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P58027

- AOFA_CANFA

UniProt

P58027 - AOFA_CANFA

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Protein

Amine oxidase [flavin-containing] A

Gene

MAOA

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity).By similarity

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FAD.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei335 – 3351Important for substrate specificityBy similarity
Sitei374 – 3741Important for catalytic activityBy similarity

GO - Molecular functioni

  1. primary amine oxidase activity Source: Ensembl

GO - Biological processi

  1. dopamine catabolic process Source: Ensembl
  2. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Catecholamine metabolism, Neurotransmitter degradation

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] A (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type A
Short name:
MAO-A
Gene namesi
Name:MAOA
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome X

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Amine oxidase [flavin-containing] APRO_0000099848Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei406 – 4061S-8alpha-FAD cysteineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP58027.

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP58027.
SMRiP58027. Positions 12-524.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 497497CytoplasmicBy similarityAdd
BLAST
Topological domaini519 – 5279Mitochondrial intermembraneBy similarity

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei498 – 51821Helical; Anchor for type IV membrane proteinBy similarityAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni520 – 5223Interaction with membrane phospholipid headgroupsBy similarity

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1231.
GeneTreeiENSGT00730000110903.
HOGENOMiHOG000221615.
HOVERGENiHBG004255.
InParanoidiP58027.
KOiK00274.
OMAiMEITHTF.
OrthoDBiEOG7K6PTP.
TreeFamiTF313314.

Family and domain databases

InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

P58027-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASREKTSIE GHMFDVVVIG GGISGLSAAK LLAEHEVDVL VLEARDRVGG
60 70 80 90 100
RTYTVRNEHV DYVDVGGAYV GPTQNRILRL SKELGLETYK VNVNERLVQY
110 120 130 140 150
VKGKTYPFRG AFPPVWNPIA YLDYNNLWRT MDNMGKEIPA DAPWEAPHAE
160 170 180 190 200
EWDKMTMKDL IDKICWTKTA RRFASLFVNI NVTSEPHEVS ALWFLWYVKQ
210 220 230 240 250
CGGTTRIFSV TNGGQERKFV GGSGQVSERI MERLGDRVKL KRPVTYVDQS
260 270 280 290 300
DDNIIIETLN HELYECKYVI SAIPPTLTAK IHFRPELPSE RNQLIQRLPM
310 320 330 340 350
GAIIKCMMYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSLPAIM
360 370 380 390 400
GFILARKADR LAKLHKEIRK RKICELYAKV LGSQEALQPV HYEEKNWCEE
410 420 430 440 450
QYSGGCYTAY FPPGIMTHYG RVIRQPFGRI YFAGTETATH WSGYMEGAVE
460 470 480 490 500
AGERTAREVL NALGRVAEKD LKTQEPESKD VPAMEITHTF WERNLPSVTG
510 520
LLKLIGFTTS VTALWIVAYK FRLLRRS
Length:527
Mass (Da):60,088
Last modified:April 27, 2001 - v1
Checksum:i3F2C3FF5CED937C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB038563 mRNA. Translation: BAB40325.1.
RefSeqiNP_001002969.1. NM_001002969.1.
UniGeneiCfa.151.

Genome annotation databases

EnsembliENSCAFT00000022939; ENSCAFP00000021307; ENSCAFG00000014435.
GeneIDi403450.
KEGGicfa:403450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB038563 mRNA. Translation: BAB40325.1 .
RefSeqi NP_001002969.1. NM_001002969.1.
UniGenei Cfa.151.

3D structure databases

ProteinModelPortali P58027.
SMRi P58027. Positions 12-524.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P58027.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000022939 ; ENSCAFP00000021307 ; ENSCAFG00000014435 .
GeneIDi 403450.
KEGGi cfa:403450.

Organism-specific databases

CTDi 4128.

Phylogenomic databases

eggNOGi COG1231.
GeneTreei ENSGT00730000110903.
HOGENOMi HOG000221615.
HOVERGENi HBG004255.
InParanoidi P58027.
KOi K00274.
OMAi MEITHTF.
OrthoDBi EOG7K6PTP.
TreeFami TF313314.

Miscellaneous databases

NextBioi 20816968.

Family and domain databases

InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

  1. Hashizume C., Mori Y.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Beagle.
    Tissue: Brain.

Entry informationi

Entry nameiAOFA_CANFA
AccessioniPrimary (citable) accession number: P58027
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3