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P57817 (MURG_PASMU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:PM0142
OrganismPasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]
Taxonomic identifier272843 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033
PRO_0000109194

Sequences

Sequence LengthMass (Da)Tools
P57817 [UniParc].

Last modified April 27, 2001. Version 1.
Checksum: D6F7EEB5DF68A46C

FASTA35438,138
        10         20         30         40         50         60 
MSEQKKRLLV MAGGTGGHVF PAIAVAQYLQ QQGWDICWLG TADRMEAQLV PKHHIPIQFI 

        70         80         90        100        110        120 
QISGLRGKGI KALLSAPFSI FRAILQARKI IKAYQPHAVL GMGGYVSGPG GIAAKLCGIP 

       130        140        150        160        170        180 
VILHEQNAVA GLTNSWLAKI ARRVLQAFPT AFPNAEVVGN PVRQTLFSQP TPEQRFAGRE 

       190        200        210        220        230        240 
GKLRVLVVGG SQGARVLNQT LPNVVAQLSD KLEVRHQVGQ GAVEQVTTLY PEHASVTITE 

       250        260        270        280        290        300 
FIDNMADAYA WADIVICRSG ALTVSELAAV GAAAIFVPFQ HKDQQQYLNA KYLADAGAAT 

       310        320        330        340        350 
IIPQAELTAE KLVSVLTQFD RETLQQMAIK AKAMATPLAA QRVAEVIIEE ANQD

« Hide

References

[1]"Complete genomic sequence of Pasteurella multocida Pm70."
May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed: 11248100] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pm70.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE004439 Genomic DNA. Translation: AAK02226.1.
RefSeqNP_245079.1. NC_002663.1.

3D structure databases

ProteinModelPortalP57817.
SMRP57817. Positions 6-344.
ModBaseSearch...

Protein family/group databases

CAZyGT28. Glycosyltransferase Family 28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1243489.
GenomeReviewsGene locus PM0142 in contig AE004439_GR.
KEGGpmu:PM0142.
NMPDRfig|272843.1.peg.142.
PATRIC22869428. VBIPasMul88067_0147.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG617076.
OMAEDHQTKN.
ProtClustDBPRK00726.

Enzyme and pathway databases

BioCycPMUL272843:PM0142-MONOMER.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
KOK02563.
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. MurG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG_PASMU
AccessionPrimary (citable) accession number: P57817
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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