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Protein

Probable phospholipid-transporting ATPase 12

Gene

ALA12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in transport of phospholipids.1 Publication

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4304-aspartylphosphate intermediateBy similarity1
Metal bindingi866MagnesiumBy similarity1
Metal bindingi870MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G26130-MONOMER
ReactomeiR-ATH-6798695 Neutrophil degranulation
R-ATH-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase 121 Publication (EC:3.6.3.11 Publication)
Short name:
AtALA121 Publication
Alternative name(s):
Aminophospholipid flippase 121 Publication
Gene namesi
Name:ALA121 Publication
Ordered Locus Names:At1g26130Imported
ORF Names:F14G11.10, F28B23.19Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G26130

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 75CytoplasmicSequence analysisAdd BLAST75
Transmembranei76 – 97HelicalSequence analysisAdd BLAST22
Topological domaini98 – 101ExtracellularSequence analysis4
Transmembranei102 – 124HelicalSequence analysisAdd BLAST23
Topological domaini125 – 306CytoplasmicSequence analysisAdd BLAST182
Transmembranei307 – 328HelicalSequence analysisAdd BLAST22
Topological domaini329 – 364ExtracellularSequence analysisAdd BLAST36
Transmembranei365 – 382HelicalSequence analysisAdd BLAST18
Topological domaini383 – 921CytoplasmicSequence analysisAdd BLAST539
Transmembranei922 – 941HelicalSequence analysisAdd BLAST20
Topological domaini942 – 955ExtracellularSequence analysisAdd BLAST14
Transmembranei956 – 975HelicalSequence analysisAdd BLAST20
Topological domaini976 – 1005CytoplasmicSequence analysisAdd BLAST30
Transmembranei1006 – 1028HelicalSequence analysisAdd BLAST23
Topological domaini1029 – 1041ExtracellularSequence analysisAdd BLAST13
Transmembranei1042 – 1064HelicalSequence analysisAdd BLAST23
Topological domaini1065 – 1070CytoplasmicSequence analysis6
Transmembranei1071 – 1091HelicalSequence analysisAdd BLAST21
Topological domaini1092 – 1108ExtracellularSequence analysisAdd BLAST17
Transmembranei1109 – 1133HelicalSequence analysisAdd BLAST25
Topological domaini1134 – 1184CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463961 – 1184Probable phospholipid-transporting ATPase 12Add BLAST1184

Proteomic databases

PaxDbiP57792
PRIDEiP57792

PTM databases

iPTMnetiP57792

Expressioni

Gene expression databases

ExpressionAtlasiP57792 baseline and differential
GenevisibleiP57792 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G26130.2

Structurei

3D structure databases

ProteinModelPortaliP57792
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITKD Eukaryota
ENOG410XPYK LUCA
HOGENOMiHOG000202528
InParanoidiP57792
KOiK01530
PhylomeDBiP57792

Family and domain databases

Gene3Di3.40.1110.101 hit
3.40.50.10001 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 2 hits
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.Curated
Isoform 1 (identifier: P57792-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATVSGRRRK RKIQLSKLFT LTGAKACFKP DHSKIGRSGF SRVVFCNQPD
60 70 80 90 100
SPEAESRNYC DNYVRTTKYT LATFLPKSLF EQFRRVANFY FLVVGILSFT
110 120 130 140 150
PLAPYTAVSA IVPLTFVILA TMFKEGVEDW RRKQQDIEVN NRKVRVHRGN
160 170 180 190 200
GNFDLREWKT LRVGDILKVE KNEFFPADLV LLSSSYEDAV CYVETMNLDG
210 220 230 240 250
ETNLKLKQGL EVTLSLREEL NFRDFEAFIK CEDPNANLYS FVGTMDLKGE
260 270 280 290 300
KYPLSPQQLL LRGSKLRNTD YIYGVVIFTG PDTKVVQNST DPPSKRSMIE
310 320 330 340 350
RKMDKIIYLM FLMVFSLAFF GSVLFGIWTR DDFQNGVMER WYLKPDDSSI
360 370 380 390 400
FFDPKRAPMA AIYHFLTALM LNSYFIPISL YVSIEIVKVL QSIFINQDIH
410 420 430 440 450
MYYEEADKPA HARTSNLNEE LGQVGTILSD KTGTLTCNSM EFIKCSIAGT
460 470 480 490 500
AYGRGVTEVE MAMDKRKGSA LVNQSNGNST EDAVAAEPAV KGFNFRDERI
510 520 530 540 550
MDGNWVTETH ADVIQKFFQL LAVCHTVIPE VDEDTGKISY EAESPDEAAF
560 570 580 590 600
VIAARELGFE FFTRTQTTIS VRELDLVTGE RVERLYSVLN VLEFSSSKKR
610 620 630 640 650
MSVIVQDQDG KLLLLCKGAD SVMFERLSES GRKYEKETRD HVNEYADAGL
660 670 680 690 700
RTLILAYREL DENEYEVFTE RISEAKNSVS ADREALIDEV TEKIEKNLVL
710 720 730 740 750
LGATAVEDKL QNGVPDCINK LAQAGIKIWV LTGDKMETAI NIGFACSLLR
760 770 780 790 800
RDMKQIIINL ETPEIQQLEK SGEKDAIAAL KENVLHQITS GKAQLKASGG
810 820 830 840 850
NAKAFALIID GKSLAYALEE DMKGIFLELA IGCASVICCR SSPKQKALVT
860 870 880 890 900
RLVKTGSGQT TLAIGDGAND VGMLQEADIG VGISGVEGMQ AVMSSDIAIA
910 920 930 940 950
QFRYLERLLL VHGHWCYRRI SKMICYFFYK NITFGFTLFL YEAYTSFSAT
960 970 980 990 1000
PAYNDWYLSL YSVFFTSLPV ICLGIFDQDV SAPFCLKFPV LYQEGVQNLL
1010 1020 1030 1040 1050
FSWRRILSWM FHGFCSAIII FFLCKTSLES QAFNHEGKTA GRDILGGTMY
1060 1070 1080 1090 1100
TCVVWVVSLQ MVLTISYFTL IQHVVVWGSV VIWYLFLMVY GSLPIRMSTD
1110 1120 1130 1140 1150
AYMVFLEALA PAPSYWITTL FVVLSTMMPY FIFSAIQMRF FPMSHGTVQL
1160 1170 1180
LRYEDQCSNS GNFEMGRQGS VRPTLVMRSH QPES
Length:1,184
Mass (Da):133,793
Last modified:April 27, 2001 - v1
Checksum:iD9B6BC0C79CDAE74
GO

Sequence cautioni

The sequence AAG50529 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079829 Genomic DNA Translation: AAG50692.1
AC084221 Genomic DNA Translation: AAG50529.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE30652.1
PIRiD86387
RefSeqiNP_001319082.1, NM_001332685.1 [P57792-1]
UniGeneiAt.49917

Genome annotation databases

EnsemblPlantsiAT1G26130.1; AT1G26130.1; AT1G26130 [P57792-1]
GeneIDi839154
GrameneiAT1G26130.1; AT1G26130.1; AT1G26130 [P57792-1]
KEGGiath:AT1G26130

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiALA12_ARATH
AccessioniPrimary (citable) accession number: P57792
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: April 25, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome