P57886 (MUTL_PASMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein mutL

Gene names

Name:	mutL
Ordered Locus Names:	PM0904

Organism

Pasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]

Taxonomic identifier

272843 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella

Protein attributes

Sequence length	617 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex By similarity. HAMAP MF_00149
Sequence similarities	Belongs to the DNA mismatch repair mutL/hexB family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mismatch repair Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 617	617	DNA mismatch repair protein mutL HAMAP MF_00149		PRO_0000177957

Sequences

	Sequence		Length	Mass (Da)
	P57886 [UniParc]. Last modified April 27, 2001. Version 1. Checksum: 8DC85F15695460AE	FASTA	617	69,798
	10 20 30 40 50 60 MAIKVLSPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIQIDIENGG STLIRIRDNG 70 80 90 100 110 120 IGIAKDELSL ALARHATSKI ASLDDLDNIL SLGFRGEALA SISSVSRLTL TSRPATQNEA 130 140 150 160 170 180 WQVYAQGREM ETTLQPASHP VGTTVEVANL FFNTPARRKF LRTDKTEFAH IDEVIRRIAL 190 200 210 220 230 240 AKMAISFTLT HNGKIVRQYR SAHDRTQKLK RVAAICGDEF VQNALEIDWK HDDLHLSGWV 250 260 270 280 290 300 AQPTFSRTQN DLSYCYINGR MVRDKIITHA IRQAYADFLS PEQYPAFVLF IDLNPNDVDV 310 320 330 340 350 360 NVHPTKHEVR FHQQRLVHDF ICQGISNALH SEQASLYQTN EACVSANYQV EESAQHEYRP 370 380 390 400 410 420 SYSKPNRAAA GQNIFDSSTT TPSTALFQTN KKNTQNRPHF STNIPATRIS KTEQAAYSAL 430 440 450 460 470 480 LSNSEMATVL PQEDGALLER KTPSILKALA LVENKALLLQ QQQQFYLLSL QQLQRLKIEL 490 500 510 520 530 540 SLQRDPVLQQ PLLIPIVFRL NPQQLTYWQQ QKTFFTQIGF EFHENLGQQR ITLNRVPSCL 550 560 570 580 590 600 RQQNLQKCII VLLSQPLDTF SHFLTTLCDV IELEQITVYA DAVTLLTETE QLLNQKQAIR 610 LSELFIELNW QAYLEKM

References

[1]	"Complete genomic sequence of Pasteurella multocida Pm70." May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed: 11248100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pm70.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004439 Genomic DNA. Translation: AAK02988.1.
RefSeq	NP_245841.1. NC_002663.1.
3D structure databases
ProteinModelPortal	P57886.
SMR	P57886. Positions 1-330.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1244251.
GenomeReviews	Gene locus PM0904 in contig AE004439_GR.
KEGG	pmu:PM0904.
NMPDR	fig|272843.1.peg.904.
PATRIC	22871017. VBIPasMul88067_0914.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG520262.
OMA	EVANLFF.
ProtClustDB	PRK00095.
Enzyme and pathway databases
BioCyc	PMUL272843:PM0904-MONOMER.
Family and domain databases
HAMAP	MF_00149. DNA_mis_repair. [Tree]
InterPro	IPR003594. ATPase-like_ATP-bd. IPR002099. DNA_mismatch_repair. IPR013507. DNA_mismatch_repair_C. IPR014762. DNA_mismatch_repair_CS. IPR020667. DNA_mismatch_repair_MutL. IPR014763. DNA_mismatch_repair_N. IPR014790. MutL_C. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K03572.
PANTHER	PTHR10073. DNA_mis_repair. 1 hit.
Pfam	PF01119. DNA_mis_repair. 1 hit. PF02518. HATPase_c. 1 hit. PF08676. MutL_C. 1 hit. [Graphical view]
SMART	SM00387. HATPase_c. 1 hit. SM00853. MutL_C. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00585. Mutl. 1 hit.
PROSITE	PS00058. DNA_MISMATCH_REPAIR_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTL_PASMU

Accession

Primary (citable) accession number: P57886

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 27, 2001
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program