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Protein

Transmembrane 9 superfamily member 2

Gene

Tm9sf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In the intracellular compartments, may function as a channel or small molecule transporter.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 9 superfamily member 2
Gene namesi
Name:Tm9sf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1915309 Tm9sf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 299LumenalSequence analysisAdd BLAST271
Transmembranei300 – 320HelicalSequence analysisAdd BLAST21
Topological domaini321 – 373CytoplasmicSequence analysisAdd BLAST53
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 397LumenalSequence analysis3
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 436CytoplasmicSequence analysisAdd BLAST18
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21
Topological domaini458 – 465LumenalSequence analysis8
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Topological domaini487 – 521CytoplasmicSequence analysisAdd BLAST35
Transmembranei522 – 542HelicalSequence analysisAdd BLAST21
Topological domaini543 – 553LumenalSequence analysisAdd BLAST11
Transmembranei554 – 574HelicalSequence analysisAdd BLAST21
Topological domaini575 – 590CytoplasmicSequence analysisAdd BLAST16
Transmembranei591 – 611HelicalSequence analysisAdd BLAST21
Topological domaini612 – 630LumenalSequence analysisAdd BLAST19
Transmembranei631 – 651HelicalSequence analysisAdd BLAST21
Topological domaini652 – 662CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000003436629 – 662Transmembrane 9 superfamily member 2Add BLAST634

Proteomic databases

EPDiP58021
PaxDbiP58021
PeptideAtlasiP58021
PRIDEiP58021

PTM databases

iPTMnetiP58021
PhosphoSitePlusiP58021
SwissPalmiP58021

Expressioni

Gene expression databases

BgeeiENSMUSG00000025544
CleanExiMM_TM9SF2
ExpressionAtlasiP58021 baseline and differential
GenevisibleiP58021 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026624

Structurei

3D structure databases

ProteinModelPortaliP58021
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1278 Eukaryota
ENOG410XPIW LUCA
GeneTreeiENSGT00530000062897
HOGENOMiHOG000216679
HOVERGENiHBG054197
InParanoidiP58021
KOiK17086
OMAiWDKYLHV
OrthoDBiEOG091G03BD
PhylomeDBiP58021
TreeFamiTF300394

Family and domain databases

InterProiView protein in InterPro
IPR004240 EMP70
PANTHERiPTHR10766 PTHR10766, 1 hit
PfamiView protein in Pfam
PF02990 EMP70, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRPPASPP AQGSRLLLLS LLLLGTVPGP RPGSAFYLPG LAPVNFCAEE
60 70 80 90 100
KSNECKADIE LFVNRLDSVE SVLPYEYTAF DFCQASEGKR PSENLGQVLF
110 120 130 140 150
GERIEPSPYK FTFNKKETCK LVCTKTYNTE KAEDKQKLDF LKKSMLLNYQ
160 170 180 190 200
HHWIVDNMPV TWCYEVEDSQ KFCNPGFPIG CYITDKGHAK DACVISSEFH
210 220 230 240 250
ERDTFYIFNH VDIKIYYHVV ETGSMGARLV AAKLEPKSFK HTHIDKPDCS
260 270 280 290 300
GPAMDISNKA SGEIKIAYTY SISFEEEKNI RWASRWDYIL ESMPHTHIQW
310 320 330 340 350
FSIMNSLVIV LFLSGMVAMI MLRTLHKDIA RYNQMDSTED AQEEFGWKLV
360 370 380 390 400
HGDIFRPPRK GMLLSVFLGS GTQILIMTFV TLFFACLGFL SPANRGALMT
410 420 430 440 450
CAVVLWVLLG TPAGYVAARF YKSFGGEKWK TNVLLTSFLC PGIVFADFFI
460 470 480 490 500
MNLILWGEGS SAAIPFGTLV AILALWFCIS VPLTFIGAYF GFKKNAIEHP
510 520 530 540 550
VRTNQIPRQI PEQSFYTKPL PGIIMGGILP FGCIFIQLFF ILNSIWSHQM
560 570 580 590 600
YYMFGFLFLV FIILVITCSE ATILLCYFHL CAEDYHWQWR SFLTSGFTAV
610 620 630 640 650
YFLIYAIHYF FSKLQITGTA STILYFGYTM IMVLIFFLFT GTIGFFACFW
660
FVTKIYSVVK VD
Length:662
Mass (Da):75,330
Last modified:April 27, 2001 - v1
Checksum:i85F113A5D21733E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003862 mRNA Translation: AAH03862.1
CCDSiCCDS27345.1
RefSeqiNP_542123.3, NM_080556.3
UniGeneiMm.275191

Genome annotation databases

EnsembliENSMUST00000026624; ENSMUSP00000026624; ENSMUSG00000025544
GeneIDi68059
KEGGimmu:68059
UCSCiuc007vaw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTM9S2_MOUSE
AccessioniPrimary (citable) accession number: P58021
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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