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Protein

CD59B glycoprotein

Gene

Cd59b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell activation Source: GO_Central
  • cell surface receptor signaling pathway Source: GO_Central
  • negative regulation of activation of membrane attack complex Source: MGI
  • negative regulation of complement activation Source: MGI
  • negative regulation of cytolysis Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-MMU-5694530. Cargo concentration in the ER.
R-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
CD59B glycoprotein
Alternative name(s):
MAC-inhibitory protein
Short name:
MAC-IP
Membrane attack complex inhibition factor
Short name:
MACIF
Protectin
CD_antigen: CD59
Gene namesi
Name:Cd59b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1888996. Cd59b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 10481CD59B glycoproteinPRO_0000036114Add
BLAST
Propeptidei105 – 12925Removed in mature formSequence analysisPRO_0000036115Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 49By similarity
Disulfide bondi29 ↔ 36By similarity
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Disulfide bondi42 ↔ 62By similarity
Disulfide bondi68 ↔ 86By similarity
Disulfide bondi87 ↔ 92By similarity
Lipidationi104 – 1041GPI-anchor amidated asparagineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP58019.
PRIDEiP58019.

PTM databases

PhosphoSiteiP58019.

Expressioni

Tissue specificityi

Widely expressed in the kidneys, brain, lungs, spleen and testis (PubMed:11471050) Testis specific (PubMed:10946279).2 Publications

Gene expression databases

BgeeiENSMUSG00000068686.
CleanExiMM_CD59B.
ExpressionAtlasiP58019. baseline and differential.
GenevisibleiP58019. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087912.

Structurei

3D structure databases

ProteinModelPortaliP58019.
SMRiP58019. Positions 24-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 10784UPAR/Ly6Add
BLAST

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J39P. Eukaryota.
ENOG410ZEQP. LUCA.
GeneTreeiENSGT00390000016309.
HOGENOMiHOG000232180.
HOVERGENiHBG005284.
InParanoidiP58019.
KOiK04008.
OMAiNKAAFSI.
OrthoDBiEOG091G11NF.
PhylomeDBiP58019.
TreeFamiTF338524.

Family and domain databases

InterProiIPR027101. CD59_glyco.
IPR016054. LY6_UPA_recep-like.
[Graphical view]
PANTHERiPTHR10036:SF9. PTHR10036:SF9. 1 hit.
SMARTiSM00134. LU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAQRGLILL LLLLAVFCST AVSLKCYNCL DPVSSCKINT TCSPNLDSCL
60 70 80 90 100
YAVAGRQVYQ QCWKLSDCNS NYIMSRLDVA GIQSKCCQWD LCNKNLDGLE
110 120
EPNNAETSSL RKTALLGTSV LVAILKFCF
Length:129
Mass (Da):14,227
Last modified:October 3, 2012 - v2
Checksum:i3B80648C8C30F635
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 323LDP → FQF no nucleotide entry (PubMed:10946279).Curated
Sequence conflicti90 – 901D → G no nucleotide entry (PubMed:10946279).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF292401 Genomic DNA. Translation: AAL04434.1.
BX640578, BX813317 Genomic DNA. Translation: CAM18975.1.
BX813317, BX640578 Genomic DNA. Translation: CAM27769.1.
BC139203 mRNA. Translation: AAI39204.1.
BC145912 mRNA. Translation: AAI45913.1.
BC171969 mRNA. Translation: AAI71969.1.
CCDSiCCDS16486.1.
RefSeqiNP_862906.1. NM_181858.1.
XP_006499865.1. XM_006499802.2.
XP_006499866.1. XM_006499803.2.
XP_006499867.1. XM_006499804.2.
XP_006499868.1. XM_006499805.2.
UniGeneiMm.359026.

Genome annotation databases

EnsembliENSMUST00000090429; ENSMUSP00000087912; ENSMUSG00000068686.
ENSMUST00000111130; ENSMUSP00000106760; ENSMUSG00000068686.
ENSMUST00000129749; ENSMUSP00000117553; ENSMUSG00000068686.
GeneIDi333883.
KEGGimmu:333883.
UCSCiuc008ljn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF292401 Genomic DNA. Translation: AAL04434.1.
BX640578, BX813317 Genomic DNA. Translation: CAM18975.1.
BX813317, BX640578 Genomic DNA. Translation: CAM27769.1.
BC139203 mRNA. Translation: AAI39204.1.
BC145912 mRNA. Translation: AAI45913.1.
BC171969 mRNA. Translation: AAI71969.1.
CCDSiCCDS16486.1.
RefSeqiNP_862906.1. NM_181858.1.
XP_006499865.1. XM_006499802.2.
XP_006499866.1. XM_006499803.2.
XP_006499867.1. XM_006499804.2.
XP_006499868.1. XM_006499805.2.
UniGeneiMm.359026.

3D structure databases

ProteinModelPortaliP58019.
SMRiP58019. Positions 24-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087912.

PTM databases

PhosphoSiteiP58019.

Proteomic databases

PaxDbiP58019.
PRIDEiP58019.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090429; ENSMUSP00000087912; ENSMUSG00000068686.
ENSMUST00000111130; ENSMUSP00000106760; ENSMUSG00000068686.
ENSMUST00000129749; ENSMUSP00000117553; ENSMUSG00000068686.
GeneIDi333883.
KEGGimmu:333883.
UCSCiuc008ljn.1. mouse.

Organism-specific databases

CTDi333883.
MGIiMGI:1888996. Cd59b.

Phylogenomic databases

eggNOGiENOG410J39P. Eukaryota.
ENOG410ZEQP. LUCA.
GeneTreeiENSGT00390000016309.
HOGENOMiHOG000232180.
HOVERGENiHBG005284.
InParanoidiP58019.
KOiK04008.
OMAiNKAAFSI.
OrthoDBiEOG091G11NF.
PhylomeDBiP58019.
TreeFamiTF338524.

Enzyme and pathway databases

ReactomeiR-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-MMU-5694530. Cargo concentration in the ER.
R-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-977606. Regulation of Complement cascade.

Miscellaneous databases

PROiP58019.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068686.
CleanExiMM_CD59B.
ExpressionAtlasiP58019. baseline and differential.
GenevisibleiP58019. MM.

Family and domain databases

InterProiIPR027101. CD59_glyco.
IPR016054. LY6_UPA_recep-like.
[Graphical view]
PANTHERiPTHR10036:SF9. PTHR10036:SF9. 1 hit.
SMARTiSM00134. LU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD59B_MOUSE
AccessioniPrimary (citable) accession number: P58019
Secondary accession number(s): Q920G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.