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P57828

- PUR9_PASMU

UniProt

P57828 - PUR9_PASMU

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, PM0222
Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciPMUL272843:GC8W-226-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:PM0222
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
ProteomesiUP000000809: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_0000192111Add
BLAST

Proteomic databases

PRIDEiP57828.

Interactioni

Protein-protein interaction databases

STRINGi272843.PM0222.

Structurei

3D structure databases

ProteinModelPortaliP57828.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiLKSTLRY.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

P57828-1 [UniParc]FASTAAdd to Basket

« Hide

MQPNRPIRQA LLSVSDKTGI VEFAQALVQR GVKLLSTGGT AKLLADHGLA    50
VTEVSDYTGF PEMMDGRVKT LHPKVHGGIL GRRGTDDEVM SQQGIEGIDM 100
VVVNLYPFAA TVAKPNCSLE EAVENIDIGG PTMVRSAAKN HQDVAIVVNN 150
SDFNAILAEM DQHQNSLTLE TRFDLAIKAF EHTAQYDAMI ANYFGQLVKP 200
YFVAEEEDAE AKCGQFPRTL NLNFIRKQTM RYGENGHQKA AFYVEQDVKE 250
ASVSTAKQLQ GKALSYNNIA DTDAALECVK SFDEPACVIV KHANPCGVAL 300
GADILAAYNR AYQTDPTSAF GGIIAFNREL DAKTAQTIID RQFVEVIIAP 350
TVAEEAKALL KAKKNVRVLE CGEWSGTQQR LDVKRVNGGL LVQEADLGMV 400
DLADLKVVSK RQPTEQELKD LLFCWKVAKF VKSNAIVYAK DNQTIGIGAG 450
QMSRVYSAKI AGIKAQDEGL DVAGCVMASD AFFPFRDGID AAAKVGIQCV 500
IHPGGSMRDQ EVIDAADEHN MVMVLTGMRH FRH 533
Length:533
Mass (Da):58,084
Last modified:April 27, 2001 - v1
Checksum:i2D2C4EB4CC0B63A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004439 Genomic DNA. Translation: AAK02306.1.
RefSeqiNP_245159.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK02306; AAK02306; PM0222.
GeneIDi1243569.
KEGGipmu:PM0222.
PATRICi22869596. VBIPasMul88067_0230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004439 Genomic DNA. Translation: AAK02306.1 .
RefSeqi NP_245159.1. NC_002663.1.

3D structure databases

ProteinModelPortali P57828.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272843.PM0222.

Proteomic databases

PRIDEi P57828.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK02306 ; AAK02306 ; PM0222 .
GeneIDi 1243569.
KEGGi pmu:PM0222.
PATRICi 22869596. VBIPasMul88067_0230.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi LKSTLRY.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci PMUL272843:GC8W-226-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pm70.

Entry informationi

Entry nameiPUR9_PASMU
AccessioniPrimary (citable) accession number: P57828
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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