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Protein

DNA polymerase sliding clamp 3

Gene

pcn3

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. Heterotrimer stimulates the Holliday junction resolvase Hjc.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clamp 3UniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homolog 3UniRule annotation
Short name:
PCNA3UniRule annotation
Gene namesi
Name:pcn3UniRule annotation
Synonyms:pcnA-1
Ordered Locus Names:SSO0405
ORF Names:C41_016
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492141 – 244DNA polymerase sliding clamp 3Add BLAST244

Interactioni

Subunit structurei

Does not individually interact with either of the other PCNA subunits, but is recruited to a PCNA1-PCNA2 heterodimer; does not form homotrimers (PubMed:12535540, PubMed:18703842). Heterotrimer which circularizes head-to-tail (head is at N-terminus, tail is at C-terminus) to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA. This subunit interacts with DNA ligase, RfcL, XPF, and weakly with DNA polymerase I (PubMed:12535540).8 Publications

Protein-protein interaction databases

STRINGi273057.SSO0405

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Helixi8 – 21Combined sources14
Beta strandi23 – 29Combined sources7
Beta strandi31 – 39Combined sources9
Beta strandi43 – 52Combined sources10
Helixi53 – 55Combined sources3
Beta strandi57 – 60Combined sources4
Beta strandi65 – 70Combined sources6
Helixi71 – 78Combined sources8
Beta strandi86 – 93Combined sources8
Beta strandi96 – 112Combined sources17
Beta strandi129 – 135Combined sources7
Helixi136 – 146Combined sources11
Turni147 – 149Combined sources3
Beta strandi151 – 158Combined sources8
Beta strandi161 – 166Combined sources6
Beta strandi172 – 177Combined sources6
Turni178 – 180Combined sources3
Beta strandi183 – 190Combined sources8
Beta strandi192 – 197Combined sources6
Helixi198 – 203Combined sources6
Helixi204 – 210Combined sources7
Beta strandi212 – 219Combined sources8
Beta strandi222 – 229Combined sources8
Helixi231 – 233Combined sources3
Beta strandi235 – 240Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HIIX-ray2.79C/Z1-244[»]
2HIKX-ray3.30C/N/Z1-244[»]
2IJXX-ray1.90A/B/C/D1-244[»]
2IX2X-ray2.20C1-244[»]
2NTIX-ray2.50C/F/I1-244[»]
ProteinModelPortaliP57765
SMRiP57765
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP57765

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488 Archaea
COG0592 LUCA
HOGENOMiHOG000222371
InParanoidiP57765
KOiK04802
OMAiSDGFDKY
OrthoDBiPOG093Z0814

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit

Sequencei

Sequence statusi: Complete.

P57765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVVYDDVRV LKDIIQALAR LVDEAVLKFK QDSVELVALD RAHISLISVN
60 70 80 90 100
LPREMFKEYD VNDEFKFGFN TQYLMKILKV AKRKEAIEIA SESPDSVIIN
110 120 130 140 150
IIGSTNREFN VRNLEVSEQE IPEINLQFDI SATISSDGFK SAISEVSTVT
160 170 180 190 200
DNVVVEGHED RILIKAEGES EVEVEFSKDT GGLQDLEFSK ESKNSYSAEY
210 220 230 240
LDDVLSLTKL SDYVKISFGN QKPLQLFFNM EGGGKVTYLL APKV
Length:244
Mass (Da):27,459
Last modified:February 21, 2001 - v1
Checksum:i191C3C1267F1F5D1
GO

Sequence cautioni

The sequence AAK40734 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA Translation: AAK40734.1 Different initiation.
PIRiG90184

Genome annotation databases

EnsemblBacteriaiAAK40734; AAK40734; SSO0405
KEGGisso:SSO0405
PATRICifig|273057.12.peg.401

Similar proteinsi

Entry informationi

Entry nameiPCNA3_SULSO
AccessioniPrimary (citable) accession number: P57765
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health