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P57759

- ERP29_MOUSE

UniProt

P57759 - ERP29_MOUSE

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Protein

Endoplasmic reticulum resident protein 29

Gene
Erp29
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.

GO - Biological processi

  1. protein secretion Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum resident protein 29
Short name:
ERp29
Gene namesi
Name:Erp29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1914647. Erp29.

Subcellular locationi

Endoplasmic reticulum lumen By similarity. Melanosome By similarity

GO - Cellular componenti

  1. cell surface Source: MGI
  2. endoplasmic reticulum Source: MGI
  3. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  4. melanosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 By similarityAdd
BLAST
Chaini35 – 262228Endoplasmic reticulum resident protein 29PRO_0000021198Add
BLAST

Proteomic databases

MaxQBiP57759.
PaxDbiP57759.
PRIDEiP57759.

2D gel databases

COMPLUYEAST-2DPAGEP57759.
REPRODUCTION-2DPAGEP57759.

PTM databases

PhosphoSiteiP57759.

Expressioni

Gene expression databases

ArrayExpressiP57759.
BgeeiP57759.
CleanExiMM_ERP29.
GenevestigatoriP57759.

Interactioni

Subunit structurei

Homodimer. Part of a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX By similarity.

Protein-protein interaction databases

BioGridi212160. 1 interaction.
IntActiP57759. 2 interactions.
MINTiMINT-1765655.

Structurei

3D structure databases

ProteinModelPortaliP57759.
SMRiP57759. Positions 35-257.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi259 – 2624Prevents secretion from ER By similarity

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG82861.
GeneTreeiENSGT00390000018566.
HOVERGENiHBG051508.
InParanoidiP57759.
KOiK09586.
OMAiPYGEKHE.
PhylomeDBiP57759.
TreeFamiTF324701.

Family and domain databases

Gene3Di1.20.1150.12. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR016855. ER_p29.
IPR011679. ER_p29_C.
IPR012883. ERp29_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF07749. ERp29. 1 hit.
PF07912. ERp29_N. 1 hit.
[Graphical view]
PIRSFiPIRSF027352. ER_p29. 1 hit.
SUPFAMiSSF47933. SSF47933. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57759-1 [UniParc]FASTAAdd to Basket

« Hide

MAAAAGVSGA ASLSPLLSVL LGLLLLFAPH GGSGLHTKGA LPLDTVTFYK    50
VIPKSKFVLV KFDTQYPYGE KQDEFKRLAE NSASSEELLV AEVGISDYGD 100
KLNMELSEKY KLDKESYPVF YLFRDGDLEN PVLYNGAVKV GAIQRWLKGQ 150
GVYLGMPGCL PAYDALAGEF IKASSIEARQ AILKQGQDGL LSVKETEKKW 200
ASQYLKIMGK ILDQGEDFPA SEMARIGKLI ENKMSDSKKE ELQKSLNILT 250
AFRKKEAEKE EL 262
Length:262
Mass (Da):28,823
Last modified:June 1, 2001 - v2
Checksum:iCA4C83757CA8732B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004795 mRNA. Translation: BAB23570.1.
AK009881 mRNA. Translation: BAB26559.1.
AK154539 mRNA. Translation: BAE32664.1.
AK168112 mRNA. Translation: BAE40083.1.
BC017125 mRNA. Translation: AAH17125.1.
CCDSiCCDS19634.1.
RefSeqiNP_080405.1. NM_026129.2.
UniGeneiMm.154570.

Genome annotation databases

EnsembliENSMUST00000130451; ENSMUSP00000117347; ENSMUSG00000029616.
GeneIDi67397.
KEGGimmu:67397.
UCSCiuc008zjf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004795 mRNA. Translation: BAB23570.1 .
AK009881 mRNA. Translation: BAB26559.1 .
AK154539 mRNA. Translation: BAE32664.1 .
AK168112 mRNA. Translation: BAE40083.1 .
BC017125 mRNA. Translation: AAH17125.1 .
CCDSi CCDS19634.1.
RefSeqi NP_080405.1. NM_026129.2.
UniGenei Mm.154570.

3D structure databases

ProteinModelPortali P57759.
SMRi P57759. Positions 35-257.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212160. 1 interaction.
IntActi P57759. 2 interactions.
MINTi MINT-1765655.

PTM databases

PhosphoSitei P57759.

2D gel databases

COMPLUYEAST-2DPAGE P57759.
REPRODUCTION-2DPAGE P57759.

Proteomic databases

MaxQBi P57759.
PaxDbi P57759.
PRIDEi P57759.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000130451 ; ENSMUSP00000117347 ; ENSMUSG00000029616 .
GeneIDi 67397.
KEGGi mmu:67397.
UCSCi uc008zjf.1. mouse.

Organism-specific databases

CTDi 10961.
MGIi MGI:1914647. Erp29.

Phylogenomic databases

eggNOGi NOG82861.
GeneTreei ENSGT00390000018566.
HOVERGENi HBG051508.
InParanoidi P57759.
KOi K09586.
OMAi PYGEKHE.
PhylomeDBi P57759.
TreeFami TF324701.

Miscellaneous databases

ChiTaRSi ERP29. mouse.
NextBioi 324462.
PROi P57759.
SOURCEi Search...

Gene expression databases

ArrayExpressi P57759.
Bgeei P57759.
CleanExi MM_ERP29.
Genevestigatori P57759.

Family and domain databases

Gene3Di 1.20.1150.12. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR016855. ER_p29.
IPR011679. ER_p29_C.
IPR012883. ERp29_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF07749. ERp29. 1 hit.
PF07912. ERp29_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF027352. ER_p29. 1 hit.
SUPFAMi SSF47933. SSF47933. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/c, C57BL/6J and NOD.
    Tissue: Lung and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. Lubec G., Klug S., Yang J.W., Zigmond M.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 115-124, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain and Hippocampus.
  4. "A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins."
    Meunier L., Usherwood Y.-K., Chung K.T., Hendershot L.M.
    Mol. Biol. Cell 13:4456-4469(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPONENT OF A CHAPERONE COMPLEX.

Entry informationi

Entry nameiERP29_MOUSE
AccessioniPrimary (citable) accession number: P57759
Secondary accession number(s): Q3THW3, Q9CQ42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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