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Protein

Monocarboxylate transporter 4

Gene

Slc16a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-433692. Proton-coupled monocarboxylate transport.
R-MMU-70268. Pyruvate metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 4
Short name:
MCT 4
Alternative name(s):
Solute carrier family 16 member 3
Gene namesi
Name:Slc16a3
Synonyms:Mct4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1933438. Slc16a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 17CytoplasmicSequence analysisAdd BLAST16
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 61ExtracellularSequence analysisAdd BLAST23
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 84CytoplasmicSequence analysis2
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 109ExtracellularSequence analysis4
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 149CytoplasmicSequence analysisAdd BLAST19
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 179ExtracellularSequence analysis9
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 231CytoplasmicSequence analysisAdd BLAST31
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 267ExtracellularSequence analysisAdd BLAST15
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Topological domaini289 – 298CytoplasmicSequence analysis10
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 321ExtracellularSequence analysis2
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 355CytoplasmicSequence analysisAdd BLAST13
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Topological domaini377 – 391ExtracellularSequence analysisAdd BLAST15
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Topological domaini413 – 470CytoplasmicSequence analysisAdd BLAST58

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002113952 – 470Monocarboxylate transporter 4Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei430PhosphoserineCombined sources1
Modified residuei465PhosphothreonineBy similarity1
Modified residuei469PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP57787.
PaxDbiP57787.
PeptideAtlasiP57787.
PRIDEiP57787.

PTM databases

iPTMnetiP57787.
PhosphoSitePlusiP57787.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025161.
ExpressionAtlasiP57787. baseline and differential.
GenevisibleiP57787. MM.

Interactioni

Protein-protein interaction databases

IntActiP57787. 1 interactor.
MINTiMINT-4102245.
STRINGi10090.ENSMUSP00000068854.

Structurei

3D structure databases

ProteinModelPortaliP57787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KCR7. Eukaryota.
ENOG4111A50. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiP57787.
KOiK08180.
OMAiMGVPDTK.
OrthoDBiEOG091G05SW.
PhylomeDBiP57787.
TreeFamiTF313792.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004743. MCT.
IPR030756. MCT4.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF27. PTHR11360:SF27. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGAVVDEGP TGIKAPDGGW GWAVLFGCFI ITGFSYAFPK AVSVFFKELM
60 70 80 90 100
HEFGIGYSDT AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASL
110 120 130 140 150
GMVAASFCRS IIQIYLTTGV ITGLGLALNF QPSLIMLNRY FNKRRPIANG
160 170 180 190 200
LAAAGSPVFL CALSPLGQLL QDHYGWRGGF LILGGLLLNC CVCAALMRPL
210 220 230 240 250
VAPQVGGGTE PRGPQRPPQR LLDLSVFRDR GFLIYAVAAS IMVLGLFVPP
260 270 280 290 300
VFVVSYAKDM GVPDTKAAFL LTILGFIDIF ARPTAGFITG LKKVRPYSVY
310 320 330 340 350
LFSFAMFFNG FTDLTGSTAT DYGGLVVFCI FFGISYGMVG ALQFEVLMAI
360 370 380 390 400
VGTQKFSSAI GLVLLLEAVA VLIGPPSGGK LLDATKVYKY VFILAGAEVL
410 420 430 440 450
TSSLVLLLGN FFCIGKRKRP EVTEPEEVAS EEKLHKPPVD VGVDSREVEH
460 470
FLKAEPEKNG EVVHTPETSV
Length:470
Mass (Da):50,373
Last modified:April 27, 2001 - v1
Checksum:i34E872AC1C625DE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178954 mRNA. Translation: AAG24271.1.
AF204397 Genomic DNA. Translation: AAF67525.1.
BC046525 mRNA. Translation: AAH46525.1.
CCDSiCCDS25761.1.
RefSeqiNP_001033742.1. NM_001038653.1.
NP_001033743.1. NM_001038654.1.
NP_109621.1. NM_030696.3.
XP_011247623.1. XM_011249321.2.
XP_011247624.1. XM_011249322.2.
UniGeneiMm.28632.

Genome annotation databases

EnsembliENSMUST00000070653; ENSMUSP00000068854; ENSMUSG00000025161.
ENSMUST00000100130; ENSMUSP00000097706; ENSMUSG00000025161.
ENSMUST00000168579; ENSMUSP00000125846; ENSMUSG00000025161.
GeneIDi80879.
KEGGimmu:80879.
UCSCiuc007muw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178954 mRNA. Translation: AAG24271.1.
AF204397 Genomic DNA. Translation: AAF67525.1.
BC046525 mRNA. Translation: AAH46525.1.
CCDSiCCDS25761.1.
RefSeqiNP_001033742.1. NM_001038653.1.
NP_001033743.1. NM_001038654.1.
NP_109621.1. NM_030696.3.
XP_011247623.1. XM_011249321.2.
XP_011247624.1. XM_011249322.2.
UniGeneiMm.28632.

3D structure databases

ProteinModelPortaliP57787.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP57787. 1 interactor.
MINTiMINT-4102245.
STRINGi10090.ENSMUSP00000068854.

PTM databases

iPTMnetiP57787.
PhosphoSitePlusiP57787.

Proteomic databases

EPDiP57787.
PaxDbiP57787.
PeptideAtlasiP57787.
PRIDEiP57787.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070653; ENSMUSP00000068854; ENSMUSG00000025161.
ENSMUST00000100130; ENSMUSP00000097706; ENSMUSG00000025161.
ENSMUST00000168579; ENSMUSP00000125846; ENSMUSG00000025161.
GeneIDi80879.
KEGGimmu:80879.
UCSCiuc007muw.1. mouse.

Organism-specific databases

CTDi9123.
MGIiMGI:1933438. Slc16a3.

Phylogenomic databases

eggNOGiENOG410KCR7. Eukaryota.
ENOG4111A50. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiP57787.
KOiK08180.
OMAiMGVPDTK.
OrthoDBiEOG091G05SW.
PhylomeDBiP57787.
TreeFamiTF313792.

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-433692. Proton-coupled monocarboxylate transport.
R-MMU-70268. Pyruvate metabolism.

Miscellaneous databases

PROiP57787.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025161.
ExpressionAtlasiP57787. baseline and differential.
GenevisibleiP57787. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004743. MCT.
IPR030756. MCT4.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF27. PTHR11360:SF27. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOT4_MOUSE
AccessioniPrimary (citable) accession number: P57787
Secondary accession number(s): Q9ES80, Q9ESF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.