Reviewed, UniProtKB/Swiss-Prot P57793 (PHGR_EUBOX)

Names and origin

Protein names	Recommended name:     Phloroglucinol reductase     EC=1.3.1.57
Organism	Eubacterium oxidoreducens
Taxonomic identifier	1732 [NCBI]
Taxonomic lineage	Bacteria › Firmicutes › Clostridia › Clostridiales › Eubacteriaceae › Eubacterium

Protein attributes

Sequence length	13 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Functions in the pathway of anaerobic degradation of trihydroxybenzenes by catalyzing reduction of the aromatic nucleus prior to ring fission.
Catalytic activity	Dihydrophloroglucinol + NADP(+) = phloroglucinol + NADPH.
Subunit structure	Homodimer.
Biophysicochemical properties	pH dependence: Optimum pH is 7.8 for the forward reaction. Temperature dependence: Optimum temperature is 40 degrees Celsius for the forward reaction.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phloroglucinol reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›13	›13	Phloroglucinol reductase		PRO_0000058379
Experimental info
	Non-terminal residue	13	1

Sequences

	Sequence		Length	Mass (Da)
	P57793-1 [UniParc]. Last modified April 27, 2001. Version 1. Checksum: 427E2E0833F1CB13	FASTA	13	1,530
	10 XVPCNKEFVX NXF

References

[1]	"Purification and properties of phloroglucinol reductase from Eubacterium oxidoreducens G-41." Haddock J.D., Ferry J.G. J. Biol. Chem. 264:4423-4427(1989) [PubMed: 2925649] [Abstract] Cited for: PROTEIN SEQUENCE, CHARACTERIZATION. Strain: G-41.

Cross-references

Sequence databases
PIR	A32453.
3D structure databases
ModBase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

PHGR_EUBOX

Accession

Primary (citable) accession number: P57793

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 27, 2001
Last modified:	November 4, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)