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P57956 (SYW_PASMU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:PM1621
OrganismPasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]
Taxonomic identifier272843 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140_B

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140_B

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140_B.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 333333Tryptophan--tRNA ligase HAMAP-Rule MF_00140_B
PRO_0000136656

Regions

Motif12 – 209"HIGH" region HAMAP-Rule MF_00140_B
Motif195 – 1995"KMSKS" region HAMAP-Rule MF_00140_B

Sites

Binding site1981ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P57956 [UniParc].

Last modified April 27, 2001. Version 1.
Checksum: 4906AC1D1C1C9AFC

FASTA33337,129
        10         20         30         40         50         60 
MSKPVVLSGV QPSGELTIGN YLGALRQWVK MQDDYECLFC IVDLHAITVR QDPESLRKAT 

        70         80         90        100        110        120 
LDVLALYLAC GIDPEKSTIF IQSHVPEHTQ LAWVLNCYTY FGEMGRMTQF KDKSARHAEN 

       130        140        150        160        170        180 
INVGLFTYPV LMAADILLYQ ANQVPVGEDQ KQHLEITRDI ANRFNALYGD LFAVPEPFIP 

       190        200        210        220        230        240 
KAGARVMSLL EPEKKMSKSD ENRNNVIGLL EDPKAVAKKI KRAVTDSDEP PVVRYDVQNK 

       250        260        270        280        290        300 
AGVSNLLDIL SGVTGKSIAE LETEFEGKMY GHLKGTVADE VSAMLTTLQE RFHHFRNNEA 

       310        320        330 
LLNDIAREGA QKARERAKAT LDAVYQAVGF VSL 

« Hide

References

[1]"Complete genomic sequence of Pasteurella multocida Pm70."
May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pm70.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004439 Genomic DNA. Translation: AAK03705.1.
RefSeqNP_246560.1. NC_002663.1.

3D structure databases

ProteinModelPortalP57956.
SMRP57956. Positions 5-331.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272843.PM1621.

Proteomic databases

PRIDEP57956.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK03705; AAK03705; PM1621.
GeneID1244968.
KEGGpmu:PM1621.
PATRIC22872535. VBIPasMul88067_1641.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059940.
KOK01867.
OMAGWGQFKP.
OrthoDBEOG686NJQ.
ProtClustDBPRK00927.

Enzyme and pathway databases

BioCycPMUL272843:GC8W-1683-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW_PASMU
AccessionPrimary (citable) accession number: P57956
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries