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P57877

- ASSY_PASMU

UniProt

P57877 - ASSY_PASMU

Protein

Argininosuccinate synthase

Gene

argG

Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei44 – 441ATP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei100 – 1001CitrullineBy similarity
    Binding sitei130 – 1301ATP; via amide nitrogenBy similarity
    Binding sitei132 – 1321AspartateBy similarity
    Binding sitei132 – 1321ATPBy similarity
    Binding sitei136 – 1361AspartateBy similarity
    Binding sitei136 – 1361CitrullineBy similarity
    Binding sitei137 – 1371AspartateBy similarity
    Binding sitei137 – 1371ATPBy similarity
    Binding sitei140 – 1401CitrullineBy similarity
    Binding sitei193 – 1931CitrullineBy similarity
    Binding sitei195 – 1951ATPBy similarity
    Binding sitei202 – 2021CitrullineBy similarity
    Binding sitei204 – 2041CitrullineBy similarity
    Binding sitei281 – 2811CitrullineBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 269ATPBy similarity

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMUL272843:GC8W-839-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthase (EC:6.3.4.5)
    Alternative name(s):
    Citrulline--aspartate ligase
    Gene namesi
    Name:argG
    Ordered Locus Names:PM0813
    OrganismiPasteurella multocida (strain Pm70)
    Taxonomic identifieri272843 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
    ProteomesiUP000000809: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Argininosuccinate synthasePRO_0000148703Add
    BLAST

    Proteomic databases

    PRIDEiP57877.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi272843.PM0813.

    Structurei

    3D structure databases

    ProteinModelPortaliP57877.
    SMRiP57877. Positions 4-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230094.
    KOiK01940.
    OMAiRIVEPIM.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00581. Arg_succ_synth_type2.
    InterProiIPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P57877-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNTILQQLP KGQKVGIAFS GGLDTSAALL WMRQKGAVPY AYTANLGQPD    50
    EEDYNAIPRK AMEYGAENAR LIDCRAQLAH EGIAAIQSGA FHISTGGVTY 100
    FNTTPLGRAV TGTMLVSAMR EDDVNIWGDG STFKGNDIER FYRYGLLTNP 150
    NLKIYKPWLD NQFIEELGGR HEMSEFLIAN GFEYKMSVEK AYSTDSNMLG 200
    ATHEAKDLEF LNTGIRIVKP IMGVAFWRDD VEVKAEEVTV RFEEGIPVAL 250
    NGKTFSDHVE LFLEANRIGG RHGLGMSDQI ENRIIEAKSR GIYEAPGMAL 300
    LHIAYERLVS GIHNEDTIEQ YRINGLRLGR LLYQGRWFDP QALMLRETAQ 350
    RWVARAITGE VTFELRRGND YSILNTESPN LTYMPERLSM EKVENAPFDP 400
    VDRIGQLTMR NLDIVDTRDK LGIYTQTGLL SISKDSFLPQ LNKKG 445
    Length:445
    Mass (Da):49,993
    Last modified:April 27, 2001 - v1
    Checksum:iF00D97C3C2C42E0A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004439 Genomic DNA. Translation: AAK02897.1.
    RefSeqiNP_245750.1. NC_002663.1.

    Genome annotation databases

    EnsemblBacteriaiAAK02897; AAK02897; PM0813.
    GeneIDi1244160.
    KEGGipmu:PM0813.
    PATRICi22870824. VBIPasMul88067_0822.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004439 Genomic DNA. Translation: AAK02897.1 .
    RefSeqi NP_245750.1. NC_002663.1.

    3D structure databases

    ProteinModelPortali P57877.
    SMRi P57877. Positions 4-441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272843.PM0813.

    Proteomic databases

    PRIDEi P57877.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK02897 ; AAK02897 ; PM0813 .
    GeneIDi 1244160.
    KEGGi pmu:PM0813.
    PATRICi 22870824. VBIPasMul88067_0822.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230094.
    KOi K01940.
    OMAi RIVEPIM.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci PMUL272843:GC8W-839-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00581. Arg_succ_synth_type2.
    InterProi IPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pm70.

    Entry informationi

    Entry nameiASSY_PASMU
    AccessioniPrimary (citable) accession number: P57877
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3