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P57771

- RGS8_HUMAN

UniProt

P57771 - RGS8_HUMAN

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Protein

Regulator of G-protein signaling 8

Gene
RGS8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 By similarity.

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiREACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 8
Short name:
RGS8
Gene namesi
Name:RGS8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:16810. RGS8.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. plasma membrane Source: RefGenome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34379.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Regulator of G-protein signaling 8PRO_0000204199Add
BLAST

Proteomic databases

PaxDbiP57771.
PRIDEiP57771.

PTM databases

PhosphoSiteiP57771.

Expressioni

Gene expression databases

ArrayExpressiP57771.
BgeeiP57771.
CleanExiHS_RGS8.
GenevestigatoriP57771.

Interactioni

Protein-protein interaction databases

BioGridi124512. 1 interaction.
DIPiDIP-59093N.
STRINGi9606.ENSP00000258302.

Structurei

Secondary structure

1
180
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi47 – 526
Turni53 – 553
Helixi57 – 615
Helixi64 – 7613
Helixi81 – 9212
Helixi98 – 11215
Helixi125 – 13410
Turni140 – 1434
Helixi144 – 15613
Helixi158 – 1636
Helixi166 – 1694

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IHDX-ray1.70A42-173[»]
2ODEX-ray1.90B/D42-180[»]
ProteinModelPortaliP57771.
SMRiP57771. Positions 46-172.

Miscellaneous databases

EvolutionaryTraceiP57771.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 171116RGSAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.

Phylogenomic databases

eggNOGiNOG251235.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
KOiK16449.
OMAiSHKSDSY.
OrthoDBiEOG7VHSZ5.
PhylomeDBiP57771.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P57771-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAALLMPRRN KGMRTRLGCL SHKSDSCSDF TAILPDKPNR ALKRLSTEEA    50
TRWADSFDVL LSHKYGVAAF RAFLKTEFSE ENLEFWLACE EFKKTRSTAK 100
LVSKAHRIFE EFVDVQAPRE VNIDFQTREA TRKNLQEPSL TCFDQAQGKV 150
HSLMEKDSYP RFLRSKMYLD LLSQSQRRLS 180
Length:180
Mass (Da):20,917
Last modified:February 21, 2001 - v1
Checksum:i198965B4C27F64C9
GO
Isoform 2 (identifier: P57771-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MAALLMPRR → MWNTLTRSLSDHPVGKDPQAMRTGQRQ

Show »
Length:198
Mass (Da):22,970
Checksum:i2A167BCE750725E5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 99MAALLMPRR → MWNTLTRSLSDHPVGKDPQA MRTGQRQ in isoform 2. VSP_036421

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF297015 mRNA. Translation: AAG45337.1.
AF300649 mRNA. Translation: AAG18443.1.
AK296514 mRNA. Translation: BAG59146.1.
AK294660 mRNA. Translation: BAG57830.1.
AL353778 Genomic DNA. Translation: CAH72421.1.
CH471067 Genomic DNA. Translation: EAW91130.1.
BC069677 mRNA. Translation: AAH69677.1.
BC069718 mRNA. Translation: AAH69718.1.
BC103865 mRNA. Translation: AAI03866.1.
BC103866 mRNA. Translation: AAI03867.1.
BC103867 mRNA. Translation: AAI03868.1.
CCDSiCCDS1349.1. [P57771-2]
CCDS41443.1. [P57771-1]
RefSeqiNP_001095920.1. NM_001102450.1. [P57771-1]
NP_203131.1. NM_033345.2. [P57771-2]
XP_005245612.1. XM_005245555.1. [P57771-1]
XP_006711660.1. XM_006711597.1. [P57771-2]
UniGeneiHs.20982.
Hs.458417.

Genome annotation databases

EnsembliENST00000258302; ENSP00000258302; ENSG00000135824. [P57771-2]
ENST00000367556; ENSP00000356527; ENSG00000135824. [P57771-1]
ENST00000367557; ENSP00000356528; ENSG00000135824. [P57771-1]
ENST00000483095; ENSP00000426289; ENSG00000135824. [P57771-1]
GeneIDi85397.
KEGGihsa:85397.
UCSCiuc001gpm.1. human. [P57771-2]
uc001gpn.1. human. [P57771-1]

Polymorphism databases

DMDMi13124465.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF297015 mRNA. Translation: AAG45337.1 .
AF300649 mRNA. Translation: AAG18443.1 .
AK296514 mRNA. Translation: BAG59146.1 .
AK294660 mRNA. Translation: BAG57830.1 .
AL353778 Genomic DNA. Translation: CAH72421.1 .
CH471067 Genomic DNA. Translation: EAW91130.1 .
BC069677 mRNA. Translation: AAH69677.1 .
BC069718 mRNA. Translation: AAH69718.1 .
BC103865 mRNA. Translation: AAI03866.1 .
BC103866 mRNA. Translation: AAI03867.1 .
BC103867 mRNA. Translation: AAI03868.1 .
CCDSi CCDS1349.1. [P57771-2 ]
CCDS41443.1. [P57771-1 ]
RefSeqi NP_001095920.1. NM_001102450.1. [P57771-1 ]
NP_203131.1. NM_033345.2. [P57771-2 ]
XP_005245612.1. XM_005245555.1. [P57771-1 ]
XP_006711660.1. XM_006711597.1. [P57771-2 ]
UniGenei Hs.20982.
Hs.458417.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2IHD X-ray 1.70 A 42-173 [» ]
2ODE X-ray 1.90 B/D 42-180 [» ]
ProteinModelPortali P57771.
SMRi P57771. Positions 46-172.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124512. 1 interaction.
DIPi DIP-59093N.
STRINGi 9606.ENSP00000258302.

Chemistry

BindingDBi P57771.
ChEMBLi CHEMBL2034803.

PTM databases

PhosphoSitei P57771.

Polymorphism databases

DMDMi 13124465.

Proteomic databases

PaxDbi P57771.
PRIDEi P57771.

Protocols and materials databases

DNASUi 85397.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258302 ; ENSP00000258302 ; ENSG00000135824 . [P57771-2 ]
ENST00000367556 ; ENSP00000356527 ; ENSG00000135824 . [P57771-1 ]
ENST00000367557 ; ENSP00000356528 ; ENSG00000135824 . [P57771-1 ]
ENST00000483095 ; ENSP00000426289 ; ENSG00000135824 . [P57771-1 ]
GeneIDi 85397.
KEGGi hsa:85397.
UCSCi uc001gpm.1. human. [P57771-2 ]
uc001gpn.1. human. [P57771-1 ]

Organism-specific databases

CTDi 85397.
GeneCardsi GC01M182610.
HGNCi HGNC:16810. RGS8.
MIMi 607189. gene.
neXtProti NX_P57771.
PharmGKBi PA34379.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG251235.
HOGENOMi HOG000233512.
HOVERGENi HBG013233.
KOi K16449.
OMAi SHKSDSY.
OrthoDBi EOG7VHSZ5.
PhylomeDBi P57771.
TreeFami TF315837.

Enzyme and pathway databases

Reactomei REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTracei P57771.
GeneWikii RGS8.
GenomeRNAii 85397.
NextBioi 75956.
PROi P57771.
SOURCEi Search...

Gene expression databases

ArrayExpressi P57771.
Bgeei P57771.
CleanExi HS_RGS8.
Genevestigatori P57771.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus."
    Sood R., Bonner T.I., Malakowska I., Stephan D.A., Robbins C.M., Connors T.D., Morgenbesser S.D., Su K., Faruque M.U., Pinkett H., Graham C., Baxevanis A.D., Klinger K.W., Landes G.M., Trent J.M., Carpten J.D.
    Genomics 73:211-222(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Thalamus.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiRGS8_HUMAN
AccessioniPrimary (citable) accession number: P57771
Secondary accession number(s): B4DGL9, Q3SYD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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