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P57816 (MRAY_PASMU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:PM0139
OrganismPasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]
Taxonomic identifier272843 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_0000108863

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane73 – 9321Helical; Potential
Transmembrane94 – 11421Helical; Potential
Transmembrane132 – 15221Helical; Potential
Transmembrane168 – 18821Helical; Potential
Transmembrane199 – 21921Helical; Potential
Transmembrane235 – 25521Helical; Potential
Transmembrane263 – 28321Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane338 – 35821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P57816 [UniParc].

Last modified April 27, 2001. Version 1.
Checksum: B9BED1987FEDBD53

FASTA36040,155
        10         20         30         40         50         60 
MLVWLGEFLQ QYYSGFNVIS YITVRAILAL LTALLVSLWI GPKVIRRLQL LKFGQEVRHD 

        70         80         90        100        110        120 
GPESHFSKRG TPTMGGVMIL FAITVSTLLW ANLANPYVWF SLFVLLGYGA IGFVDDYRKI 

       130        140        150        160        170        180 
TRKNTDGLIA RWKYFWLSVI ALVAAFGMYA IGKDTDATRL VVPFFKEIMP QLGLFYIILT 

       190        200        210        220        230        240 
YFVIVGTSNA VNLTDGLDGL AIMPTVLVAG AFALIAWATG NVNFAEYLHI PYIKFSAELV 

       250        260        270        280        290        300 
VFCTAIVGAG LGFLWFNTYP AQVFMGDVGS LALGGALGVV AVLVRQEFLL VIMGGVFVVE 

       310        320        330        340        350        360 
TLSVILQVGS YKLRKQRIFR MAPIHHHFEL KGWPEPRVIV RFWIISLMLV LVGLVTLKLR

« Hide

References

[1]"Complete genomic sequence of Pasteurella multocida Pm70."
May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed: 11248100] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pm70.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE004439 Genomic DNA. Translation: AAK02223.1.
RefSeqNP_245076.1. NC_002663.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1243486.
GenomeReviewsGene locus PM0139 in contig AE004439_GR.
KEGGpmu:PM0139.
NMPDRfig|272843.1.peg.139.
PATRIC22869422. VBIPasMul88067_0144.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycPMUL272843:PM0139-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_PASMU
AccessionPrimary (citable) accession number: P57816
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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