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Protein

Regulator of G-protein signaling 8

Gene

RGS8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiREACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 8
Short name:
RGS8
Gene namesi
Name:RGS8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16810. RGS8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34379.

Polymorphism and mutation databases

BioMutaiRGS8.
DMDMi13124465.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Regulator of G-protein signaling 8PRO_0000204199Add
BLAST

Proteomic databases

PaxDbiP57771.
PRIDEiP57771.

PTM databases

PhosphoSiteiP57771.

Expressioni

Gene expression databases

BgeeiP57771.
CleanExiHS_RGS8.
ExpressionAtlasiP57771. baseline.
GenevisibleiP57771. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-10216117,EBI-618309

Protein-protein interaction databases

BioGridi124512. 3 interactions.
DIPiDIP-59093N.
IntActiP57771. 1 interaction.
STRINGi9606.ENSP00000258302.

Structurei

Secondary structure

1
180
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi47 – 526Combined sources
Turni53 – 553Combined sources
Helixi57 – 615Combined sources
Helixi64 – 7613Combined sources
Helixi81 – 9212Combined sources
Helixi98 – 11215Combined sources
Helixi125 – 13410Combined sources
Turni140 – 1434Combined sources
Helixi144 – 15613Combined sources
Helixi158 – 1636Combined sources
Helixi166 – 1694Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IHDX-ray1.70A42-173[»]
2ODEX-ray1.90B/D42-180[»]
ProteinModelPortaliP57771.
SMRiP57771. Positions 46-172.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP57771.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 171116RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG251235.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP57771.
KOiK16449.
OMAiLPPAHET.
OrthoDBiEOG7VHSZ5.
PhylomeDBiP57771.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P57771-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALLMPRRN KGMRTRLGCL SHKSDSCSDF TAILPDKPNR ALKRLSTEEA
60 70 80 90 100
TRWADSFDVL LSHKYGVAAF RAFLKTEFSE ENLEFWLACE EFKKTRSTAK
110 120 130 140 150
LVSKAHRIFE EFVDVQAPRE VNIDFQTREA TRKNLQEPSL TCFDQAQGKV
160 170 180
HSLMEKDSYP RFLRSKMYLD LLSQSQRRLS
Length:180
Mass (Da):20,917
Last modified:February 21, 2001 - v1
Checksum:i198965B4C27F64C9
GO
Isoform 2 (identifier: P57771-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MAALLMPRR → MWNTLTRSLSDHPVGKDPQAMRTGQRQ

Show »
Length:198
Mass (Da):22,970
Checksum:i2A167BCE750725E5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 99MAALLMPRR → MWNTLTRSLSDHPVGKDPQA MRTGQRQ in isoform 2. 2 PublicationsVSP_036421

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297015 mRNA. Translation: AAG45337.1.
AF300649 mRNA. Translation: AAG18443.1.
AK296514 mRNA. Translation: BAG59146.1.
AK294660 mRNA. Translation: BAG57830.1.
AL353778 Genomic DNA. Translation: CAH72421.1.
CH471067 Genomic DNA. Translation: EAW91130.1.
BC069677 mRNA. Translation: AAH69677.1.
BC069718 mRNA. Translation: AAH69718.1.
BC103865 mRNA. Translation: AAI03866.1.
BC103866 mRNA. Translation: AAI03867.1.
BC103867 mRNA. Translation: AAI03868.1.
CCDSiCCDS1349.1. [P57771-2]
CCDS41443.1. [P57771-1]
RefSeqiNP_001095920.1. NM_001102450.1. [P57771-1]
NP_203131.1. NM_033345.2. [P57771-2]
XP_005245612.1. XM_005245555.2. [P57771-1]
XP_011508387.1. XM_011510085.1. [P57771-2]
XP_011508388.1. XM_011510086.1. [P57771-2]
XP_011508389.1. XM_011510087.1. [P57771-2]
XP_011508390.1. XM_011510088.1. [P57771-2]
XP_011508391.1. XM_011510089.1. [P57771-2]
XP_011508392.1. XM_011510090.1. [P57771-1]
UniGeneiHs.20982.
Hs.458417.

Genome annotation databases

EnsembliENST00000258302; ENSP00000258302; ENSG00000135824. [P57771-2]
ENST00000367556; ENSP00000356527; ENSG00000135824.
ENST00000367557; ENSP00000356528; ENSG00000135824.
ENST00000483095; ENSP00000426289; ENSG00000135824.
GeneIDi85397.
KEGGihsa:85397.
UCSCiuc001gpm.1. human. [P57771-2]
uc001gpn.1. human. [P57771-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297015 mRNA. Translation: AAG45337.1.
AF300649 mRNA. Translation: AAG18443.1.
AK296514 mRNA. Translation: BAG59146.1.
AK294660 mRNA. Translation: BAG57830.1.
AL353778 Genomic DNA. Translation: CAH72421.1.
CH471067 Genomic DNA. Translation: EAW91130.1.
BC069677 mRNA. Translation: AAH69677.1.
BC069718 mRNA. Translation: AAH69718.1.
BC103865 mRNA. Translation: AAI03866.1.
BC103866 mRNA. Translation: AAI03867.1.
BC103867 mRNA. Translation: AAI03868.1.
CCDSiCCDS1349.1. [P57771-2]
CCDS41443.1. [P57771-1]
RefSeqiNP_001095920.1. NM_001102450.1. [P57771-1]
NP_203131.1. NM_033345.2. [P57771-2]
XP_005245612.1. XM_005245555.2. [P57771-1]
XP_011508387.1. XM_011510085.1. [P57771-2]
XP_011508388.1. XM_011510086.1. [P57771-2]
XP_011508389.1. XM_011510087.1. [P57771-2]
XP_011508390.1. XM_011510088.1. [P57771-2]
XP_011508391.1. XM_011510089.1. [P57771-2]
XP_011508392.1. XM_011510090.1. [P57771-1]
UniGeneiHs.20982.
Hs.458417.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IHDX-ray1.70A42-173[»]
2ODEX-ray1.90B/D42-180[»]
ProteinModelPortaliP57771.
SMRiP57771. Positions 46-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124512. 3 interactions.
DIPiDIP-59093N.
IntActiP57771. 1 interaction.
STRINGi9606.ENSP00000258302.

Chemistry

BindingDBiP57771.
ChEMBLiCHEMBL2034803.
GuidetoPHARMACOLOGYi2813.

PTM databases

PhosphoSiteiP57771.

Polymorphism and mutation databases

BioMutaiRGS8.
DMDMi13124465.

Proteomic databases

PaxDbiP57771.
PRIDEiP57771.

Protocols and materials databases

DNASUi85397.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258302; ENSP00000258302; ENSG00000135824. [P57771-2]
ENST00000367556; ENSP00000356527; ENSG00000135824.
ENST00000367557; ENSP00000356528; ENSG00000135824.
ENST00000483095; ENSP00000426289; ENSG00000135824.
GeneIDi85397.
KEGGihsa:85397.
UCSCiuc001gpm.1. human. [P57771-2]
uc001gpn.1. human. [P57771-1]

Organism-specific databases

CTDi85397.
GeneCardsiGC01M182610.
HGNCiHGNC:16810. RGS8.
MIMi607189. gene.
neXtProtiNX_P57771.
PharmGKBiPA34379.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG251235.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiP57771.
KOiK16449.
OMAiLPPAHET.
OrthoDBiEOG7VHSZ5.
PhylomeDBiP57771.
TreeFamiTF315837.

Enzyme and pathway databases

ReactomeiREACT_19231. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTraceiP57771.
GeneWikiiRGS8.
GenomeRNAii85397.
NextBioi75956.
PROiP57771.
SOURCEiSearch...

Gene expression databases

BgeeiP57771.
CleanExiHS_RGS8.
ExpressionAtlasiP57771. baseline.
GenevisibleiP57771. HS.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus."
    Sood R., Bonner T.I., Malakowska I., Stephan D.A., Robbins C.M., Connors T.D., Morgenbesser S.D., Su K., Faruque M.U., Pinkett H., Graham C., Baxevanis A.D., Klinger K.W., Landes G.M., Trent J.M., Carpten J.D.
    Genomics 73:211-222(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Thalamus.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiRGS8_HUMAN
AccessioniPrimary (citable) accession number: P57771
Secondary accession number(s): B4DGL9, Q3SYD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: July 22, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.