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Protein

CAAX prenyl protease 2

Gene

Rce1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (By similarity).By similarity1 Publication

Enzyme regulationi

Deubiquitination by USP17L2/USP17 negatively regulates the proteolytic activity toward Ras GTPases.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei175Proton donor/acceptorBy similarity1
Active sitei208Proton donor/acceptorBy similarity1
Sitei261Transition state stabilizerBy similarity1
Sitei265Transition state stabilizerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

BRENDAi3.4.99.B1 3474
ReactomeiR-MMU-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPSiM79.002

Names & Taxonomyi

Protein namesi
Recommended name:
CAAX prenyl protease 2 (EC:3.4.22.-)
Alternative name(s):
Farnesylated proteins-converting enzyme 2
Short name:
FACE-2
Prenyl protein-specific endoprotease 2
RCE1 homolog
Gene namesi
Name:Rce1
Synonyms:Face2, Rce1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1336895 Rce1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice show defective Ras processing and mislocalization of Ras within cells.1 Publication

Chemistry databases

ChEMBLiCHEMBL1075287

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001948312 – 329CAAX prenyl protease 2Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Post-translational modificationi

Ubiquitinated. Undergoes 'Lys-48'-and 'Lys-63'-linked ubiquitination. 'Lys-48' ubiquitination induces its degradation. Deubiquitinated by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains (By similarity).By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

EPDiP57791
MaxQBiP57791
PaxDbiP57791
PeptideAtlasiP57791
PRIDEiP57791

PTM databases

iPTMnetiP57791
PhosphoSitePlusiP57791
SwissPalmiP57791

Expressioni

Gene expression databases

BgeeiENSMUSG00000024889
ExpressionAtlasiP57791 baseline and differential
GenevisibleiP57791 MM

Interactioni

Protein-protein interaction databases

BioGridi202838, 2 interactors
STRINGi10090.ENSMUSP00000025823

Structurei

3D structure databases

ProteinModelPortaliP57791
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase U48 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4130 Eukaryota
ENOG410YPVA LUCA
GeneTreeiENSGT00390000004124
HOGENOMiHOG000006037
HOVERGENiHBG002541
InParanoidiP57791
KOiK08658
OMAiLFQFTYT
OrthoDBiEOG091G0HB9
PhylomeDBiP57791
TreeFamiTF313800

Family and domain databases

InterProiView protein in InterPro
IPR003675 CAAX_protease
PfamiView protein in Pfam
PF02517 Abi, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57791-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALGGDGLR LLSVSRPERQ PESAALSGPG SGLCCWVSVF SCFSLACSYV
60 70 80 90 100
GSLYVWKSEL PRDHPAVIKR RSTSVLVVSS LSPLCVLLWR ELTGIQPGTS
110 120 130 140 150
LLTLMGFRLE GIFPAALLPL LLTMILFLGP LMQLSMDCPC DLTDGLKVVL
160 170 180 190 200
APRSWARCLT DMRWLRNQVI APLTEELVFR ACMLPMLAPC TGLGPAVFTC
210 220 230 240 250
PLFFGVAHFH HIIEQLRFRQ SSVGSIFVSA AFQFSYTAVF GAYTAFLFIR
260 270 280 290 300
TGHLIGPVLC HSFCNYMGFP AVCAALEHPQ KWPLLAGYAL GVGLFLLLLQ
310 320
PLTDPKLYGS LPLCMLLERT GASETLLCS
Length:329
Mass (Da):35,867
Last modified:April 27, 2001 - v1
Checksum:iC2A49617EDC77EC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17 – 27PERQPESAALS → QSGTRVSRAE (PubMed:16141072).CuratedAdd BLAST11
Sequence conflicti62R → K in BAB28566 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251644 Genomic DNA Translation: CAC17013.1
AJ251645 mRNA Translation: CAC17014.1
AK012946 mRNA Translation: BAB28566.1
CCDSiCCDS29432.1
RefSeqiNP_075620.1, NM_023131.1
UniGeneiMm.391143

Genome annotation databases

EnsembliENSMUST00000025823; ENSMUSP00000025823; ENSMUSG00000024889
GeneIDi19671
KEGGimmu:19671
UCSCiuc008gaj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFACE2_MOUSE
AccessioniPrimary (citable) accession number: P57791
Secondary accession number(s): Q9CSF8, Q9EP68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: April 25, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health