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P57999

- ZAN_RABIT

UniProt

P57999 - ZAN_RABIT

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Protein
Zonadhesin
Gene
ZAN
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling By similarity.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Zonadhesin
Gene namesi
Name:ZAN
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Cell membrane; Single-pass type I membrane protein
Note: Exclusively on the apical region of the sperm head By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 2235›2235Extracellular Reviewed prediction
Add
BLAST
Transmembranei2236 – 225621Helical; Reviewed prediction
Add
BLAST
Topological domaini2257 – 228226Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 2282›2282Zonadhesin
PRO_0000055637Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi112 – 1121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi272 – 2721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi541 – 5411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi569 – 5691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1141 – 11411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1259 – 12591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1270 – 12701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1355 – 13551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1467 – 14671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1483 – 14831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1662 – 16621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1997 – 19971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2178 – 21781N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2189 ↔ 2200 By similarity
Disulfide bondi2194 ↔ 2209 By similarity
Disulfide bondi2211 ↔ 2220 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Probably forms covalent oligomers By similarity.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000025091.

Structurei

3D structure databases

ProteinModelPortaliP57999.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – 147›147MAM 1
Add
BLAST
Domaini150 – 315166MAM 2
Add
BLAST
Domaini501 – 55050TIL 1
Add
BLAST
Domaini551 – 60555VWFC 1
Add
BLAST
Domaini611 – 826216VWFD 1
Add
BLAST
Domaini881 – 93454TIL 2
Add
BLAST
Domaini935 – 99056VWFC 2
Add
BLAST
Domaini996 – 1213218VWFD 2
Add
BLAST
Domaini1267 – 132256TIL 3
Add
BLAST
Domaini1323 – 137957VWFC 3
Add
BLAST
Domaini1385 – 1591207VWFD 3
Add
BLAST
Domaini1670 – 172657TIL 4
Add
BLAST
Domaini1727 – 178256VWFC 4
Add
BLAST
Domaini1788 – 1991204VWFD 4
Add
BLAST
Domaini2076 – 212954TIL 5
Add
BLAST
Domaini2130 – 218455VWFC 5
Add
BLAST
Domaini2185 – 222137EGF-like
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni315 – 49818426 X approximate heptapeptide repeats (mucin-like domain)
Add
BLAST

Domaini

The MAM domains probably mediate sperm adhesion to the zona pellucida.
During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate trapping of spermatozoa or promoting adhesion to the oviductal isthmus.
The VWFD domains 2 and 3 may mediate covalent oligomerization (By similarity to human intestinal mucin MUC2).

Sequence similaritiesi

Contains 1 EGF-like domain.
Contains at least 2 MAM domains.
Contains 5 VWFC domains.
Contains 4 VWFD domains.

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000168448.
HOVERGENiHBG000375.

Family and domain databases

InterProiIPR008985. ConA-like_lec_gl_sf.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000998. MAM_dom.
IPR002919. TIL_dom.
IPR025615. TILa_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 4 hits.
PF00008. EGF. 1 hit.
PF00629. MAM. 2 hits.
PF01826. TIL. 5 hits.
PF12714. TILa. 5 hits.
PF00094. VWD. 4 hits.
[Graphical view]
SMARTiSM00832. C8. 4 hits.
SM00181. EGF. 1 hit.
SM00137. MAM. 1 hit.
SM00214. VWC. 3 hits.
SM00216. VWD. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF57567. SSF57567. 5 hits.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 1 hit.
PS50060. MAM_2. 2 hits.
PS51233. VWFD. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P57999-1 [UniParc]FASTAAdd to Basket

« Hide

MFFATGRASA FSHPCGRTAV SLREERRIKK RKRQDGFYML LDPKNAKPRQ     50
KSVLLSPLSQ SAGCLTLSFH YTLWGQSPGA ALSVLASVLG SIRKHTLFSG 100
QPSPNWQPVS VNYSGPGQIQ FTVVGVFGDV PEPAVAVDAI SIAPCGESFP 150
QCVFEDAAHP FCDWLQASED GGRWAWTDKD MLAQERSLMR ESPHTGHHYI 200
YLEADKFSRP GQSVRLVSRP FCAPGDVCVE FSYHMYGLGE GTTLQFLLGS 250
PAGSTPVSLW NRVGSQSPDW LNASVTIPSG HQQPMQLVFE AIRGSNTAFV 300
VAMSFILINH GTCHVPVPPV IPIKTLVIPT EQPTVPAEGT TEPPEGTIEL 350
PEGTTKLPEE TTELPEEITE PPKETTIPTE PPTVPTEPPT VPTEPPTVPT 400
EKPTVLTEKP TVPTEETSIP TEPPTVPTEK PTVATEPPTV PTEEPTVATE 450
KPTVPTEETT PPTTARSTLT SLEPTTHTPS TSLTSTTLST TTTPSPTTVS 500
CPANAHYESC ACPASCKHPK ASCKPPCQPG CVCDPGLVFS NNSCIKASSC 550
PCLYNNNNYE PEAEWFSPNC TELCHCWPGG RIECQISQCK THTKCQLKNG 600
QYECQPYGTA TCFVYGDPHY VTFDGRHFGF MGKCTYIVAQ PCSKSTDSFF 650
RVTAKNEERG QEGMSCLSRV DVTLSETVVT LLKGRRTLVG GQRVTLPAMP 700
AKGVFLGPSG RFVELQTDFG LRVRWDGDQQ LLVTVPSAYF QKLCGLCGNY 750
DGHSSNDNLK ADGQPAQSEE ELGNSWQWAQ DEDKECQKNQ ANPPSCDTAL 800
QTKMSGPQFC GQLVDSRGVF KTCLLHLKAS SFFDNCVFDT CNFQGLQLML 850
CAHMSAVTAA CQDAGYAVKP WREPQFCPLA CPPNSRYSLC TSPCPKTCHT 900
GYVGMPCPEQ CLEGCECNPG FILSGLECVP SAQCGCLDPS RGYFKVGEQW 950
FKSDCKQLCI CEGSNQIRCQ PWKCGPHEVC SQQSGIYGCH SQGSATCSAS 1000
GDPHYLTFDG ALHHFMGTCN YVLTQPCRHR PQENSFVVSA TNEIRDGNLE 1050
VSLRPSCPRC RSSALKISLV KGHKVVLNGR RVALPVWPSR GQVTVRPSGN 1100
FMLLYTNFGL RVRYDGNHLV EVTVPSSYAG QLCGLCGNYN NNSLDDILGP 1150
YKRPVGNSVQ LGAAWKLEEG SETGCFLQGG KPSSCHEDMG DTWNKNCEVL 1200
VNPLGPFSQC HKVVPPEVSF TSCVHGQCGT KGDSLTLCRS LQAYASLCSL 1250
AGQALAWRNS TFCPLKCPPN SSYSPCGSPC PGTCLSLNHP KDCPITLPCV 1300
EGCECQNGYI LSGTSCVPLN QCGCTDFEGS YHLVRESWYT DNTCSRLCTC 1350
SLHNNITCRQ TACKPGQQCW AVDGLLRCRD SGMGVCQVTG DSRYLSFDGS 1400
SHPLQGACTY VLAKVCHPNM DLPFFKVSAS NEKSSAGGTN AVSLHQVYIE 1450
FSGSLVTLQK GNLVLINGTR VALPATSQIR GLNISSSRTH TIVSFWIGAQ 1500
IKFDGNHVLK ITIPAAYYEK VCGICGNYNG EPEDELMMPS DELAASDLEF 1550
VKSWKDNNID PNCQKSQEGK GKPQEEQGPS GSSKKASCSP ADLQKVQEQC 1600
QAALQTPAWA ECASRVDLRP FLLDCMNSLC EFRGSLQPLC KALQALGAAC 1650
RSKGLQPPIW RNSSFCPLAC PAYSTYTNCL PSCSPSCFDP DGRCEGARAP 1700
SSCAEGCTCQ PGYVLSKNKC VAKDQCSCRD AQGGSIPSGK SWVSSGCSQK 1750
CACTEGSIQC RAFHCPSRSH CKLNSNGNSN CVSEKSDQCS IFGGPHYRTF 1800
DRFSFGFRGR MTYVLIKTVD ELPDGVERLL VQARNKMYPP WNKVFLQEII 1850
TTVYGYKVQL QRDLVLVVNN QKMAVPYKPE DRLRVSMQGQ RLFLITDFEM 1900
VVSFDGRNAA VITLPSMYQG LVRGLCGNYD SDRRNEMMLP NGAITTNVDV 1950
FGNSWEVKTE DSVLRFRRAL QVEADGKEKE TGSYRSECSQ EQLALVNSTQ 2000
ACRVLVDPQG PFAACHQTVA PEPFQEHCVS DLCASRDPKE HEELRCQVLS 2050
GYSITCQEAG IALAGWRDHT HCAMVCPANT VYQSCMTPCP ESCANLAAPR 2100
DCEGPCVEGC ASLPGYAFSG AQSLPLANCG CTSNGIYYQL GHSFVTADCS 2150
QRCTCASSGV LLCEPFSCRP GESCTLGNLT RGCFRESPCL RNPCQNDGRC 2200
REQGTSFTCE CEPGYGGHLC TEPRDVLLPP KPDTSNLVAI LLGMLVSLVV 2250
TVPVLARKCV SRKRRRWREK TQSEPRSAPG RR 2282
Length:2,282
Mass (Da):248,292
Last modified:November 16, 2001 - v2
Checksum:i380FA81093454892
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF244982 mRNA. Translation: AAF63342.2.
RefSeqiNP_001075550.1. NM_001082081.1.
UniGeneiOcu.2652.

Genome annotation databases

GeneIDi100008761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF244982 mRNA. Translation: AAF63342.2 .
RefSeqi NP_001075550.1. NM_001082081.1.
UniGenei Ocu.2652.

3D structure databases

ProteinModelPortali P57999.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000025091.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100008761.

Organism-specific databases

CTDi 7455.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000168448.
HOVERGENi HBG000375.

Family and domain databases

InterProi IPR008985. ConA-like_lec_gl_sf.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000998. MAM_dom.
IPR002919. TIL_dom.
IPR025615. TILa_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 4 hits.
PF00008. EGF. 1 hit.
PF00629. MAM. 2 hits.
PF01826. TIL. 5 hits.
PF12714. TILa. 5 hits.
PF00094. VWD. 4 hits.
[Graphical view ]
SMARTi SM00832. C8. 4 hits.
SM00181. EGF. 1 hit.
SM00137. MAM. 1 hit.
SM00214. VWC. 3 hits.
SM00216. VWD. 4 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
SSF57567. SSF57567. 5 hits.
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 1 hit.
PS50060. MAM_2. 2 hits.
PS51233. VWFD. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Zonadhesin: characterization, localization, and zona pellucida binding."
    Lea I.A., Sivashanmugam P., O'Rand M.G.
    Biol. Reprod. 65:1691-1700(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZAN_RABIT
AccessioniPrimary (citable) accession number: P57999
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 16, 2001
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi