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P57799

- ASSY_LACLA

UniProt

P57799 - ASSY_LACLA

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Protein
Argininosuccinate synthase
Gene
argG, LL0124, L126739
Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871Citrulline By similarity
Binding sitei117 – 1171ATP; via amide nitrogen By similarity
Binding sitei119 – 1191Aspartate By similarity
Binding sitei123 – 1231Aspartate By similarity
Binding sitei123 – 1231Citrulline By similarity
Binding sitei124 – 1241Aspartate By similarity
Binding sitei127 – 1271Citrulline By similarity
Binding sitei175 – 1751Citrulline By similarity
Binding sitei260 – 2601Citrulline By similarity
Binding sitei272 – 2721Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-142-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:LL0124
ORF Names:L126739
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Argininosuccinate synthaseUniRule annotation
PRO_0000148600Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272623.L126739.

Structurei

3D structure databases

ProteinModelPortaliP57799.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
OMAiKANALYM.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P57799-1 [UniParc]FASTAAdd to Basket

« Hide

MMGNKKIVLA YSGGLDTSVA VKWLTDKGFD VIADCMDVGE GKDLNFIHDK    50
ALQVGAVESV VLDCKEEFAK IFVGAALKGN LMYENKYPLV SALSRPLIAQ 100
KLVEVAKEKG ATAIAHGCTG KGNDQVRFEV AIHSLAPELE VIAPVREWHW 150
AREEEIEYAN QNGVPIPADL DNPYSIDMNL WGRAIEAGVL ENPWNTCPED 200
AFFMTNSVEN APNEAEFIEV EFKEGLPIAL NGKSLELHEI IKKVNIIAGK 250
HGIGRIDHIE NRLVGIKSRE FYECPAAITL LKAHKDLEDL TFVRELAHFK 300
PVLENELANL IYNGLWFNPA TKALIAYLDE TQKVVNGIVK IKLYKGLATP 350
VGRKSTNSLY SEKLATYTAA DEFDQAAAVG FIKLWGLPTQ VNAQVNLK 398
Length:398
Mass (Da):43,961
Last modified:April 27, 2001 - v1
Checksum:i11411DF9C9274712
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005176 Genomic DNA. Translation: AAK04222.1.
PIRiD86640.

Genome annotation databases

EnsemblBacteriaiAAK04222; AAK04222; L126739.
PATRICi22292402. VBILacLac136773_0137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005176 Genomic DNA. Translation: AAK04222.1 .
PIRi D86640.

3D structure databases

ProteinModelPortali P57799.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272623.L126739.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK04222 ; AAK04222 ; L126739 .
PATRICi 22292402. VBILacLac136773_0137.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
OMAi KANALYM.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci LLAC272623:GHSH-142-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiASSY_LACLA
AccessioniPrimary (citable) accession number: P57799
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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