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P57818 (MURC_PASMU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramate--L-alanine ligase
EC=6.3.2.8
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
Gene names
Name:murC
Ordered Locus Names:PM0143
OrganismPasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]
Taxonomic identifier272843 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella

Protein attributes

Sequence length482 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00046

Catalytic activity

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046

Subcellular location

Cytoplasm By similarity HAMAP MF_00046.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 482482UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046
PRO_0000182127

Regions

Nucleotide binding131 – 1377ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P57818 [UniParc].

Last modified April 27, 2001. Version 1.
Checksum: 98667510E7A2D503

FASTA48252,731
        10         20         30         40         50         60 
MMNSKCGKAF QQRVRDMIPE MRRVRQIHFV GIGGAGMGGI AEVLLNEGYF VTGSDIMESA 

        70         80         90        100        110        120 
VTARLTSLGA KIAFSHAAEN IDGASVVVVS SAIRADNVEV VAAQERRIPV IQRAQMLAEI 

       130        140        150        160        170        180 
MRFRHGIAVA GTHGKTTTTA MISMIYAEAG LDPTFVNGGL VKSAGTNAHL GCSRYLIAEA 

       190        200        210        220        230        240 
DESDASFLHL QPMVSVVTNI EPDHMETYHG SFEEMKHTYV NFLHNLPFYG LAVLCADDDV 

       250        260        270        280        290        300 
LTELTPKVGR QVITYGFSEK ADYRIEDYQQ TGFQGHYTVI TPSGERIDVL LNVPGRHNAL 

       310        320        330        340        350        360 
NATAALVVAK EEGIGNEAIL AALADFQGAG RRFDQLGQFI RPNGKVMLVD DYGHHPTEVG 

       370        380        390        400        410        420 
VTIQAARQGW ENKRIAMIFQ PHRYSRTRDL FDDFVQVLSQ VDVLIMLDVY AAGETPIAGA 

       430        440        450        460        470        480 
DSRSLCRSIR NLGKVDPIFV SDHRQLGEIL DQVLQDGDLI LAQGAGNVSK IARQLAETWT 


KE

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References

[1]"Complete genomic sequence of Pasteurella multocida Pm70."
May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed: 11248100] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pm70.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE004439 Genomic DNA. Translation: AAK02227.1.
RefSeqNP_245080.1. NC_002663.1.

3D structure databases

ProteinModelPortalP57818.
SMRP57818. Positions 18-479.
ModBaseSearch...

Proteomic databases

PRIDEP57818.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1243490.
GenomeReviewsGene locus PM0143 in contig AE004439_GR.
KEGGpmu:PM0143.
NMPDRfig|272843.1.peg.143.
PATRIC22869430. VBIPasMul88067_0148.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG476594.
OMAYQPHRYS.
ProtClustDBPRK00421.

Enzyme and pathway databases

BioCycPMUL272843:PM0143-MONOMER.

Family and domain databases

HAMAPMF_00046. MurC.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01924.
PANTHERPTHR23135:SF5. PTHR23135:SF5. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01082. MurC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURC_PASMU
AccessionPrimary (citable) accession number: P57818
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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