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Protein

Serine/threonine-protein kinase PknG

Gene

pknG

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei190ATPPROSITE-ProRule annotation1
Active sitei289Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi166 – 174ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknG (EC:2.7.11.1)
Gene namesi
Name:pknG
Ordered Locus Names:ML0304
ORF Names:MLCB1450.19c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0304.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001712151 – 763Serine/threonine-protein kinase PknGAdd BLAST763

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0304.

Structurei

3D structure databases

ProteinModelPortaliP57993.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini160 – 406Protein kinasePROSITE-ProRule annotationAdd BLAST247

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107Q25. Bacteria.
COG0515. LUCA.
HOGENOMiHOG000049016.
OrthoDBiPOG091H0264.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR031634. PknG_rubred.
IPR031636. PknG_TPR.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF16919. PknG_rubred. 1 hit.
PF16918. PknG_TPR. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKREHMDHDT EDVGQAAQRA DPPSGTTEGR LQSTQAIFRP NFDDDDDLLH
60 70 80 90 100
ISVPSVDTEP QDRITPATRV LPPIRQLGGG LVEIRRVRDI DPLEALMTNP
110 120 130 140 150
VVPESKRFCW NCGRPVGRSE LEGQEADGAQ GAKEGWCPYC GSPYSFLPQL
160 170 180 190 200
SPGDIVAGQY EVKGCIAHGG LGWVYLAFDH NVNDRPVVLK GLVHSGDAEA
210 220 230 240 250
QASAVAERQF LAEVVHPQIV QIFNFVEHKD TSGDPVGYIV MEYIGGRSLK
260 270 280 290 300
RGSKKGNVEK LPVAEAIAYL LEILPALSYL HSIGLVYNDL KPENIMLTEE
310 320 330 340 350
QLKLIDLGAV SRINSFGCIY GTPGYQAPEI VRTGPTVATD IYTVGRTLAA
360 370 380 390 400
LTLNLRTRNG RYMDGLPEDD PVLTTYDSFA RLLHRAINPD PRRRFSSAEE
410 420 430 440 450
MSAQLMGVLR EVVAQDTGVP RAGLSTIFSP SRSTFGVDLL VAHTDVYLDG
460 470 480 490 500
RLHSEKLTAK DIVTALQVPL VDPTDVAAPV LQATVLSQPV QTLDSLRAAR
510 520 530 540 550
HGMLDAQGID LAESVELPLM EVRALLDLGD VVKANRKLDD LADRVSCQWR
560 570 580 590 600
LVWYRAVADL LTGDYASATK HFTEVLNTFP GELAPKLALA ATAELAGESD
610 620 630 640 650
EHKFYRTVWH TNDGVVSAAF GLARFQSAEG DRTGAVCTLD EVPPTSRHFT
660 670 680 690 700
TARLTSAVTL LSGRSTNEIT EQQIRDAARR VETLPPTEPR VLQIRALVLG
710 720 730 740 750
CAMDWLADNQ ASANHILGFP FTKHGLRLGV EASLRSLARV APTQRHRYTL
760
VDMANKVRPT STL
Length:763
Mass (Da):83,470
Last modified:August 14, 2001 - v2
Checksum:i9B42725EB49C1199
GO

Sequence cautioni

The sequence CAC29812 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035159 Genomic DNA. Translation: CAA22703.1.
AL583918 Genomic DNA. Translation: CAC29812.1. Different initiation.
PIRiH86946.
T44735.
RefSeqiWP_010907662.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29812; CAC29812; CAC29812.
PATRICi18051046. VBIMycLep78757_0472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035159 Genomic DNA. Translation: CAA22703.1.
AL583918 Genomic DNA. Translation: CAC29812.1. Different initiation.
PIRiH86946.
T44735.
RefSeqiWP_010907662.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP57993.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0304.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC29812; CAC29812; CAC29812.
PATRICi18051046. VBIMycLep78757_0472.

Organism-specific databases

LepromaiML0304.

Phylogenomic databases

eggNOGiENOG4107Q25. Bacteria.
COG0515. LUCA.
HOGENOMiHOG000049016.
OrthoDBiPOG091H0264.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR031634. PknG_rubred.
IPR031636. PknG_TPR.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF16919. PknG_rubred. 1 hit.
PF16918. PknG_TPR. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKNG_MYCLE
AccessioniPrimary (citable) accession number: P57993
Secondary accession number(s): Q9ZBL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 14, 2001
Last modified: October 5, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.