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P57963

- GLMS_PASMU

UniProt

P57963 - GLMS_PASMU

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene
glmS, PM1731
Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei605 – 6051For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciPMUL272843:GC8W-1801-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:PM1731
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
ProteomesiUP000000809: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 610609Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationPRO_0000135364Add
BLAST

Proteomic databases

PRIDEiP57963.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272843.PM1731.

Structurei

3D structure databases

ProteinModelPortaliP57963.
SMRiP57963. Positions 2-610.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 218217Glutamine amidotransferase type-2Add
BLAST
Domaini285 – 426142SIS 1Add
BLAST
Domaini459 – 600142SIS 2Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57963-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGAIAQ RDVAEILVNG LHRLEYRGYD SAGIAIVDQE KRLQRVRCLG    50
KVQVLAEAVA AEKITGGTGI AHTRWATHGA PSEDNAHPHV SGQFAVVHNG 100
IIENYEQLRI DLQQKGYQFL SQTDTEVIAH LVHWVMRNET SLLRAVQQVV 150
KQLKGAYGMV VMDCEQPNHL VAARSGSPLV IGLGIGENFL ASDQLALLNV 200
TRRFIFLEEG DVAEITRRTV DIYDVNGHPV QRDSQDSHLT HDATEKGTFR 250
HFMQKEIFEQ PRAILNTLEG RLHQHNVLVD SIGNGAERLL EQVEHIQIVA 300
CGTSYNAGMV ARYWFEHLAG ISCDVEIASE FRYRKFVTRP KSLLITLSQS 350
GETADTLAAL RLAKEKGYMG AMTICNVAGS SLVRESDLAF MTRAGVEIGV 400
ASTKAFTTQL ATLLMLVIAI GKVTGNISLS QEEELVKALQ SLPAEIEKAL 450
AFNQQIESLA QDFADKHHAL FLGRGEYYPI AMEGALKLKE ISYIHAEAYA 500
AGELKHGPLA LIDADMPVIV VAPTNDLLEK VKSNIEEVRS RGGQLYVFAD 550
KEAGFTETEG MKIMTMPKVN EVIAPIFYTI PMQLLAYHVA LIKGTDVDQP 600
RNLAKAVTVE 610
Length:610
Mass (Da):67,140
Last modified:January 23, 2007 - v2
Checksum:iC878C407B56C3AC1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004439 Genomic DNA. Translation: AAK03815.1.
RefSeqiNP_246670.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK03815; AAK03815; PM1731.
GeneIDi1245078.
KEGGipmu:PM1731.
PATRICi22872775. VBIPasMul88067_1753.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004439 Genomic DNA. Translation: AAK03815.1 .
RefSeqi NP_246670.1. NC_002663.1.

3D structure databases

ProteinModelPortali P57963.
SMRi P57963. Positions 2-610.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272843.PM1731.

Protein family/group databases

MEROPSi C44.971.

Proteomic databases

PRIDEi P57963.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK03815 ; AAK03815 ; PM1731 .
GeneIDi 1245078.
KEGGi pmu:PM1731.
PATRICi 22872775. VBIPasMul88067_1753.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci PMUL272843:GC8W-1801-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pm70.

Entry informationi

Entry nameiGLMS_PASMU
AccessioniPrimary (citable) accession number: P57963
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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