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P57791

- FACE2_MOUSE

UniProt

P57791 - FACE2_MOUSE

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Protein
CAAX prenyl protease 2
Gene
Rce1, Face2, Rce1a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 By similarity.

Enzyme regulationi

Deubiquitination by USP17L2/USP17 negatively regulates the proteolytic activity toward Ras GTPases By similarity.

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB

GO - Biological processi

  1. CAAX-box protein processing Source: UniProtKB
  2. proteolysis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

MEROPSiM79.002.

Names & Taxonomyi

Protein namesi
Recommended name:
CAAX prenyl protease 2 (EC:3.4.22.-)
Alternative name(s):
Farnesylated proteins-converting enzyme 2
Short name:
FACE-2
Prenyl protein-specific endoprotease 2
RCE1 homolog
Gene namesi
Name:Rce1
Synonyms:Face2, Rce1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1336895. Rce1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621Helical; Reviewed prediction
Add
BLAST
Transmembranei75 – 9521Helical; Reviewed prediction
Add
BLAST
Transmembranei112 – 13221Helical; Reviewed prediction
Add
BLAST
Transmembranei193 – 21321Helical; Reviewed prediction
Add
BLAST
Transmembranei226 – 24621Helical; Reviewed prediction
Add
BLAST
Transmembranei254 – 27421Helical; Reviewed prediction
Add
BLAST
Transmembranei282 – 30221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice show defective Ras processing and mislocalization of Ras within cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 329328CAAX prenyl protease 2
PRO_0000194831Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Post-translational modificationi

Ubiquitinated. Undergoes 'Lys-48'-and 'Lys-63'-linked ubiquitination. 'Lys-48' ubiquitination induces its degradation. Deubiquitinated by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains By similarity.

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

PaxDbiP57791.
PRIDEiP57791.

PTM databases

PhosphoSiteiP57791.

Expressioni

Gene expression databases

ArrayExpressiP57791.
BgeeiP57791.
GenevestigatoriP57791.

Structurei

3D structure databases

ProteinModelPortaliP57791.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase U48 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG264307.
GeneTreeiENSGT00390000004124.
HOGENOMiHOG000006037.
HOVERGENiHBG002541.
InParanoidiP57791.
KOiK08658.
OMAiYSAFLFA.
OrthoDBiEOG7F24TC.
PhylomeDBiP57791.
TreeFamiTF313800.

Family and domain databases

InterProiIPR003675. CAAX_protease.
[Graphical view]
PfamiPF02517. Abi. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57791-1 [UniParc]FASTAAdd to Basket

« Hide

MAALGGDGLR LLSVSRPERQ PESAALSGPG SGLCCWVSVF SCFSLACSYV    50
GSLYVWKSEL PRDHPAVIKR RSTSVLVVSS LSPLCVLLWR ELTGIQPGTS 100
LLTLMGFRLE GIFPAALLPL LLTMILFLGP LMQLSMDCPC DLTDGLKVVL 150
APRSWARCLT DMRWLRNQVI APLTEELVFR ACMLPMLAPC TGLGPAVFTC 200
PLFFGVAHFH HIIEQLRFRQ SSVGSIFVSA AFQFSYTAVF GAYTAFLFIR 250
TGHLIGPVLC HSFCNYMGFP AVCAALEHPQ KWPLLAGYAL GVGLFLLLLQ 300
PLTDPKLYGS LPLCMLLERT GASETLLCS 329
Length:329
Mass (Da):35,867
Last modified:April 27, 2001 - v1
Checksum:iC2A49617EDC77EC8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 2711PERQPESAALS → QSGTRVSRAE1 Publication
Add
BLAST
Sequence conflicti62 – 621R → K in BAB28566. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ251644 Genomic DNA. Translation: CAC17013.1.
AJ251645 mRNA. Translation: CAC17014.1.
AK012946 mRNA. Translation: BAB28566.1.
CCDSiCCDS29432.1.
RefSeqiNP_075620.1. NM_023131.1.
UniGeneiMm.391143.

Genome annotation databases

EnsembliENSMUST00000025823; ENSMUSP00000025823; ENSMUSG00000024889.
GeneIDi19671.
KEGGimmu:19671.
UCSCiuc008gaj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ251644 Genomic DNA. Translation: CAC17013.1 .
AJ251645 mRNA. Translation: CAC17014.1 .
AK012946 mRNA. Translation: BAB28566.1 .
CCDSi CCDS29432.1.
RefSeqi NP_075620.1. NM_023131.1.
UniGenei Mm.391143.

3D structure databases

ProteinModelPortali P57791.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL1075287.

Protein family/group databases

MEROPSi M79.002.

PTM databases

PhosphoSitei P57791.

Proteomic databases

PaxDbi P57791.
PRIDEi P57791.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025823 ; ENSMUSP00000025823 ; ENSMUSG00000024889 .
GeneIDi 19671.
KEGGi mmu:19671.
UCSCi uc008gaj.1. mouse.

Organism-specific databases

CTDi 9986.
MGIi MGI:1336895. Rce1.

Phylogenomic databases

eggNOGi NOG264307.
GeneTreei ENSGT00390000004124.
HOGENOMi HOG000006037.
HOVERGENi HBG002541.
InParanoidi P57791.
KOi K08658.
OMAi YSAFLFA.
OrthoDBi EOG7F24TC.
PhylomeDBi P57791.
TreeFami TF313800.

Miscellaneous databases

NextBioi 296986.
PROi P57791.
SOURCEi Search...

Gene expression databases

ArrayExpressi P57791.
Bgeei P57791.
Genevestigatori P57791.

Family and domain databases

InterProi IPR003675. CAAX_protease.
[Graphical view ]
Pfami PF02517. Abi. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and expression analysis of the gene encoding the murine Caax protease Face-2."
    Cadinanos J., Freije J.M.P.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-329.
    Strain: C57BL/6J.
    Tissue: Embryo.
  3. "Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells."
    Kim E., Ambroziak P., Otto J.C., Taylor B., Ashby M., Shannon K., Casey P.J., Young S.G.
    J. Biol. Chem. 274:8383-8390(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiFACE2_MOUSE
AccessioniPrimary (citable) accession number: P57791
Secondary accession number(s): Q9CSF8, Q9EP68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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