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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei622ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMUL272843:G1FZ8-1283-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PM1214
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
Proteomesi
  • UP000000809 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520591 – 860Leucine--tRNA ligaseAdd BLAST860

Proteomic databases

PRIDEiP57923

Interactioni

Protein-protein interaction databases

STRINGi272843.PM1214

Structurei

3D structure databases

ProteinModelPortaliP57923
SMRiP57923
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi619 – 623"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

P57923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEQYRPDLI EAEVQQYWAE NKTFKAIKDT NKPKYYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVSRYQRMNG KNVLQPMGWD AFGLPAEGAA IKNKTAPAKW
110 120 130 140 150
TYENIDYMKN QLKILGFGFD WDREVTTCKP DYYKWEQWFF TELYKKGLVY
160 170 180 190 200
KKTSTVNWCP NDETVLANEQ VHEGCCWRCD TPVEQKEIPQ WFIKITDYAE
210 220 230 240 250
QLLGGLDHLP LWPDQVKTMQ RNWIGRSEGV EITFQLANSE DNLTVYTTRP
260 270 280 290 300
DTFFGVSYVA VAAAHPLAEK AAENNPELAQ FIQECKNTKV AEAELATMEK
310 320 330 340 350
KGMATGVYAI HPLTGEKVPV WVANFVLMHY GTGAVMAVPG HDERDAEFAR
360 370 380 390 400
KYGLPLLNVI KPINGEPLLE HELPYCEHGI LFNSGEFNGL DFDAAFNAIA
410 420 430 440 450
DKLEALGKGK RQVNYRLRDW GVSRQRYWGA PIPMLTLENG EVVPAPLQDL
460 470 480 490 500
PIELPEDVVM DGVKSPIKAD PEWAKTTYNG QPALKETDTF DTFMESSWYY
510 520 530 540 550
ARYTSPKFAE AMLDADEANY WLPVDQYIGG IEHATMHLLY FRFFHKLLRD
560 570 580 590 600
AGFVTSDEPA DKLLCQGMVL ADAFYYTSPT NERIWVSPTE VTLERDEKGR
610 620 630 640 650
ILKAFDKEGR ELVHSGMTKM SKSKNNGIDP QEMVEKYGAD TVRLFMMFAS
660 670 680 690 700
PAEMTLEWQE SGVEGAKRFL GRLWNLVFEY NKHPAETTVE PTALSSAQKA
710 720 730 740 750
LRRDVHKTIA KVSDDIGRRQ TFNTAIAAIM ELMNKLTKAP LVEVQDRAIM
760 770 780 790 800
AEALSAVVRM LYPITPHICF QLWKDLGNTE AIDFAPWVEA DAAAMVDDEK
810 820 830 840 850
LVVVQVNGKV RAKVTVPAEM SEDDIKQVAL ADSNVAKHLE GLNIVKTIYV
860
PGKLFSFVAK
Length:860
Mass (Da):97,623
Last modified:April 27, 2001 - v1
Checksum:i30C4308EF6D99E5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004439 Genomic DNA Translation: AAK03298.1
RefSeqiWP_010907077.1, NC_002663.1

Genome annotation databases

EnsemblBacteriaiAAK03298; AAK03298; PM1214
KEGGipmu:PM1214
PATRICifig|272843.6.peg.1224

Similar proteinsi

Entry informationi

Entry nameiSYL_PASMU
AccessioniPrimary (citable) accession number: P57923
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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