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Protein

Amine oxidase [flavin-containing] A

Gene

MAOA

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity).By similarity

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei335Important for substrate specificityBy similarity1
Sitei374Important for catalytic activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCatecholamine metabolism, Neurotransmitter degradation
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-CFA-141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
R-CFA-181430 Norepinephrine Neurotransmitter Release Cycle
R-CFA-379397 Enzymatic degradation of dopamine by COMT
R-CFA-379398 Enzymatic degradation of Dopamine by monoamine oxidase
R-CFA-380612 Metabolism of serotonin

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] A (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type A
Short name:
MAO-A
Gene namesi
Name:MAOA
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome X

Organism-specific databases

VGNCiVGNC:42953 MAOA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 497CytoplasmicBy similarityAdd BLAST497
Transmembranei498 – 518Helical; Anchor for type IV membrane proteinBy similarityAdd BLAST21
Topological domaini519 – 527Mitochondrial intermembraneBy similarity9

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000998481 – 527Amine oxidase [flavin-containing] AAdd BLAST527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei383PhosphoserineBy similarity1
Modified residuei406S-8alpha-FAD cysteineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP58027
PRIDEiP58027

Expressioni

Gene expression databases

BgeeiENSCAFG00000014435

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000021307

Structurei

3D structure databases

ProteinModelPortaliP58027
SMRiP58027
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni520 – 522Interaction with membrane phospholipid headgroupsBy similarity3

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0029 Eukaryota
ENOG410XSNC LUCA
GeneTreeiENSGT00730000110903
HOGENOMiHOG000221615
HOVERGENiHBG004255
InParanoidiP58027
KOiK00274
OMAiEWTRGAY
OrthoDBiEOG091G0G7P
TreeFamiTF313314

Family and domain databases

Gene3Di3.50.50.60, 4 hits
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
IPR001613 Flavin_amine_oxidase
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
PRINTSiPR00757 AMINEOXDASEF
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

P58027-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASREKTSIE GHMFDVVVIG GGISGLSAAK LLAEHEVDVL VLEARDRVGG
60 70 80 90 100
RTYTVRNEHV DYVDVGGAYV GPTQNRILRL SKELGLETYK VNVNERLVQY
110 120 130 140 150
VKGKTYPFRG AFPPVWNPIA YLDYNNLWRT MDNMGKEIPA DAPWEAPHAE
160 170 180 190 200
EWDKMTMKDL IDKICWTKTA RRFASLFVNI NVTSEPHEVS ALWFLWYVKQ
210 220 230 240 250
CGGTTRIFSV TNGGQERKFV GGSGQVSERI MERLGDRVKL KRPVTYVDQS
260 270 280 290 300
DDNIIIETLN HELYECKYVI SAIPPTLTAK IHFRPELPSE RNQLIQRLPM
310 320 330 340 350
GAIIKCMMYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSLPAIM
360 370 380 390 400
GFILARKADR LAKLHKEIRK RKICELYAKV LGSQEALQPV HYEEKNWCEE
410 420 430 440 450
QYSGGCYTAY FPPGIMTHYG RVIRQPFGRI YFAGTETATH WSGYMEGAVE
460 470 480 490 500
AGERTAREVL NALGRVAEKD LKTQEPESKD VPAMEITHTF WERNLPSVTG
510 520
LLKLIGFTTS VTALWIVAYK FRLLRRS
Length:527
Mass (Da):60,088
Last modified:April 27, 2001 - v1
Checksum:i3F2C3FF5CED937C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038563 mRNA Translation: BAB40325.1
RefSeqiNP_001002969.1, NM_001002969.1
UniGeneiCfa.151

Genome annotation databases

EnsembliENSCAFT00000022939; ENSCAFP00000021307; ENSCAFG00000014435
GeneIDi403450
KEGGicfa:403450

Similar proteinsi

Entry informationi

Entry nameiAOFA_CANLF
AccessioniPrimary (citable) accession number: P58027
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health