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P57991

- UVRB_MYCLE

UniProt

P57991 - UVRB_MYCLE

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Protein
UvrABC system protein B
Gene
uvrB, ML1387
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 488ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP
  3. excinuclease ABC activity Source: UniProtKB-HAMAP
  4. helicase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. SOS response Source: UniProtKB-HAMAP
  2. nucleotide-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein B
Short name:
Protein UvrB
Alternative name(s):
Excinuclease ABC subunit B
Gene namesi
Name:uvrB
Ordered Locus Names:ML1387
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1387.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 698698UvrABC system protein BUniRule annotation
PRO_0000138408Add
BLAST

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex By similarity.

Protein-protein interaction databases

STRINGi272631.ML1387.

Structurei

3D structure databases

ProteinModelPortaliP57991.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 414387Helicase ATP-binding
Add
BLAST
Domaini432 – 598167Helicase C-terminal
Add
BLAST
Domaini653 – 68836UVR
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi94 – 11724Beta-hairpinUniRule annotation
Add
BLAST

Domaini

The beta-hairpin motif is involved in DNA binding By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.
Contains 1 UVR domain.

Phylogenomic databases

eggNOGiCOG0556.
HOGENOMiHOG000073580.
KOiK03702.
OMAiLEKQMHE.
OrthoDBiEOG6B360R.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
4.10.860.10. 1 hit.
HAMAPiMF_00204. UvrB.
InterProiIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view]
PANTHERiPTHR24029. PTHR24029. 1 hit.
PfamiPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00631. uvrb. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57991-1 [UniParc]FASTAAdd to Basket

« Hide

MRVGGRFEVI SPHEPAGDQP AAIDELQRRI LAGERDVVLL GATGTGKSAT    50
TAWLIERLQR PTLVMAPNKT LAAQLANELR GMLPHNAVEY FVSYYDYYQP 100
EAYIAQTDTY IEKDSSINDD VERLRHSATS SLLSRRDVVV VASVSCIYGL 150
GTPQSYLDRS VELAVSNEVP RDGLLRLLVD VQYTRNDLSF TRGSFRVRGD 200
TVEIIPSYEE LAVRIEFFGD EIEALYYLHP LTGEVIRQVD SLRIFPATHY 250
VAGPERMAQA ISAIEEELAE RLAEFERQGK LLEAQRLRMR TNYDIEMMRQ 300
VGFCSGIENY SRHIDGRGPG TPPATLLDYF PEDFLLVIDE SHVTVPQIGG 350
MYEGDMSRKR NLVEYGFRLP SACDNRPLTW EEFADRIGQT VYLSATPGPY 400
ELSQSGGEFV EQVIRPTGLV DPKVVVKPTK GQIDDLIGEI RKRANADQRV 450
LVTTLTKKMA EDLTDYLLEM GIRVRYLHSE VDTLRRVELL RQLRLGDYDV 500
LVGINLLREG LDLPEVSLVA ILDADKEGFL RSARSLIQTI GRAARNVSGE 550
VHMYADTITD SMTEAIDETE RRRAKQIAYN NANGIDPQPL RKKIADILDQ 600
VYREADDTDT VQVGGSGRNV SRGRRAQSEP VRSVSVGVFE GRDTAGMPRA 650
ELADLIKDLT AQMMAAASDL QFELAARFRD EIADLKKELR GMDAAGLK 698
Length:698
Mass (Da):78,159
Last modified:April 27, 2001 - v1
Checksum:i7A68B02871502E6F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL583921 Genomic DNA. Translation: CAC31768.1.
PIRiE87082.
RefSeqiNP_301986.1. NC_002677.1.
WP_010908307.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31768; CAC31768; CAC31768.
GeneIDi910520.
KEGGimle:ML1387.
PATRICi18055294. VBIMycLep78757_2580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL583921 Genomic DNA. Translation: CAC31768.1 .
PIRi E87082.
RefSeqi NP_301986.1. NC_002677.1.
WP_010908307.1. NC_002677.1.

3D structure databases

ProteinModelPortali P57991.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML1387.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC31768 ; CAC31768 ; CAC31768 .
GeneIDi 910520.
KEGGi mle:ML1387.
PATRICi 18055294. VBIMycLep78757_2580.

Organism-specific databases

Lepromai ML1387.

Phylogenomic databases

eggNOGi COG0556.
HOGENOMi HOG000073580.
KOi K03702.
OMAi LEKQMHE.
OrthoDBi EOG6B360R.

Family and domain databases

Gene3Di 3.40.50.300. 4 hits.
4.10.860.10. 1 hit.
HAMAPi MF_00204. UvrB.
InterProi IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view ]
PANTHERi PTHR24029. PTHR24029. 1 hit.
Pfami PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00631. uvrb. 1 hit.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiUVRB_MYCLE
AccessioniPrimary (citable) accession number: P57991
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi