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P57923

- SYL_PASMU

UniProt

P57923 - SYL_PASMU

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Protein
Leucine--tRNA ligase
Gene
leuS, PM1214
Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMUL272843:GC8W-1264-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:PM1214
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
ProteomesiUP000000809: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860Leucine--tRNA ligaseUniRule annotation
PRO_0000152059Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272843.PM1214.

Structurei

3D structure databases

ProteinModelPortaliP57923.
SMRiP57923. Positions 228-413.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi619 – 6235"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57923-1 [UniParc]FASTAAdd to Basket

« Hide

MQEQYRPDLI EAEVQQYWAE NKTFKAIKDT NKPKYYCLSM FPYPSGRLHM    50
GHVRNYTIGD VVSRYQRMNG KNVLQPMGWD AFGLPAEGAA IKNKTAPAKW 100
TYENIDYMKN QLKILGFGFD WDREVTTCKP DYYKWEQWFF TELYKKGLVY 150
KKTSTVNWCP NDETVLANEQ VHEGCCWRCD TPVEQKEIPQ WFIKITDYAE 200
QLLGGLDHLP LWPDQVKTMQ RNWIGRSEGV EITFQLANSE DNLTVYTTRP 250
DTFFGVSYVA VAAAHPLAEK AAENNPELAQ FIQECKNTKV AEAELATMEK 300
KGMATGVYAI HPLTGEKVPV WVANFVLMHY GTGAVMAVPG HDERDAEFAR 350
KYGLPLLNVI KPINGEPLLE HELPYCEHGI LFNSGEFNGL DFDAAFNAIA 400
DKLEALGKGK RQVNYRLRDW GVSRQRYWGA PIPMLTLENG EVVPAPLQDL 450
PIELPEDVVM DGVKSPIKAD PEWAKTTYNG QPALKETDTF DTFMESSWYY 500
ARYTSPKFAE AMLDADEANY WLPVDQYIGG IEHATMHLLY FRFFHKLLRD 550
AGFVTSDEPA DKLLCQGMVL ADAFYYTSPT NERIWVSPTE VTLERDEKGR 600
ILKAFDKEGR ELVHSGMTKM SKSKNNGIDP QEMVEKYGAD TVRLFMMFAS 650
PAEMTLEWQE SGVEGAKRFL GRLWNLVFEY NKHPAETTVE PTALSSAQKA 700
LRRDVHKTIA KVSDDIGRRQ TFNTAIAAIM ELMNKLTKAP LVEVQDRAIM 750
AEALSAVVRM LYPITPHICF QLWKDLGNTE AIDFAPWVEA DAAAMVDDEK 800
LVVVQVNGKV RAKVTVPAEM SEDDIKQVAL ADSNVAKHLE GLNIVKTIYV 850
PGKLFSFVAK 860
Length:860
Mass (Da):97,623
Last modified:April 27, 2001 - v1
Checksum:i30C4308EF6D99E5A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004439 Genomic DNA. Translation: AAK03298.1.
RefSeqiNP_246151.1. NC_002663.1.
WP_010907077.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK03298; AAK03298; PM1214.
GeneIDi1244561.
KEGGipmu:PM1214.
PATRICi22871679. VBIPasMul88067_1224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004439 Genomic DNA. Translation: AAK03298.1 .
RefSeqi NP_246151.1. NC_002663.1.
WP_010907077.1. NC_002663.1.

3D structure databases

ProteinModelPortali P57923.
SMRi P57923. Positions 228-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272843.PM1214.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK03298 ; AAK03298 ; PM1214 .
GeneIDi 1244561.
KEGGi pmu:PM1214.
PATRICi 22871679. VBIPasMul88067_1224.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PMUL272843:GC8W-1264-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pm70.

Entry informationi

Entry nameiSYL_PASMU
AccessioniPrimary (citable) accession number: P57923
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi