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P57759 (ERP29_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endoplasmic reticulum resident protein 29

Short name=ERp29
Gene names
Name:Erp29
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.

Subunit structure

Homodimer. Part of a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity. Melanosome By similarity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 By similarity
Chain35 – 262228Endoplasmic reticulum resident protein 29
PRO_0000021198

Regions

Motif259 – 2624Prevents secretion from ER By similarity

Sequences

Sequence LengthMass (Da)Tools
P57759 [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: CA4C83757CA8732B

FASTA26228,823
        10         20         30         40         50         60 
MAAAAGVSGA ASLSPLLSVL LGLLLLFAPH GGSGLHTKGA LPLDTVTFYK VIPKSKFVLV 

        70         80         90        100        110        120 
KFDTQYPYGE KQDEFKRLAE NSASSEELLV AEVGISDYGD KLNMELSEKY KLDKESYPVF 

       130        140        150        160        170        180 
YLFRDGDLEN PVLYNGAVKV GAIQRWLKGQ GVYLGMPGCL PAYDALAGEF IKASSIEARQ 

       190        200        210        220        230        240 
AILKQGQDGL LSVKETEKKW ASQYLKIMGK ILDQGEDFPA SEMARIGKLI ENKMSDSKKE 

       250        260 
ELQKSLNILT AFRKKEAEKE EL 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: BALB/c, C57BL/6J and NOD.
Tissue: Lung and Tongue.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[3]Lubec G., Klug S., Yang J.W., Zigmond M.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 115-124, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Brain and Hippocampus.
[4]"A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins."
Meunier L., Usherwood Y.-K., Chung K.T., Hendershot L.M.
Mol. Biol. Cell 13:4456-4469(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: COMPONENT OF A CHAPERONE COMPLEX.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK004795 mRNA. Translation: BAB23570.1.
AK009881 mRNA. Translation: BAB26559.1.
AK154539 mRNA. Translation: BAE32664.1.
AK168112 mRNA. Translation: BAE40083.1.
BC017125 mRNA. Translation: AAH17125.1.
RefSeqNP_080405.1. NM_026129.2.
UniGeneMm.154570.

3D structure databases

ProteinModelPortalP57759.
SMRP57759. Positions 35-257.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid212160. 1 interaction.
IntActP57759. 2 interactions.
MINTMINT-1765655.

PTM databases

PhosphoSiteP57759.

2D gel databases

COMPLUYEAST-2DPAGEP57759.
REPRODUCTION-2DPAGEP57759.

Proteomic databases

PaxDbP57759.
PRIDEP57759.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000130451; ENSMUSP00000117347; ENSMUSG00000029616.
GeneID67397.
KEGGmmu:67397.
UCSCuc008zjf.1. mouse.

Organism-specific databases

CTD10961.
MGIMGI:1914647. Erp29.

Phylogenomic databases

eggNOGNOG82861.
GeneTreeENSGT00390000018566.
HOVERGENHBG051508.
InParanoidP57759.
KOK09586.
OMAPYGEKHE.
PhylomeDBP57759.
TreeFamTF324701.

Gene expression databases

ArrayExpressP57759.
BgeeP57759.
CleanExMM_ERP29.
GenevestigatorP57759.

Family and domain databases

Gene3D1.20.1150.12. 1 hit.
3.40.30.10. 1 hit.
InterProIPR016855. ER_p29.
IPR011679. ER_p29_C.
IPR012883. ERp29_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF07749. ERp29. 1 hit.
PF07912. ERp29_N. 1 hit.
[Graphical view]
PIRSFPIRSF027352. ER_p29. 1 hit.
SUPFAMSSF47933. SSF47933. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSERP29. mouse.
NextBio324462.
PROP57759.
SOURCESearch...

Entry information

Entry nameERP29_MOUSE
AccessionPrimary (citable) accession number: P57759
Secondary accession number(s): Q3THW3, Q9CQ42
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot