P57774 (NPY_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pro-neuropeptide Y

Cleaved into the following 2 chains:

1. Neuropeptide Y
   Alternative name(s):
   Neuropeptide tyrosine
   Short name=NPY
2. C-flanking peptide of NPY
   Short name=CPON

Gene names

Name:

Npy

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	97 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone By similarity.
Subcellular location	Secreted.
Tissue specificity	One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.
Sequence similarities	Belongs to the NPY family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Neuropeptide
PTM	Amidation Cleavage on pair of basic residues
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adult feeding behavior Inferred from sequence or structural similarity. Source: HGNC central nervous system neuron development Inferred from electronic annotation. Source: Compara cerebral cortex development Inferred from electronic annotation. Source: Compara neuron projection development Inferred from electronic annotation. Source: Compara neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of appetite Inferred from sequence or structural similarity. Source: HGNC regulation of blood pressure Inferred from direct assay PubMed 9623984. Source: MGI
Cellular_component	extracellular space Inferred from sequence or structural similarity. Source: HGNC
Molecular_function	G-protein coupled receptor binding Inferred from direct assay PubMed 10698177. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	By similarity
	Peptide	29 – 64	36	Neuropeptide Y		PRO_0000025325
	Peptide	68 – 97	30	C-flanking peptide of NPY		PRO_0000025326
Amino acid modifications
	Modified residue	64	1	Tyrosine amide By similarity
Experimental info
	Sequence conflict	42	1	A → R in AAG01330. Ref.4
	Sequence conflict	42	1	A → R in AAG01331. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P57774 [UniParc]. Last modified June 1, 2001. Version 2. Checksum: 7E0CE28FA330844E	FASTA	97	10,874
	10 20 30 40 50 60 MLGNKRMGLC GLTLALSLLV CLGILAEGYP SKPDNPGEDA PAEDMARYYS ALRHYINLIT 70 80 90 RQRYGKRSSP ETLISDLLMK ESTENAPRTR LEDPSMW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Hennessey K., Chua S. Jr. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
[4]	"Multiple obesity QTLs identified in an intercross between the NZO (New Zealand obese) and the SM (small) mouse strains." Taylor B.A., Wnek C., Schroeder D., Phillips S.J. Mamm. Genome 12:95-103(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-89. Strain: NZO and SM/J. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF273768 mRNA. Translation: AAG00945.1. AK002982 mRNA. Translation: BAB22495.1. BC043012 mRNA. Translation: AAH43012.1. AF286198 mRNA. Translation: AAG01330.1. AF286199 mRNA. Translation: AAG01331.1.
IPI	IPI00118874.
RefSeq	NP_075945.1. NM_023456.2.
UniGene	Mm.154796.
3D structure databases
ProteinModelPortal	P57774.
SMR	P57774. Positions 29-64.
ModBase	Search...
PTM databases
PhosphoSite	P57774.
Proteomic databases
PaxDb	P57774.
PRIDE	P57774.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000031843; ENSMUSP00000031843; ENSMUSG00000029819.
GeneID	109648.
KEGG	mmu:109648.
UCSC	uc009bwt.1. mouse.
Organism-specific databases
CTD	4852.
MGI	MGI:97374. Npy.
Phylogenomic databases
eggNOG	NOG45909.
GeneTree	ENSGT00390000010775.
HOGENOM	HOG000252942.
HOVERGEN	HBG006485.
InParanoid	P57774.
KO	K05232.
OMA	RFEDPSM.
OrthoDB	EOG4PVP19.
Gene expression databases
Bgee	P57774.
CleanEx	MM_NPY.
Genevestigator	P57774.
GermOnline	ENSMUSG00000029819. Mus musculus.
Family and domain databases
InterPro	IPR001955. Pancreatic_hormone-like. IPR020392. Pancreatic_hormone-like_CS. [Graphical view]
PANTHER	PTHR10533. PTHR10533. 1 hit.
Pfam	PF00159. Hormone_3. 1 hit. [Graphical view]
PRINTS	PR00278. PANCHORMONE.
ProDom	PD001267. Pancreatic_hormone-like. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00309. PAH. 1 hit. [Graphical view]
PROSITE	PS00265. PANCREATIC_HORMONE_1. 1 hit. PS50276. PANCREATIC_HORMONE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	362501.
SOURCE	Search...

Entry information

Entry name

NPY_MOUSE

Accession

Primary (citable) accession number: P57774
Secondary accession number(s): Q925V2, Q9ET27

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program