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P57993

- PKNG_MYCLE

UniProt

P57993 - PKNG_MYCLE

Protein

Serine/threonine-protein kinase PknG

Gene

pknG

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (14 Aug 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei190 – 1901ATPPROSITE-ProRule annotation
    Active sitei289 – 2891Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi166 – 1749ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase PknG (EC:2.7.11.1)
    Gene namesi
    Name:pknG
    Ordered Locus Names:ML0304
    ORF Names:MLCB1450.19c
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0304.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 763763Serine/threonine-protein kinase PknGPRO_0000171215Add
    BLAST

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML0304.

    Structurei

    3D structure databases

    ProteinModelPortaliP57993.
    SMRiP57993. Positions 77-759.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini160 – 406247Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000049016.
    KOiK14949.
    OrthoDBiEOG6B35XT.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57993-1 [UniParc]FASTAAdd to Basket

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    MKREHMDHDT EDVGQAAQRA DPPSGTTEGR LQSTQAIFRP NFDDDDDLLH    50
    ISVPSVDTEP QDRITPATRV LPPIRQLGGG LVEIRRVRDI DPLEALMTNP 100
    VVPESKRFCW NCGRPVGRSE LEGQEADGAQ GAKEGWCPYC GSPYSFLPQL 150
    SPGDIVAGQY EVKGCIAHGG LGWVYLAFDH NVNDRPVVLK GLVHSGDAEA 200
    QASAVAERQF LAEVVHPQIV QIFNFVEHKD TSGDPVGYIV MEYIGGRSLK 250
    RGSKKGNVEK LPVAEAIAYL LEILPALSYL HSIGLVYNDL KPENIMLTEE 300
    QLKLIDLGAV SRINSFGCIY GTPGYQAPEI VRTGPTVATD IYTVGRTLAA 350
    LTLNLRTRNG RYMDGLPEDD PVLTTYDSFA RLLHRAINPD PRRRFSSAEE 400
    MSAQLMGVLR EVVAQDTGVP RAGLSTIFSP SRSTFGVDLL VAHTDVYLDG 450
    RLHSEKLTAK DIVTALQVPL VDPTDVAAPV LQATVLSQPV QTLDSLRAAR 500
    HGMLDAQGID LAESVELPLM EVRALLDLGD VVKANRKLDD LADRVSCQWR 550
    LVWYRAVADL LTGDYASATK HFTEVLNTFP GELAPKLALA ATAELAGESD 600
    EHKFYRTVWH TNDGVVSAAF GLARFQSAEG DRTGAVCTLD EVPPTSRHFT 650
    TARLTSAVTL LSGRSTNEIT EQQIRDAARR VETLPPTEPR VLQIRALVLG 700
    CAMDWLADNQ ASANHILGFP FTKHGLRLGV EASLRSLARV APTQRHRYTL 750
    VDMANKVRPT STL 763
    Length:763
    Mass (Da):83,470
    Last modified:August 14, 2001 - v2
    Checksum:i9B42725EB49C1199
    GO

    Sequence cautioni

    The sequence CAC29812.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035159 Genomic DNA. Translation: CAA22703.1.
    AL583918 Genomic DNA. Translation: CAC29812.1. Different initiation.
    PIRiH86946.
    T44735.
    RefSeqiNP_301338.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC29812; CAC29812; CAC29812.
    GeneIDi908881.
    KEGGimle:ML0304.
    PATRICi18051046. VBIMycLep78757_0472.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035159 Genomic DNA. Translation: CAA22703.1 .
    AL583918 Genomic DNA. Translation: CAC29812.1 . Different initiation.
    PIRi H86946.
    T44735.
    RefSeqi NP_301338.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali P57993.
    SMRi P57993. Positions 77-759.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0304.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC29812 ; CAC29812 ; CAC29812 .
    GeneIDi 908881.
    KEGGi mle:ML0304.
    PATRICi 18051046. VBIMycLep78757_0472.

    Organism-specific databases

    Lepromai ML0304.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000049016.
    KOi K14949.
    OrthoDBi EOG6B35XT.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiPKNG_MYCLE
    AccessioniPrimary (citable) accession number: P57993
    Secondary accession number(s): Q9ZBL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3