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P57774

- NPY_MOUSE

UniProt

P57774 - NPY_MOUSE

Protein

Pro-neuropeptide Y

Gene

Npy

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor binding Source: MGI

    GO - Biological processi

    1. adult feeding behavior Source: HGNC
    2. central nervous system neuron development Source: Ensembl
    3. cerebral cortex development Source: Ensembl
    4. neuron projection development Source: Ensembl
    5. neuropeptide signaling pathway Source: UniProtKB-KW
    6. positive regulation of appetite Source: HGNC
    7. regulation of blood pressure Source: MGI

    Keywords - Molecular functioni

    Neuropeptide

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pro-neuropeptide Y
    Cleaved into the following 2 chains:
    Alternative name(s):
    Neuropeptide tyrosine
    Short name:
    NPY
    Gene namesi
    Name:Npy
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:97374. Npy.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: HGNC

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828By similarityAdd
    BLAST
    Peptidei29 – 6436Neuropeptide YPRO_0000025325Add
    BLAST
    Peptidei68 – 9730C-flanking peptide of NPYPRO_0000025326Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei64 – 641Tyrosine amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiP57774.
    PRIDEiP57774.

    PTM databases

    PhosphoSiteiP57774.

    Expressioni

    Tissue specificityi

    One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.

    Gene expression databases

    BgeeiP57774.
    CleanExiMM_NPY.
    GenevestigatoriP57774.

    Structurei

    3D structure databases

    ProteinModelPortaliP57774.
    SMRiP57774. Positions 29-64.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NPY family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45909.
    GeneTreeiENSGT00390000010775.
    HOGENOMiHOG000252942.
    HOVERGENiHBG006485.
    InParanoidiP57774.
    KOiK05232.
    OMAiFEDPSMW.
    OrthoDBiEOG7WDN4S.
    PhylomeDBiP57774.
    TreeFamiTF332778.

    Family and domain databases

    InterProiIPR001955. Pancreatic_hormone-like.
    IPR020392. Pancreatic_hormone-like_CS.
    [Graphical view]
    PANTHERiPTHR10533. PTHR10533. 1 hit.
    PfamiPF00159. Hormone_3. 1 hit.
    [Graphical view]
    PRINTSiPR00278. PANCHORMONE.
    ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00309. PAH. 1 hit.
    [Graphical view]
    PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
    PS50276. PANCREATIC_HORMONE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P57774-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGNKRMGLC GLTLALSLLV CLGILAEGYP SKPDNPGEDA PAEDMARYYS   50
    ALRHYINLIT RQRYGKRSSP ETLISDLLMK ESTENAPRTR LEDPSMW 97
    Length:97
    Mass (Da):10,874
    Last modified:June 1, 2001 - v2
    Checksum:i7E0CE28FA330844E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421A → R in AAG01330. (PubMed:11210195)Curated
    Sequence conflicti42 – 421A → R in AAG01331. (PubMed:11210195)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF273768 mRNA. Translation: AAG00945.1.
    AK002982 mRNA. Translation: BAB22495.1.
    BC043012 mRNA. Translation: AAH43012.1.
    AF286198 mRNA. Translation: AAG01330.1.
    AF286199 mRNA. Translation: AAG01331.1.
    CCDSiCCDS39488.1.
    RefSeqiNP_075945.1. NM_023456.2.
    UniGeneiMm.154796.

    Genome annotation databases

    EnsembliENSMUST00000031843; ENSMUSP00000031843; ENSMUSG00000029819.
    GeneIDi109648.
    KEGGimmu:109648.
    UCSCiuc009bwt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF273768 mRNA. Translation: AAG00945.1 .
    AK002982 mRNA. Translation: BAB22495.1 .
    BC043012 mRNA. Translation: AAH43012.1 .
    AF286198 mRNA. Translation: AAG01330.1 .
    AF286199 mRNA. Translation: AAG01331.1 .
    CCDSi CCDS39488.1.
    RefSeqi NP_075945.1. NM_023456.2.
    UniGenei Mm.154796.

    3D structure databases

    ProteinModelPortali P57774.
    SMRi P57774. Positions 29-64.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P57774.

    Proteomic databases

    PaxDbi P57774.
    PRIDEi P57774.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031843 ; ENSMUSP00000031843 ; ENSMUSG00000029819 .
    GeneIDi 109648.
    KEGGi mmu:109648.
    UCSCi uc009bwt.1. mouse.

    Organism-specific databases

    CTDi 4852.
    MGIi MGI:97374. Npy.

    Phylogenomic databases

    eggNOGi NOG45909.
    GeneTreei ENSGT00390000010775.
    HOGENOMi HOG000252942.
    HOVERGENi HBG006485.
    InParanoidi P57774.
    KOi K05232.
    OMAi FEDPSMW.
    OrthoDBi EOG7WDN4S.
    PhylomeDBi P57774.
    TreeFami TF332778.

    Miscellaneous databases

    NextBioi 362501.
    PROi P57774.
    SOURCEi Search...

    Gene expression databases

    Bgeei P57774.
    CleanExi MM_NPY.
    Genevestigatori P57774.

    Family and domain databases

    InterProi IPR001955. Pancreatic_hormone-like.
    IPR020392. Pancreatic_hormone-like_CS.
    [Graphical view ]
    PANTHERi PTHR10533. PTHR10533. 1 hit.
    Pfami PF00159. Hormone_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00278. PANCHORMONE.
    ProDomi PD001267. Pancreatic_hormone-like. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00309. PAH. 1 hit.
    [Graphical view ]
    PROSITEi PS00265. PANCREATIC_HORMONE_1. 1 hit.
    PS50276. PANCREATIC_HORMONE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Hennessey K., Chua S. Jr.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Multiple obesity QTLs identified in an intercross between the NZO (New Zealand obese) and the SM (small) mouse strains."
      Taylor B.A., Wnek C., Schroeder D., Phillips S.J.
      Mamm. Genome 12:95-103(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-89.
      Strain: NZO and SM/J.
      Tissue: Brain.
    5. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiNPY_MOUSE
    AccessioniPrimary (citable) accession number: P57774
    Secondary accession number(s): Q925V2, Q9ET27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3