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P57787 (MOT4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Monocarboxylate transporter 4

Short name=MCT 4
Alternative name(s):
Solute carrier family 16 member 3
Gene names
Name:Slc16a3
Synonyms:Mct4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 470469Monocarboxylate transporter 4
PRO_0000211395

Regions

Topological domain2 – 1716Cytoplasmic Potential
Transmembrane18 – 3821Helical; Potential
Topological domain39 – 6123Extracellular Potential
Transmembrane62 – 8221Helical; Potential
Topological domain83 – 842Cytoplasmic Potential
Transmembrane85 – 10521Helical; Potential
Topological domain106 – 1094Extracellular Potential
Transmembrane110 – 13021Helical; Potential
Topological domain131 – 14919Cytoplasmic Potential
Transmembrane150 – 17021Helical; Potential
Topological domain171 – 1799Extracellular Potential
Transmembrane180 – 20021Helical; Potential
Topological domain201 – 23131Cytoplasmic Potential
Transmembrane232 – 25221Helical; Potential
Topological domain253 – 26715Extracellular Potential
Transmembrane268 – 28821Helical; Potential
Topological domain289 – 29810Cytoplasmic Potential
Transmembrane299 – 31921Helical; Potential
Topological domain320 – 3212Extracellular Potential
Transmembrane322 – 34221Helical; Potential
Topological domain343 – 35513Cytoplasmic Potential
Transmembrane356 – 37621Helical; Potential
Topological domain377 – 39115Extracellular Potential
Transmembrane392 – 41221Helical; Potential
Topological domain413 – 47058Cytoplasmic Potential

Amino acid modifications

Modified residue4301Phosphoserine Ref.3
Modified residue4651Phosphothreonine By similarity
Modified residue4691Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P57787 [UniParc].

Last modified April 27, 2001. Version 1.
Checksum: 34E872AC1C625DE7

FASTA47050,373
        10         20         30         40         50         60 
MGGAVVDEGP TGIKAPDGGW GWAVLFGCFI ITGFSYAFPK AVSVFFKELM HEFGIGYSDT 

        70         80         90        100        110        120 
AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASL GMVAASFCRS IIQIYLTTGV 

       130        140        150        160        170        180 
ITGLGLALNF QPSLIMLNRY FNKRRPIANG LAAAGSPVFL CALSPLGQLL QDHYGWRGGF 

       190        200        210        220        230        240 
LILGGLLLNC CVCAALMRPL VAPQVGGGTE PRGPQRPPQR LLDLSVFRDR GFLIYAVAAS 

       250        260        270        280        290        300 
IMVLGLFVPP VFVVSYAKDM GVPDTKAAFL LTILGFIDIF ARPTAGFITG LKKVRPYSVY 

       310        320        330        340        350        360 
LFSFAMFFNG FTDLTGSTAT DYGGLVVFCI FFGISYGMVG ALQFEVLMAI VGTQKFSSAI 

       370        380        390        400        410        420 
GLVLLLEAVA VLIGPPSGGK LLDATKVYKY VFILAGAEVL TSSLVLLLGN FFCIGKRKRP 

       430        440        450        460        470 
EVTEPEEVAS EEKLHKPPVD VGVDSREVEH FLKAEPEKNG EVVHTPETSV 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of mouse MCT3 and MCT4."
Yoon H., Philp N.J.
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C3H.
Tissue: Skeletal muscle.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: 129.
Tissue: Mammary gland.
[3]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF178954 mRNA. Translation: AAG24271.1.
AF204397 Genomic DNA. Translation: AAF67525.1.
BC046525 mRNA. Translation: AAH46525.1.
CCDSCCDS25761.1.
RefSeqNP_001033742.1. NM_001038653.1.
NP_001033743.1. NM_001038654.1.
NP_109621.1. NM_030696.3.
UniGeneMm.28632.

3D structure databases

ProteinModelPortalP57787.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP57787. 1 interaction.
MINTMINT-4102245.

PTM databases

PhosphoSiteP57787.

Proteomic databases

PaxDbP57787.
PRIDEP57787.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000070653; ENSMUSP00000068854; ENSMUSG00000025161.
ENSMUST00000100130; ENSMUSP00000097706; ENSMUSG00000025161.
ENSMUST00000168579; ENSMUSP00000125846; ENSMUSG00000025161.
GeneID80879.
KEGGmmu:80879.
UCSCuc007muw.1. mouse.

Organism-specific databases

CTD9123.
MGIMGI:1933438. Slc16a3.

Phylogenomic databases

eggNOGNOG321880.
HOGENOMHOG000280688.
HOVERGENHBG006384.
InParanoidP57787.
KOK08180.
OMAMFARPAS.
OrthoDBEOG7W9RTN.
PhylomeDBP57787.
TreeFamTF313792.

Gene expression databases

ArrayExpressP57787.
BgeeP57787.
GenevestigatorP57787.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004743. Monocarb_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
TIGRFAMsTIGR00892. 2A0113. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio350183.
PROP57787.
SOURCESearch...

Entry information

Entry nameMOT4_MOUSE
AccessionPrimary (citable) accession number: P57787
Secondary accession number(s): Q9ES80, Q9ESF8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot