AEBAE99A48BC206
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB047271 mRNA. Translation: BAB40418.1.
    RefSeqiNP_001166452.1. NM_001172981.1.

    Genome annotation databases

    GeneIDi100135573.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB047271 mRNA. Translation: BAB40418.1 .
    RefSeqi NP_001166452.1. NM_001172981.1.

    3D structure databases

    ProteinModelPortali P58028.
    SMRi P58028. Positions 4-496.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000000879.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100135573.

    Organism-specific databases

    CTDi 4129.

    Phylogenomic databases

    eggNOGi COG1231.
    HOGENOMi HOG000221615.
    HOVERGENi HBG004255.
    InParanoidi P58028.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002937. Amino_oxidase.
    IPR001613. Flavin_amine_oxidase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01593. Amino_oxidase. 1 hit.
    [Graphical view ]
    PRINTSi PR00757. AMINEOXDASEF.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequences of putative cDNAs for guinea-pig monoamine oxidase."
      Yaekashiwa N., Tamate H.B., Takeuchi T., Sugimoto H., Shibata K., Kinemuchi H.
      Inflammopharmacology 11:145-154(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain and Liver.

    Entry informationi

    Entry nameiAOFB_CAVPO
    AccessioniPrimary (citable) accession number: P58028
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3