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P57789

- KCNKA_HUMAN

UniProt

P57789 - KCNKA_HUMAN

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Protein

Potassium channel subfamily K member 10

Gene
KCNK10, TREK2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.

GO - Molecular functioni

  1. potassium channel activity Source: ProtInc
  2. voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

  1. signal transduction Source: ProtInc
  2. synaptic transmission Source: Reactome
  3. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75819. TWIK related potassium channel (TREK).

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 10
Alternative name(s):
Outward rectifying potassium channel protein TREK-2
TREK-2 K(+) channel subunit
Gene namesi
Name:KCNK10
Synonyms:TREK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:6273. KCNK10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7171Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei72 – 9221Helical; Reviewed predictionAdd
BLAST
Intramembranei154 – 18027Pore-forming; Name=Pore-forming 1; Reviewed predictionAdd
BLAST
Transmembranei182 – 20221Helical; Reviewed predictionAdd
BLAST
Topological domaini203 – 23331Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei234 – 25421Helical; Reviewed predictionAdd
BLAST
Intramembranei263 – 29432Pore-forming; Name=Pore-forming 2; Reviewed predictionAdd
BLAST
Transmembranei299 – 31921Helical; Reviewed predictionAdd
BLAST
Topological domaini320 – 538219Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30053.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Potassium channel subfamily K member 10PRO_0000101758Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi144 – 1441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi147 – 1471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi148 – 1481N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP57789.
PRIDEiP57789.

PTM databases

PhosphoSiteiP57789.

Expressioni

Tissue specificityi

Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.

Gene expression databases

ArrayExpressiP57789.
BgeeiP57789.
CleanExiHS_KCNK10.
GenevestigatoriP57789.

Organism-specific databases

HPAiHPA030462.

Interactioni

Protein-protein interaction databases

BioGridi119924. 2 interactions.
IntActiP57789. 2 interactions.
MINTiMINT-4050532.
STRINGi9606.ENSP00000310568.

Structurei

Secondary structure

1
538
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi69 – 11547
Helixi121 – 13616
Beta strandi151 – 1533
Helixi154 – 16512
Helixi178 – 22245
Helixi232 – 24716
Helixi249 – 25810
Helixi263 – 27412
Beta strandi280 – 2823
Helixi296 – 32530

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BW5X-ray3.20A/B/C/D62-335[»]
ProteinModelPortaliP57789.
SMRiP57789. Positions 68-327.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308296.
HOGENOMiHOG000013106.
HOVERGENiHBG052234.
KOiK04920.
OMAiQLNKHGQ.
OrthoDBiEOG77M8NK.
PhylomeDBiP57789.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003976. 2pore_dom_K_chnl_TREK.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform A (identifier: P57789-1) [UniParc]FASTAAdd to Basket

Also known as: TREK-2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFFLYTDFFL SLVAVPAAAP VCQPKSATNG QPPAPAPTPT PRLSISSRAT    50
VVARMEGTSQ GGLQTVMKWK TVVAIFVVVV VYLVTGGLVF RALEQPFESS 100
QKNTIALEKA EFLRDHVCVS PQELETLIQH ALDADNAGVS PIGNSSNNSS 150
HWDLGSAFFF AGTVITTIGY GNIAPSTEGG KIFCILYAIF GIPLFGFLLA 200
GIGDQLGTIF GKSIARVEKV FRKKQVSQTK IRVISTILFI LAGCIVFVTI 250
PAVIFKYIEG WTALESIYFV VVTLTTVGFG DFVAGGNAGI NYREWYKPLV 300
WFWILVGLAY FAAVLSMIGD WLRVLSKKTK EEVGEIKAHA AEWKANVTAE 350
FRETRRRLSV EIHDKLQRAA TIRSMERRRL GLDQRAHSLD MLSPEKRSVF 400
AALDTGRFKA SSQESINNRP NNLRLKGPEQ LNKHGQGASE DNIINKFGST 450
SRLTKRKNKD LKKTLPEDVQ KIYKTFRNYS LDEEKKEEET EKMCNSDNSS 500
TAMLTDCIQQ HAELENGMIP TDTKDREPEN NSLLEDRN 538
Length:538
Mass (Da):59,765
Last modified:April 27, 2001 - v1
Checksum:i8EA615B08D147FBC
GO
Isoform B (identifier: P57789-4) [UniParc]FASTAAdd to Basket

Also known as: TREK-2b

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MFFLYTDFFLSL → MEDGFKGDRTEGCRSDS

Show »
Length:543
Mass (Da):60,111
Checksum:i17DB1AFAFAB07C46
GO
Isoform C (identifier: P57789-3) [UniParc]FASTAAdd to Basket

Also known as: TREK-2c

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MFFLYTDFFLSL → MKFPIETPRKQVNWDPK

Show »
Length:543
Mass (Da):60,335
Checksum:iB158DF9AF076444D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701K → Q.
Corresponds to variant rs398263 [ dbSNP | Ensembl ].
VAR_060216
Natural varianti512 – 5121A → T.1 Publication
Corresponds to variant rs17762463 [ dbSNP | Ensembl ].
VAR_052428

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1212MFFLY…FFLSL → MEDGFKGDRTEGCRSDS in isoform B. VSP_006697Add
BLAST
Alternative sequencei1 – 1212MFFLY…FFLSL → MKFPIETPRKQVNWDPK in isoform C. VSP_006698Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti529 – 5291E → G in AAL95705. 1 Publication
Sequence conflicti529 – 5291E → G in AAL95706. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF279890 mRNA. Translation: AAG15191.1.
AF385399 mRNA. Translation: AAL95705.1.
AF385400 mRNA. Translation: AAL95706.1.
EU978938 mRNA. Translation: ACH86097.1.
EU978939 mRNA. Translation: ACH86098.1.
EU978940 mRNA. Translation: ACH86099.1.
EU978941 mRNA. Translation: ACH86100.1.
AK313499 mRNA. Translation: BAG36281.1.
AK315263 mRNA. Translation: BAG37680.1.
AL049834 Genomic DNA. No translation available.
AL133279 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81373.1.
CH471061 Genomic DNA. Translation: EAW81374.1.
CH471061 Genomic DNA. Translation: EAW81375.1.
BC075021 mRNA. Translation: AAH75021.1.
BC075022 mRNA. Translation: AAH75022.1.
CCDSiCCDS9880.1. [P57789-1]
CCDS9881.1. [P57789-3]
CCDS9882.1. [P57789-4]
RefSeqiNP_066984.1. NM_021161.4. [P57789-1]
NP_612190.1. NM_138317.2. [P57789-3]
NP_612191.1. NM_138318.2. [P57789-4]
UniGeneiHs.560255.

Genome annotation databases

EnsembliENST00000312350; ENSP00000310568; ENSG00000100433. [P57789-4]
ENST00000319231; ENSP00000312811; ENSG00000100433. [P57789-3]
ENST00000340700; ENSP00000343104; ENSG00000100433. [P57789-1]
GeneIDi54207.
KEGGihsa:54207.
UCSCiuc001xwm.3. human. [P57789-4]
uc001xwn.3. human. [P57789-3]
uc001xwo.3. human. [P57789-1]

Polymorphism databases

DMDMi13431412.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF279890 mRNA. Translation: AAG15191.1 .
AF385399 mRNA. Translation: AAL95705.1 .
AF385400 mRNA. Translation: AAL95706.1 .
EU978938 mRNA. Translation: ACH86097.1 .
EU978939 mRNA. Translation: ACH86098.1 .
EU978940 mRNA. Translation: ACH86099.1 .
EU978941 mRNA. Translation: ACH86100.1 .
AK313499 mRNA. Translation: BAG36281.1 .
AK315263 mRNA. Translation: BAG37680.1 .
AL049834 Genomic DNA. No translation available.
AL133279 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81373.1 .
CH471061 Genomic DNA. Translation: EAW81374.1 .
CH471061 Genomic DNA. Translation: EAW81375.1 .
BC075021 mRNA. Translation: AAH75021.1 .
BC075022 mRNA. Translation: AAH75022.1 .
CCDSi CCDS9880.1. [P57789-1 ]
CCDS9881.1. [P57789-3 ]
CCDS9882.1. [P57789-4 ]
RefSeqi NP_066984.1. NM_021161.4. [P57789-1 ]
NP_612190.1. NM_138317.2. [P57789-3 ]
NP_612191.1. NM_138318.2. [P57789-4 ]
UniGenei Hs.560255.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BW5 X-ray 3.20 A/B/C/D 62-335 [» ]
ProteinModelPortali P57789.
SMRi P57789. Positions 68-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119924. 2 interactions.
IntActi P57789. 2 interactions.
MINTi MINT-4050532.
STRINGi 9606.ENSP00000310568.

Chemistry

ChEMBLi CHEMBL2331041.
GuidetoPHARMACOLOGYi 521.

PTM databases

PhosphoSitei P57789.

Polymorphism databases

DMDMi 13431412.

Proteomic databases

PaxDbi P57789.
PRIDEi P57789.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000312350 ; ENSP00000310568 ; ENSG00000100433 . [P57789-4 ]
ENST00000319231 ; ENSP00000312811 ; ENSG00000100433 . [P57789-3 ]
ENST00000340700 ; ENSP00000343104 ; ENSG00000100433 . [P57789-1 ]
GeneIDi 54207.
KEGGi hsa:54207.
UCSCi uc001xwm.3. human. [P57789-4 ]
uc001xwn.3. human. [P57789-3 ]
uc001xwo.3. human. [P57789-1 ]

Organism-specific databases

CTDi 54207.
GeneCardsi GC14M089829.
HGNCi HGNC:6273. KCNK10.
HPAi HPA030462.
MIMi 605873. gene.
neXtProti NX_P57789.
PharmGKBi PA30053.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG308296.
HOGENOMi HOG000013106.
HOVERGENi HBG052234.
KOi K04920.
OMAi QLNKHGQ.
OrthoDBi EOG77M8NK.
PhylomeDBi P57789.
TreeFami TF313947.

Enzyme and pathway databases

Reactomei REACT_75819. TWIK related potassium channel (TREK).

Miscellaneous databases

GeneWikii KCNK10.
GenomeRNAii 54207.
NextBioi 56534.
PROi P57789.
SOURCEi Search...

Gene expression databases

ArrayExpressi P57789.
Bgeei P57789.
CleanExi HS_KCNK10.
Genevestigatori P57789.

Family and domain databases

InterProi IPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003976. 2pore_dom_K_chnl_TREK.
[Graphical view ]
Pfami PF07885. Ion_trans_2. 2 hits.
[Graphical view ]
PRINTSi PR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids and Gs, Gi, and Gq protein-coupled receptors."
    Lesage F., Terrenoire C., Romey G., Lazdunski M.
    J. Biol. Chem. 275:28398-28405(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
  2. "Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2."
    Gu W., Schlichthorl G., Hirsch J.R., Engels H., Karschin C., Karschin A., Derst C., Steinlein O.K., Daut J.
    J. Physiol. (Lond.) 539:657-668(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND C).
  3. "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein."
    Gierten J., Ficker E., Bloehs R., Schlomer K., Kathofer S., Scholz E., Zitron E., Kiesecker C., Bauer A., Becker R., Katus H.A., Karle C.A., Thomas D.
    Br. J. Pharmacol. 154:1680-1690(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C).
    Tissue: Brain, Kidney and Pancreas.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND C), VARIANT THR-512.
    Tissue: Brain and Cerebellum.
  5. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).

Entry informationi

Entry nameiKCNKA_HUMAN
AccessioniPrimary (citable) accession number: P57789
Secondary accession number(s): B2R8T4
, B2RCT3, B5TJL4, Q6B014, Q8TDK7, Q8TDK8, Q9HB59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: September 3, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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