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P58027 (AOFA_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Amine oxidase [flavin-containing] A

EC=1.4.3.4
Alternative name(s):
Monoamine oxidase type A
Short name=MAO-A
Gene names
Name:MAOA
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine By similarity.

Catalytic activity

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactor

FAD By similarity.

Subunit structure

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.

Subcellular location

Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side By similarity.

Sequence similarities

Belongs to the flavin monoamine oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Amine oxidase [flavin-containing] A
PRO_0000099848

Regions

Topological domain1 – 497497Cytoplasmic By similarity
Transmembrane498 – 51821Helical; Anchor for type IV membrane protein; By similarity
Topological domain519 – 5279Mitochondrial intermembrane By similarity
Region520 – 5223Interaction with membrane phospholipid headgroups By similarity

Sites

Site3351Important for substrate specificity By similarity
Site3741Important for catalytic activity By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue4061S-8alpha-FAD cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P58027 [UniParc].

Last modified April 27, 2001. Version 1.
Checksum: 3F2C3FF5CED937C1

FASTA52760,088
        10         20         30         40         50         60 
MASREKTSIE GHMFDVVVIG GGISGLSAAK LLAEHEVDVL VLEARDRVGG RTYTVRNEHV 

        70         80         90        100        110        120 
DYVDVGGAYV GPTQNRILRL SKELGLETYK VNVNERLVQY VKGKTYPFRG AFPPVWNPIA 

       130        140        150        160        170        180 
YLDYNNLWRT MDNMGKEIPA DAPWEAPHAE EWDKMTMKDL IDKICWTKTA RRFASLFVNI 

       190        200        210        220        230        240 
NVTSEPHEVS ALWFLWYVKQ CGGTTRIFSV TNGGQERKFV GGSGQVSERI MERLGDRVKL 

       250        260        270        280        290        300 
KRPVTYVDQS DDNIIIETLN HELYECKYVI SAIPPTLTAK IHFRPELPSE RNQLIQRLPM 

       310        320        330        340        350        360 
GAIIKCMMYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSLPAIM GFILARKADR 

       370        380        390        400        410        420 
LAKLHKEIRK RKICELYAKV LGSQEALQPV HYEEKNWCEE QYSGGCYTAY FPPGIMTHYG 

       430        440        450        460        470        480 
RVIRQPFGRI YFAGTETATH WSGYMEGAVE AGERTAREVL NALGRVAEKD LKTQEPESKD 

       490        500        510        520 
VPAMEITHTF WERNLPSVTG LLKLIGFTTS VTALWIVAYK FRLLRRS 

« Hide

References

[1]Hashizume C., Mori Y.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Beagle.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB038563 mRNA. Translation: BAB40325.1.
RefSeqNP_001002969.1. NM_001002969.1.
UniGeneCfa.151.

3D structure databases

ProteinModelPortalP58027.
SMRP58027. Positions 12-524.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP58027.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000022939; ENSCAFP00000021307; ENSCAFG00000014435.
GeneID403450.
KEGGcfa:403450.

Organism-specific databases

CTD4128.

Phylogenomic databases

eggNOGCOG1231.
GeneTreeENSGT00730000110903.
HOGENOMHOG000221615.
HOVERGENHBG004255.
InParanoidP58027.
KOK00274.
OMAMEITHTF.
OrthoDBEOG7K6PTP.
TreeFamTF313314.

Family and domain databases

InterProIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSPR00757. AMINEOXDASEF.
ProtoNetSearch...

Other

NextBio20816968.

Entry information

Entry nameAOFA_CANFA
AccessionPrimary (citable) accession number: P58027
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 14, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families