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P58019

- CD59B_MOUSE

UniProt

P58019 - CD59B_MOUSE

Protein

CD59B glycoprotein

Gene

Cd59b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore By similarity.By similarity

    GO - Molecular functioni

    1. complement binding Source: RefGenome

    GO - Biological processi

    1. cell activation Source: RefGenome
    2. cell surface receptor signaling pathway Source: RefGenome
    3. negative regulation of activation of membrane attack complex Source: MGI
    4. negative regulation of complement activation Source: MGI
    5. negative regulation of cytolysis Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_198562. Regulation of Complement cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD59B glycoprotein
    Alternative name(s):
    MAC-inhibitory protein
    Short name:
    MAC-IP
    Membrane attack complex inhibition factor
    Short name:
    MACIF
    Protectin
    CD_antigen: CD59
    Gene namesi
    Name:Cd59b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1888996. Cd59b.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. cell surface Source: MGI
    3. extracellular region Source: RefGenome
    4. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 10481CD59B glycoproteinPRO_0000036114Add
    BLAST
    Propeptidei105 – 12925Removed in mature formSequence AnalysisPRO_0000036115Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi26 ↔ 49By similarity
    Disulfide bondi29 ↔ 36By similarity
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi42 ↔ 62By similarity
    Disulfide bondi68 ↔ 86By similarity
    Disulfide bondi87 ↔ 92By similarity
    Lipidationi104 – 1041GPI-anchor amidated asparagineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PRIDEiP58019.

    PTM databases

    PhosphoSiteiP58019.

    Expressioni

    Tissue specificityi

    Widely expressed in the kidneys, brain, lungs, spleen and testis (PubMed:11471050) Testis specific (PubMed:10946279).2 Publications

    Gene expression databases

    ArrayExpressiP58019.
    CleanExiMM_CD59B.
    GenevestigatoriP58019.

    Structurei

    3D structure databases

    ProteinModelPortaliP58019.
    SMRiP58019. Positions 24-95.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 10784UPAR/Ly6Add
    BLAST

    Sequence similaritiesi

    Contains 1 UPAR/Ly6 domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG83475.
    GeneTreeiENSGT00390000016309.
    HOGENOMiHOG000232180.
    HOVERGENiHBG005284.
    InParanoidiP58019.
    KOiK04008.
    OMAiKMNCILL.
    PhylomeDBiP58019.
    TreeFamiTF338524.

    Family and domain databases

    InterProiIPR027101. CD59_glyco.
    IPR016054. LY6_UPA_recep-like.
    IPR001526. LY6_UPAR.
    [Graphical view]
    PANTHERiPTHR10036:SF6. PTHR10036:SF6. 1 hit.
    PfamiPF00021. UPAR_LY6. 1 hit.
    [Graphical view]
    SMARTiSM00134. LU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P58019-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRAQRGLILL LLLLAVFCST AVSLKCYNCL DPVSSCKINT TCSPNLDSCL    50
    YAVAGRQVYQ QCWKLSDCNS NYIMSRLDVA GIQSKCCQWD LCNKNLDGLE 100
    EPNNAETSSL RKTALLGTSV LVAILKFCF 129
    Length:129
    Mass (Da):14,227
    Last modified:October 3, 2012 - v2
    Checksum:i3B80648C8C30F635
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti30 – 323LDP → FQF no nucleotide entry (PubMed:10946279)Curated
    Sequence conflicti90 – 901D → G no nucleotide entry (PubMed:10946279)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF292401 Genomic DNA. Translation: AAL04434.1.
    BX640578, BX813317 Genomic DNA. Translation: CAM18975.1.
    BX813317, BX640578 Genomic DNA. Translation: CAM27769.1.
    BC139203 mRNA. Translation: AAI39204.1.
    BC145912 mRNA. Translation: AAI45913.1.
    BC171969 mRNA. Translation: AAI71969.1.
    CCDSiCCDS16486.1.
    RefSeqiNP_862906.1. NM_181858.1.
    XP_006499865.1. XM_006499802.1.
    XP_006499866.1. XM_006499803.1.
    XP_006499867.1. XM_006499804.1.
    XP_006499868.1. XM_006499805.1.
    UniGeneiMm.359026.

    Genome annotation databases

    EnsembliENSMUST00000090429; ENSMUSP00000087912; ENSMUSG00000068686.
    ENSMUST00000111130; ENSMUSP00000106760; ENSMUSG00000068686.
    ENSMUST00000129749; ENSMUSP00000117553; ENSMUSG00000068686.
    GeneIDi333883.
    KEGGimmu:333883.
    UCSCiuc008ljn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF292401 Genomic DNA. Translation: AAL04434.1 .
    BX640578 , BX813317 Genomic DNA. Translation: CAM18975.1 .
    BX813317 , BX640578 Genomic DNA. Translation: CAM27769.1 .
    BC139203 mRNA. Translation: AAI39204.1 .
    BC145912 mRNA. Translation: AAI45913.1 .
    BC171969 mRNA. Translation: AAI71969.1 .
    CCDSi CCDS16486.1.
    RefSeqi NP_862906.1. NM_181858.1.
    XP_006499865.1. XM_006499802.1.
    XP_006499866.1. XM_006499803.1.
    XP_006499867.1. XM_006499804.1.
    XP_006499868.1. XM_006499805.1.
    UniGenei Mm.359026.

    3D structure databases

    ProteinModelPortali P58019.
    SMRi P58019. Positions 24-95.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P58019.

    Proteomic databases

    PRIDEi P58019.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000090429 ; ENSMUSP00000087912 ; ENSMUSG00000068686 .
    ENSMUST00000111130 ; ENSMUSP00000106760 ; ENSMUSG00000068686 .
    ENSMUST00000129749 ; ENSMUSP00000117553 ; ENSMUSG00000068686 .
    GeneIDi 333883.
    KEGGi mmu:333883.
    UCSCi uc008ljn.1. mouse.

    Organism-specific databases

    CTDi 333883.
    MGIi MGI:1888996. Cd59b.

    Phylogenomic databases

    eggNOGi NOG83475.
    GeneTreei ENSGT00390000016309.
    HOGENOMi HOG000232180.
    HOVERGENi HBG005284.
    InParanoidi P58019.
    KOi K04008.
    OMAi KMNCILL.
    PhylomeDBi P58019.
    TreeFami TF338524.

    Enzyme and pathway databases

    Reactomei REACT_198562. Regulation of Complement cascade.

    Miscellaneous databases

    NextBioi 400074.
    PROi P58019.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P58019.
    CleanExi MM_CD59B.
    Genevestigatori P58019.

    Family and domain databases

    InterProi IPR027101. CD59_glyco.
    IPR016054. LY6_UPA_recep-like.
    IPR001526. LY6_UPAR.
    [Graphical view ]
    PANTHERi PTHR10036:SF6. PTHR10036:SF6. 1 hit.
    Pfami PF00021. UPAR_LY6. 1 hit.
    [Graphical view ]
    SMARTi SM00134. LU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and functional characterization of a new gene encoding the mouse terminal complement inhibitor CD59."
      Qian Y.-M., Qin X., Miwa T., Sun X., Halperin J.A., Song W.-C.
      J. Immunol. 165:2528-2534(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE, TISSUE SPECIFICITY.
      Strain: 129/Sv.
    2. "Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b."
      Qin X., Miwa T., Aktas H., Gao M., Lee C., Qian Y.M., Morton C.C., Shahsafaei A., Song W.C., Halperin J.A.
      Mamm. Genome 12:582-589(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Strain: 129/Sv.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCD59B_MOUSE
    AccessioniPrimary (citable) accession number: P58019
    Secondary accession number(s): Q920G7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3