Skip Header

Contribute Send feedback
Read comments (?) or add your own

P57792 (ALA12_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative phospholipid-transporting ATPase 12
Short name=AtALA12
EC=3.6.3.1
Alternative name(s):
Aminophospholipid flippase 12
Gene names
Name:ALA12
Ordered Locus Names:At1g26130
ORF Names:F28B23.19, F14G11.10
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length1184 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in transport of phospholipids Potential.

Catalytic activity

ATP + H2O + phospholipid(In) = ADP + phosphate + phospholipid(Out).

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]

Sequence caution

The sequence AAG50529.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: P57792-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11841184Putative phospholipid-transporting ATPase 12
PRO_0000046396

Regions

Topological domain1 – 7575Cytoplasmic Potential
Transmembrane76 – 9722Helical; Potential
Topological domain98 – 1014Extracellular Potential
Transmembrane102 – 12423Helical; Potential
Topological domain125 – 306182Cytoplasmic Potential
Transmembrane307 – 32822Helical; Potential
Topological domain329 – 36436Extracellular Potential
Transmembrane365 – 38218Helical; Potential
Topological domain383 – 921539Cytoplasmic Potential
Transmembrane922 – 94120Helical; Potential
Topological domain942 – 95514Extracellular Potential
Transmembrane956 – 97520Helical; Potential
Topological domain976 – 100530Cytoplasmic Potential
Transmembrane1006 – 102823Helical; Potential
Topological domain1029 – 104113Extracellular Potential
Transmembrane1042 – 106423Helical; Potential
Topological domain1065 – 10706Cytoplasmic Potential
Transmembrane1071 – 109121Helical; Potential
Topological domain1092 – 110817Extracellular Potential
Transmembrane1109 – 113325Helical; Potential
Topological domain1134 – 118451Cytoplasmic Potential

Sites

Active site43014-aspartylphosphate intermediate By similarity
Metal binding8661Magnesium By similarity
Metal binding8701Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 27, 2001. Version 1.
Checksum: D9B6BC0C79CDAE74

FASTA1,184133,793
        10         20         30         40         50         60 
MATVSGRRRK RKIQLSKLFT LTGAKACFKP DHSKIGRSGF SRVVFCNQPD SPEAESRNYC 

        70         80         90        100        110        120 
DNYVRTTKYT LATFLPKSLF EQFRRVANFY FLVVGILSFT PLAPYTAVSA IVPLTFVILA 

       130        140        150        160        170        180 
TMFKEGVEDW RRKQQDIEVN NRKVRVHRGN GNFDLREWKT LRVGDILKVE KNEFFPADLV 

       190        200        210        220        230        240 
LLSSSYEDAV CYVETMNLDG ETNLKLKQGL EVTLSLREEL NFRDFEAFIK CEDPNANLYS 

       250        260        270        280        290        300 
FVGTMDLKGE KYPLSPQQLL LRGSKLRNTD YIYGVVIFTG PDTKVVQNST DPPSKRSMIE 

       310        320        330        340        350        360 
RKMDKIIYLM FLMVFSLAFF GSVLFGIWTR DDFQNGVMER WYLKPDDSSI FFDPKRAPMA 

       370        380        390        400        410        420 
AIYHFLTALM LNSYFIPISL YVSIEIVKVL QSIFINQDIH MYYEEADKPA HARTSNLNEE 

       430        440        450        460        470        480 
LGQVGTILSD KTGTLTCNSM EFIKCSIAGT AYGRGVTEVE MAMDKRKGSA LVNQSNGNST 

       490        500        510        520        530        540 
EDAVAAEPAV KGFNFRDERI MDGNWVTETH ADVIQKFFQL LAVCHTVIPE VDEDTGKISY 

       550        560        570        580        590        600 
EAESPDEAAF VIAARELGFE FFTRTQTTIS VRELDLVTGE RVERLYSVLN VLEFSSSKKR 

       610        620        630        640        650        660 
MSVIVQDQDG KLLLLCKGAD SVMFERLSES GRKYEKETRD HVNEYADAGL RTLILAYREL 

       670        680        690        700        710        720 
DENEYEVFTE RISEAKNSVS ADREALIDEV TEKIEKNLVL LGATAVEDKL QNGVPDCINK 

       730        740        750        760        770        780 
LAQAGIKIWV LTGDKMETAI NIGFACSLLR RDMKQIIINL ETPEIQQLEK SGEKDAIAAL 

       790        800        810        820        830        840 
KENVLHQITS GKAQLKASGG NAKAFALIID GKSLAYALEE DMKGIFLELA IGCASVICCR 

       850        860        870        880        890        900 
SSPKQKALVT RLVKTGSGQT TLAIGDGAND VGMLQEADIG VGISGVEGMQ AVMSSDIAIA 

       910        920        930        940        950        960 
QFRYLERLLL VHGHWCYRRI SKMICYFFYK NITFGFTLFL YEAYTSFSAT PAYNDWYLSL 

       970        980        990       1000       1010       1020 
YSVFFTSLPV ICLGIFDQDV SAPFCLKFPV LYQEGVQNLL FSWRRILSWM FHGFCSAIII 

      1030       1040       1050       1060       1070       1080 
FFLCKTSLES QAFNHEGKTA GRDILGGTMY TCVVWVVSLQ MVLTISYFTL IQHVVVWGSV 

      1090       1100       1110       1120       1130       1140 
VIWYLFLMVY GSLPIRMSTD AYMVFLEALA PAPSYWITTL FVVLSTMMPY FIFSAIQMRF 

      1150       1160       1170       1180 
FPMSHGTVQL LRYEDQCSNS GNFEMGRQGS VRPTLVMRSH QPES

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed: 11130712] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC079829 Genomic DNA. Translation: AAG50692.1.
AC084221 Genomic DNA. Translation: AAG50529.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30652.1.
IPIIPI00519052.
PIRD86387.
RefSeqNP_173938.1. NM_102378.2.
UniGeneAt.49917.

3D structure databases

ProteinModelPortalP57792.
SMRP57792. Positions 837-901.
ModBaseSearch...

Proteomic databases

PRIDEP57792.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G26130.1; AT1G26130.1; AT1G26130.
GeneID839154.
GenomeReviewsGene locus AT1G26130 in contig CT485782_GR.
KEGGath:AT1G26130.
NMPDRfig|3702.1.peg.2929.

Organism-specific databases

TAIRAt1g26130.

Phylogenomic databases

eggNOGKOG0206.
GeneTreeEPGT00070000028188.
HOGENOMHBG745019.
InParanoidP57792.
OMAENEYEVF.
PhylomeDBP57792.
ProtClustDBCLSN2679593.

Gene expression databases

ArrayExpressP57792.
GenevestigatorP57792.
GermOnlineAT1G26130. Arabidopsis thaliana.

Family and domain databases

InterProIPR023306. ATPase_cation_domN.
IPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR006539. ATPase_P-typ_Plipid-transl.
IPR023214. HAD-like_dom.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 2 hits.
G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KOK01530.
PfamPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SUPFAMSSF81660. ATPase_cation_domN. 1 hit.
SSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALA12_ARATH
AccessionPrimary (citable) accession number: P57792
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: December 14, 2011
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents