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P57993 (PKNG_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase PknG
EC=2.7.11.1
Gene names
Name:pknG
Ordered Locus Names:ML0304
ORF Names:MLCB1450.19c
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium ›

Protein attributes

Sequence length763 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Post-translational modification

Autophosphorylated By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence caution

The sequence CAC29812.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 763763Serine/threonine-protein kinase PknG
PRO_0000171215

Regions

Domain160 – 406247Protein kinase
Nucleotide binding166 – 1749ATP By similarity

Sites

Active site2891Proton acceptor By similarity
Binding site1901ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P57993 [UniParc].

Last modified August 14, 2001. Version 2.
Checksum: 9B42725EB49C1199

FASTA76383,470
        10         20         30         40         50         60 
MKREHMDHDT EDVGQAAQRA DPPSGTTEGR LQSTQAIFRP NFDDDDDLLH ISVPSVDTEP 

        70         80         90        100        110        120 
QDRITPATRV LPPIRQLGGG LVEIRRVRDI DPLEALMTNP VVPESKRFCW NCGRPVGRSE 

       130        140        150        160        170        180 
LEGQEADGAQ GAKEGWCPYC GSPYSFLPQL SPGDIVAGQY EVKGCIAHGG LGWVYLAFDH 

       190        200        210        220        230        240 
NVNDRPVVLK GLVHSGDAEA QASAVAERQF LAEVVHPQIV QIFNFVEHKD TSGDPVGYIV 

       250        260        270        280        290        300 
MEYIGGRSLK RGSKKGNVEK LPVAEAIAYL LEILPALSYL HSIGLVYNDL KPENIMLTEE 

       310        320        330        340        350        360 
QLKLIDLGAV SRINSFGCIY GTPGYQAPEI VRTGPTVATD IYTVGRTLAA LTLNLRTRNG 

       370        380        390        400        410        420 
RYMDGLPEDD PVLTTYDSFA RLLHRAINPD PRRRFSSAEE MSAQLMGVLR EVVAQDTGVP 

       430        440        450        460        470        480 
RAGLSTIFSP SRSTFGVDLL VAHTDVYLDG RLHSEKLTAK DIVTALQVPL VDPTDVAAPV 

       490        500        510        520        530        540 
LQATVLSQPV QTLDSLRAAR HGMLDAQGID LAESVELPLM EVRALLDLGD VVKANRKLDD 

       550        560        570        580        590        600 
LADRVSCQWR LVWYRAVADL LTGDYASATK HFTEVLNTFP GELAPKLALA ATAELAGESD 

       610        620        630        640        650        660 
EHKFYRTVWH TNDGVVSAAF GLARFQSAEG DRTGAVCTLD EVPPTSRHFT TARLTSAVTL 

       670        680        690        700        710        720 
LSGRSTNEIT EQQIRDAARR VETLPPTEPR VLQIRALVLG CAMDWLADNQ ASANHILGFP 

       730        740        750        760 
FTKHGLRLGV EASLRSLARV APTQRHRYTL VDMANKVRPT STL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL035159 Genomic DNA. Translation: CAA22703.1.
AL583918 Genomic DNA. Translation: CAC29812.1. Different initiation.
PIRH86946.
T44735.
RefSeqNP_301338.1. NC_002677.1.

3D structure databases

ProteinModelPortalP57993.
SMRP57993. Positions 77-759.
ModBaseSearch...

Protein-protein interaction databases

STRING272631.ML0304.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC29812; CAC29812; CAC29812.
GeneID908881.
KEGGmle:ML0304.
PATRIC18051046. VBIMycLep78757_0472.

Organism-specific databases

LepromaML0304.
CMRSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000049016.
KOK14949.
ProtClustDBCLSK790502.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. False negative.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePKNG_MYCLE
AccessionPrimary (citable) accession number: P57993
Secondary accession number(s): Q9ZBL8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 14, 2001
Last modified: May 1, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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