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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei251ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMUL272843:G1FZ8-1180-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:PM1115
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
Proteomesi
  • UP000000809 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001196191 – 480Glutamate--tRNA ligaseAdd BLAST480

Proteomic databases

PRIDEiP57906

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272843.PM1115

Structurei

3D structure databases

ProteinModelPortaliP57906
SMRiP57906
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi21 – 31"HIGH" regionUniRule annotationAdd BLAST11
Motifi248 – 252"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiHYINTLP

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

P57906-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAEALFDLD PGVKVRTRFA PSPTGYLHVG GARTALYSWL YAKHHQGEFV
60 70 80 90 100
LRIEDTDLER STPEATAAIL EGMAWLNLAW EHGPYFQTKR FDRYNQVIDQ
110 120 130 140 150
MIEQGLAYRC YCSKERLEDL RNTQEQNKQK PRYDRHCLGD HKHSPEQPHV
160 170 180 190 200
VRFKNPTEGS VVFEDAVRGR IEISNAELDD LIIRRTDGSP TYNFCVVVDD
210 220 230 240 250
WDMGITHVVR GEDHINNTPR QINILKALGA PIPTYAHVSM ILGDDGQKLS
260 270 280 290 300
KRHGAVSVMQ YRDDGYLPEA LLNYLVRLGW GHGDQEIFSV EEMIKLFELE
310 320 330 340 350
SVSKSASAFN TEKLLWLNHH YIRELPAEYV AKHLAWHYQD QGIDTSNGPA
360 370 380 390 400
LEDIVKMLAE RCKTLKEMAA ASRYFFEDFD SFDEAAVKKH FKVAAIEPLE
410 420 430 440 450
KVKEKLTALD SWDLHSTHQA IEQTAAELEL GMGKVGMPLR VAVTGSGQSP
460 470 480
SMDVTLVGIG KARTLVRIQK AIDFIKSQNV
Length:480
Mass (Da):54,480
Last modified:April 27, 2001 - v1
Checksum:i027A0DA08C4B62DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004439 Genomic DNA Translation: AAK03199.1
RefSeqiWP_010907023.1, NC_002663.1

Genome annotation databases

EnsemblBacteriaiAAK03199; AAK03199; PM1115
KEGGipmu:PM1115
PATRICifig|272843.6.peg.1128

Entry informationi

Entry nameiSYE_PASMU
AccessioniPrimary (citable) accession number: P57906
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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