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Protein

Probable phospholipid-transporting ATPase 12

Gene

ALA12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in transport of phospholipids.1 Publication

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei430 – 43014-aspartylphosphate intermediateBy similarity
Metal bindingi866 – 8661MagnesiumBy similarity
Metal bindingi870 – 8701MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G26130-MONOMER.
ARA:GQT-873-MONOMER.
ReactomeiR-ATH-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase 121 Publication (EC:3.6.3.11 Publication)
Short name:
AtALA121 Publication
Alternative name(s):
Aminophospholipid flippase 121 Publication
Gene namesi
Name:ALA121 Publication
Ordered Locus Names:At1g26130Imported
ORF Names:F14G11.10, F28B23.19Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G26130.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575CytoplasmicSequence analysisAdd
BLAST
Transmembranei76 – 9722HelicalSequence analysisAdd
BLAST
Topological domaini98 – 1014ExtracellularSequence analysis
Transmembranei102 – 12423HelicalSequence analysisAdd
BLAST
Topological domaini125 – 306182CytoplasmicSequence analysisAdd
BLAST
Transmembranei307 – 32822HelicalSequence analysisAdd
BLAST
Topological domaini329 – 36436ExtracellularSequence analysisAdd
BLAST
Transmembranei365 – 38218HelicalSequence analysisAdd
BLAST
Topological domaini383 – 921539CytoplasmicSequence analysisAdd
BLAST
Transmembranei922 – 94120HelicalSequence analysisAdd
BLAST
Topological domaini942 – 95514ExtracellularSequence analysisAdd
BLAST
Transmembranei956 – 97520HelicalSequence analysisAdd
BLAST
Topological domaini976 – 100530CytoplasmicSequence analysisAdd
BLAST
Transmembranei1006 – 102823HelicalSequence analysisAdd
BLAST
Topological domaini1029 – 104113ExtracellularSequence analysisAdd
BLAST
Transmembranei1042 – 106423HelicalSequence analysisAdd
BLAST
Topological domaini1065 – 10706CytoplasmicSequence analysis
Transmembranei1071 – 109121HelicalSequence analysisAdd
BLAST
Topological domaini1092 – 110817ExtracellularSequence analysisAdd
BLAST
Transmembranei1109 – 113325HelicalSequence analysisAdd
BLAST
Topological domaini1134 – 118451CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11841184Probable phospholipid-transporting ATPase 12PRO_0000046396Add
BLAST

Proteomic databases

PaxDbiP57792.
PRIDEiP57792.

PTM databases

iPTMnetiP57792.

Expressioni

Gene expression databases

ExpressionAtlasiP57792. baseline and differential.
GenevisibleiP57792. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G26130.2.

Structurei

3D structure databases

ProteinModelPortaliP57792.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITKD. Eukaryota.
ENOG410XPYK. LUCA.
HOGENOMiHOG000202528.
InParanoidiP57792.
KOiK01530.
PhylomeDBiP57792.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.Curated
Isoform 1 (identifier: P57792-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATVSGRRRK RKIQLSKLFT LTGAKACFKP DHSKIGRSGF SRVVFCNQPD
60 70 80 90 100
SPEAESRNYC DNYVRTTKYT LATFLPKSLF EQFRRVANFY FLVVGILSFT
110 120 130 140 150
PLAPYTAVSA IVPLTFVILA TMFKEGVEDW RRKQQDIEVN NRKVRVHRGN
160 170 180 190 200
GNFDLREWKT LRVGDILKVE KNEFFPADLV LLSSSYEDAV CYVETMNLDG
210 220 230 240 250
ETNLKLKQGL EVTLSLREEL NFRDFEAFIK CEDPNANLYS FVGTMDLKGE
260 270 280 290 300
KYPLSPQQLL LRGSKLRNTD YIYGVVIFTG PDTKVVQNST DPPSKRSMIE
310 320 330 340 350
RKMDKIIYLM FLMVFSLAFF GSVLFGIWTR DDFQNGVMER WYLKPDDSSI
360 370 380 390 400
FFDPKRAPMA AIYHFLTALM LNSYFIPISL YVSIEIVKVL QSIFINQDIH
410 420 430 440 450
MYYEEADKPA HARTSNLNEE LGQVGTILSD KTGTLTCNSM EFIKCSIAGT
460 470 480 490 500
AYGRGVTEVE MAMDKRKGSA LVNQSNGNST EDAVAAEPAV KGFNFRDERI
510 520 530 540 550
MDGNWVTETH ADVIQKFFQL LAVCHTVIPE VDEDTGKISY EAESPDEAAF
560 570 580 590 600
VIAARELGFE FFTRTQTTIS VRELDLVTGE RVERLYSVLN VLEFSSSKKR
610 620 630 640 650
MSVIVQDQDG KLLLLCKGAD SVMFERLSES GRKYEKETRD HVNEYADAGL
660 670 680 690 700
RTLILAYREL DENEYEVFTE RISEAKNSVS ADREALIDEV TEKIEKNLVL
710 720 730 740 750
LGATAVEDKL QNGVPDCINK LAQAGIKIWV LTGDKMETAI NIGFACSLLR
760 770 780 790 800
RDMKQIIINL ETPEIQQLEK SGEKDAIAAL KENVLHQITS GKAQLKASGG
810 820 830 840 850
NAKAFALIID GKSLAYALEE DMKGIFLELA IGCASVICCR SSPKQKALVT
860 870 880 890 900
RLVKTGSGQT TLAIGDGAND VGMLQEADIG VGISGVEGMQ AVMSSDIAIA
910 920 930 940 950
QFRYLERLLL VHGHWCYRRI SKMICYFFYK NITFGFTLFL YEAYTSFSAT
960 970 980 990 1000
PAYNDWYLSL YSVFFTSLPV ICLGIFDQDV SAPFCLKFPV LYQEGVQNLL
1010 1020 1030 1040 1050
FSWRRILSWM FHGFCSAIII FFLCKTSLES QAFNHEGKTA GRDILGGTMY
1060 1070 1080 1090 1100
TCVVWVVSLQ MVLTISYFTL IQHVVVWGSV VIWYLFLMVY GSLPIRMSTD
1110 1120 1130 1140 1150
AYMVFLEALA PAPSYWITTL FVVLSTMMPY FIFSAIQMRF FPMSHGTVQL
1160 1170 1180
LRYEDQCSNS GNFEMGRQGS VRPTLVMRSH QPES
Length:1,184
Mass (Da):133,793
Last modified:April 27, 2001 - v1
Checksum:iD9B6BC0C79CDAE74
GO

Sequence cautioni

The sequence AAG50529 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079829 Genomic DNA. Translation: AAG50692.1.
AC084221 Genomic DNA. Translation: AAG50529.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30652.1.
PIRiD86387.
RefSeqiNP_173938.1. NM_102378.2. [P57792-1]
UniGeneiAt.49917.

Genome annotation databases

EnsemblPlantsiAT1G26130.1; AT1G26130.1; AT1G26130. [P57792-1]
GeneIDi839154.
KEGGiath:AT1G26130.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079829 Genomic DNA. Translation: AAG50692.1.
AC084221 Genomic DNA. Translation: AAG50529.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30652.1.
PIRiD86387.
RefSeqiNP_173938.1. NM_102378.2. [P57792-1]
UniGeneiAt.49917.

3D structure databases

ProteinModelPortaliP57792.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G26130.2.

PTM databases

iPTMnetiP57792.

Proteomic databases

PaxDbiP57792.
PRIDEiP57792.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G26130.1; AT1G26130.1; AT1G26130. [P57792-1]
GeneIDi839154.
KEGGiath:AT1G26130.

Organism-specific databases

TAIRiAT1G26130.

Phylogenomic databases

eggNOGiENOG410ITKD. Eukaryota.
ENOG410XPYK. LUCA.
HOGENOMiHOG000202528.
InParanoidiP57792.
KOiK01530.
PhylomeDBiP57792.

Enzyme and pathway databases

BioCyciARA:AT1G26130-MONOMER.
ARA:GQT-873-MONOMER.
ReactomeiR-ATH-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiP57792.

Gene expression databases

ExpressionAtlasiP57792. baseline and differential.
GenevisibleiP57792. AT.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALA12_ARATH
AccessioniPrimary (citable) accession number: P57792
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: July 6, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.