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P57789

- KCNKA_HUMAN

UniProt

P57789 - KCNKA_HUMAN

Protein

Potassium channel subfamily K member 10

Gene

KCNK10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.

    GO - Molecular functioni

    1. potassium channel activity Source: ProtInc
    2. voltage-gated ion channel activity Source: UniProtKB-KW

    GO - Biological processi

    1. signal transduction Source: ProtInc
    2. synaptic transmission Source: Reactome
    3. transport Source: ProtInc

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75819. TWIK related potassium channel (TREK).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel subfamily K member 10
    Alternative name(s):
    Outward rectifying potassium channel protein TREK-2
    TREK-2 K(+) channel subunit
    Gene namesi
    Name:KCNK10
    Synonyms:TREK2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:6273. KCNK10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30053.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 538538Potassium channel subfamily K member 10PRO_0000101758Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP57789.
    PRIDEiP57789.

    PTM databases

    PhosphoSiteiP57789.

    Expressioni

    Tissue specificityi

    Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.

    Gene expression databases

    ArrayExpressiP57789.
    BgeeiP57789.
    CleanExiHS_KCNK10.
    GenevestigatoriP57789.

    Organism-specific databases

    HPAiHPA030462.

    Interactioni

    Protein-protein interaction databases

    BioGridi119924. 2 interactions.
    IntActiP57789. 2 interactions.
    MINTiMINT-4050532.
    STRINGi9606.ENSP00000310568.

    Structurei

    Secondary structure

    1
    538
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi69 – 11547
    Helixi121 – 13616
    Beta strandi151 – 1533
    Helixi154 – 16512
    Helixi178 – 22245
    Helixi232 – 24716
    Helixi249 – 25810
    Helixi263 – 27412
    Beta strandi280 – 2823
    Helixi296 – 32530

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4BW5X-ray3.20A/B/C/D62-335[»]
    ProteinModelPortaliP57789.
    SMRiP57789. Positions 68-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7171CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini203 – 23331CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini320 – 538219CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei154 – 18027Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
    BLAST
    Intramembranei263 – 29432Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei299 – 31921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG308296.
    HOGENOMiHOG000013106.
    HOVERGENiHBG052234.
    KOiK04920.
    OMAiQLNKHGQ.
    OrthoDBiEOG77M8NK.
    PhylomeDBiP57789.
    TreeFamiTF313947.

    Family and domain databases

    InterProiIPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR003976. 2pore_dom_K_chnl_TREK.
    [Graphical view]
    PfamiPF07885. Ion_trans_2. 2 hits.
    [Graphical view]
    PRINTSiPR01333. 2POREKCHANEL.
    PR01499. TREKCHANNEL.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: P57789-1) [UniParc]FASTAAdd to Basket

    Also known as: TREK-2a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFFLYTDFFL SLVAVPAAAP VCQPKSATNG QPPAPAPTPT PRLSISSRAT    50
    VVARMEGTSQ GGLQTVMKWK TVVAIFVVVV VYLVTGGLVF RALEQPFESS 100
    QKNTIALEKA EFLRDHVCVS PQELETLIQH ALDADNAGVS PIGNSSNNSS 150
    HWDLGSAFFF AGTVITTIGY GNIAPSTEGG KIFCILYAIF GIPLFGFLLA 200
    GIGDQLGTIF GKSIARVEKV FRKKQVSQTK IRVISTILFI LAGCIVFVTI 250
    PAVIFKYIEG WTALESIYFV VVTLTTVGFG DFVAGGNAGI NYREWYKPLV 300
    WFWILVGLAY FAAVLSMIGD WLRVLSKKTK EEVGEIKAHA AEWKANVTAE 350
    FRETRRRLSV EIHDKLQRAA TIRSMERRRL GLDQRAHSLD MLSPEKRSVF 400
    AALDTGRFKA SSQESINNRP NNLRLKGPEQ LNKHGQGASE DNIINKFGST 450
    SRLTKRKNKD LKKTLPEDVQ KIYKTFRNYS LDEEKKEEET EKMCNSDNSS 500
    TAMLTDCIQQ HAELENGMIP TDTKDREPEN NSLLEDRN 538
    Length:538
    Mass (Da):59,765
    Last modified:April 27, 2001 - v1
    Checksum:i8EA615B08D147FBC
    GO
    Isoform B (identifier: P57789-4) [UniParc]FASTAAdd to Basket

    Also known as: TREK-2b

    The sequence of this isoform differs from the canonical sequence as follows:
         1-12: MFFLYTDFFLSL → MEDGFKGDRTEGCRSDS

    Show »
    Length:543
    Mass (Da):60,111
    Checksum:i17DB1AFAFAB07C46
    GO
    Isoform C (identifier: P57789-3) [UniParc]FASTAAdd to Basket

    Also known as: TREK-2c

    The sequence of this isoform differs from the canonical sequence as follows:
         1-12: MFFLYTDFFLSL → MKFPIETPRKQVNWDPK

    Show »
    Length:543
    Mass (Da):60,335
    Checksum:iB158DF9AF076444D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti529 – 5291E → G in AAL95705. (PubMed:11897838)Curated
    Sequence conflicti529 – 5291E → G in AAL95706. (PubMed:11897838)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti70 – 701K → Q.
    Corresponds to variant rs398263 [ dbSNP | Ensembl ].
    VAR_060216
    Natural varianti512 – 5121A → T.1 Publication
    Corresponds to variant rs17762463 [ dbSNP | Ensembl ].
    VAR_052428

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1212MFFLY…FFLSL → MEDGFKGDRTEGCRSDS in isoform B. 3 PublicationsVSP_006697Add
    BLAST
    Alternative sequencei1 – 1212MFFLY…FFLSL → MKFPIETPRKQVNWDPK in isoform C. 3 PublicationsVSP_006698Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF279890 mRNA. Translation: AAG15191.1.
    AF385399 mRNA. Translation: AAL95705.1.
    AF385400 mRNA. Translation: AAL95706.1.
    EU978938 mRNA. Translation: ACH86097.1.
    EU978939 mRNA. Translation: ACH86098.1.
    EU978940 mRNA. Translation: ACH86099.1.
    EU978941 mRNA. Translation: ACH86100.1.
    AK313499 mRNA. Translation: BAG36281.1.
    AK315263 mRNA. Translation: BAG37680.1.
    AL049834 Genomic DNA. No translation available.
    AL133279 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW81373.1.
    CH471061 Genomic DNA. Translation: EAW81374.1.
    CH471061 Genomic DNA. Translation: EAW81375.1.
    BC075021 mRNA. Translation: AAH75021.1.
    BC075022 mRNA. Translation: AAH75022.1.
    CCDSiCCDS9880.1. [P57789-1]
    CCDS9881.1. [P57789-3]
    CCDS9882.1. [P57789-4]
    RefSeqiNP_066984.1. NM_021161.4. [P57789-1]
    NP_612190.1. NM_138317.2. [P57789-3]
    NP_612191.1. NM_138318.2. [P57789-4]
    UniGeneiHs.560255.

    Genome annotation databases

    GeneIDi54207.
    KEGGihsa:54207.
    UCSCiuc001xwm.3. human. [P57789-4]
    uc001xwn.3. human. [P57789-3]
    uc001xwo.3. human. [P57789-1]

    Polymorphism databases

    DMDMi13431412.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF279890 mRNA. Translation: AAG15191.1 .
    AF385399 mRNA. Translation: AAL95705.1 .
    AF385400 mRNA. Translation: AAL95706.1 .
    EU978938 mRNA. Translation: ACH86097.1 .
    EU978939 mRNA. Translation: ACH86098.1 .
    EU978940 mRNA. Translation: ACH86099.1 .
    EU978941 mRNA. Translation: ACH86100.1 .
    AK313499 mRNA. Translation: BAG36281.1 .
    AK315263 mRNA. Translation: BAG37680.1 .
    AL049834 Genomic DNA. No translation available.
    AL133279 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW81373.1 .
    CH471061 Genomic DNA. Translation: EAW81374.1 .
    CH471061 Genomic DNA. Translation: EAW81375.1 .
    BC075021 mRNA. Translation: AAH75021.1 .
    BC075022 mRNA. Translation: AAH75022.1 .
    CCDSi CCDS9880.1. [P57789-1 ]
    CCDS9881.1. [P57789-3 ]
    CCDS9882.1. [P57789-4 ]
    RefSeqi NP_066984.1. NM_021161.4. [P57789-1 ]
    NP_612190.1. NM_138317.2. [P57789-3 ]
    NP_612191.1. NM_138318.2. [P57789-4 ]
    UniGenei Hs.560255.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4BW5 X-ray 3.20 A/B/C/D 62-335 [» ]
    ProteinModelPortali P57789.
    SMRi P57789. Positions 68-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119924. 2 interactions.
    IntActi P57789. 2 interactions.
    MINTi MINT-4050532.
    STRINGi 9606.ENSP00000310568.

    Chemistry

    ChEMBLi CHEMBL2331041.
    GuidetoPHARMACOLOGYi 521.

    PTM databases

    PhosphoSitei P57789.

    Polymorphism databases

    DMDMi 13431412.

    Proteomic databases

    PaxDbi P57789.
    PRIDEi P57789.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 54207.
    KEGGi hsa:54207.
    UCSCi uc001xwm.3. human. [P57789-4 ]
    uc001xwn.3. human. [P57789-3 ]
    uc001xwo.3. human. [P57789-1 ]

    Organism-specific databases

    CTDi 54207.
    GeneCardsi GC14M089829.
    HGNCi HGNC:6273. KCNK10.
    HPAi HPA030462.
    MIMi 605873. gene.
    neXtProti NX_P57789.
    PharmGKBi PA30053.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG308296.
    HOGENOMi HOG000013106.
    HOVERGENi HBG052234.
    KOi K04920.
    OMAi QLNKHGQ.
    OrthoDBi EOG77M8NK.
    PhylomeDBi P57789.
    TreeFami TF313947.

    Enzyme and pathway databases

    Reactomei REACT_75819. TWIK related potassium channel (TREK).

    Miscellaneous databases

    GeneWikii KCNK10.
    GenomeRNAii 54207.
    NextBioi 56534.
    PROi P57789.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P57789.
    Bgeei P57789.
    CleanExi HS_KCNK10.
    Genevestigatori P57789.

    Family and domain databases

    InterProi IPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR003976. 2pore_dom_K_chnl_TREK.
    [Graphical view ]
    Pfami PF07885. Ion_trans_2. 2 hits.
    [Graphical view ]
    PRINTSi PR01333. 2POREKCHANEL.
    PR01499. TREKCHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids and Gs, Gi, and Gq protein-coupled receptors."
      Lesage F., Terrenoire C., Romey G., Lazdunski M.
      J. Biol. Chem. 275:28398-28405(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    2. "Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2."
      Gu W., Schlichthorl G., Hirsch J.R., Engels H., Karschin C., Karschin A., Derst C., Steinlein O.K., Daut J.
      J. Physiol. (Lond.) 539:657-668(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND C).
    3. "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein."
      Gierten J., Ficker E., Bloehs R., Schlomer K., Kathofer S., Scholz E., Zitron E., Kiesecker C., Bauer A., Becker R., Katus H.A., Karle C.A., Thomas D.
      Br. J. Pharmacol. 154:1680-1690(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C).
      Tissue: Brain, Kidney and Pancreas.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND C), VARIANT THR-512.
      Tissue: Brain and Cerebellum.
    5. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).

    Entry informationi

    Entry nameiKCNKA_HUMAN
    AccessioniPrimary (citable) accession number: P57789
    Secondary accession number(s): B2R8T4
    , B2RCT3, B5TJL4, Q6B014, Q8TDK7, Q8TDK8, Q9HB59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3