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Protein

Potassium channel subfamily K member 10

Gene

KCNK10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.

GO - Molecular functioni

  • potassium channel activity Source: ProtInc
  • potassium ion leak channel activity Source: GO_Central
  • voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-1299503 TWIK related potassium channel (TREK)
R-HSA-5576886 Phase 4 - resting membrane potential

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 10
Alternative name(s):
Outward rectifying potassium channel protein TREK-2
TREK-2 K(+) channel subunit
Gene namesi
Name:KCNK10
Synonyms:TREK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100433.15
HGNCiHGNC:6273 KCNK10
MIMi605873 gene
neXtProtiNX_P57789

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 71CytoplasmicSequence analysisAdd BLAST71
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Intramembranei154 – 180Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST27
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 233CytoplasmicSequence analysisAdd BLAST31
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Intramembranei263 – 294Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST32
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 538CytoplasmicSequence analysisAdd BLAST219

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54207
OpenTargetsiENSG00000100433
PharmGKBiPA30053

Chemistry databases

ChEMBLiCHEMBL2331041

Polymorphism and mutation databases

BioMutaiKCNK10
DMDMi13431412

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017581 – 538Potassium channel subfamily K member 10Add BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP57789
PeptideAtlasiP57789
PRIDEiP57789

PTM databases

iPTMnetiP57789
PhosphoSitePlusiP57789

Expressioni

Tissue specificityi

Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.

Gene expression databases

BgeeiENSG00000100433
CleanExiHS_KCNK10
ExpressionAtlasiP57789 baseline and differential
GenevisibleiP57789 HS

Organism-specific databases

HPAiHPA030462

Interactioni

Protein-protein interaction databases

BioGridi1199241 interactor.
DIPiDIP-44050N
IntActiP57789 1 interactor.
STRINGi9606.ENSP00000310568

Structurei

Secondary structure

1538
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi69 – 115Combined sources47
Helixi121 – 136Combined sources16
Turni145 – 148Combined sources4
Beta strandi151 – 153Combined sources3
Helixi154 – 165Combined sources12
Helixi178 – 222Combined sources45
Turni223 – 225Combined sources3
Helixi232 – 247Combined sources16
Helixi249 – 258Combined sources10
Helixi263 – 274Combined sources12
Beta strandi280 – 282Combined sources3
Beta strandi288 – 290Combined sources3
Helixi296 – 325Combined sources30

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BW5X-ray3.20A/B/C/D62-335[»]
4XDJX-ray3.80A/B/C/D62-335[»]
4XDKX-ray3.60A/B/C/D62-335[»]
4XDLX-ray3.50A/B/C/D62-335[»]
ProteinModelPortaliP57789
SMRiP57789
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1418 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118858
HOGENOMiHOG000013106
HOVERGENiHBG052234
InParanoidiP57789
KOiK04920
OMAiKFPIETP
OrthoDBiEOG091G0E3R
PhylomeDBiP57789
TreeFamiTF313947

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003976 2pore_dom_K_chnl_TREK
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PRINTSiPR01333 2POREKCHANEL
PR01499 TREKCHANNEL

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P57789-1) [UniParc]FASTAAdd to basket
Also known as: TREK-2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFFLYTDFFL SLVAVPAAAP VCQPKSATNG QPPAPAPTPT PRLSISSRAT
60 70 80 90 100
VVARMEGTSQ GGLQTVMKWK TVVAIFVVVV VYLVTGGLVF RALEQPFESS
110 120 130 140 150
QKNTIALEKA EFLRDHVCVS PQELETLIQH ALDADNAGVS PIGNSSNNSS
160 170 180 190 200
HWDLGSAFFF AGTVITTIGY GNIAPSTEGG KIFCILYAIF GIPLFGFLLA
210 220 230 240 250
GIGDQLGTIF GKSIARVEKV FRKKQVSQTK IRVISTILFI LAGCIVFVTI
260 270 280 290 300
PAVIFKYIEG WTALESIYFV VVTLTTVGFG DFVAGGNAGI NYREWYKPLV
310 320 330 340 350
WFWILVGLAY FAAVLSMIGD WLRVLSKKTK EEVGEIKAHA AEWKANVTAE
360 370 380 390 400
FRETRRRLSV EIHDKLQRAA TIRSMERRRL GLDQRAHSLD MLSPEKRSVF
410 420 430 440 450
AALDTGRFKA SSQESINNRP NNLRLKGPEQ LNKHGQGASE DNIINKFGST
460 470 480 490 500
SRLTKRKNKD LKKTLPEDVQ KIYKTFRNYS LDEEKKEEET EKMCNSDNSS
510 520 530
TAMLTDCIQQ HAELENGMIP TDTKDREPEN NSLLEDRN
Length:538
Mass (Da):59,765
Last modified:April 27, 2001 - v1
Checksum:i8EA615B08D147FBC
GO
Isoform B (identifier: P57789-4) [UniParc]FASTAAdd to basket
Also known as: TREK-2b

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MFFLYTDFFLSL → MEDGFKGDRTEGCRSDS

Show »
Length:543
Mass (Da):60,111
Checksum:i17DB1AFAFAB07C46
GO
Isoform C (identifier: P57789-3) [UniParc]FASTAAdd to basket
Also known as: TREK-2c

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MFFLYTDFFLSL → MKFPIETPRKQVNWDPK

Show »
Length:543
Mass (Da):60,335
Checksum:iB158DF9AF076444D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti529E → G in AAL95705 (PubMed:11897838).Curated1
Sequence conflicti529E → G in AAL95706 (PubMed:11897838).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06021670K → Q. Corresponds to variant dbSNP:rs398263Ensembl.1
Natural variantiVAR_052428512A → T1 PublicationCorresponds to variant dbSNP:rs17762463Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0066971 – 12MFFLY…FFLSL → MEDGFKGDRTEGCRSDS in isoform B. 3 PublicationsAdd BLAST12
Alternative sequenceiVSP_0066981 – 12MFFLY…FFLSL → MKFPIETPRKQVNWDPK in isoform C. 3 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279890 mRNA Translation: AAG15191.1
AF385399 mRNA Translation: AAL95705.1
AF385400 mRNA Translation: AAL95706.1
EU978938 mRNA Translation: ACH86097.1
EU978939 mRNA Translation: ACH86098.1
EU978940 mRNA Translation: ACH86099.1
EU978941 mRNA Translation: ACH86100.1
AK313499 mRNA Translation: BAG36281.1
AK315263 mRNA Translation: BAG37680.1
AL049834 Genomic DNA No translation available.
AL133279 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81373.1
CH471061 Genomic DNA Translation: EAW81374.1
CH471061 Genomic DNA Translation: EAW81375.1
BC075021 mRNA Translation: AAH75021.1
BC075022 mRNA Translation: AAH75022.1
CCDSiCCDS9880.1 [P57789-1]
CCDS9881.1 [P57789-3]
CCDS9882.1 [P57789-4]
RefSeqiNP_066984.1, NM_021161.4 [P57789-1]
NP_612190.1, NM_138317.2 [P57789-3]
NP_612191.1, NM_138318.2 [P57789-4]
UniGeneiHs.560255

Genome annotation databases

EnsembliENST00000312350; ENSP00000310568; ENSG00000100433 [P57789-4]
ENST00000319231; ENSP00000312811; ENSG00000100433 [P57789-3]
ENST00000340700; ENSP00000343104; ENSG00000100433 [P57789-1]
GeneIDi54207
KEGGihsa:54207
UCSCiuc001xwm.4 human [P57789-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKCNKA_HUMAN
AccessioniPrimary (citable) accession number: P57789
Secondary accession number(s): B2R8T4
, B2RCT3, B5TJL4, Q6B014, Q8TDK7, Q8TDK8, Q9HB59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: March 28, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome