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P57855

- TRPC_PASMU

UniProt

P57855 - TRPC_PASMU

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Protein

Tryptophan biosynthesis protein TrpCF

Gene
trpC, PM0580
Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain By similarity.UniRule annotation

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
  2. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Isomerase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciPMUL272843:GC8W-601-MONOMER.
UniPathwayiUPA00035; UER00042.
UPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan biosynthesis protein TrpCF
Including the following 2 domains:
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpC
Ordered Locus Names:PM0580
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
ProteomesiUP000000809: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Tryptophan biosynthesis protein TrpCFUniRule annotationPRO_0000154282Add
BLAST

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi272843.PM0580.

Structurei

3D structure databases

ProteinModelPortaliP57855.
SMRiP57855. Positions 5-270.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 267267Indole-3-glycerol phosphate synthaseUniRule annotationAdd
BLAST
Regioni268 – 469202N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotationAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the TrpC family.
In the C-terminal section; belongs to the TrpF family.

Phylogenomic databases

eggNOGiCOG0134.
HOGENOMiHOG000280458.
KOiK13498.
OMAiEKYFQGD.
OrthoDBiEOG6WT8JX.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
HAMAPiMF_00134_B. IGPS_B.
MF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57855-1 [UniParc]FASTAAdd to Basket

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MTQAFPSILQ KIIQDKTTWI AEKQAQLPLA SFQDQLERSD RDFYQAMQQG    50
SKQRPSYILE CKKASPSKGL IRAAFDLTEI AEVYQHYATV ISVLTDEKYF 100
QGHFADIAQV RQRVTQPILC KDFILSEYQV YLARYAQADA ILLMLSVLND 150
ERYTQLATLA HQLGMGVLTE TSNEAEFARA LALKAKVIGV NNRNLHDLSV 200
DIQRVAQITQ HYADQIPPET KIISESGIYQ HQQIRDLRHV ADGFLIGSSL 250
MQHTDLNHAV RSLLFGEHKV CGLTRPQDVR AVYQQGALYG GLIFVTHSKR 300
CISLRQAQEL VTQAPLRFVG VFQDQSIAFI CHLATQLRLH AVQLHGNESH 350
EFIRQLRDEL PVNCEIWRAI CIESSGTSPC QIVENKNIDR YIFDSKTHQQ 400
RGGTGKTFDW QLIPHHLKPK SMLAGGITPE NIPLALAQGC LGLDLNSGLE 450
TYPGVKSHQK VVAAFAQLR 469
Length:469
Mass (Da):52,851
Last modified:April 27, 2001 - v1
Checksum:iCD1FD2866ADF10C8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004439 Genomic DNA. Translation: AAK02664.1.
RefSeqiNP_245517.1. NC_002663.1.
WP_010906737.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK02664; AAK02664; PM0580.
GeneIDi1243927.
KEGGipmu:PM0580.
PATRICi22870342. VBIPasMul88067_0587.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004439 Genomic DNA. Translation: AAK02664.1 .
RefSeqi NP_245517.1. NC_002663.1.
WP_010906737.1. NC_002663.1.

3D structure databases

ProteinModelPortali P57855.
SMRi P57855. Positions 5-270.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272843.PM0580.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK02664 ; AAK02664 ; PM0580 .
GeneIDi 1243927.
KEGGi pmu:PM0580.
PATRICi 22870342. VBIPasMul88067_0587.

Phylogenomic databases

eggNOGi COG0134.
HOGENOMi HOG000280458.
KOi K13498.
OMAi EKYFQGD.
OrthoDBi EOG6WT8JX.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .
UPA00035 ; UER00043 .
BioCyci PMUL272843:GC8W-601-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 2 hits.
HAMAPi MF_00134_B. IGPS_B.
MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 2 hits.
PROSITEi PS00614. IGPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pm70.

Entry informationi

Entry nameiTRPC_PASMU
AccessioniPrimary (citable) accession number: P57855
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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