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P58027

- AOFA_CANFA

UniProt

P58027 - AOFA_CANFA

Protein

Amine oxidase [flavin-containing] A

Gene

MAOA

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine By similarity.By similarity

    Catalytic activityi

    RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

    Cofactori

    FAD.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei335 – 3351Important for substrate specificityBy similarity
    Sitei374 – 3741Important for catalytic activityBy similarity

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW

    GO - Biological processi

    1. dopamine catabolic process Source: Ensembl
    2. neurotransmitter catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Catecholamine metabolism, Neurotransmitter degradation

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Amine oxidase [flavin-containing] A (EC:1.4.3.4)
    Alternative name(s):
    Monoamine oxidase type A
    Short name:
    MAO-A
    Gene namesi
    Name:MAOA
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome X

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 527527Amine oxidase [flavin-containing] APRO_0000099848Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei406 – 4061S-8alpha-FAD cysteineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiP58027.

    Interactioni

    Subunit structurei

    Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP58027.
    SMRiP58027. Positions 12-524.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 497497CytoplasmicBy similarityAdd
    BLAST
    Topological domaini519 – 5279Mitochondrial intermembraneBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei498 – 51821Helical; Anchor for type IV membrane proteinBy similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni520 – 5223Interaction with membrane phospholipid headgroupsBy similarity

    Sequence similaritiesi

    Belongs to the flavin monoamine oxidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1231.
    GeneTreeiENSGT00730000110903.
    HOGENOMiHOG000221615.
    HOVERGENiHBG004255.
    InParanoidiP58027.
    KOiK00274.
    OMAiMEITHTF.
    OrthoDBiEOG7K6PTP.
    TreeFamiTF313314.

    Family and domain databases

    InterProiIPR002937. Amino_oxidase.
    IPR001613. Flavin_amine_oxidase.
    [Graphical view]
    PfamiPF01593. Amino_oxidase. 1 hit.
    [Graphical view]
    PRINTSiPR00757. AMINEOXDASEF.

    Sequencei

    Sequence statusi: Complete.

    P58027-1 [UniParc]FASTAAdd to Basket

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    MASREKTSIE GHMFDVVVIG GGISGLSAAK LLAEHEVDVL VLEARDRVGG    50
    RTYTVRNEHV DYVDVGGAYV GPTQNRILRL SKELGLETYK VNVNERLVQY 100
    VKGKTYPFRG AFPPVWNPIA YLDYNNLWRT MDNMGKEIPA DAPWEAPHAE 150
    EWDKMTMKDL IDKICWTKTA RRFASLFVNI NVTSEPHEVS ALWFLWYVKQ 200
    CGGTTRIFSV TNGGQERKFV GGSGQVSERI MERLGDRVKL KRPVTYVDQS 250
    DDNIIIETLN HELYECKYVI SAIPPTLTAK IHFRPELPSE RNQLIQRLPM 300
    GAIIKCMMYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSLPAIM 350
    GFILARKADR LAKLHKEIRK RKICELYAKV LGSQEALQPV HYEEKNWCEE 400
    QYSGGCYTAY FPPGIMTHYG RVIRQPFGRI YFAGTETATH WSGYMEGAVE 450
    AGERTAREVL NALGRVAEKD LKTQEPESKD VPAMEITHTF WERNLPSVTG 500
    LLKLIGFTTS VTALWIVAYK FRLLRRS 527
    Length:527
    Mass (Da):60,088
    Last modified:April 27, 2001 - v1
    Checksum:i3F2C3FF5CED937C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB038563 mRNA. Translation: BAB40325.1.
    RefSeqiNP_001002969.1. NM_001002969.1.
    UniGeneiCfa.151.

    Genome annotation databases

    EnsembliENSCAFT00000022939; ENSCAFP00000021307; ENSCAFG00000014435.
    GeneIDi403450.
    KEGGicfa:403450.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB038563 mRNA. Translation: BAB40325.1 .
    RefSeqi NP_001002969.1. NM_001002969.1.
    UniGenei Cfa.151.

    3D structure databases

    ProteinModelPortali P58027.
    SMRi P58027. Positions 12-524.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P58027.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000022939 ; ENSCAFP00000021307 ; ENSCAFG00000014435 .
    GeneIDi 403450.
    KEGGi cfa:403450.

    Organism-specific databases

    CTDi 4128.

    Phylogenomic databases

    eggNOGi COG1231.
    GeneTreei ENSGT00730000110903.
    HOGENOMi HOG000221615.
    HOVERGENi HBG004255.
    InParanoidi P58027.
    KOi K00274.
    OMAi MEITHTF.
    OrthoDBi EOG7K6PTP.
    TreeFami TF313314.

    Miscellaneous databases

    NextBioi 20816968.

    Family and domain databases

    InterProi IPR002937. Amino_oxidase.
    IPR001613. Flavin_amine_oxidase.
    [Graphical view ]
    Pfami PF01593. Amino_oxidase. 1 hit.
    [Graphical view ]
    PRINTSi PR00757. AMINEOXDASEF.
    ProtoNeti Search...

    Publicationsi

    1. Hashizume C., Mori Y.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Beagle.
      Tissue: Brain.

    Entry informationi

    Entry nameiAOFA_CANFA
    AccessioniPrimary (citable) accession number: P58027
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3