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Protein

Protein translocase subunit SecA 1

Gene

secA1

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi101 – 108ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-847-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecA 1UniRule annotation
Gene namesi
Name:secA1UniRule annotation
Ordered Locus Names:ML0779
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0779

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation
  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095941 – 940Protein translocase subunit SecA 1Add BLAST940

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0779

Structurei

3D structure databases

ProteinModelPortaliP57996
SMRiP57996
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6 Bacteria
COG0653 LUCA
HOGENOMiHOG000218168
KOiK03070
OMAiFEYDEVM
OrthoDBiPOG091H01RS

Family and domain databases

HAMAPiMF_01382 SecA, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000185 SecA
IPR020937 SecA_CS
IPR011115 SecA_DEAD
IPR014018 SecA_motor_DEAD
IPR011130 SecA_preprotein_X-link_dom
IPR011116 SecA_Wing/Scaffold
IPR036266 SecA_Wing/Scaffold_sf
IPR036670 SecA_X-link_sf
PANTHERiPTHR30612 PTHR30612, 2 hits
PfamiView protein in Pfam
PF07517 SecA_DEAD, 1 hit
PF01043 SecA_PP_bind, 1 hit
PF07516 SecA_SW, 1 hit
PRINTSiPR00906 SECA
SMARTiView protein in SMART
SM00957 SecA_DEAD, 1 hit
SM00958 SecA_PP_bind, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
SSF81767 SSF81767, 1 hit
SSF81886 SSF81886, 1 hit
TIGRFAMsiTIGR00963 secA, 1 hit
PROSITEiView protein in PROSITE
PS01312 SECA, 1 hit
PS51196 SECA_MOTOR_DEAD, 1 hit

Sequencei

Sequence statusi: Complete.

P57996-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKLLRLGE GRIVKRLKRV AEYVNTLSDN VEKLTDVELK AKTDEFKQRL
60 70 80 90 100
ADEKNPESLD DLLPEAFAVA REAAWRVLDQ RPFDVQVMGG AALHLGNVAE
110 120 130 140 150
MKTGEGKTLT CVLPAYLNAL AGKGVHIVTV NDYLAKRDSE WMGRVHRFLG
160 170 180 190 200
LQVGVILASM TPDERRVAYN ADITYGTNNE FGFDYLRDNM AHSLDDLVQR
210 220 230 240 250
GHSYAIVDEV DSILIDEART PLIISGSADG ASNWYTEFAR LVRLMDKDVH
260 270 280 290 300
YEVDLRKRTV GVHEKGMEFV EDQLGIDNLY EVANSPLVSY LNNALKAKEL
310 320 330 340 350
FNRDKDYIVR DGEVLIVDEF TGRVLIGRRY NEGMHQAIEA KEHVEIKAEN
360 370 380 390 400
QTLATITLQN YFRLYDKLAG MTGTAQTEAA ELHEIYKLGV VAIPTNKPMI
410 420 430 440 450
REDRSDLIYK TEEAKYMAVV DDVAERYEKG QPVLIGTTSV ERSEYLSRQF
460 470 480 490 500
TKRHIPHNVL NAKYHEQEAG IVAVAGRRGG VTVATNMAGR GTDIVLGGNV
510 520 530 540 550
DFLTDQRLRR RGLDPVETPD EYEQAWHSEL PKVKEEAGQE AAEVIEAGGL
560 570 580 590 600
YVLGTERHES RRIDNQLRGR SGRQGDPGES RFYLSLGDEL MRRFHGATLE
610 620 630 640 650
ALLTRLNLPD DVPIEAKMVT RAIKSAQTQV EQQNFEVRKN VLKYDEVMNQ
660 670 680 690 700
QRKVIYAERR RILEGESLQQ QALGMVRDVI TAYIDGATTD SYVEDWDLDA
710 720 730 740 750
LWSALGTLYP VGIKHESLTH ADEDSECDEL SRDELLEALL IDAQHAYAAR
760 770 780 790 800
EAELAELAGE GAMRQLERNV LLNVVDRKWR EHLYEMDYLK EGIGLRAMAQ
810 820 830 840 850
RDPLVEYQRE GYDMFMAMLD GVKEESVGFL FNLAVEAVPA SHVAPVEIPE
860 870 880 890 900
GFTGLVADVE AIRPREEASS ALRTKDIDNE STGLTYSGPS EDGSTQVQLN
910 920 930 940
SGGGQKTPAG IPVGASRRER REAARRRGRG AKPSRSVKKR
Length:940
Mass (Da):105,528
Last modified:April 27, 2001 - v1
Checksum:i00AAEBF62D76DD71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583919 Genomic DNA Translation: CAC30288.1
PIRiD87006
RefSeqiNP_301603.1, NC_002677.1
WP_010907927.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30288; CAC30288; CAC30288
GeneIDi909735
KEGGimle:ML0779
PATRICifig|272631.5.peg.1398

Similar proteinsi

Entry informationi

Entry nameiSECA1_MYCLE
AccessioniPrimary (citable) accession number: P57996
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: April 25, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health