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P57993

- PKNG_MYCLE

UniProt

P57993 - PKNG_MYCLE

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Protein

Serine/threonine-protein kinase PknG

Gene

pknG

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei190 – 1901ATPPROSITE-ProRule annotation
Active sitei289 – 2891Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi166 – 1749ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknG (EC:2.7.11.1)
Gene namesi
Name:pknG
Ordered Locus Names:ML0304
ORF Names:MLCB1450.19c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0304.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Serine/threonine-protein kinase PknGPRO_0000171215Add
BLAST

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0304.

Structurei

3D structure databases

ProteinModelPortaliP57993.
SMRiP57993. Positions 77-759.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini160 – 406247Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000049016.
KOiK14949.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57993-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKREHMDHDT EDVGQAAQRA DPPSGTTEGR LQSTQAIFRP NFDDDDDLLH
60 70 80 90 100
ISVPSVDTEP QDRITPATRV LPPIRQLGGG LVEIRRVRDI DPLEALMTNP
110 120 130 140 150
VVPESKRFCW NCGRPVGRSE LEGQEADGAQ GAKEGWCPYC GSPYSFLPQL
160 170 180 190 200
SPGDIVAGQY EVKGCIAHGG LGWVYLAFDH NVNDRPVVLK GLVHSGDAEA
210 220 230 240 250
QASAVAERQF LAEVVHPQIV QIFNFVEHKD TSGDPVGYIV MEYIGGRSLK
260 270 280 290 300
RGSKKGNVEK LPVAEAIAYL LEILPALSYL HSIGLVYNDL KPENIMLTEE
310 320 330 340 350
QLKLIDLGAV SRINSFGCIY GTPGYQAPEI VRTGPTVATD IYTVGRTLAA
360 370 380 390 400
LTLNLRTRNG RYMDGLPEDD PVLTTYDSFA RLLHRAINPD PRRRFSSAEE
410 420 430 440 450
MSAQLMGVLR EVVAQDTGVP RAGLSTIFSP SRSTFGVDLL VAHTDVYLDG
460 470 480 490 500
RLHSEKLTAK DIVTALQVPL VDPTDVAAPV LQATVLSQPV QTLDSLRAAR
510 520 530 540 550
HGMLDAQGID LAESVELPLM EVRALLDLGD VVKANRKLDD LADRVSCQWR
560 570 580 590 600
LVWYRAVADL LTGDYASATK HFTEVLNTFP GELAPKLALA ATAELAGESD
610 620 630 640 650
EHKFYRTVWH TNDGVVSAAF GLARFQSAEG DRTGAVCTLD EVPPTSRHFT
660 670 680 690 700
TARLTSAVTL LSGRSTNEIT EQQIRDAARR VETLPPTEPR VLQIRALVLG
710 720 730 740 750
CAMDWLADNQ ASANHILGFP FTKHGLRLGV EASLRSLARV APTQRHRYTL
760
VDMANKVRPT STL
Length:763
Mass (Da):83,470
Last modified:August 14, 2001 - v2
Checksum:i9B42725EB49C1199
GO

Sequence cautioni

The sequence CAC29812.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035159 Genomic DNA. Translation: CAA22703.1.
AL583918 Genomic DNA. Translation: CAC29812.1. Different initiation.
PIRiH86946.
T44735.
RefSeqiNP_301338.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29812; CAC29812; CAC29812.
GeneIDi908881.
KEGGimle:ML0304.
PATRICi18051046. VBIMycLep78757_0472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035159 Genomic DNA. Translation: CAA22703.1 .
AL583918 Genomic DNA. Translation: CAC29812.1 . Different initiation.
PIRi H86946.
T44735.
RefSeqi NP_301338.1. NC_002677.1.

3D structure databases

ProteinModelPortali P57993.
SMRi P57993. Positions 77-759.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0304.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC29812 ; CAC29812 ; CAC29812 .
GeneIDi 908881.
KEGGi mle:ML0304.
PATRICi 18051046. VBIMycLep78757_0472.

Organism-specific databases

Lepromai ML0304.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000049016.
KOi K14949.
OrthoDBi EOG6B35XT.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiPKNG_MYCLE
AccessioniPrimary (citable) accession number: P57993
Secondary accession number(s): Q9ZBL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 14, 2001
Last modified: October 1, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3