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P57787

- MOT4_MOUSE

UniProt

P57787 - MOT4_MOUSE

Protein

Monocarboxylate transporter 4

Gene

Slc16a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate By similarity.By similarity

    GO - Molecular functioni

    1. secondary active monocarboxylate transmembrane transporter activity Source: InterPro
    2. symporter activity Source: UniProtKB-KW

    Keywords - Biological processi

    Symport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_211508. Basigin interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Monocarboxylate transporter 4
    Short name:
    MCT 4
    Alternative name(s):
    Solute carrier family 16 member 3
    Gene namesi
    Name:Slc16a3
    Synonyms:Mct4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1933438. Slc16a3.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. actin cytoskeleton Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. nuclear membrane Source: Ensembl
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 470469Monocarboxylate transporter 4PRO_0000211395Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei430 – 4301Phosphoserine1 Publication
    Modified residuei465 – 4651PhosphothreonineBy similarity
    Modified residuei469 – 4691PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP57787.
    PRIDEiP57787.

    PTM databases

    PhosphoSiteiP57787.

    Expressioni

    Gene expression databases

    ArrayExpressiP57787.
    BgeeiP57787.
    GenevestigatoriP57787.

    Interactioni

    Protein-protein interaction databases

    IntActiP57787. 1 interaction.
    MINTiMINT-4102245.

    Structurei

    3D structure databases

    ProteinModelPortaliP57787.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 1716CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini39 – 6123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini83 – 842CytoplasmicSequence Analysis
    Topological domaini106 – 1094ExtracellularSequence Analysis
    Topological domaini131 – 14919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini171 – 1799ExtracellularSequence Analysis
    Topological domaini201 – 23131CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini253 – 26715ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini289 – 29810CytoplasmicSequence Analysis
    Topological domaini320 – 3212ExtracellularSequence Analysis
    Topological domaini343 – 35513CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini377 – 39115ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini413 – 47058CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei180 – 20021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei299 – 31921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei322 – 34221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei356 – 37621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei392 – 41221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG321880.
    HOGENOMiHOG000280688.
    HOVERGENiHBG006384.
    InParanoidiP57787.
    KOiK08180.
    OMAiMFARPAS.
    OrthoDBiEOG7W9RTN.
    PhylomeDBiP57787.
    TreeFamiTF313792.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004743. Monocarb_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00892. 2A0113. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P57787-1 [UniParc]FASTAAdd to Basket

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    MGGAVVDEGP TGIKAPDGGW GWAVLFGCFI ITGFSYAFPK AVSVFFKELM    50
    HEFGIGYSDT AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASL 100
    GMVAASFCRS IIQIYLTTGV ITGLGLALNF QPSLIMLNRY FNKRRPIANG 150
    LAAAGSPVFL CALSPLGQLL QDHYGWRGGF LILGGLLLNC CVCAALMRPL 200
    VAPQVGGGTE PRGPQRPPQR LLDLSVFRDR GFLIYAVAAS IMVLGLFVPP 250
    VFVVSYAKDM GVPDTKAAFL LTILGFIDIF ARPTAGFITG LKKVRPYSVY 300
    LFSFAMFFNG FTDLTGSTAT DYGGLVVFCI FFGISYGMVG ALQFEVLMAI 350
    VGTQKFSSAI GLVLLLEAVA VLIGPPSGGK LLDATKVYKY VFILAGAEVL 400
    TSSLVLLLGN FFCIGKRKRP EVTEPEEVAS EEKLHKPPVD VGVDSREVEH 450
    FLKAEPEKNG EVVHTPETSV 470
    Length:470
    Mass (Da):50,373
    Last modified:April 27, 2001 - v1
    Checksum:i34E872AC1C625DE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF178954 mRNA. Translation: AAG24271.1.
    AF204397 Genomic DNA. Translation: AAF67525.1.
    BC046525 mRNA. Translation: AAH46525.1.
    CCDSiCCDS25761.1.
    RefSeqiNP_001033742.1. NM_001038653.1.
    NP_001033743.1. NM_001038654.1.
    NP_109621.1. NM_030696.3.
    UniGeneiMm.28632.

    Genome annotation databases

    EnsembliENSMUST00000070653; ENSMUSP00000068854; ENSMUSG00000025161.
    ENSMUST00000100130; ENSMUSP00000097706; ENSMUSG00000025161.
    ENSMUST00000168579; ENSMUSP00000125846; ENSMUSG00000025161.
    GeneIDi80879.
    KEGGimmu:80879.
    UCSCiuc007muw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF178954 mRNA. Translation: AAG24271.1 .
    AF204397 Genomic DNA. Translation: AAF67525.1 .
    BC046525 mRNA. Translation: AAH46525.1 .
    CCDSi CCDS25761.1.
    RefSeqi NP_001033742.1. NM_001038653.1.
    NP_001033743.1. NM_001038654.1.
    NP_109621.1. NM_030696.3.
    UniGenei Mm.28632.

    3D structure databases

    ProteinModelPortali P57787.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P57787. 1 interaction.
    MINTi MINT-4102245.

    PTM databases

    PhosphoSitei P57787.

    Proteomic databases

    PaxDbi P57787.
    PRIDEi P57787.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000070653 ; ENSMUSP00000068854 ; ENSMUSG00000025161 .
    ENSMUST00000100130 ; ENSMUSP00000097706 ; ENSMUSG00000025161 .
    ENSMUST00000168579 ; ENSMUSP00000125846 ; ENSMUSG00000025161 .
    GeneIDi 80879.
    KEGGi mmu:80879.
    UCSCi uc007muw.1. mouse.

    Organism-specific databases

    CTDi 9123.
    MGIi MGI:1933438. Slc16a3.

    Phylogenomic databases

    eggNOGi NOG321880.
    HOGENOMi HOG000280688.
    HOVERGENi HBG006384.
    InParanoidi P57787.
    KOi K08180.
    OMAi MFARPAS.
    OrthoDBi EOG7W9RTN.
    PhylomeDBi P57787.
    TreeFami TF313792.

    Enzyme and pathway databases

    Reactomei REACT_211508. Basigin interactions.

    Miscellaneous databases

    NextBioi 350183.
    PROi P57787.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P57787.
    Bgeei P57787.
    Genevestigatori P57787.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004743. Monocarb_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    TIGRFAMsi TIGR00892. 2A0113. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of mouse MCT3 and MCT4."
      Yoon H., Philp N.J.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C3H.
      Tissue: Skeletal muscle.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129.
      Tissue: Mammary gland.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMOT4_MOUSE
    AccessioniPrimary (citable) accession number: P57787
    Secondary accession number(s): Q9ES80, Q9ESF8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3