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Protein

Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

Gene

apaH

Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.By similarity

Catalytic activityi

P1,P4-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC:3.6.1.41)
Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase
Gene namesi
Name:apaH
Ordered Locus Names:PM1210
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
Proteomesi
  • UP000000809 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001980011 – 275Bis(5'-nucleosyl)-tetraphosphatase, symmetricalAdd BLAST275

Interactioni

Protein-protein interaction databases

STRINGi272843.PM1210.

Structurei

3D structure databases

ProteinModelPortaliP57922.
SMRiP57922.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Ap4A hydrolase family.Curated

Phylogenomic databases

eggNOGiENOG4105DDT. Bacteria.
COG0639. LUCA.
HOGENOMiHOG000251871.
KOiK01525.
OMAiMPWFDVP.

Family and domain databases

CDDicd07422. MPP_ApaH. 1 hit.
Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00199. ApaH. 1 hit.
InterProiView protein in InterPro
IPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
PANTHERiPTHR24032:SF49. PTHR24032:SF49. 1 hit.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.

Sequencei

Sequence statusi: Complete.

P57922-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYLVGDLQ GCYDELQRLL EKVQFDSTQD QLYLVGDLVA RGDKSLECLR
60 70 80 90 100
FVKSLGKSAK TVLGNHDLHL ISTALGIKKV KVRDRVDAIF HAPDFEELID
110 120 130 140 150
WLRHQPLLVH NEQQNFLMTH AGISPDWDLA TAKQCAHEVE NVLRHGDYHN
160 170 180 190 200
LIENMYENRP DRWHDDLQGL DRLRYSINVF TRMRFCYWDH RLDFDCKLPP
210 220 230 240 250
ESAPEELTPW FNLANPLYQT IPIVFGHWAS LVNTTTPNNI YALDTGCVWG
260 270
NRMTMLRWED KQYFSQHAVK NYRDF
Length:275
Mass (Da):32,225
Last modified:April 27, 2001 - v1
Checksum:iF31422F7C61D6D84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004439 Genomic DNA. Translation: AAK03294.1.
RefSeqiWP_005751893.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK03294; AAK03294; PM1210.
KEGGipmu:PM1210.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAPAH_PASMU
AccessioniPrimary (citable) accession number: P57922
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: June 7, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families