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Protein

Endoplasmic reticulum resident protein 29

Gene

Erp29

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.

GO - Biological processi

  1. protein secretion Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum resident protein 29
Short name:
ERp29
Gene namesi
Name:Erp29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1914647. Erp29.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation. Melanosome By similarity

GO - Cellular componenti

  1. cell surface Source: MGI
  2. endoplasmic reticulum Source: MGI
  3. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  4. extracellular vesicular exosome Source: Ensembl
  5. melanosome Source: UniProtKB-SubCell
  6. membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434By similarityAdd
BLAST
Chaini35 – 262228Endoplasmic reticulum resident protein 29PRO_0000021198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 661Phosphotyrosine; by PKDCCBy similarity
Modified residuei68 – 681Phosphotyrosine; by PKDCCBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP57759.
PaxDbiP57759.
PRIDEiP57759.

2D gel databases

COMPLUYEAST-2DPAGEP57759.
REPRODUCTION-2DPAGEP57759.

PTM databases

PhosphoSiteiP57759.

Expressioni

Gene expression databases

BgeeiP57759.
CleanExiMM_ERP29.
ExpressionAtlasiP57759. baseline and differential.
GenevestigatoriP57759.

Interactioni

Subunit structurei

Homodimer. Part of a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX (By similarity).By similarity

Protein-protein interaction databases

BioGridi212160. 1 interaction.
IntActiP57759. 2 interactions.
MINTiMINT-1765655.

Structurei

3D structure databases

ProteinModelPortaliP57759.
SMRiP57759. Positions 35-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi259 – 2624Prevents secretion from ERPROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG82861.
GeneTreeiENSGT00390000018566.
HOVERGENiHBG051508.
InParanoidiP57759.
KOiK09586.
OMAiGEKYKLD.
PhylomeDBiP57759.
TreeFamiTF324701.

Family and domain databases

Gene3Di1.20.1150.12. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR016855. ER_p29.
IPR011679. ER_p29_C.
IPR012883. ERp29_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF07749. ERp29. 1 hit.
PF07912. ERp29_N. 1 hit.
[Graphical view]
PIRSFiPIRSF027352. ER_p29. 1 hit.
SUPFAMiSSF47933. SSF47933. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P57759-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAAGVSGA ASLSPLLSVL LGLLLLFAPH GGSGLHTKGA LPLDTVTFYK
60 70 80 90 100
VIPKSKFVLV KFDTQYPYGE KQDEFKRLAE NSASSEELLV AEVGISDYGD
110 120 130 140 150
KLNMELSEKY KLDKESYPVF YLFRDGDLEN PVLYNGAVKV GAIQRWLKGQ
160 170 180 190 200
GVYLGMPGCL PAYDALAGEF IKASSIEARQ AILKQGQDGL LSVKETEKKW
210 220 230 240 250
ASQYLKIMGK ILDQGEDFPA SEMARIGKLI ENKMSDSKKE ELQKSLNILT
260
AFRKKEAEKE EL
Length:262
Mass (Da):28,823
Last modified:June 1, 2001 - v2
Checksum:iCA4C83757CA8732B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004795 mRNA. Translation: BAB23570.1.
AK009881 mRNA. Translation: BAB26559.1.
AK154539 mRNA. Translation: BAE32664.1.
AK168112 mRNA. Translation: BAE40083.1.
BC017125 mRNA. Translation: AAH17125.1.
CCDSiCCDS19634.1.
RefSeqiNP_080405.1. NM_026129.2.
UniGeneiMm.154570.

Genome annotation databases

EnsembliENSMUST00000130451; ENSMUSP00000117347; ENSMUSG00000029616.
GeneIDi67397.
KEGGimmu:67397.
UCSCiuc008zjf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004795 mRNA. Translation: BAB23570.1.
AK009881 mRNA. Translation: BAB26559.1.
AK154539 mRNA. Translation: BAE32664.1.
AK168112 mRNA. Translation: BAE40083.1.
BC017125 mRNA. Translation: AAH17125.1.
CCDSiCCDS19634.1.
RefSeqiNP_080405.1. NM_026129.2.
UniGeneiMm.154570.

3D structure databases

ProteinModelPortaliP57759.
SMRiP57759. Positions 35-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212160. 1 interaction.
IntActiP57759. 2 interactions.
MINTiMINT-1765655.

PTM databases

PhosphoSiteiP57759.

2D gel databases

COMPLUYEAST-2DPAGEP57759.
REPRODUCTION-2DPAGEP57759.

Proteomic databases

MaxQBiP57759.
PaxDbiP57759.
PRIDEiP57759.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000130451; ENSMUSP00000117347; ENSMUSG00000029616.
GeneIDi67397.
KEGGimmu:67397.
UCSCiuc008zjf.1. mouse.

Organism-specific databases

CTDi10961.
MGIiMGI:1914647. Erp29.

Phylogenomic databases

eggNOGiNOG82861.
GeneTreeiENSGT00390000018566.
HOVERGENiHBG051508.
InParanoidiP57759.
KOiK09586.
OMAiGEKYKLD.
PhylomeDBiP57759.
TreeFamiTF324701.

Miscellaneous databases

ChiTaRSiErp29. mouse.
NextBioi324462.
PROiP57759.
SOURCEiSearch...

Gene expression databases

BgeeiP57759.
CleanExiMM_ERP29.
ExpressionAtlasiP57759. baseline and differential.
GenevestigatoriP57759.

Family and domain databases

Gene3Di1.20.1150.12. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR016855. ER_p29.
IPR011679. ER_p29_C.
IPR012883. ERp29_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF07749. ERp29. 1 hit.
PF07912. ERp29_N. 1 hit.
[Graphical view]
PIRSFiPIRSF027352. ER_p29. 1 hit.
SUPFAMiSSF47933. SSF47933. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/c, C57BL/6J and NOD.
    Tissue: Lung and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. Lubec G., Klug S., Yang J.W., Zigmond M.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 115-124, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain and Hippocampus.
  4. "A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins."
    Meunier L., Usherwood Y.-K., Chung K.T., Hendershot L.M.
    Mol. Biol. Cell 13:4456-4469(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPONENT OF A CHAPERONE COMPLEX.

Entry informationi

Entry nameiERP29_MOUSE
AccessioniPrimary (citable) accession number: P57759
Secondary accession number(s): Q3THW3, Q9CQ42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 1, 2001
Last modified: January 7, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.