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Protein

UvrABC system protein B

Gene

uvrB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 48ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-1525-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein BUniRule annotation
Short name:
Protein UvrBUniRule annotation
Alternative name(s):
Excinuclease ABC subunit BUniRule annotation
Gene namesi
Name:uvrBUniRule annotation
Ordered Locus Names:ML1387
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1387

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001384081 – 698UvrABC system protein BAdd BLAST698

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML1387

Structurei

3D structure databases

ProteinModelPortaliP57991
SMRiP57991
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 414Helicase ATP-bindingUniRule annotationAdd BLAST387
Domaini432 – 598Helicase C-terminalUniRule annotationAdd BLAST167
Domaini653 – 688UVRUniRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi94 – 117Beta-hairpinAdd BLAST24

Domaini

The beta-hairpin motif is involved in DNA binding.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCW Bacteria
COG0556 LUCA
HOGENOMiHOG000073580
KOiK03702
OMAiRYMHSEI
OrthoDBiPOG091H02LK

Family and domain databases

CDDicd00079 HELICc, 1 hit
HAMAPiMF_00204 UvrB, 1 hit
InterProiView protein in InterPro
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR001943 UVR_dom
IPR036876 UVR_dom_sf
IPR004807 UvrB
IPR024759 UvrB_YAD/RRR_dom
PANTHERiPTHR24029 PTHR24029, 1 hit
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF04851 ResIII, 1 hit
PF02151 UVR, 1 hit
PF12344 UvrB, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF46600 SSF46600, 1 hit
SSF52540 SSF52540, 3 hits
TIGRFAMsiTIGR00631 uvrb, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50151 UVR, 1 hit

Sequencei

Sequence statusi: Complete.

P57991-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVGGRFEVI SPHEPAGDQP AAIDELQRRI LAGERDVVLL GATGTGKSAT
60 70 80 90 100
TAWLIERLQR PTLVMAPNKT LAAQLANELR GMLPHNAVEY FVSYYDYYQP
110 120 130 140 150
EAYIAQTDTY IEKDSSINDD VERLRHSATS SLLSRRDVVV VASVSCIYGL
160 170 180 190 200
GTPQSYLDRS VELAVSNEVP RDGLLRLLVD VQYTRNDLSF TRGSFRVRGD
210 220 230 240 250
TVEIIPSYEE LAVRIEFFGD EIEALYYLHP LTGEVIRQVD SLRIFPATHY
260 270 280 290 300
VAGPERMAQA ISAIEEELAE RLAEFERQGK LLEAQRLRMR TNYDIEMMRQ
310 320 330 340 350
VGFCSGIENY SRHIDGRGPG TPPATLLDYF PEDFLLVIDE SHVTVPQIGG
360 370 380 390 400
MYEGDMSRKR NLVEYGFRLP SACDNRPLTW EEFADRIGQT VYLSATPGPY
410 420 430 440 450
ELSQSGGEFV EQVIRPTGLV DPKVVVKPTK GQIDDLIGEI RKRANADQRV
460 470 480 490 500
LVTTLTKKMA EDLTDYLLEM GIRVRYLHSE VDTLRRVELL RQLRLGDYDV
510 520 530 540 550
LVGINLLREG LDLPEVSLVA ILDADKEGFL RSARSLIQTI GRAARNVSGE
560 570 580 590 600
VHMYADTITD SMTEAIDETE RRRAKQIAYN NANGIDPQPL RKKIADILDQ
610 620 630 640 650
VYREADDTDT VQVGGSGRNV SRGRRAQSEP VRSVSVGVFE GRDTAGMPRA
660 670 680 690
ELADLIKDLT AQMMAAASDL QFELAARFRD EIADLKKELR GMDAAGLK
Length:698
Mass (Da):78,159
Last modified:April 27, 2001 - v1
Checksum:i7A68B02871502E6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583921 Genomic DNA Translation: CAC31768.1
PIRiE87082
RefSeqiNP_301986.1, NC_002677.1
WP_010908307.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC31768; CAC31768; CAC31768
GeneIDi910520
KEGGimle:ML1387
PATRICifig|272631.5.peg.2580

Similar proteinsi

Entry informationi

Entry nameiUVRB_MYCLE
AccessioniPrimary (citable) accession number: P57991
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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