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P57771

- RGS8_HUMAN

UniProt

P57771 - RGS8_HUMAN

Protein

Regulator of G-protein signaling 8

Gene

RGS8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (21 Feb 2001)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 By similarity.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Enzyme and pathway databases

    ReactomeiREACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 8
    Short name:
    RGS8
    Gene namesi
    Name:RGS8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:16810. RGS8.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. plasma membrane Source: RefGenome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34379.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 180180Regulator of G-protein signaling 8PRO_0000204199Add
    BLAST

    Proteomic databases

    PaxDbiP57771.
    PRIDEiP57771.

    PTM databases

    PhosphoSiteiP57771.

    Expressioni

    Gene expression databases

    ArrayExpressiP57771.
    BgeeiP57771.
    CleanExiHS_RGS8.
    GenevestigatoriP57771.

    Interactioni

    Protein-protein interaction databases

    BioGridi124512. 1 interaction.
    DIPiDIP-59093N.
    STRINGi9606.ENSP00000258302.

    Structurei

    Secondary structure

    1
    180
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi47 – 526
    Turni53 – 553
    Helixi57 – 615
    Helixi64 – 7613
    Helixi81 – 9212
    Helixi98 – 11215
    Helixi125 – 13410
    Turni140 – 1434
    Helixi144 – 15613
    Helixi158 – 1636
    Helixi166 – 1694

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2IHDX-ray1.70A42-173[»]
    2ODEX-ray1.90B/D42-180[»]
    ProteinModelPortaliP57771.
    SMRiP57771. Positions 46-172.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP57771.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini56 – 171116RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG251235.
    HOGENOMiHOG000233512.
    HOVERGENiHBG013233.
    KOiK16449.
    OMAiSHKSDSY.
    OrthoDBiEOG7VHSZ5.
    PhylomeDBiP57771.
    TreeFamiTF315837.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P57771-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAALLMPRRN KGMRTRLGCL SHKSDSCSDF TAILPDKPNR ALKRLSTEEA    50
    TRWADSFDVL LSHKYGVAAF RAFLKTEFSE ENLEFWLACE EFKKTRSTAK 100
    LVSKAHRIFE EFVDVQAPRE VNIDFQTREA TRKNLQEPSL TCFDQAQGKV 150
    HSLMEKDSYP RFLRSKMYLD LLSQSQRRLS 180
    Length:180
    Mass (Da):20,917
    Last modified:February 21, 2001 - v1
    Checksum:i198965B4C27F64C9
    GO
    Isoform 2 (identifier: P57771-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: MAALLMPRR → MWNTLTRSLSDHPVGKDPQAMRTGQRQ

    Show »
    Length:198
    Mass (Da):22,970
    Checksum:i2A167BCE750725E5
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 99MAALLMPRR → MWNTLTRSLSDHPVGKDPQA MRTGQRQ in isoform 2. 2 PublicationsVSP_036421

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF297015 mRNA. Translation: AAG45337.1.
    AF300649 mRNA. Translation: AAG18443.1.
    AK296514 mRNA. Translation: BAG59146.1.
    AK294660 mRNA. Translation: BAG57830.1.
    AL353778 Genomic DNA. Translation: CAH72421.1.
    CH471067 Genomic DNA. Translation: EAW91130.1.
    BC069677 mRNA. Translation: AAH69677.1.
    BC069718 mRNA. Translation: AAH69718.1.
    BC103865 mRNA. Translation: AAI03866.1.
    BC103866 mRNA. Translation: AAI03867.1.
    BC103867 mRNA. Translation: AAI03868.1.
    CCDSiCCDS1349.1. [P57771-2]
    CCDS41443.1. [P57771-1]
    RefSeqiNP_001095920.1. NM_001102450.1. [P57771-1]
    NP_203131.1. NM_033345.2. [P57771-2]
    XP_005245612.1. XM_005245555.1. [P57771-1]
    XP_006711660.1. XM_006711597.1. [P57771-2]
    UniGeneiHs.20982.
    Hs.458417.

    Genome annotation databases

    EnsembliENST00000258302; ENSP00000258302; ENSG00000135824. [P57771-2]
    ENST00000367556; ENSP00000356527; ENSG00000135824. [P57771-1]
    ENST00000367557; ENSP00000356528; ENSG00000135824. [P57771-1]
    ENST00000483095; ENSP00000426289; ENSG00000135824. [P57771-1]
    GeneIDi85397.
    KEGGihsa:85397.
    UCSCiuc001gpm.1. human. [P57771-2]
    uc001gpn.1. human. [P57771-1]

    Polymorphism databases

    DMDMi13124465.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF297015 mRNA. Translation: AAG45337.1 .
    AF300649 mRNA. Translation: AAG18443.1 .
    AK296514 mRNA. Translation: BAG59146.1 .
    AK294660 mRNA. Translation: BAG57830.1 .
    AL353778 Genomic DNA. Translation: CAH72421.1 .
    CH471067 Genomic DNA. Translation: EAW91130.1 .
    BC069677 mRNA. Translation: AAH69677.1 .
    BC069718 mRNA. Translation: AAH69718.1 .
    BC103865 mRNA. Translation: AAI03866.1 .
    BC103866 mRNA. Translation: AAI03867.1 .
    BC103867 mRNA. Translation: AAI03868.1 .
    CCDSi CCDS1349.1. [P57771-2 ]
    CCDS41443.1. [P57771-1 ]
    RefSeqi NP_001095920.1. NM_001102450.1. [P57771-1 ]
    NP_203131.1. NM_033345.2. [P57771-2 ]
    XP_005245612.1. XM_005245555.1. [P57771-1 ]
    XP_006711660.1. XM_006711597.1. [P57771-2 ]
    UniGenei Hs.20982.
    Hs.458417.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2IHD X-ray 1.70 A 42-173 [» ]
    2ODE X-ray 1.90 B/D 42-180 [» ]
    ProteinModelPortali P57771.
    SMRi P57771. Positions 46-172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124512. 1 interaction.
    DIPi DIP-59093N.
    STRINGi 9606.ENSP00000258302.

    Chemistry

    BindingDBi P57771.
    ChEMBLi CHEMBL2034803.

    PTM databases

    PhosphoSitei P57771.

    Polymorphism databases

    DMDMi 13124465.

    Proteomic databases

    PaxDbi P57771.
    PRIDEi P57771.

    Protocols and materials databases

    DNASUi 85397.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258302 ; ENSP00000258302 ; ENSG00000135824 . [P57771-2 ]
    ENST00000367556 ; ENSP00000356527 ; ENSG00000135824 . [P57771-1 ]
    ENST00000367557 ; ENSP00000356528 ; ENSG00000135824 . [P57771-1 ]
    ENST00000483095 ; ENSP00000426289 ; ENSG00000135824 . [P57771-1 ]
    GeneIDi 85397.
    KEGGi hsa:85397.
    UCSCi uc001gpm.1. human. [P57771-2 ]
    uc001gpn.1. human. [P57771-1 ]

    Organism-specific databases

    CTDi 85397.
    GeneCardsi GC01M182610.
    HGNCi HGNC:16810. RGS8.
    MIMi 607189. gene.
    neXtProti NX_P57771.
    PharmGKBi PA34379.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG251235.
    HOGENOMi HOG000233512.
    HOVERGENi HBG013233.
    KOi K16449.
    OMAi SHKSDSY.
    OrthoDBi EOG7VHSZ5.
    PhylomeDBi P57771.
    TreeFami TF315837.

    Enzyme and pathway databases

    Reactomei REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    EvolutionaryTracei P57771.
    GeneWikii RGS8.
    GenomeRNAii 85397.
    NextBioi 75956.
    PROi P57771.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P57771.
    Bgeei P57771.
    CleanExi HS_RGS8.
    Genevestigatori P57771.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus."
      Sood R., Bonner T.I., Malakowska I., Stephan D.A., Robbins C.M., Connors T.D., Morgenbesser S.D., Su K., Faruque M.U., Pinkett H., Graham C., Baxevanis A.D., Klinger K.W., Landes G.M., Trent J.M., Carpten J.D.
      Genomics 73:211-222(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Thalamus.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).

    Entry informationi

    Entry nameiRGS8_HUMAN
    AccessioniPrimary (citable) accession number: P57771
    Secondary accession number(s): B4DGL9, Q3SYD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: February 21, 2001
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3