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P58019 (CD59B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CD59B glycoprotein
Alternative name(s):
MAC-inhibitory protein
Short name=MAC-IP
Membrane attack complex inhibition factor
Short name=MACIF
Protectin
CD_antigen=CD59
Gene names
Name:Cd59b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length129 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore By similarity.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor.

Tissue specificity

Widely expressed in the kidneys, brain, lungs, spleen and testis (Ref.2) Testis specific (Ref.1). Ref.1 Ref.2

Sequence similarities

Contains 1 UPAR/Ly6 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 10481CD59B glycoprotein
PRO_0000036114
Propeptide105 – 12925Removed in mature form Potential
PRO_0000036115

Regions

Domain24 – 10784UPAR/Ly6

Amino acid modifications

Lipidation1041GPI-anchor amidated asparagine Potential
Glycosylation391N-linked (GlcNAc...) Potential
Disulfide bond26 ↔ 49 By similarity
Disulfide bond29 ↔ 36 By similarity
Disulfide bond42 ↔ 62 By similarity
Disulfide bond68 ↔ 86 By similarity
Disulfide bond87 ↔ 92 By similarity

Experimental info

Sequence conflict30 – 323LDP → FQF no nucleotide entry Ref.1
Sequence conflict901D → G no nucleotide entry Ref.1

Sequences

Sequence LengthMass (Da)Tools
P58019 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 3B80648C8C30F635

FASTA12914,227
        10         20         30         40         50         60 
MRAQRGLILL LLLLAVFCST AVSLKCYNCL DPVSSCKINT TCSPNLDSCL YAVAGRQVYQ 

        70         80         90        100        110        120 
QCWKLSDCNS NYIMSRLDVA GIQSKCCQWD LCNKNLDGLE EPNNAETSSL RKTALLGTSV 


LVAILKFCF 

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References

« Hide 'large scale' references
[1]"Identification and functional characterization of a new gene encoding the mouse terminal complement inhibitor CD59."
Qian Y.-M., Qin X., Miwa T., Sun X., Halperin J.A., Song W.-C.
J. Immunol. 165:2528-2534(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE, TISSUE SPECIFICITY.
Strain: 129/Sv.
[2]"Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b."
Qin X., Miwa T., Aktas H., Gao M., Lee C., Qian Y.M., Morton C.C., Shahsafaei A., Song W.C., Halperin J.A.
Mamm. Genome 12:582-589(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
Strain: 129/Sv.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF292401 Genomic DNA. Translation: AAL04434.1.
BX640578, BX813317 Genomic DNA. Translation: CAM18975.1.
BX813317, BX640578 Genomic DNA. Translation: CAM27769.1.
BC139203 mRNA. Translation: AAI39204.1.
BC145912 mRNA. Translation: AAI45913.1.
BC171969 mRNA. Translation: AAI71969.1.
RefSeqNP_862906.1. NM_181858.1.
XP_006499865.1. XM_006499802.1.
XP_006499866.1. XM_006499803.1.
XP_006499867.1. XM_006499804.1.
XP_006499868.1. XM_006499805.1.
UniGeneMm.359026.

3D structure databases

ProteinModelPortalP58019.
SMRP58019. Positions 24-95.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP58019.

Proteomic databases

PRIDEP58019.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000090429; ENSMUSP00000087912; ENSMUSG00000068686.
ENSMUST00000111130; ENSMUSP00000106760; ENSMUSG00000068686.
ENSMUST00000129749; ENSMUSP00000117553; ENSMUSG00000068686.
GeneID333883.
KEGGmmu:333883.
UCSCuc008ljn.1. mouse.

Organism-specific databases

CTD333883.
MGIMGI:1888996. Cd59b.

Phylogenomic databases

eggNOGNOG83475.
GeneTreeENSGT00390000016309.
HOGENOMHOG000232180.
HOVERGENHBG005284.
InParanoidP58019.
KOK04008.
OMAGHSLTCY.
PhylomeDBP58019.
TreeFamTF338524.

Gene expression databases

ArrayExpressP58019.
CleanExMM_CD59B.
GenevestigatorP58019.

Family and domain databases

InterProIPR027101. CD59_glyco.
IPR016054. LY6_UPA_recep-like.
IPR001526. LY6_UPAR.
[Graphical view]
PANTHERPTHR10036:SF0. PTHR10036:SF0. 1 hit.
PfamPF00021. UPAR_LY6. 1 hit.
[Graphical view]
SMARTSM00134. LU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio400074.
PROP58019.
SOURCESearch...

Entry information

Entry nameCD59B_MOUSE
AccessionPrimary (citable) accession number: P58019
Secondary accession number(s): Q920G7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 3, 2012
Last modified: April 16, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot