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P57787

- MOT4_MOUSE

UniProt

P57787 - MOT4_MOUSE

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Protein

Monocarboxylate transporter 4

Gene

Slc16a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl
  2. secondary active monocarboxylate transmembrane transporter activity Source: InterPro
  3. symporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_211508. Basigin interactions.
REACT_253080. Pyruvate metabolism.
REACT_259683. Proton-coupled monocarboxylate transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 4
Short name:
MCT 4
Alternative name(s):
Solute carrier family 16 member 3
Gene namesi
Name:Slc16a3
Synonyms:Mct4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1933438. Slc16a3.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1716CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei18 – 3821HelicalSequence AnalysisAdd
BLAST
Topological domaini39 – 6123ExtracellularSequence AnalysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST
Topological domaini83 – 842CytoplasmicSequence Analysis
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST
Topological domaini106 – 1094ExtracellularSequence Analysis
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Topological domaini131 – 14919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence AnalysisAdd
BLAST
Topological domaini171 – 1799ExtracellularSequence Analysis
Transmembranei180 – 20021HelicalSequence AnalysisAdd
BLAST
Topological domaini201 – 23131CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST
Topological domaini253 – 26715ExtracellularSequence AnalysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence AnalysisAdd
BLAST
Topological domaini289 – 29810CytoplasmicSequence Analysis
Transmembranei299 – 31921HelicalSequence AnalysisAdd
BLAST
Topological domaini320 – 3212ExtracellularSequence Analysis
Transmembranei322 – 34221HelicalSequence AnalysisAdd
BLAST
Topological domaini343 – 35513CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei356 – 37621HelicalSequence AnalysisAdd
BLAST
Topological domaini377 – 39115ExtracellularSequence AnalysisAdd
BLAST
Transmembranei392 – 41221HelicalSequence AnalysisAdd
BLAST
Topological domaini413 – 47058CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. actin cytoskeleton Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. nuclear membrane Source: Ensembl
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 470469Monocarboxylate transporter 4PRO_0000211395Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei430 – 4301Phosphoserine1 Publication
Modified residuei465 – 4651PhosphothreonineBy similarity
Modified residuei469 – 4691PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP57787.
PaxDbiP57787.
PRIDEiP57787.

PTM databases

PhosphoSiteiP57787.

Expressioni

Gene expression databases

BgeeiP57787.
ExpressionAtlasiP57787. baseline and differential.
GenevestigatoriP57787.

Interactioni

Protein-protein interaction databases

IntActiP57787. 1 interaction.
MINTiMINT-4102245.

Structurei

3D structure databases

ProteinModelPortaliP57787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG321880.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiP57787.
KOiK08180.
OMAiMFARPAS.
OrthoDBiEOG7W9RTN.
PhylomeDBiP57787.
TreeFamiTF313792.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004743. Monocarb_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57787-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGGAVVDEGP TGIKAPDGGW GWAVLFGCFI ITGFSYAFPK AVSVFFKELM
60 70 80 90 100
HEFGIGYSDT AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASL
110 120 130 140 150
GMVAASFCRS IIQIYLTTGV ITGLGLALNF QPSLIMLNRY FNKRRPIANG
160 170 180 190 200
LAAAGSPVFL CALSPLGQLL QDHYGWRGGF LILGGLLLNC CVCAALMRPL
210 220 230 240 250
VAPQVGGGTE PRGPQRPPQR LLDLSVFRDR GFLIYAVAAS IMVLGLFVPP
260 270 280 290 300
VFVVSYAKDM GVPDTKAAFL LTILGFIDIF ARPTAGFITG LKKVRPYSVY
310 320 330 340 350
LFSFAMFFNG FTDLTGSTAT DYGGLVVFCI FFGISYGMVG ALQFEVLMAI
360 370 380 390 400
VGTQKFSSAI GLVLLLEAVA VLIGPPSGGK LLDATKVYKY VFILAGAEVL
410 420 430 440 450
TSSLVLLLGN FFCIGKRKRP EVTEPEEVAS EEKLHKPPVD VGVDSREVEH
460 470
FLKAEPEKNG EVVHTPETSV
Length:470
Mass (Da):50,373
Last modified:April 27, 2001 - v1
Checksum:i34E872AC1C625DE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178954 mRNA. Translation: AAG24271.1.
AF204397 Genomic DNA. Translation: AAF67525.1.
BC046525 mRNA. Translation: AAH46525.1.
CCDSiCCDS25761.1.
RefSeqiNP_001033742.1. NM_001038653.1.
NP_001033743.1. NM_001038654.1.
NP_109621.1. NM_030696.3.
UniGeneiMm.28632.

Genome annotation databases

EnsembliENSMUST00000070653; ENSMUSP00000068854; ENSMUSG00000025161.
ENSMUST00000100130; ENSMUSP00000097706; ENSMUSG00000025161.
ENSMUST00000168579; ENSMUSP00000125846; ENSMUSG00000025161.
GeneIDi80879.
KEGGimmu:80879.
UCSCiuc007muw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178954 mRNA. Translation: AAG24271.1 .
AF204397 Genomic DNA. Translation: AAF67525.1 .
BC046525 mRNA. Translation: AAH46525.1 .
CCDSi CCDS25761.1.
RefSeqi NP_001033742.1. NM_001038653.1.
NP_001033743.1. NM_001038654.1.
NP_109621.1. NM_030696.3.
UniGenei Mm.28632.

3D structure databases

ProteinModelPortali P57787.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P57787. 1 interaction.
MINTi MINT-4102245.

PTM databases

PhosphoSitei P57787.

Proteomic databases

MaxQBi P57787.
PaxDbi P57787.
PRIDEi P57787.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000070653 ; ENSMUSP00000068854 ; ENSMUSG00000025161 .
ENSMUST00000100130 ; ENSMUSP00000097706 ; ENSMUSG00000025161 .
ENSMUST00000168579 ; ENSMUSP00000125846 ; ENSMUSG00000025161 .
GeneIDi 80879.
KEGGi mmu:80879.
UCSCi uc007muw.1. mouse.

Organism-specific databases

CTDi 9123.
MGIi MGI:1933438. Slc16a3.

Phylogenomic databases

eggNOGi NOG321880.
HOGENOMi HOG000280688.
HOVERGENi HBG006384.
InParanoidi P57787.
KOi K08180.
OMAi MFARPAS.
OrthoDBi EOG7W9RTN.
PhylomeDBi P57787.
TreeFami TF313792.

Enzyme and pathway databases

Reactomei REACT_211508. Basigin interactions.
REACT_253080. Pyruvate metabolism.
REACT_259683. Proton-coupled monocarboxylate transport.

Miscellaneous databases

NextBioi 350183.
PROi P57787.
SOURCEi Search...

Gene expression databases

Bgeei P57787.
ExpressionAtlasi P57787. baseline and differential.
Genevestigatori P57787.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004743. Monocarb_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00892. 2A0113. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of mouse MCT3 and MCT4."
    Yoon H., Philp N.J.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C3H.
    Tissue: Skeletal muscle.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary gland.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMOT4_MOUSE
AccessioniPrimary (citable) accession number: P57787
Secondary accession number(s): Q9ES80, Q9ESF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 26, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3