P57772 (SELB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Selenocysteine-specific elongation factor

Alternative name(s):
Elongation factor sec
Eukaryotic elongation factor, selenocysteine-tRNA-specific

Gene names

Name:	EEFSEC
Synonyms:	SELB

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	596 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.
Subcellular location	Cytoplasm Potential. Nucleus Potential.
Sequence similarities	Belongs to the GTP-binding elongation factor family. SelB subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Non-traceable author statement. Source: UniProtKB translation elongation factor activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 596	596	Selenocysteine-specific elongation factor		PRO_0000091478
Regions
	Nucleotide binding	14 – 21	8	GTP Potential
	Nucleotide binding	92 – 96	5	GTP Potential
	Nucleotide binding	146 – 150	5	GTP Potential
	Motif	547 – 553	7	Nuclear localization signal Potential
Natural variations
	Natural variant	435	1	A → V. Corresponds to variant rs34326479 [ dbSNP | Ensembl ].		VAR_055712
Experimental info
	Sequence conflict	577	1	L → F in AAG13375. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P57772 [UniParc]. Last modified September 22, 2009. Version 4. Checksum: C92C43E3F250F686	FASTA	596	65,305
	10 20 30 40 50 60 MAGRRVNVNV GVLGHIDSGK TALARALSTT ASTAAFDKQP QSRERGITLD LGFSCFSVPL 70 80 90 100 110 120 PARLRSSLPE FQAAPEAEPE PGEPLLQVTL VDCPGHASLI RTIIGGAQII DLMMLVIDVT 130 140 150 160 170 180 KGMQTQSAEC LVIGQIACQK LVVVLNKIDL LPEGKRQAAI DKMTKKMQKT LENTKFRGAP 190 200 210 220 230 240 IIPVAAKPGG PEAPETEAPQ GIPELIELLT SQISIPTRDP SGPFLMSVDH CFSIKGQGTV 250 260 270 280 290 300 MTGTILSGSI SLGDSVEIPA LKVVKKVKSM QMFHMPITSA MQGDRLGICV TQFDPKLLER 310 320 330 340 350 360 GLVCAPESLH TVHAALISVE KIPYFRGPLQ TKAKFHITVG HETVMGRLMF FSPAPDNFDQ 370 380 390 400 410 420 EPILDSFNFS QEYLFQEQYL SKDLTPAVTD NDEADKKAGQ ATEGHCPRQQ WALVEFEKPV 430 440 450 460 470 480 TCPRLCLVIG SRLDADIHTN TCRLAFHGIL LHGLEDRNYA DSFLPRLKVY KLKHKHGLVE 490 500 510 520 530 540 RAMDDYSVIG RSLFKKETNI QLFVGLKVHL STGELGIIDS AFGQSGKFKI HIPGGLSPES 550 560 570 580 590 KKILTPALKK RARAGRGEAT RQEESAERSE PSQHVVLSLT FKRYVFDTHK RMVQSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Characterization of mSelB, a novel mammalian elongation factor for selenoprotein translation." Fagegaltier D., Hubert N., Yamada K., Mizutani T., Carbon P., Krol A. EMBO J. 19:4796-4805(2000) [PubMed: 10970870] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 71-596.
[3]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL449214 Genomic DNA. No translation available. AL449210 Genomic DNA. No translation available. AL449217 Genomic DNA. No translation available. AF268872 mRNA. Translation: AAG13375.1.
IPI	IPI00028050.
RefSeq	NP_068756.2. NM_021937.3.
UniGene	Hs.477498.
3D structure databases
ProteinModelPortal	P57772.
SMR	P57772. Positions 6-539.
ModBase	Search...
Protein-protein interaction databases
STRING	P57772.
PTM databases
PhosphoSite	P57772.
Polymorphism databases
DMDM	259016384.
Proteomic databases
PRIDE	P57772.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000254730; ENSP00000254730; ENSG00000132394.
GeneID	60678.
KEGG	hsa:60678.
Organism-specific databases
CTD	60678.
GeneCards	GC03P127872.
HGNC	HGNC:24614. EEFSEC.
HPA	HPA035795.
MIM	607695. gene.
neXtProt	NX_P57772.
PharmGKB	PA142671916.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG04505.
HOGENOM	HBG521874.
HOVERGEN	HBG017788.
InParanoid	P57772.
OMA	LFQEQYL.
OrthoDB	EOG42NJ03.
PhylomeDB	P57772.
Gene expression databases
ArrayExpress	P57772.
Bgee	P57772.
CleanEx	HS_EEFSEC.
Genevestigator	P57772.
GermOnline	ENSG00000132394. Homo sapiens.
Family and domain databases
InterPro	IPR000795. ProtSyn_GTP-bd. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Pfam	PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SUPFAM	SSF50447. Translat_factor. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. False negative. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

SELB_HUMAN

Accession

Primary (citable) accession number: P57772

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	September 22, 2009
Last modified:	January 25, 2012
This is version 85 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.