UniProtKB - P57789 (KCNKA_HUMAN)
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Protein
Potassium channel subfamily K member 10
Gene
KCNK10
Organism
Homo sapiens (Human)
Status
Functioni
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
GO - Molecular functioni
- potassium channel activity Source: ProtInc
- potassium ion leak channel activity Source: GO_Central
- voltage-gated ion channel activity Source: UniProtKB-KW
GO - Biological processi
- memory Source: Ensembl
- potassium ion transmembrane transport Source: GO_Central
- regulation of ion transmembrane transport Source: UniProtKB-KW
- signal transduction Source: ProtInc
- stabilization of membrane potential Source: GO_Central
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
Reactomei | R-HSA-1299503 TWIK related potassium channel (TREK) R-HSA-5576886 Phase 4 - resting membrane potential |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium channel subfamily K member 10Alternative name(s): Outward rectifying potassium channel protein TREK-2 TREK-2 K(+) channel subunit |
Gene namesi | Name:KCNK10 Synonyms:TREK2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000100433.15 |
HGNCi | HGNC:6273 KCNK10 |
MIMi | 605873 gene |
neXtProti | NX_P57789 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 71 | CytoplasmicSequence analysisAdd BLAST | 71 | |
Transmembranei | 72 – 92 | HelicalSequence analysisAdd BLAST | 21 | |
Intramembranei | 154 – 180 | Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST | 27 | |
Transmembranei | 182 – 202 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 203 – 233 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 234 – 254 | HelicalSequence analysisAdd BLAST | 21 | |
Intramembranei | 263 – 294 | Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST | 32 | |
Transmembranei | 299 – 319 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 320 – 538 | CytoplasmicSequence analysisAdd BLAST | 219 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 54207 |
OpenTargetsi | ENSG00000100433 |
PharmGKBi | PA30053 |
Chemistry databases
ChEMBLi | CHEMBL2331041 |
Polymorphism and mutation databases
BioMutai | KCNK10 |
DMDMi | 13431412 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000101758 | 1 – 538 | Potassium channel subfamily K member 10Add BLAST | 538 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 144 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 147 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 148 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | P57789 |
PeptideAtlasi | P57789 |
PRIDEi | P57789 |
PTM databases
iPTMneti | P57789 |
PhosphoSitePlusi | P57789 |
Expressioni
Tissue specificityi
Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.
Gene expression databases
Bgeei | ENSG00000100433 |
CleanExi | HS_KCNK10 |
ExpressionAtlasi | P57789 baseline and differential |
Genevisiblei | P57789 HS |
Organism-specific databases
HPAi | HPA030462 |
Interactioni
Protein-protein interaction databases
BioGridi | 1199241 interactor. |
DIPi | DIP-44050N |
IntActi | P57789 1 interactor. |
STRINGi | 9606.ENSP00000310568 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 69 – 115 | Combined sources | 47 | |
Helixi | 121 – 136 | Combined sources | 16 | |
Turni | 145 – 148 | Combined sources | 4 | |
Beta strandi | 151 – 153 | Combined sources | 3 | |
Helixi | 154 – 165 | Combined sources | 12 | |
Helixi | 178 – 222 | Combined sources | 45 | |
Turni | 223 – 225 | Combined sources | 3 | |
Helixi | 232 – 247 | Combined sources | 16 | |
Helixi | 249 – 258 | Combined sources | 10 | |
Helixi | 263 – 274 | Combined sources | 12 | |
Beta strandi | 280 – 282 | Combined sources | 3 | |
Beta strandi | 288 – 290 | Combined sources | 3 | |
Helixi | 296 – 325 | Combined sources | 30 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4BW5 | X-ray | 3.20 | A/B/C/D | 62-335 | [»] | |
4XDJ | X-ray | 3.80 | A/B/C/D | 62-335 | [»] | |
4XDK | X-ray | 3.60 | A/B/C/D | 62-335 | [»] | |
4XDL | X-ray | 3.50 | A/B/C/D | 62-335 | [»] | |
ProteinModelPortali | P57789 | |||||
SMRi | P57789 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1418 Eukaryota COG1226 LUCA |
GeneTreei | ENSGT00760000118858 |
HOGENOMi | HOG000013106 |
HOVERGENi | HBG052234 |
InParanoidi | P57789 |
KOi | K04920 |
OMAi | KFPIETP |
OrthoDBi | EOG091G0E3R |
PhylomeDBi | P57789 |
TreeFami | TF313947 |
Family and domain databases
InterProi | View protein in InterPro IPR003280 2pore_dom_K_chnl IPR003976 2pore_dom_K_chnl_TREK IPR013099 K_chnl_dom |
Pfami | View protein in Pfam PF07885 Ion_trans_2, 2 hits |
PRINTSi | PR01333 2POREKCHANEL PR01499 TREKCHANNEL |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform A (identifier: P57789-1) [UniParc]FASTAAdd to basket
Also known as: TREK-2a
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MFFLYTDFFL SLVAVPAAAP VCQPKSATNG QPPAPAPTPT PRLSISSRAT
60 70 80 90 100
VVARMEGTSQ GGLQTVMKWK TVVAIFVVVV VYLVTGGLVF RALEQPFESS
110 120 130 140 150
QKNTIALEKA EFLRDHVCVS PQELETLIQH ALDADNAGVS PIGNSSNNSS
160 170 180 190 200
HWDLGSAFFF AGTVITTIGY GNIAPSTEGG KIFCILYAIF GIPLFGFLLA
210 220 230 240 250
GIGDQLGTIF GKSIARVEKV FRKKQVSQTK IRVISTILFI LAGCIVFVTI
260 270 280 290 300
PAVIFKYIEG WTALESIYFV VVTLTTVGFG DFVAGGNAGI NYREWYKPLV
310 320 330 340 350
WFWILVGLAY FAAVLSMIGD WLRVLSKKTK EEVGEIKAHA AEWKANVTAE
360 370 380 390 400
FRETRRRLSV EIHDKLQRAA TIRSMERRRL GLDQRAHSLD MLSPEKRSVF
410 420 430 440 450
AALDTGRFKA SSQESINNRP NNLRLKGPEQ LNKHGQGASE DNIINKFGST
460 470 480 490 500
SRLTKRKNKD LKKTLPEDVQ KIYKTFRNYS LDEEKKEEET EKMCNSDNSS
510 520 530
TAMLTDCIQQ HAELENGMIP TDTKDREPEN NSLLEDRN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 529 | E → G in AAL95705 (PubMed:11897838).Curated | 1 | |
Sequence conflicti | 529 | E → G in AAL95706 (PubMed:11897838).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060216 | 70 | K → Q. Corresponds to variant dbSNP:rs398263Ensembl. | 1 | |
Natural variantiVAR_052428 | 512 | A → T1 PublicationCorresponds to variant dbSNP:rs17762463Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006697 | 1 – 12 | MFFLY…FFLSL → MEDGFKGDRTEGCRSDS in isoform B. 3 PublicationsAdd BLAST | 12 | |
Alternative sequenceiVSP_006698 | 1 – 12 | MFFLY…FFLSL → MKFPIETPRKQVNWDPK in isoform C. 3 PublicationsAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF279890 mRNA Translation: AAG15191.1 AF385399 mRNA Translation: AAL95705.1 AF385400 mRNA Translation: AAL95706.1 EU978938 mRNA Translation: ACH86097.1 EU978939 mRNA Translation: ACH86098.1 EU978940 mRNA Translation: ACH86099.1 EU978941 mRNA Translation: ACH86100.1 AK313499 mRNA Translation: BAG36281.1 AK315263 mRNA Translation: BAG37680.1 AL049834 Genomic DNA No translation available. AL133279 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81373.1 CH471061 Genomic DNA Translation: EAW81374.1 CH471061 Genomic DNA Translation: EAW81375.1 BC075021 mRNA Translation: AAH75021.1 BC075022 mRNA Translation: AAH75022.1 |
CCDSi | CCDS9880.1 [P57789-1] CCDS9881.1 [P57789-3] CCDS9882.1 [P57789-4] |
RefSeqi | NP_066984.1, NM_021161.4 [P57789-1] NP_612190.1, NM_138317.2 [P57789-3] NP_612191.1, NM_138318.2 [P57789-4] |
UniGenei | Hs.560255 |
Genome annotation databases
Ensembli | ENST00000312350; ENSP00000310568; ENSG00000100433 [P57789-4] ENST00000319231; ENSP00000312811; ENSG00000100433 [P57789-3] ENST00000340700; ENSP00000343104; ENSG00000100433 [P57789-1] |
GeneIDi | 54207 |
KEGGi | hsa:54207 |
UCSCi | uc001xwm.4 human [P57789-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | KCNKA_HUMAN | |
Accessioni | P57789Primary (citable) accession number: P57789 Secondary accession number(s): B2R8T4 Q9HB59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | April 27, 2001 | |
Last modified: | March 28, 2018 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |