P57876 (OTC_PASMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	PM0808

Organism

Pasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]

Taxonomic identifier

272843 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_0000112977
Regions
	Region	57 – 61	5	Carbamoyl phosphate binding By similarity
	Region	274 – 277	4	Ornithine binding By similarity
Sites
	Binding site	108	1	Carbamoyl phosphate By similarity
	Binding site	135	1	Carbamoyl phosphate By similarity
	Site	32	1	Important for structural integrity By similarity
	Site	148	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	P57876 [UniParc]. Last modified April 27, 2001. Version 1. Checksum: DE7B62199F9DFC45	FASTA	334	37,653
	10 20 30 40 50 60 MPLNLRHRHF LRLMDFTPTE IQFLLDLSAN LKKAKYTGTE QPRLKGKNIA LIFEKTSTRT 70 80 90 100 110 120 RCSFEVAAYD QGANVTYIGP SGSQIGHKES MKDTARVLGR MYDGIQYRGY GQELVEILAQ 130 140 150 160 170 180 YSGVPVWNGL TDDFHPTQIL ADFLTMLEHG EGKRLNQMKM AYLGDARNNM GNSFVEGAAL 190 200 210 220 230 240 MGMDLRLVAP KAYWPEQKLL DEVAEMAKKT GAKITCTENV EEGVKGVDFL YTDIWVSMGE 250 260 270 280 290 300 PEEAWEQRIN LMKPYQVNKA LLEKTGNPKV KFMHCLPAFH DENTTVGKEM AQKYGMNGLE 310 320 330 VTDEVFESDA SIVFDEAENR MHTIKAVMVA TLGQ

References

[1]	"Complete genomic sequence of Pasteurella multocida Pm70." May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed: 11248100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pm70.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004439 Genomic DNA. Translation: AAK02892.1.
RefSeq	NP_245745.1. NC_002663.1.
3D structure databases
ProteinModelPortal	P57876.
SMR	P57876. Positions 7-334.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1244155.
GenomeReviews	Gene locus PM0808 in contig AE004439_GR.
KEGG	pmu:PM0808.
NMPDR	fig|272843.1.peg.808.
PATRIC	22870814. VBIPasMul88067_0817.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG579429.
OMA	DFRIFAP.
ProtClustDB	PRK02102.
Enzyme and pathway databases
BioCyc	PMUL272843:PM0808-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_PASMU

Accession

Primary (citable) accession number: P57876

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 27, 2001
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program