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Protein

CD59B glycoprotein

Gene

Cd59b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell activation Source: GO_Central
  • cell surface receptor signaling pathway Source: GO_Central
  • negative regulation of activation of membrane attack complex Source: MGI
  • negative regulation of complement activation Source: MGI
  • negative regulation of cytolysis Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-5694530 Cargo concentration in the ER
R-MMU-6798695 Neutrophil degranulation
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
CD59B glycoprotein
Alternative name(s):
MAC-inhibitory protein
Short name:
MAC-IP
Membrane attack complex inhibition factor
Short name:
MACIF
Protectin
CD_antigen: CD59
Gene namesi
Name:Cd59b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1888996 Cd59b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003611424 – 104CD59B glycoproteinAdd BLAST81
PropeptideiPRO_0000036115105 – 129Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 49By similarity
Disulfide bondi29 ↔ 36By similarity
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi42 ↔ 62By similarity
Disulfide bondi68 ↔ 86By similarity
Disulfide bondi87 ↔ 92By similarity
Lipidationi104GPI-anchor amidated asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP58019
PRIDEiP58019

PTM databases

PhosphoSitePlusiP58019

Expressioni

Tissue specificityi

Widely expressed in the kidneys, brain, lungs, spleen and testis (PubMed:11471050) Testis specific (PubMed:10946279).2 Publications

Gene expression databases

BgeeiENSMUSG00000068686
CleanExiMM_CD59B
ExpressionAtlasiP58019 baseline and differential
GenevisibleiP58019 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087912

Structurei

3D structure databases

ProteinModelPortaliP58019
SMRiP58019
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 107UPAR/Ly6Add BLAST84

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J39P Eukaryota
ENOG410ZEQP LUCA
GeneTreeiENSGT00390000016309
HOGENOMiHOG000232180
HOVERGENiHBG005284
InParanoidiP58019
KOiK04008
OMAiNSDLCNS
OrthoDBiEOG091G11NF
PhylomeDBiP58019
TreeFamiTF338524

Family and domain databases

InterProiView protein in InterPro
IPR027101 CD59_glyco
IPR016054 LY6_UPA_recep-like
PANTHERiPTHR10036:SF9 PTHR10036:SF9, 1 hit
SMARTiView protein in SMART
SM00134 LU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAQRGLILL LLLLAVFCST AVSLKCYNCL DPVSSCKINT TCSPNLDSCL
60 70 80 90 100
YAVAGRQVYQ QCWKLSDCNS NYIMSRLDVA GIQSKCCQWD LCNKNLDGLE
110 120
EPNNAETSSL RKTALLGTSV LVAILKFCF
Length:129
Mass (Da):14,227
Last modified:October 3, 2012 - v2
Checksum:i3B80648C8C30F635
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30 – 32LDP → FQF no nucleotide entry (PubMed:10946279).Curated3
Sequence conflicti90D → G no nucleotide entry (PubMed:10946279).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF292401 Genomic DNA Translation: AAL04434.1
BX640578, BX813317 Genomic DNA Translation: CAM18975.1
BX813317, BX640578 Genomic DNA Translation: CAM27769.1
BC139203 mRNA Translation: AAI39204.1
BC145912 mRNA Translation: AAI45913.1
BC171969 mRNA Translation: AAI71969.1
CCDSiCCDS16486.1
RefSeqiNP_862906.1, NM_181858.1
XP_006499865.1, XM_006499802.3
XP_006499866.1, XM_006499803.3
XP_006499867.1, XM_006499804.2
XP_006499868.1, XM_006499805.2
UniGeneiMm.359026

Genome annotation databases

EnsembliENSMUST00000090429; ENSMUSP00000087912; ENSMUSG00000068686
ENSMUST00000111130; ENSMUSP00000106760; ENSMUSG00000068686
ENSMUST00000129749; ENSMUSP00000117553; ENSMUSG00000068686
GeneIDi333883
KEGGimmu:333883
UCSCiuc008ljn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCD59B_MOUSE
AccessioniPrimary (citable) accession number: P58019
Secondary accession number(s): Q920G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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