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UniProtKB - P57789 (KCNKA_HUMAN)

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Protein

Potassium channel subfamily K member 10

Gene

KCNK10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.

GO - Molecular functioni

  • potassium channel activity Source: ProtInc
  • potassium ion leak channel activity Source: GO_Central
  • voltage-gated ion channel activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  • memory Source: Ensembl
  • potassium ion transmembrane transport Source: GO_Central
  • signal transduction Source: ProtInc
  • stabilization of membrane potential Source: GO_Central
  • transport Source: ProtInc
Complete GO annotation...

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-1299503. TWIK related potassium channel (TREK).
R-HSA-5576886. Phase 4 - resting membrane potential.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 10
Alternative name(s):
Outward rectifying potassium channel protein TREK-2
TREK-2 K(+) channel subunit
Gene namesi
Name:KCNK10
Synonyms:TREK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:6273. KCNK10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 71CytoplasmicSequence analysisAdd BLAST71
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Intramembranei154 – 180Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST27
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 233CytoplasmicSequence analysisAdd BLAST31
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Intramembranei263 – 294Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST32
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 538CytoplasmicSequence analysisAdd BLAST219

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54207.
OpenTargetsiENSG00000100433.
PharmGKBiPA30053.

Chemistry databases

ChEMBLiCHEMBL2331041.
GuidetoPHARMACOLOGYi521.

Polymorphism and mutation databases

BioMutaiKCNK10.
DMDMi13431412.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017581 – 538Potassium channel subfamily K member 10Add BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP57789.
PeptideAtlasiP57789.
PRIDEiP57789.

PTM databases

iPTMnetiP57789.
PhosphoSitePlusiP57789.

Expressioni

Tissue specificityi

Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.

Gene expression databases

BgeeiENSG00000100433.
CleanExiHS_KCNK10.
ExpressionAtlasiP57789. baseline and differential.
GenevisibleiP57789. HS.

Organism-specific databases

HPAiHPA030462.

Interactioni

Protein-protein interaction databases

BioGridi119924. 1 interactor.
DIPiDIP-44050N.
IntActiP57789. 2 interactors.
MINTiMINT-4050532.
STRINGi9606.ENSP00000310568.

Structurei

Secondary structure

1538
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi69 – 115Combined sources47
Helixi121 – 136Combined sources16
Turni145 – 148Combined sources4
Beta strandi151 – 153Combined sources3
Helixi154 – 165Combined sources12
Helixi178 – 222Combined sources45
Turni223 – 225Combined sources3
Helixi232 – 247Combined sources16
Helixi249 – 258Combined sources10
Helixi263 – 274Combined sources12
Beta strandi280 – 282Combined sources3
Beta strandi288 – 290Combined sources3
Helixi296 – 325Combined sources30

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BW5X-ray3.20A/B/C/D62-335[»]
4XDJX-ray3.80A/B/C/D62-335[»]
4XDKX-ray3.60A/B/C/D62-335[»]
4XDLX-ray3.50A/B/C/D62-335[»]
ProteinModelPortaliP57789.
SMRiP57789.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013106.
HOVERGENiHBG052234.
InParanoidiP57789.
KOiK04920.
OMAiKQVNWDP.
OrthoDBiEOG091G0E3R.
PhylomeDBiP57789.
TreeFamiTF313947.

Family and domain databases

InterProiView protein in InterPro
IPR003280. 2pore_dom_K_chnl.
IPR003976. 2pore_dom_K_chnl_TREK.
IPR013099. K_chnl_dom.
PfamiView protein in Pfam
PF07885. Ion_trans_2. 2 hits.
PRINTSiPR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P57789-1) [UniParc]FASTAAdd to basket
Also known as: TREK-2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFFLYTDFFL SLVAVPAAAP VCQPKSATNG QPPAPAPTPT PRLSISSRAT 
        60         70         80         90        100
VVARMEGTSQ GGLQTVMKWK TVVAIFVVVV VYLVTGGLVF RALEQPFESS 
       110        120        130        140        150
QKNTIALEKA EFLRDHVCVS PQELETLIQH ALDADNAGVS PIGNSSNNSS 
       160        170        180        190        200
HWDLGSAFFF AGTVITTIGY GNIAPSTEGG KIFCILYAIF GIPLFGFLLA 
       210        220        230        240        250
GIGDQLGTIF GKSIARVEKV FRKKQVSQTK IRVISTILFI LAGCIVFVTI 
       260        270        280        290        300
PAVIFKYIEG WTALESIYFV VVTLTTVGFG DFVAGGNAGI NYREWYKPLV 
       310        320        330        340        350
WFWILVGLAY FAAVLSMIGD WLRVLSKKTK EEVGEIKAHA AEWKANVTAE 
       360        370        380        390        400
FRETRRRLSV EIHDKLQRAA TIRSMERRRL GLDQRAHSLD MLSPEKRSVF 
       410        420        430        440        450
AALDTGRFKA SSQESINNRP NNLRLKGPEQ LNKHGQGASE DNIINKFGST 
       460        470        480        490        500
SRLTKRKNKD LKKTLPEDVQ KIYKTFRNYS LDEEKKEEET EKMCNSDNSS 
       510        520        530 
TAMLTDCIQQ HAELENGMIP TDTKDREPEN NSLLEDRN
Length:538
Mass (Da):59,765
Last modified:April 27, 2001 - v1
Checksum:i8EA615B08D147FBC
GO
Isoform B (identifier: P57789-4) [UniParc]FASTAAdd to basket
Also known as: TREK-2b

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MFFLYTDFFLSL → MEDGFKGDRTEGCRSDS

Show »
Length:543
Mass (Da):60,111
Checksum:i17DB1AFAFAB07C46
GO
Isoform C (identifier: P57789-3) [UniParc]FASTAAdd to basket
Also known as: TREK-2c

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MFFLYTDFFLSL → MKFPIETPRKQVNWDPK

Show »
Length:543
Mass (Da):60,335
Checksum:iB158DF9AF076444D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti529E → G in AAL95705 (PubMed:11897838).Curated1
Sequence conflicti529E → G in AAL95706 (PubMed:11897838).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06021670K → Q. Corresponds to variant dbSNP:rs398263Ensembl.1
Natural variantiVAR_052428512A → T1 PublicationCorresponds to variant dbSNP:rs17762463Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0066971 – 12MFFLY…FFLSL → MEDGFKGDRTEGCRSDS in isoform B. 3 PublicationsAdd BLAST12
Alternative sequenceiVSP_0066981 – 12MFFLY…FFLSL → MKFPIETPRKQVNWDPK in isoform C. 3 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279890 mRNA. Translation: AAG15191.1.
AF385399 mRNA. Translation: AAL95705.1.
AF385400 mRNA. Translation: AAL95706.1.
EU978938 mRNA. Translation: ACH86097.1.
EU978939 mRNA. Translation: ACH86098.1.
EU978940 mRNA. Translation: ACH86099.1.
EU978941 mRNA. Translation: ACH86100.1.
AK313499 mRNA. Translation: BAG36281.1.
AK315263 mRNA. Translation: BAG37680.1.
AL049834 Genomic DNA. No translation available.
AL133279 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81373.1.
CH471061 Genomic DNA. Translation: EAW81374.1.
CH471061 Genomic DNA. Translation: EAW81375.1.
BC075021 mRNA. Translation: AAH75021.1.
BC075022 mRNA. Translation: AAH75022.1.
CCDSiCCDS9880.1. [P57789-1]
CCDS9881.1. [P57789-3]
CCDS9882.1. [P57789-4]
RefSeqiNP_066984.1. NM_021161.4. [P57789-1]
NP_612190.1. NM_138317.2. [P57789-3]
NP_612191.1. NM_138318.2. [P57789-4]
UniGeneiHs.560255.

Genome annotation databases

EnsembliENST00000312350; ENSP00000310568; ENSG00000100433. [P57789-4]
ENST00000319231; ENSP00000312811; ENSG00000100433. [P57789-3]
ENST00000340700; ENSP00000343104; ENSG00000100433. [P57789-1]
GeneIDi54207.
KEGGihsa:54207.
UCSCiuc001xwm.4. human. [P57789-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKCNKA_HUMAN
AccessioniPrimary (citable) accession number: P57789
Secondary accession number(s): B2R8T4
, B2RCT3, B5TJL4, Q6B014, Q8TDK7, Q8TDK8, Q9HB59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: July 5, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families