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P57991

- UVRB_MYCLE

UniProt

P57991 - UVRB_MYCLE

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Protein

UvrABC system protein B

Gene

uvrB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 488ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP
  3. excinuclease ABC activity Source: UniProtKB-HAMAP
  4. helicase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. nucleotide-excision repair Source: UniProtKB-HAMAP
  2. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein BUniRule annotation
Short name:
Protein UvrBUniRule annotation
Alternative name(s):
Excinuclease ABC subunit BUniRule annotation
Gene namesi
Name:uvrBUniRule annotation
Ordered Locus Names:ML1387
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1387.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 698698UvrABC system protein BPRO_0000138408Add
BLAST

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML1387.

Structurei

3D structure databases

ProteinModelPortaliP57991.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 414387Helicase ATP-bindingUniRule annotationAdd
BLAST
Domaini432 – 598167Helicase C-terminalUniRule annotationAdd
BLAST
Domaini653 – 68836UVRUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi94 – 11724Beta-hairpinAdd
BLAST

Domaini

The beta-hairpin motif is involved in DNA binding.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.UniRule annotation
Contains 1 helicase ATP-binding domain.UniRule annotation
Contains 1 helicase C-terminal domain.UniRule annotation
Contains 1 UVR domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0556.
HOGENOMiHOG000073580.
KOiK03702.
OMAiLEKQMHE.
OrthoDBiEOG6B360R.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
4.10.860.10. 1 hit.
HAMAPiMF_00204. UvrB.
InterProiIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view]
PANTHERiPTHR24029. PTHR24029. 1 hit.
PfamiPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00631. uvrb. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57991-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVGGRFEVI SPHEPAGDQP AAIDELQRRI LAGERDVVLL GATGTGKSAT
60 70 80 90 100
TAWLIERLQR PTLVMAPNKT LAAQLANELR GMLPHNAVEY FVSYYDYYQP
110 120 130 140 150
EAYIAQTDTY IEKDSSINDD VERLRHSATS SLLSRRDVVV VASVSCIYGL
160 170 180 190 200
GTPQSYLDRS VELAVSNEVP RDGLLRLLVD VQYTRNDLSF TRGSFRVRGD
210 220 230 240 250
TVEIIPSYEE LAVRIEFFGD EIEALYYLHP LTGEVIRQVD SLRIFPATHY
260 270 280 290 300
VAGPERMAQA ISAIEEELAE RLAEFERQGK LLEAQRLRMR TNYDIEMMRQ
310 320 330 340 350
VGFCSGIENY SRHIDGRGPG TPPATLLDYF PEDFLLVIDE SHVTVPQIGG
360 370 380 390 400
MYEGDMSRKR NLVEYGFRLP SACDNRPLTW EEFADRIGQT VYLSATPGPY
410 420 430 440 450
ELSQSGGEFV EQVIRPTGLV DPKVVVKPTK GQIDDLIGEI RKRANADQRV
460 470 480 490 500
LVTTLTKKMA EDLTDYLLEM GIRVRYLHSE VDTLRRVELL RQLRLGDYDV
510 520 530 540 550
LVGINLLREG LDLPEVSLVA ILDADKEGFL RSARSLIQTI GRAARNVSGE
560 570 580 590 600
VHMYADTITD SMTEAIDETE RRRAKQIAYN NANGIDPQPL RKKIADILDQ
610 620 630 640 650
VYREADDTDT VQVGGSGRNV SRGRRAQSEP VRSVSVGVFE GRDTAGMPRA
660 670 680 690
ELADLIKDLT AQMMAAASDL QFELAARFRD EIADLKKELR GMDAAGLK
Length:698
Mass (Da):78,159
Last modified:April 27, 2001 - v1
Checksum:i7A68B02871502E6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583921 Genomic DNA. Translation: CAC31768.1.
PIRiE87082.
RefSeqiNP_301986.1. NC_002677.1.
WP_010908307.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31768; CAC31768; CAC31768.
GeneIDi910520.
KEGGimle:ML1387.
PATRICi18055294. VBIMycLep78757_2580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583921 Genomic DNA. Translation: CAC31768.1 .
PIRi E87082.
RefSeqi NP_301986.1. NC_002677.1.
WP_010908307.1. NC_002677.1.

3D structure databases

ProteinModelPortali P57991.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML1387.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC31768 ; CAC31768 ; CAC31768 .
GeneIDi 910520.
KEGGi mle:ML1387.
PATRICi 18055294. VBIMycLep78757_2580.

Organism-specific databases

Lepromai ML1387.

Phylogenomic databases

eggNOGi COG0556.
HOGENOMi HOG000073580.
KOi K03702.
OMAi LEKQMHE.
OrthoDBi EOG6B360R.

Family and domain databases

Gene3Di 3.40.50.300. 4 hits.
4.10.860.10. 1 hit.
HAMAPi MF_00204. UvrB.
InterProi IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view ]
PANTHERi PTHR24029. PTHR24029. 1 hit.
Pfami PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00631. uvrb. 1 hit.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiUVRB_MYCLE
AccessioniPrimary (citable) accession number: P57991
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3