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Protein

Sorting nexin-16

Gene

SNX16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei144 – 1441Phosphatidylinositol 3-phosphateCurated
Binding sitei146 – 1461Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei184 – 1841Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • phosphatidylinositol binding Source: UniProtKB

GO - Biological processi

  • early endosome to late endosome transport Source: UniProtKB
  • endosome to lysosome transport Source: UniProtKB
  • protein targeting to lysosome Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-16
Gene namesi
Name:SNX16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:14980. SNX16.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GOC
  • early endosome Source: UniProtKB
  • early endosome membrane Source: UniProtKB-SubCell
  • extrinsic component of endosome membrane Source: UniProtKB
  • late endosome Source: UniProtKB
  • late endosome membrane Source: UniProtKB-SubCell
  • lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi144 – 1441R → A: Abolishes binding to membranes enriched in phosphatidylinositol 3-phosphate. 1 Publication
Mutagenesisi145 – 1451Y → A: Abolishes binding to phosphatidylinositol 3-phosphate. 1 Publication

Organism-specific databases

PharmGKBiPA134972049.

Polymorphism and mutation databases

BioMutaiSNX16.
DMDMi116242795.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Sorting nexin-16PRO_0000213863Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei222 – 2221PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP57768.
MaxQBiP57768.
PaxDbiP57768.
PRIDEiP57768.

PTM databases

iPTMnetiP57768.
PhosphoSiteiP57768.

Expressioni

Tissue specificityi

Detected in placenta, lung, liver,heart and pancreas.1 Publication

Gene expression databases

BgeeiP57768.
CleanExiHS_SNX16.
ExpressionAtlasiP57768. baseline and differential.
GenevisibleiP57768. HS.

Organism-specific databases

HPAiHPA024730.
HPA024731.
HPA024817.

Interactioni

Subunit structurei

Homooligomer. Interacts with EGFR (By similarity).By similarity

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122051. 7 interactions.
IntActiP57768. 4 interactions.
STRINGi9606.ENSP00000322652.

Structurei

3D structure databases

ProteinModelPortaliP57768.
SMRiP57768. Positions 107-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini105 – 218114PXPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili223 – 27856Sequence analysisAdd
BLAST

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.1 Publication

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IMHW. Eukaryota.
ENOG410Z8KU. LUCA.
GeneTreeiENSGT00390000005651.
HOGENOMiHOG000013075.
HOVERGENiHBG057106.
InParanoidiP57768.
KOiK17928.
OMAiMGNFKQT.
OrthoDBiEOG7QG455.
PhylomeDBiP57768.
TreeFamiTF324116.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P57768-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPYVPVPM PIGNSASSFT TNRNQRSSSF GSVSTSSNSS KGQLEDSNMG
60 70 80 90 100
NFKQTSVPDQ MDNTSSVCSS PLIRTKFTGT ASSIEYSTRP RDTEEQNPET
110 120 130 140 150
VNWEDRPSTP TILGYEVMEE RAKFTVYKIL VKKTPEESWV VFRRYTDFSR
160 170 180 190 200
LNDKLKEMFP GFRLALPPKR WFKDNYNADF LEDRQLGLQA FLQNLVAHKD
210 220 230 240 250
IANCLAVREF LCLDDPPGPF DSLEESRAFC ETLEETNYRL QKELLEKQKE
260 270 280 290 300
MESLKKLLSE KQLHIDTLEN RIRTLSLEPE ESLDVSETEG EQILKVESSA
310 320 330 340
LEVDQDVLDE ESRADNKPCL SFSEPENAVS EIEVAEVAYD AEED
Length:344
Mass (Da):39,167
Last modified:October 17, 2006 - v2
Checksum:i213744E94B5B3BB8
GO
Isoform 2 (identifier: P57768-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-154: Missing.

Note: No experimental confirmation available.
Show »
Length:315
Mass (Da):35,566
Checksum:iC4930631DA99C4D3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti308 – 3114LDEE → WMR in AAG25676 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti98 – 981P → L.
Corresponds to variant rs16919654 [ dbSNP | Ensembl ].
VAR_052479

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei126 – 15429Missing in isoform 2. 1 PublicationVSP_042944Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305779 mRNA. Translation: AAG25676.1.
AK290903 mRNA. Translation: BAF83592.1.
AL833763 mRNA. Translation: CAH56235.1.
AC087349 Genomic DNA. No translation available.
AC132219 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87108.1.
CH471068 Genomic DNA. Translation: EAW87109.1.
BC033630 mRNA. Translation: AAH33630.1.
CCDSiCCDS6234.1. [P57768-1]
CCDS6235.1. [P57768-2]
RefSeqiNP_071416.2. NM_022133.3. [P57768-1]
NP_690049.1. NM_152836.2. [P57768-1]
NP_690050.1. NM_152837.2. [P57768-2]
XP_011515875.1. XM_011517573.1. [P57768-1]
UniGeneiHs.492121.

Genome annotation databases

EnsembliENST00000345957; ENSP00000322652; ENSG00000104497. [P57768-1]
ENST00000353788; ENSP00000322631; ENSG00000104497. [P57768-2]
ENST00000396330; ENSP00000379621; ENSG00000104497. [P57768-1]
GeneIDi64089.
KEGGihsa:64089.
UCSCiuc003ycn.4. human. [P57768-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305779 mRNA. Translation: AAG25676.1.
AK290903 mRNA. Translation: BAF83592.1.
AL833763 mRNA. Translation: CAH56235.1.
AC087349 Genomic DNA. No translation available.
AC132219 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87108.1.
CH471068 Genomic DNA. Translation: EAW87109.1.
BC033630 mRNA. Translation: AAH33630.1.
CCDSiCCDS6234.1. [P57768-1]
CCDS6235.1. [P57768-2]
RefSeqiNP_071416.2. NM_022133.3. [P57768-1]
NP_690049.1. NM_152836.2. [P57768-1]
NP_690050.1. NM_152837.2. [P57768-2]
XP_011515875.1. XM_011517573.1. [P57768-1]
UniGeneiHs.492121.

3D structure databases

ProteinModelPortaliP57768.
SMRiP57768. Positions 107-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122051. 7 interactions.
IntActiP57768. 4 interactions.
STRINGi9606.ENSP00000322652.

PTM databases

iPTMnetiP57768.
PhosphoSiteiP57768.

Polymorphism and mutation databases

BioMutaiSNX16.
DMDMi116242795.

Proteomic databases

EPDiP57768.
MaxQBiP57768.
PaxDbiP57768.
PRIDEiP57768.

Protocols and materials databases

DNASUi64089.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345957; ENSP00000322652; ENSG00000104497. [P57768-1]
ENST00000353788; ENSP00000322631; ENSG00000104497. [P57768-2]
ENST00000396330; ENSP00000379621; ENSG00000104497. [P57768-1]
GeneIDi64089.
KEGGihsa:64089.
UCSCiuc003ycn.4. human. [P57768-1]

Organism-specific databases

CTDi64089.
GeneCardsiSNX16.
HGNCiHGNC:14980. SNX16.
HPAiHPA024730.
HPA024731.
HPA024817.
MIMi614903. gene.
neXtProtiNX_P57768.
PharmGKBiPA134972049.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMHW. Eukaryota.
ENOG410Z8KU. LUCA.
GeneTreeiENSGT00390000005651.
HOGENOMiHOG000013075.
HOVERGENiHBG057106.
InParanoidiP57768.
KOiK17928.
OMAiMGNFKQT.
OrthoDBiEOG7QG455.
PhylomeDBiP57768.
TreeFamiTF324116.

Miscellaneous databases

GenomeRNAii64089.
PROiP57768.
SOURCEiSearch...

Gene expression databases

BgeeiP57768.
CleanExiHS_SNX16.
ExpressionAtlasiP57768. baseline and differential.
GenevisibleiP57768. HS.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Hanson B.J., Hong W.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Esophagus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Stomach.
  4. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas.
  7. "Evidence for a role of SNX16 in regulating traffic between the early and later endosomal compartments."
    Hanson B.J., Hong W.
    J. Biol. Chem. 278:34617-34630(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, DOMAIN PX, MUTAGENESIS OF TYR-145, TISSUE SPECIFICITY.
  8. Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-144.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSNX16_HUMAN
AccessioniPrimary (citable) accession number: P57768
Secondary accession number(s): A8K4D8, Q658L0, Q8N4U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 17, 2006
Last modified: June 8, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.