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P57993

- PKNG_MYCLE

UniProt

P57993 - PKNG_MYCLE

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Protein

Serine/threonine-protein kinase PknG

Gene
pknG, ML0304, MLCB1450.19c
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei190 – 1901ATP By similarity
Active sitei289 – 2891Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi166 – 1749ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknG (EC:2.7.11.1)
Gene namesi
Name:pknG
Ordered Locus Names:ML0304
ORF Names:MLCB1450.19c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0304.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Serine/threonine-protein kinase PknGPRO_0000171215Add
BLAST

Post-translational modificationi

Autophosphorylated By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0304.

Structurei

3D structure databases

ProteinModelPortaliP57993.
SMRiP57993. Positions 77-759.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini160 – 406247Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000049016.
KOiK14949.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57993-1 [UniParc]FASTAAdd to Basket

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MKREHMDHDT EDVGQAAQRA DPPSGTTEGR LQSTQAIFRP NFDDDDDLLH    50
ISVPSVDTEP QDRITPATRV LPPIRQLGGG LVEIRRVRDI DPLEALMTNP 100
VVPESKRFCW NCGRPVGRSE LEGQEADGAQ GAKEGWCPYC GSPYSFLPQL 150
SPGDIVAGQY EVKGCIAHGG LGWVYLAFDH NVNDRPVVLK GLVHSGDAEA 200
QASAVAERQF LAEVVHPQIV QIFNFVEHKD TSGDPVGYIV MEYIGGRSLK 250
RGSKKGNVEK LPVAEAIAYL LEILPALSYL HSIGLVYNDL KPENIMLTEE 300
QLKLIDLGAV SRINSFGCIY GTPGYQAPEI VRTGPTVATD IYTVGRTLAA 350
LTLNLRTRNG RYMDGLPEDD PVLTTYDSFA RLLHRAINPD PRRRFSSAEE 400
MSAQLMGVLR EVVAQDTGVP RAGLSTIFSP SRSTFGVDLL VAHTDVYLDG 450
RLHSEKLTAK DIVTALQVPL VDPTDVAAPV LQATVLSQPV QTLDSLRAAR 500
HGMLDAQGID LAESVELPLM EVRALLDLGD VVKANRKLDD LADRVSCQWR 550
LVWYRAVADL LTGDYASATK HFTEVLNTFP GELAPKLALA ATAELAGESD 600
EHKFYRTVWH TNDGVVSAAF GLARFQSAEG DRTGAVCTLD EVPPTSRHFT 650
TARLTSAVTL LSGRSTNEIT EQQIRDAARR VETLPPTEPR VLQIRALVLG 700
CAMDWLADNQ ASANHILGFP FTKHGLRLGV EASLRSLARV APTQRHRYTL 750
VDMANKVRPT STL 763
Length:763
Mass (Da):83,470
Last modified:August 14, 2001 - v2
Checksum:i9B42725EB49C1199
GO

Sequence cautioni

The sequence CAC29812.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035159 Genomic DNA. Translation: CAA22703.1.
AL583918 Genomic DNA. Translation: CAC29812.1. Different initiation.
PIRiH86946.
T44735.
RefSeqiNP_301338.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29812; CAC29812; CAC29812.
GeneIDi908881.
KEGGimle:ML0304.
PATRICi18051046. VBIMycLep78757_0472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035159 Genomic DNA. Translation: CAA22703.1 .
AL583918 Genomic DNA. Translation: CAC29812.1 . Different initiation.
PIRi H86946.
T44735.
RefSeqi NP_301338.1. NC_002677.1.

3D structure databases

ProteinModelPortali P57993.
SMRi P57993. Positions 77-759.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0304.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC29812 ; CAC29812 ; CAC29812 .
GeneIDi 908881.
KEGGi mle:ML0304.
PATRICi 18051046. VBIMycLep78757_0472.

Organism-specific databases

Lepromai ML0304.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000049016.
KOi K14949.
OrthoDBi EOG6B35XT.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiPKNG_MYCLE
AccessioniPrimary (citable) accession number: P57993
Secondary accession number(s): Q9ZBL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 14, 2001
Last modified: May 14, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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