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P57774

- NPY_MOUSE

UniProt

P57774 - NPY_MOUSE

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Protein

Pro-neuropeptide Y

Gene

Npy

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei30 – 312Cleavage; by FAPBy similarity

GO - Molecular functioni

  1. G-protein coupled receptor binding Source: MGI

GO - Biological processi

  1. adult feeding behavior Source: HGNC
  2. central nervous system neuron development Source: Ensembl
  3. cerebral cortex development Source: Ensembl
  4. neuron projection development Source: Ensembl
  5. neuropeptide signaling pathway Source: UniProtKB-KW
  6. positive regulation of appetite Source: HGNC
  7. regulation of blood pressure Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_235286. Peptide ligand-binding receptors.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-neuropeptide Y
Cleaved into the following 2 chains:
Alternative name(s):
Neuropeptide tyrosine
Short name:
NPY
Gene namesi
Name:Npy
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:97374. Npy.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828By similarityAdd
BLAST
Peptidei29 – 6436Neuropeptide YPRO_0000025325Add
BLAST
Peptidei68 – 9730C-flanking peptide of NPYPRO_0000025326Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641Tyrosine amideBy similarity

Post-translational modificationi

The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP57774.
PRIDEiP57774.

PTM databases

PhosphoSiteiP57774.

Expressioni

Tissue specificityi

One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.

Gene expression databases

BgeeiP57774.
CleanExiMM_NPY.
GenevestigatoriP57774.

Structurei

3D structure databases

ProteinModelPortaliP57774.
SMRiP57774. Positions 29-64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45909.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiP57774.
KOiK05232.
OMAiFEDPSMW.
OrthoDBiEOG7WDN4S.
PhylomeDBiP57774.
TreeFamiTF332778.

Family and domain databases

InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57774-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGNKRMGLC GLTLALSLLV CLGILAEGYP SKPDNPGEDA PAEDMARYYS
60 70 80 90
ALRHYINLIT RQRYGKRSSP ETLISDLLMK ESTENAPRTR LEDPSMW
Length:97
Mass (Da):10,874
Last modified:June 1, 2001 - v2
Checksum:i7E0CE28FA330844E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421A → R in AAG01330. (PubMed:11210195)Curated
Sequence conflicti42 – 421A → R in AAG01331. (PubMed:11210195)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273768 mRNA. Translation: AAG00945.1.
AK002982 mRNA. Translation: BAB22495.1.
BC043012 mRNA. Translation: AAH43012.1.
AF286198 mRNA. Translation: AAG01330.1.
AF286199 mRNA. Translation: AAG01331.1.
CCDSiCCDS39488.1.
RefSeqiNP_075945.1. NM_023456.2.
UniGeneiMm.154796.

Genome annotation databases

EnsembliENSMUST00000031843; ENSMUSP00000031843; ENSMUSG00000029819.
GeneIDi109648.
KEGGimmu:109648.
UCSCiuc009bwt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273768 mRNA. Translation: AAG00945.1 .
AK002982 mRNA. Translation: BAB22495.1 .
BC043012 mRNA. Translation: AAH43012.1 .
AF286198 mRNA. Translation: AAG01330.1 .
AF286199 mRNA. Translation: AAG01331.1 .
CCDSi CCDS39488.1.
RefSeqi NP_075945.1. NM_023456.2.
UniGenei Mm.154796.

3D structure databases

ProteinModelPortali P57774.
SMRi P57774. Positions 29-64.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P57774.

Proteomic databases

PaxDbi P57774.
PRIDEi P57774.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031843 ; ENSMUSP00000031843 ; ENSMUSG00000029819 .
GeneIDi 109648.
KEGGi mmu:109648.
UCSCi uc009bwt.1. mouse.

Organism-specific databases

CTDi 4852.
MGIi MGI:97374. Npy.

Phylogenomic databases

eggNOGi NOG45909.
GeneTreei ENSGT00390000010775.
HOGENOMi HOG000252942.
HOVERGENi HBG006485.
InParanoidi P57774.
KOi K05232.
OMAi FEDPSMW.
OrthoDBi EOG7WDN4S.
PhylomeDBi P57774.
TreeFami TF332778.

Enzyme and pathway databases

Reactomei REACT_235286. Peptide ligand-binding receptors.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi 362501.
PROi P57774.
SOURCEi Search...

Gene expression databases

Bgeei P57774.
CleanExi MM_NPY.
Genevestigatori P57774.

Family and domain databases

InterProi IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view ]
PANTHERi PTHR10533. PTHR10533. 1 hit.
Pfami PF00159. Hormone_3. 1 hit.
[Graphical view ]
PRINTSi PR00278. PANCHORMONE.
ProDomi PD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00309. PAH. 1 hit.
[Graphical view ]
PROSITEi PS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Hennessey K., Chua S. Jr.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Multiple obesity QTLs identified in an intercross between the NZO (New Zealand obese) and the SM (small) mouse strains."
    Taylor B.A., Wnek C., Schroeder D., Phillips S.J.
    Mamm. Genome 12:95-103(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-89.
    Strain: NZO and SM/J.
    Tissue: Brain.
  5. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiNPY_MOUSE
AccessioniPrimary (citable) accession number: P57774
Secondary accession number(s): Q925V2, Q9ET27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3