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P57828

- PUR9_PASMU

UniProt

P57828 - PUR9_PASMU

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciPMUL272843:GC8W-226-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurH
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
    Alternative name(s):
    AICAR transformylase
    IMP cyclohydrolase (EC:3.5.4.10)
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
    Gene namesi
    Name:purH
    Ordered Locus Names:PM0222
    OrganismiPasteurella multocida (strain Pm70)
    Taxonomic identifieri272843 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
    ProteomesiUP000000809: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 533533Bifunctional purine biosynthesis protein PurHPRO_0000192111Add
    BLAST

    Proteomic databases

    PRIDEiP57828.

    Interactioni

    Protein-protein interaction databases

    STRINGi272843.PM0222.

    Structurei

    3D structure databases

    ProteinModelPortaliP57828.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.By similarity

    Sequence similaritiesi

    Belongs to the PurH family.Curated

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230372.
    KOiK00602.
    OMAiLKSTLRY.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P57828-1 [UniParc]FASTAAdd to Basket

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    MQPNRPIRQA LLSVSDKTGI VEFAQALVQR GVKLLSTGGT AKLLADHGLA    50
    VTEVSDYTGF PEMMDGRVKT LHPKVHGGIL GRRGTDDEVM SQQGIEGIDM 100
    VVVNLYPFAA TVAKPNCSLE EAVENIDIGG PTMVRSAAKN HQDVAIVVNN 150
    SDFNAILAEM DQHQNSLTLE TRFDLAIKAF EHTAQYDAMI ANYFGQLVKP 200
    YFVAEEEDAE AKCGQFPRTL NLNFIRKQTM RYGENGHQKA AFYVEQDVKE 250
    ASVSTAKQLQ GKALSYNNIA DTDAALECVK SFDEPACVIV KHANPCGVAL 300
    GADILAAYNR AYQTDPTSAF GGIIAFNREL DAKTAQTIID RQFVEVIIAP 350
    TVAEEAKALL KAKKNVRVLE CGEWSGTQQR LDVKRVNGGL LVQEADLGMV 400
    DLADLKVVSK RQPTEQELKD LLFCWKVAKF VKSNAIVYAK DNQTIGIGAG 450
    QMSRVYSAKI AGIKAQDEGL DVAGCVMASD AFFPFRDGID AAAKVGIQCV 500
    IHPGGSMRDQ EVIDAADEHN MVMVLTGMRH FRH 533
    Length:533
    Mass (Da):58,084
    Last modified:April 27, 2001 - v1
    Checksum:i2D2C4EB4CC0B63A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004439 Genomic DNA. Translation: AAK02306.1.
    RefSeqiNP_245159.1. NC_002663.1.

    Genome annotation databases

    EnsemblBacteriaiAAK02306; AAK02306; PM0222.
    GeneIDi1243569.
    KEGGipmu:PM0222.
    PATRICi22869596. VBIPasMul88067_0230.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004439 Genomic DNA. Translation: AAK02306.1 .
    RefSeqi NP_245159.1. NC_002663.1.

    3D structure databases

    ProteinModelPortali P57828.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272843.PM0222.

    Proteomic databases

    PRIDEi P57828.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK02306 ; AAK02306 ; PM0222 .
    GeneIDi 1243569.
    KEGGi pmu:PM0222.
    PATRICi 22869596. VBIPasMul88067_0230.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230372.
    KOi K00602.
    OMAi LKSTLRY.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci PMUL272843:GC8W-226-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pm70.

    Entry informationi

    Entry nameiPUR9_PASMU
    AccessioniPrimary (citable) accession number: P57828
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3