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Protein

Sestrin-2

Gene

SESN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the reduction of peroxiredoxins.1 Publication

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-5628897. TP53 Regulates Metabolic Genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Sestrin-2
Alternative name(s):
Hi95
Gene namesi
Name:SESN2
Synonyms:SEST2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20746. SESN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134882791.

Polymorphism and mutation databases

BioMutaiSESN2.
DMDMi13633882.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Sestrin-2PRO_0000221181Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei249 – 2491PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP58004.
MaxQBiP58004.
PaxDbiP58004.
PRIDEiP58004.

PTM databases

iPTMnetiP58004.
PhosphoSiteiP58004.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiP58004.
CleanExiHS_SESN2.
GenevisibleiP58004. HS.

Organism-specific databases

HPAiHPA018191.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SQSTM1Q135015EBI-3939642,EBI-307104
Ulk1O704055EBI-3939642,EBI-8390771From a different organism.

Protein-protein interaction databases

BioGridi123724. 12 interactions.
IntActiP58004. 7 interactions.
MINTiMINT-4715291.
STRINGi9606.ENSP00000253063.

Structurei

Secondary structure

1
480
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi68 – 714Combined sources
Turni72 – 743Combined sources
Helixi78 – 836Combined sources
Helixi87 – 10216Combined sources
Helixi109 – 12113Combined sources
Turni122 – 1243Combined sources
Helixi126 – 13813Combined sources
Helixi143 – 1475Combined sources
Helixi149 – 1513Combined sources
Helixi154 – 1574Combined sources
Helixi160 – 1689Combined sources
Helixi170 – 1723Combined sources
Helixi175 – 1828Combined sources
Beta strandi185 – 1873Combined sources
Helixi191 – 21323Combined sources
Beta strandi228 – 2303Combined sources
Beta strandi235 – 2373Combined sources
Helixi257 – 27014Combined sources
Helixi283 – 29210Combined sources
Helixi313 – 3153Combined sources
Beta strandi328 – 3303Combined sources
Helixi339 – 3413Combined sources
Turni344 – 3474Combined sources
Helixi348 – 3558Combined sources
Helixi357 – 37115Combined sources
Beta strandi378 – 3803Combined sources
Helixi387 – 40014Combined sources
Helixi411 – 4166Combined sources
Helixi419 – 43012Combined sources
Helixi432 – 4343Combined sources
Helixi437 – 4426Combined sources
Helixi449 – 47931Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5CUFX-ray3.50A/B/C/D/E1-480[»]
5DJ4X-ray2.70A/B/C/D/E1-480[»]
ProteinModelPortaliP58004.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sestrin family.Curated

Phylogenomic databases

eggNOGiKOG3746. Eukaryota.
ENOG410XP7Z. LUCA.
GeneTreeiENSGT00440000040103.
HOGENOMiHOG000232949.
HOVERGENiHBG054648.
InParanoidiP58004.
KOiK10141.
OMAiASSWRHY.
OrthoDBiEOG7SBNNF.
PhylomeDBiP58004.
TreeFamiTF314230.

Family and domain databases

Gene3Di1.20.1290.10. 1 hit.
InterProiIPR029032. AhpD-like.
IPR006730. Sestrin.
[Graphical view]
PfamiPF04636. PA26. 1 hit.
[Graphical view]
SUPFAMiSSF69118. SSF69118. 1 hit.

Sequencei

Sequence statusi: Complete.

P58004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVADSECRA ELKDYLRFAP GGVGDSGPGE EQRESRARRG PRGPSAFIPV
60 70 80 90 100
EEVLREGAES LEQHLGLEAL MSSGRVDNLA VVMGLHPDYF TSFWRLHYLL
110 120 130 140 150
LHTDGPLASS WRHYIAIMAA ARHQCSYLVG SHMAEFLQTG GDPEWLLGLH
160 170 180 190 200
RAPEKLRKLS EINKLLAHRP WLITKEHIQA LLKTGEHTWS LAELIQALVL
210 220 230 240 250
LTHCHSLSSF VFGCGILPEG DADGSPAPQA PTPPSEQSSP PSRDPLNNSG
260 270 280 290 300
GFESARDVEA LMERMQQLQE SLLRDEGTSQ EEMESRFELE KSESLLVTPS
310 320 330 340 350
ADILEPSPHP DMLCFVEDPT FGYEDFTRRG AQAPPTFRAQ DYTWEDHGYS
360 370 380 390 400
LIQRLYPEGG QLLDEKFQAA YSLTYNTIAM HSGVDTSVLR RAIWNYIHCV
410 420 430 440 450
FGIRYDDYDY GEVNQLLERN LKVYIKTVAC YPEKTTRRMY NLFWRHFRHS
460 470 480
EKVHVNLLLL EARMQAALLY ALRAITRYMT
Length:480
Mass (Da):54,494
Last modified:April 27, 2001 - v1
Checksum:i9C13371316D84060
GO

Sequence cautioni

The sequence BAB55438.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti320 – 3201T → A.
Corresponds to variant rs2274848 [ dbSNP | Ensembl ].
VAR_022101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY123223 mRNA. Translation: AAM92261.1.
AL136551 mRNA. Translation: CAB66486.1.
AK027896 mRNA. Translation: BAB55438.1. Different initiation.
AK025640 mRNA. No translation available.
AK315710 mRNA. Translation: BAG38070.1.
AL353622 Genomic DNA. Translation: CAI19133.1.
CH471059 Genomic DNA. Translation: EAX07703.1.
BC013304 mRNA. Translation: AAH13304.1.
BC033719 mRNA. Translation: AAH33719.1.
CCDSiCCDS321.1.
RefSeqiNP_113647.1. NM_031459.4.
UniGeneiHs.469543.

Genome annotation databases

EnsembliENST00000253063; ENSP00000253063; ENSG00000130766.
GeneIDi83667.
KEGGihsa:83667.
UCSCiuc001bps.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY123223 mRNA. Translation: AAM92261.1.
AL136551 mRNA. Translation: CAB66486.1.
AK027896 mRNA. Translation: BAB55438.1. Different initiation.
AK025640 mRNA. No translation available.
AK315710 mRNA. Translation: BAG38070.1.
AL353622 Genomic DNA. Translation: CAI19133.1.
CH471059 Genomic DNA. Translation: EAX07703.1.
BC013304 mRNA. Translation: AAH13304.1.
BC033719 mRNA. Translation: AAH33719.1.
CCDSiCCDS321.1.
RefSeqiNP_113647.1. NM_031459.4.
UniGeneiHs.469543.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5CUFX-ray3.50A/B/C/D/E1-480[»]
5DJ4X-ray2.70A/B/C/D/E1-480[»]
ProteinModelPortaliP58004.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123724. 12 interactions.
IntActiP58004. 7 interactions.
MINTiMINT-4715291.
STRINGi9606.ENSP00000253063.

PTM databases

iPTMnetiP58004.
PhosphoSiteiP58004.

Polymorphism and mutation databases

BioMutaiSESN2.
DMDMi13633882.

Proteomic databases

EPDiP58004.
MaxQBiP58004.
PaxDbiP58004.
PRIDEiP58004.

Protocols and materials databases

DNASUi83667.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253063; ENSP00000253063; ENSG00000130766.
GeneIDi83667.
KEGGihsa:83667.
UCSCiuc001bps.4. human.

Organism-specific databases

CTDi83667.
GeneCardsiSESN2.
HGNCiHGNC:20746. SESN2.
HPAiHPA018191.
MIMi607767. gene.
neXtProtiNX_P58004.
PharmGKBiPA134882791.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3746. Eukaryota.
ENOG410XP7Z. LUCA.
GeneTreeiENSGT00440000040103.
HOGENOMiHOG000232949.
HOVERGENiHBG054648.
InParanoidiP58004.
KOiK10141.
OMAiASSWRHY.
OrthoDBiEOG7SBNNF.
PhylomeDBiP58004.
TreeFamiTF314230.

Enzyme and pathway databases

ReactomeiR-HSA-5628897. TP53 Regulates Metabolic Genes.

Miscellaneous databases

ChiTaRSiSESN2. human.
GeneWikiiSESN2.
GenomeRNAii83667.
NextBioi72643.
PROiP58004.
SOURCEiSearch...

Gene expression databases

BgeeiP58004.
CleanExiHS_SESN2.
GenevisibleiP58004. HS.

Family and domain databases

Gene3Di1.20.1290.10. 1 hit.
InterProiIPR029032. AhpD-like.
IPR006730. Sestrin.
[Graphical view]
PfamiPF04636. PA26. 1 hit.
[Graphical view]
SUPFAMiSSF69118. SSF69118. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability."
    Budanov A.V., Shoshani T., Faerman A., Zelin E., Kamer I., Kalinski H., Gorodin S., Fishman A., Chajut A., Einat P., Skaliter R., Gudkov A.V., Chumakov P.M., Feinstein E.
    Oncogene 21:6017-6031(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hepatoma and Testis.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Muscle.
  7. "PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse."
    Peeters H., Debeer P., Bairoch A., Wilquet V., Huysmans C., Parthoens E., Fryns J.-P., Gewillig M., Nakamura Y., Niikawa N., Van De Ven W., Devriendt K.
    Hum. Genet. 112:573-580(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD."
    Budanov A.V., Sablina A.A., Feinstein E., Koonin E.V., Chumakov P.M.
    Science 304:596-600(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-249, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSESN2_HUMAN
AccessioniPrimary (citable) accession number: P58004
Secondary accession number(s): Q5T7D0, Q96SI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: April 13, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.