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P57787

- MOT4_MOUSE

UniProt

P57787 - MOT4_MOUSE

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Protein
Monocarboxylate transporter 4
Gene
Slc16a3, Mct4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate By similarity.

GO - Molecular functioni

  1. secondary active monocarboxylate transmembrane transporter activity Source: InterPro
  2. symporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_211508. Basigin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 4
Short name:
MCT 4
Alternative name(s):
Solute carrier family 16 member 3
Gene namesi
Name:Slc16a3
Synonyms:Mct4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1933438. Slc16a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1716Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei18 – 3821Helical; Reviewed prediction
Add
BLAST
Topological domaini39 – 6123Extracellular Reviewed prediction
Add
BLAST
Transmembranei62 – 8221Helical; Reviewed prediction
Add
BLAST
Topological domaini83 – 842Cytoplasmic Reviewed prediction
Transmembranei85 – 10521Helical; Reviewed prediction
Add
BLAST
Topological domaini106 – 1094Extracellular Reviewed prediction
Transmembranei110 – 13021Helical; Reviewed prediction
Add
BLAST
Topological domaini131 – 14919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei150 – 17021Helical; Reviewed prediction
Add
BLAST
Topological domaini171 – 1799Extracellular Reviewed prediction
Transmembranei180 – 20021Helical; Reviewed prediction
Add
BLAST
Topological domaini201 – 23131Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei232 – 25221Helical; Reviewed prediction
Add
BLAST
Topological domaini253 – 26715Extracellular Reviewed prediction
Add
BLAST
Transmembranei268 – 28821Helical; Reviewed prediction
Add
BLAST
Topological domaini289 – 29810Cytoplasmic Reviewed prediction
Transmembranei299 – 31921Helical; Reviewed prediction
Add
BLAST
Topological domaini320 – 3212Extracellular Reviewed prediction
Transmembranei322 – 34221Helical; Reviewed prediction
Add
BLAST
Topological domaini343 – 35513Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei356 – 37621Helical; Reviewed prediction
Add
BLAST
Topological domaini377 – 39115Extracellular Reviewed prediction
Add
BLAST
Transmembranei392 – 41221Helical; Reviewed prediction
Add
BLAST
Topological domaini413 – 47058Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. actin cytoskeleton Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. nuclear membrane Source: Ensembl
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 470469Monocarboxylate transporter 4
PRO_0000211395Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei430 – 4301Phosphoserine1 Publication
Modified residuei465 – 4651Phosphothreonine By similarity
Modified residuei469 – 4691Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP57787.
PRIDEiP57787.

PTM databases

PhosphoSiteiP57787.

Expressioni

Gene expression databases

ArrayExpressiP57787.
BgeeiP57787.
GenevestigatoriP57787.

Interactioni

Protein-protein interaction databases

IntActiP57787. 1 interaction.
MINTiMINT-4102245.

Structurei

3D structure databases

ProteinModelPortaliP57787.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG321880.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiP57787.
KOiK08180.
OMAiMFARPAS.
OrthoDBiEOG7W9RTN.
PhylomeDBiP57787.
TreeFamiTF313792.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004743. Monocarb_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57787-1 [UniParc]FASTAAdd to Basket

« Hide

MGGAVVDEGP TGIKAPDGGW GWAVLFGCFI ITGFSYAFPK AVSVFFKELM    50
HEFGIGYSDT AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASL 100
GMVAASFCRS IIQIYLTTGV ITGLGLALNF QPSLIMLNRY FNKRRPIANG 150
LAAAGSPVFL CALSPLGQLL QDHYGWRGGF LILGGLLLNC CVCAALMRPL 200
VAPQVGGGTE PRGPQRPPQR LLDLSVFRDR GFLIYAVAAS IMVLGLFVPP 250
VFVVSYAKDM GVPDTKAAFL LTILGFIDIF ARPTAGFITG LKKVRPYSVY 300
LFSFAMFFNG FTDLTGSTAT DYGGLVVFCI FFGISYGMVG ALQFEVLMAI 350
VGTQKFSSAI GLVLLLEAVA VLIGPPSGGK LLDATKVYKY VFILAGAEVL 400
TSSLVLLLGN FFCIGKRKRP EVTEPEEVAS EEKLHKPPVD VGVDSREVEH 450
FLKAEPEKNG EVVHTPETSV 470
Length:470
Mass (Da):50,373
Last modified:April 27, 2001 - v1
Checksum:i34E872AC1C625DE7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF178954 mRNA. Translation: AAG24271.1.
AF204397 Genomic DNA. Translation: AAF67525.1.
BC046525 mRNA. Translation: AAH46525.1.
CCDSiCCDS25761.1.
RefSeqiNP_001033742.1. NM_001038653.1.
NP_001033743.1. NM_001038654.1.
NP_109621.1. NM_030696.3.
UniGeneiMm.28632.

Genome annotation databases

EnsembliENSMUST00000070653; ENSMUSP00000068854; ENSMUSG00000025161.
ENSMUST00000100130; ENSMUSP00000097706; ENSMUSG00000025161.
ENSMUST00000168579; ENSMUSP00000125846; ENSMUSG00000025161.
GeneIDi80879.
KEGGimmu:80879.
UCSCiuc007muw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF178954 mRNA. Translation: AAG24271.1 .
AF204397 Genomic DNA. Translation: AAF67525.1 .
BC046525 mRNA. Translation: AAH46525.1 .
CCDSi CCDS25761.1.
RefSeqi NP_001033742.1. NM_001038653.1.
NP_001033743.1. NM_001038654.1.
NP_109621.1. NM_030696.3.
UniGenei Mm.28632.

3D structure databases

ProteinModelPortali P57787.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P57787. 1 interaction.
MINTi MINT-4102245.

PTM databases

PhosphoSitei P57787.

Proteomic databases

PaxDbi P57787.
PRIDEi P57787.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000070653 ; ENSMUSP00000068854 ; ENSMUSG00000025161 .
ENSMUST00000100130 ; ENSMUSP00000097706 ; ENSMUSG00000025161 .
ENSMUST00000168579 ; ENSMUSP00000125846 ; ENSMUSG00000025161 .
GeneIDi 80879.
KEGGi mmu:80879.
UCSCi uc007muw.1. mouse.

Organism-specific databases

CTDi 9123.
MGIi MGI:1933438. Slc16a3.

Phylogenomic databases

eggNOGi NOG321880.
HOGENOMi HOG000280688.
HOVERGENi HBG006384.
InParanoidi P57787.
KOi K08180.
OMAi MFARPAS.
OrthoDBi EOG7W9RTN.
PhylomeDBi P57787.
TreeFami TF313792.

Enzyme and pathway databases

Reactomei REACT_211508. Basigin interactions.

Miscellaneous databases

NextBioi 350183.
PROi P57787.
SOURCEi Search...

Gene expression databases

ArrayExpressi P57787.
Bgeei P57787.
Genevestigatori P57787.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004743. Monocarb_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00892. 2A0113. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of mouse MCT3 and MCT4."
    Yoon H., Philp N.J.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C3H.
    Tissue: Skeletal muscle.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary gland.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMOT4_MOUSE
AccessioniPrimary (citable) accession number: P57787
Secondary accession number(s): Q9ES80, Q9ESF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: September 3, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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