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P58027

- AOFA_CANFA

UniProt

P58027 - AOFA_CANFA

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Protein
Amine oxidase [flavin-containing] A
Gene
MAOA
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine By similarity.

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FAD By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei335 – 3351Important for substrate specificity By similarity
Sitei374 – 3741Important for catalytic activity By similarity

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW

GO - Biological processi

  1. dopamine catabolic process Source: Ensembl
  2. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Catecholamine metabolism, Neurotransmitter degradation

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] A (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type A
Short name:
MAO-A
Gene namesi
Name:MAOA
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 497497Cytoplasmic By similarity
Add
BLAST
Transmembranei498 – 51821Helical; Anchor for type IV membrane protein; By similarity
Add
BLAST
Topological domaini519 – 5279Mitochondrial intermembrane By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Amine oxidase [flavin-containing] A
PRO_0000099848Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei406 – 4061S-8alpha-FAD cysteine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP58027.

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP58027.
SMRiP58027. Positions 12-524.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni520 – 5223Interaction with membrane phospholipid headgroups By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1231.
GeneTreeiENSGT00730000110903.
HOGENOMiHOG000221615.
HOVERGENiHBG004255.
InParanoidiP58027.
KOiK00274.
OMAiMEITHTF.
OrthoDBiEOG7K6PTP.
TreeFamiTF313314.

Family and domain databases

InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

P58027-1 [UniParc]FASTAAdd to Basket

« Hide

MASREKTSIE GHMFDVVVIG GGISGLSAAK LLAEHEVDVL VLEARDRVGG    50
RTYTVRNEHV DYVDVGGAYV GPTQNRILRL SKELGLETYK VNVNERLVQY 100
VKGKTYPFRG AFPPVWNPIA YLDYNNLWRT MDNMGKEIPA DAPWEAPHAE 150
EWDKMTMKDL IDKICWTKTA RRFASLFVNI NVTSEPHEVS ALWFLWYVKQ 200
CGGTTRIFSV TNGGQERKFV GGSGQVSERI MERLGDRVKL KRPVTYVDQS 250
DDNIIIETLN HELYECKYVI SAIPPTLTAK IHFRPELPSE RNQLIQRLPM 300
GAIIKCMMYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSLPAIM 350
GFILARKADR LAKLHKEIRK RKICELYAKV LGSQEALQPV HYEEKNWCEE 400
QYSGGCYTAY FPPGIMTHYG RVIRQPFGRI YFAGTETATH WSGYMEGAVE 450
AGERTAREVL NALGRVAEKD LKTQEPESKD VPAMEITHTF WERNLPSVTG 500
LLKLIGFTTS VTALWIVAYK FRLLRRS 527
Length:527
Mass (Da):60,088
Last modified:April 27, 2001 - v1
Checksum:i3F2C3FF5CED937C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB038563 mRNA. Translation: BAB40325.1.
RefSeqiNP_001002969.1. NM_001002969.1.
UniGeneiCfa.151.

Genome annotation databases

EnsembliENSCAFT00000022939; ENSCAFP00000021307; ENSCAFG00000014435.
GeneIDi403450.
KEGGicfa:403450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB038563 mRNA. Translation: BAB40325.1 .
RefSeqi NP_001002969.1. NM_001002969.1.
UniGenei Cfa.151.

3D structure databases

ProteinModelPortali P58027.
SMRi P58027. Positions 12-524.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P58027.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000022939 ; ENSCAFP00000021307 ; ENSCAFG00000014435 .
GeneIDi 403450.
KEGGi cfa:403450.

Organism-specific databases

CTDi 4128.

Phylogenomic databases

eggNOGi COG1231.
GeneTreei ENSGT00730000110903.
HOGENOMi HOG000221615.
HOVERGENi HBG004255.
InParanoidi P58027.
KOi K00274.
OMAi MEITHTF.
OrthoDBi EOG7K6PTP.
TreeFami TF313314.

Miscellaneous databases

NextBioi 20816968.

Family and domain databases

InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

  1. Hashizume C., Mori Y.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Beagle.
    Tissue: Brain.

Entry informationi

Entry nameiAOFA_CANFA
AccessioniPrimary (citable) accession number: P58027
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 14, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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