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Protein

Protein translocase subunit SecA 1

Gene

secA1

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi101 – 108ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecA 1UniRule annotation
Gene namesi
Name:secA1UniRule annotation
Ordered Locus Names:ML0779
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0779.

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095941 – 940Protein translocase subunit SecA 1Add BLAST940

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0779.

Structurei

3D structure databases

ProteinModelPortaliP57996.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
OrthoDBiPOG091H01RS.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57996-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKLLRLGE GRIVKRLKRV AEYVNTLSDN VEKLTDVELK AKTDEFKQRL
60 70 80 90 100
ADEKNPESLD DLLPEAFAVA REAAWRVLDQ RPFDVQVMGG AALHLGNVAE
110 120 130 140 150
MKTGEGKTLT CVLPAYLNAL AGKGVHIVTV NDYLAKRDSE WMGRVHRFLG
160 170 180 190 200
LQVGVILASM TPDERRVAYN ADITYGTNNE FGFDYLRDNM AHSLDDLVQR
210 220 230 240 250
GHSYAIVDEV DSILIDEART PLIISGSADG ASNWYTEFAR LVRLMDKDVH
260 270 280 290 300
YEVDLRKRTV GVHEKGMEFV EDQLGIDNLY EVANSPLVSY LNNALKAKEL
310 320 330 340 350
FNRDKDYIVR DGEVLIVDEF TGRVLIGRRY NEGMHQAIEA KEHVEIKAEN
360 370 380 390 400
QTLATITLQN YFRLYDKLAG MTGTAQTEAA ELHEIYKLGV VAIPTNKPMI
410 420 430 440 450
REDRSDLIYK TEEAKYMAVV DDVAERYEKG QPVLIGTTSV ERSEYLSRQF
460 470 480 490 500
TKRHIPHNVL NAKYHEQEAG IVAVAGRRGG VTVATNMAGR GTDIVLGGNV
510 520 530 540 550
DFLTDQRLRR RGLDPVETPD EYEQAWHSEL PKVKEEAGQE AAEVIEAGGL
560 570 580 590 600
YVLGTERHES RRIDNQLRGR SGRQGDPGES RFYLSLGDEL MRRFHGATLE
610 620 630 640 650
ALLTRLNLPD DVPIEAKMVT RAIKSAQTQV EQQNFEVRKN VLKYDEVMNQ
660 670 680 690 700
QRKVIYAERR RILEGESLQQ QALGMVRDVI TAYIDGATTD SYVEDWDLDA
710 720 730 740 750
LWSALGTLYP VGIKHESLTH ADEDSECDEL SRDELLEALL IDAQHAYAAR
760 770 780 790 800
EAELAELAGE GAMRQLERNV LLNVVDRKWR EHLYEMDYLK EGIGLRAMAQ
810 820 830 840 850
RDPLVEYQRE GYDMFMAMLD GVKEESVGFL FNLAVEAVPA SHVAPVEIPE
860 870 880 890 900
GFTGLVADVE AIRPREEASS ALRTKDIDNE STGLTYSGPS EDGSTQVQLN
910 920 930 940
SGGGQKTPAG IPVGASRRER REAARRRGRG AKPSRSVKKR
Length:940
Mass (Da):105,528
Last modified:April 27, 2001 - v1
Checksum:i00AAEBF62D76DD71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583919 Genomic DNA. Translation: CAC30288.1.
PIRiD87006.
RefSeqiNP_301603.1. NC_002677.1.
WP_010907927.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30288; CAC30288; CAC30288.
GeneIDi909735.
KEGGimle:ML0779.
PATRICi18052904. VBIMycLep78757_1398.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583919 Genomic DNA. Translation: CAC30288.1.
PIRiD87006.
RefSeqiNP_301603.1. NC_002677.1.
WP_010907927.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP57996.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0779.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30288; CAC30288; CAC30288.
GeneIDi909735.
KEGGimle:ML0779.
PATRICi18052904. VBIMycLep78757_1398.

Organism-specific databases

LepromaiML0779.

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
OrthoDBiPOG091H01RS.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECA1_MYCLE
AccessioniPrimary (citable) accession number: P57996
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: October 5, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.