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Protein

Potassium channel subfamily K member 10

Gene

KCNK10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.

GO - Molecular functioni

  • potassium channel activity Source: ProtInc
  • potassium ion leak channel activity Source: GO_Central
  • voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

  • memory Source: Ensembl
  • signal transduction Source: ProtInc
  • stabilization of membrane potential Source: GO_Central
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100433-MONOMER.
ReactomeiR-HSA-1299503. TWIK related potassium channel (TREK).
R-HSA-5576886. Phase 4 - resting membrane potential.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 10
Alternative name(s):
Outward rectifying potassium channel protein TREK-2
TREK-2 K(+) channel subunit
Gene namesi
Name:KCNK10
Synonyms:TREK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:6273. KCNK10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 71CytoplasmicSequence analysisAdd BLAST71
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Intramembranei154 – 180Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST27
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 233CytoplasmicSequence analysisAdd BLAST31
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Intramembranei263 – 294Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST32
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 538CytoplasmicSequence analysisAdd BLAST219

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54207.
OpenTargetsiENSG00000100433.
PharmGKBiPA30053.

Chemistry databases

ChEMBLiCHEMBL2331041.

Polymorphism and mutation databases

BioMutaiKCNK10.
DMDMi13431412.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017581 – 538Potassium channel subfamily K member 10Add BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1
Glycosylationi147N-linked (GlcNAc...)Sequence analysis1
Glycosylationi148N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP57789.
PeptideAtlasiP57789.
PRIDEiP57789.

PTM databases

iPTMnetiP57789.
PhosphoSitePlusiP57789.

Expressioni

Tissue specificityi

Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.

Gene expression databases

BgeeiENSG00000100433.
CleanExiHS_KCNK10.
ExpressionAtlasiP57789. baseline and differential.
GenevisibleiP57789. HS.

Organism-specific databases

HPAiHPA030462.

Interactioni

Protein-protein interaction databases

BioGridi119924. 1 interactor.
DIPiDIP-44050N.
IntActiP57789. 2 interactors.
MINTiMINT-4050532.
STRINGi9606.ENSP00000310568.

Structurei

Secondary structure

1538
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi69 – 115Combined sources47
Helixi121 – 136Combined sources16
Turni145 – 148Combined sources4
Beta strandi151 – 153Combined sources3
Helixi154 – 165Combined sources12
Helixi178 – 222Combined sources45
Turni223 – 225Combined sources3
Helixi232 – 247Combined sources16
Helixi249 – 258Combined sources10
Helixi263 – 274Combined sources12
Beta strandi280 – 282Combined sources3
Beta strandi288 – 290Combined sources3
Helixi296 – 325Combined sources30

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BW5X-ray3.20A/B/C/D62-335[»]
4XDJX-ray3.80A/B/C/D62-335[»]
4XDKX-ray3.60A/B/C/D62-335[»]
4XDLX-ray3.50A/B/C/D62-335[»]
ProteinModelPortaliP57789.
SMRiP57789.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013106.
HOVERGENiHBG052234.
InParanoidiP57789.
KOiK04920.
OMAiKQVNWDP.
OrthoDBiEOG091G0E3R.
PhylomeDBiP57789.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003976. 2pore_dom_K_chnl_TREK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P57789-1) [UniParc]FASTAAdd to basket
Also known as: TREK-2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFFLYTDFFL SLVAVPAAAP VCQPKSATNG QPPAPAPTPT PRLSISSRAT
60 70 80 90 100
VVARMEGTSQ GGLQTVMKWK TVVAIFVVVV VYLVTGGLVF RALEQPFESS
110 120 130 140 150
QKNTIALEKA EFLRDHVCVS PQELETLIQH ALDADNAGVS PIGNSSNNSS
160 170 180 190 200
HWDLGSAFFF AGTVITTIGY GNIAPSTEGG KIFCILYAIF GIPLFGFLLA
210 220 230 240 250
GIGDQLGTIF GKSIARVEKV FRKKQVSQTK IRVISTILFI LAGCIVFVTI
260 270 280 290 300
PAVIFKYIEG WTALESIYFV VVTLTTVGFG DFVAGGNAGI NYREWYKPLV
310 320 330 340 350
WFWILVGLAY FAAVLSMIGD WLRVLSKKTK EEVGEIKAHA AEWKANVTAE
360 370 380 390 400
FRETRRRLSV EIHDKLQRAA TIRSMERRRL GLDQRAHSLD MLSPEKRSVF
410 420 430 440 450
AALDTGRFKA SSQESINNRP NNLRLKGPEQ LNKHGQGASE DNIINKFGST
460 470 480 490 500
SRLTKRKNKD LKKTLPEDVQ KIYKTFRNYS LDEEKKEEET EKMCNSDNSS
510 520 530
TAMLTDCIQQ HAELENGMIP TDTKDREPEN NSLLEDRN
Length:538
Mass (Da):59,765
Last modified:April 27, 2001 - v1
Checksum:i8EA615B08D147FBC
GO
Isoform B (identifier: P57789-4) [UniParc]FASTAAdd to basket
Also known as: TREK-2b

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MFFLYTDFFLSL → MEDGFKGDRTEGCRSDS

Show »
Length:543
Mass (Da):60,111
Checksum:i17DB1AFAFAB07C46
GO
Isoform C (identifier: P57789-3) [UniParc]FASTAAdd to basket
Also known as: TREK-2c

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MFFLYTDFFLSL → MKFPIETPRKQVNWDPK

Show »
Length:543
Mass (Da):60,335
Checksum:iB158DF9AF076444D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti529E → G in AAL95705 (PubMed:11897838).Curated1
Sequence conflicti529E → G in AAL95706 (PubMed:11897838).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06021670K → Q.Corresponds to variant rs398263dbSNPEnsembl.1
Natural variantiVAR_052428512A → T.1 PublicationCorresponds to variant rs17762463dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0066971 – 12MFFLY…FFLSL → MEDGFKGDRTEGCRSDS in isoform B. 3 PublicationsAdd BLAST12
Alternative sequenceiVSP_0066981 – 12MFFLY…FFLSL → MKFPIETPRKQVNWDPK in isoform C. 3 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279890 mRNA. Translation: AAG15191.1.
AF385399 mRNA. Translation: AAL95705.1.
AF385400 mRNA. Translation: AAL95706.1.
EU978938 mRNA. Translation: ACH86097.1.
EU978939 mRNA. Translation: ACH86098.1.
EU978940 mRNA. Translation: ACH86099.1.
EU978941 mRNA. Translation: ACH86100.1.
AK313499 mRNA. Translation: BAG36281.1.
AK315263 mRNA. Translation: BAG37680.1.
AL049834 Genomic DNA. No translation available.
AL133279 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81373.1.
CH471061 Genomic DNA. Translation: EAW81374.1.
CH471061 Genomic DNA. Translation: EAW81375.1.
BC075021 mRNA. Translation: AAH75021.1.
BC075022 mRNA. Translation: AAH75022.1.
CCDSiCCDS9880.1. [P57789-1]
CCDS9881.1. [P57789-3]
CCDS9882.1. [P57789-4]
RefSeqiNP_066984.1. NM_021161.4. [P57789-1]
NP_612190.1. NM_138317.2. [P57789-3]
NP_612191.1. NM_138318.2. [P57789-4]
UniGeneiHs.560255.

Genome annotation databases

EnsembliENST00000312350; ENSP00000310568; ENSG00000100433. [P57789-4]
ENST00000319231; ENSP00000312811; ENSG00000100433. [P57789-3]
ENST00000340700; ENSP00000343104; ENSG00000100433. [P57789-1]
GeneIDi54207.
KEGGihsa:54207.
UCSCiuc001xwm.4. human. [P57789-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279890 mRNA. Translation: AAG15191.1.
AF385399 mRNA. Translation: AAL95705.1.
AF385400 mRNA. Translation: AAL95706.1.
EU978938 mRNA. Translation: ACH86097.1.
EU978939 mRNA. Translation: ACH86098.1.
EU978940 mRNA. Translation: ACH86099.1.
EU978941 mRNA. Translation: ACH86100.1.
AK313499 mRNA. Translation: BAG36281.1.
AK315263 mRNA. Translation: BAG37680.1.
AL049834 Genomic DNA. No translation available.
AL133279 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81373.1.
CH471061 Genomic DNA. Translation: EAW81374.1.
CH471061 Genomic DNA. Translation: EAW81375.1.
BC075021 mRNA. Translation: AAH75021.1.
BC075022 mRNA. Translation: AAH75022.1.
CCDSiCCDS9880.1. [P57789-1]
CCDS9881.1. [P57789-3]
CCDS9882.1. [P57789-4]
RefSeqiNP_066984.1. NM_021161.4. [P57789-1]
NP_612190.1. NM_138317.2. [P57789-3]
NP_612191.1. NM_138318.2. [P57789-4]
UniGeneiHs.560255.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BW5X-ray3.20A/B/C/D62-335[»]
4XDJX-ray3.80A/B/C/D62-335[»]
4XDKX-ray3.60A/B/C/D62-335[»]
4XDLX-ray3.50A/B/C/D62-335[»]
ProteinModelPortaliP57789.
SMRiP57789.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119924. 1 interactor.
DIPiDIP-44050N.
IntActiP57789. 2 interactors.
MINTiMINT-4050532.
STRINGi9606.ENSP00000310568.

Chemistry databases

ChEMBLiCHEMBL2331041.

PTM databases

iPTMnetiP57789.
PhosphoSitePlusiP57789.

Polymorphism and mutation databases

BioMutaiKCNK10.
DMDMi13431412.

Proteomic databases

PaxDbiP57789.
PeptideAtlasiP57789.
PRIDEiP57789.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312350; ENSP00000310568; ENSG00000100433. [P57789-4]
ENST00000319231; ENSP00000312811; ENSG00000100433. [P57789-3]
ENST00000340700; ENSP00000343104; ENSG00000100433. [P57789-1]
GeneIDi54207.
KEGGihsa:54207.
UCSCiuc001xwm.4. human. [P57789-1]

Organism-specific databases

CTDi54207.
DisGeNETi54207.
GeneCardsiKCNK10.
HGNCiHGNC:6273. KCNK10.
HPAiHPA030462.
MIMi605873. gene.
neXtProtiNX_P57789.
OpenTargetsiENSG00000100433.
PharmGKBiPA30053.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013106.
HOVERGENiHBG052234.
InParanoidiP57789.
KOiK04920.
OMAiKQVNWDP.
OrthoDBiEOG091G0E3R.
PhylomeDBiP57789.
TreeFamiTF313947.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100433-MONOMER.
ReactomeiR-HSA-1299503. TWIK related potassium channel (TREK).
R-HSA-5576886. Phase 4 - resting membrane potential.

Miscellaneous databases

ChiTaRSiKCNK10. human.
GeneWikiiKCNK10.
GenomeRNAii54207.
PROiP57789.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100433.
CleanExiHS_KCNK10.
ExpressionAtlasiP57789. baseline and differential.
GenevisibleiP57789. HS.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003976. 2pore_dom_K_chnl_TREK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNKA_HUMAN
AccessioniPrimary (citable) accession number: P57789
Secondary accession number(s): B2R8T4
, B2RCT3, B5TJL4, Q6B014, Q8TDK7, Q8TDK8, Q9HB59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 2, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.