P57854 (TRPA_PASMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tryptophan synthase alpha chain
EC=4.2.1.20

Gene names

Name:	trpA
Ordered Locus Names:	PM0577

Organism

Pasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]

Taxonomic identifier

272843 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. HAMAP MF_00131
Catalytic activity	L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. HAMAP MF_00131
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP MF_00131
Subunit structure	Tetramer of two alpha and two beta chains By similarity.
Sequence similarities	Belongs to the TrpA family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	tryptophan synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Tryptophan synthase alpha chain HAMAP MF_00131		PRO_0000098819
Sites
	Active site	49	1	Proton acceptor By similarity
	Active site	60	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P57854 [UniParc]. Last modified April 27, 2001. Version 1. Checksum: DBB25999AC8A5FC3	FASTA	268	29,439
	10 20 30 40 50 60 MRRFDTLFSQ LQQKQQGAFV PFVTLCDPNL AQSFEIIQTL VENGADALEL GFPFSDPMLD 70 80 90 100 110 120 GPVIQAANQR ALVAGCSTDA SFQLLTQVRS TYPTLPISLL LCANLVYAQG IERFYQRCAE 130 140 150 160 170 180 VGVDAVLIAD LPLFAHREFT VMAEKYSIQQ VFICPPNACE DTIKRVAQQT QGYTYLVSRS 190 200 210 220 230 240 GVTGVENQQS ADNLKTLVER LKAYQAPPIL QGFGISQPQQ VSDVLKIGVN GAISGSATVQ 250 260 IIEKYHHDPQ ACLAELAQFT QKMKQATT

References

[1]	"Complete genomic sequence of Pasteurella multocida Pm70." May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed: 11248100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pm70.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004439 Genomic DNA. Translation: AAK02661.1.
RefSeq	NP_245514.1. NC_002663.1.
3D structure databases
ProteinModelPortal	P57854.
SMR	P57854. Positions 3-267.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1243924.
GenomeReviews	Gene locus PM0577 in contig AE004439_GR.
KEGG	pmu:PM0577.
NMPDR	fig|272843.1.peg.577.
PATRIC	22870336. VBIPasMul88067_0584.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG391690.
OMA	NPIYIYG.
ProtClustDB	PRK13111.
Enzyme and pathway databases
BioCyc	PMUL272843:PM0577-MONOMER.
Family and domain databases
HAMAP	MF_00131. Trp_synth_alpha. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011060. RibuloseP-bd_barrel. IPR018204. Trp_synthase_alpha_AS. IPR002028. Trp_synthase_suA. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01695.
Pfam	PF00290. Trp_syntA. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMs	TIGR00262. TrpA. 1 hit.
PROSITE	PS00167. TRP_SYNTHASE_ALPHA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPA_PASMU

Accession

Primary (citable) accession number: P57854

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 27, 2001
Last modified:	January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program