Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P57757

- CTNS_MOUSE

UniProt

P57757 - CTNS_MOUSE

Protein

Cystinosin

Gene

Ctns

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (21 Feb 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Thought to transport cystine out of lysosomes.

    GO - Molecular functioni

    1. L-cystine transmembrane transporter activity Source: MGI

    GO - Biological processi

    1. adult walking behavior Source: MGI
    2. ATP metabolic process Source: Ensembl
    3. brain development Source: Ensembl
    4. glutathione metabolic process Source: Ensembl
    5. grooming behavior Source: MGI
    6. L-cystine transport Source: MGI
    7. lens development in camera-type eye Source: MGI
    8. long-term memory Source: MGI
    9. visual learning Source: MGI

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cystinosin
    Gene namesi
    Name:Ctns
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1932872. Ctns.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. late endosome Source: Ensembl
    3. lysosomal membrane Source: UniProtKB-SubCell
    4. lysosome Source: MGI
    5. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367CystinosinPRO_0000205515Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi66 – 661N-linked (GlcNAc...)1 Publication
    Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP57757.

    Expressioni

    Gene expression databases

    ArrayExpressiP57757.
    BgeeiP57757.
    CleanExiMM_CTNS.
    GenevestigatoriP57757.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 121121LumenalSequence AnalysisAdd
    BLAST
    Topological domaini143 – 16119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini183 – 20523LumenalSequence AnalysisAdd
    BLAST
    Topological domaini227 – 23711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 2613LumenalSequence Analysis
    Topological domaini283 – 29715CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini319 – 33517LumenalSequence AnalysisAdd
    BLAST
    Topological domaini357 – 36711CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei122 – 14221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei162 – 18221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei336 – 35621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini123 – 18967PQ-loop 1Add
    BLAST
    Domaini263 – 32866PQ-loop 2Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi362 – 3665Lysosomal targeting motifSequence Analysis

    Sequence similaritiesi

    Belongs to the cystinosin family.Curated
    Contains 2 PQ-loop domains.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG266153.
    HOGENOMiHOG000192503.
    HOVERGENiHBG003083.
    InParanoidiP57757.
    KOiK12386.
    OMAiFQVTSQN.
    OrthoDBiEOG7T1RBM.
    PhylomeDBiP57757.
    TreeFamiTF313589.

    Family and domain databases

    InterProiIPR005282. LC_transporter.
    IPR006603. PQ-loop_rpt.
    [Graphical view]
    PANTHERiPTHR13131. PTHR13131. 1 hit.
    PfamiPF04193. PQ-loop. 2 hits.
    [Graphical view]
    SMARTiSM00679. CTNS. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00951. 2A43. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P57757-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRNWLLILT LFLLMFIEKY ESTVSLTAPP TVKLENGSST NVDITLGHPL    50
    NSTLVITFEV TFRSKNLTIV ELPDEVIVPR GEKNASFQVT SQNIGQVTVF 100
    LHGNHSNQTC PRIRFLVIHS RIVSIINQVI GWIYFMAWSV SFYPQVIQNW 150
    RRKSVIGLSF DFLALNLTGF VAYSVFNIGL LWVPYIQEEF LLKYPNGVNP 200
    VDSNDAFFSL HAVALTLIVI LQCCLYERGN QRVSWPSIGF LVLAWLFVLV 250
    TMIVAAVGIT TWLQFLFCFS YIKLIITLIK YFPQAYMNFY YKSTKGWSIG 300
    GVLLDFTGGS FSLLQMFLQS YNNDQWTLIF GDPTKFGLGV FTIFFDVVFF 350
    IQHFYLYRKK PGYDQLN 367
    Length:367
    Mass (Da):42,203
    Last modified:February 21, 2001 - v1
    Checksum:i651DF351189C419E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250670 mRNA. Translation: CAC19455.1.
    AK078511 mRNA. Translation: BAC37316.1.
    BC005479 mRNA. Translation: AAH05479.1.
    CCDSiCCDS25001.1.
    RefSeqiNP_112541.1. NM_031251.4.
    XP_006534596.1. XM_006534533.1.
    XP_006534597.1. XM_006534534.1.
    XP_006536368.1. XM_006536305.1.
    XP_006536369.1. XM_006536306.1.
    UniGeneiMm.259852.

    Genome annotation databases

    EnsembliENSMUST00000006103; ENSMUSP00000006103; ENSMUSG00000005949.
    ENSMUST00000108476; ENSMUSP00000104116; ENSMUSG00000005949.
    GeneIDi83429.
    KEGGimmu:83429.
    UCSCiuc007kae.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250670 mRNA. Translation: CAC19455.1 .
    AK078511 mRNA. Translation: BAC37316.1 .
    BC005479 mRNA. Translation: AAH05479.1 .
    CCDSi CCDS25001.1.
    RefSeqi NP_112541.1. NM_031251.4.
    XP_006534596.1. XM_006534533.1.
    XP_006534597.1. XM_006534534.1.
    XP_006536368.1. XM_006536305.1.
    XP_006536369.1. XM_006536306.1.
    UniGenei Mm.259852.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P57757.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006103 ; ENSMUSP00000006103 ; ENSMUSG00000005949 .
    ENSMUST00000108476 ; ENSMUSP00000104116 ; ENSMUSG00000005949 .
    GeneIDi 83429.
    KEGGi mmu:83429.
    UCSCi uc007kae.1. mouse.

    Organism-specific databases

    CTDi 1497.
    MGIi MGI:1932872. Ctns.

    Phylogenomic databases

    eggNOGi NOG266153.
    HOGENOMi HOG000192503.
    HOVERGENi HBG003083.
    InParanoidi P57757.
    KOi K12386.
    OMAi FQVTSQN.
    OrthoDBi EOG7T1RBM.
    PhylomeDBi P57757.
    TreeFami TF313589.

    Miscellaneous databases

    NextBioi 350546.
    PROi P57757.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P57757.
    Bgeei P57757.
    CleanExi MM_CTNS.
    Genevestigatori P57757.

    Family and domain databases

    InterProi IPR005282. LC_transporter.
    IPR006603. PQ-loop_rpt.
    [Graphical view ]
    PANTHERi PTHR13131. PTHR13131. 1 hit.
    Pfami PF04193. PQ-loop. 2 hits.
    [Graphical view ]
    SMARTi SM00679. CTNS. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00951. 2A43. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterisation of the murine homologue of the gene responsible for cystinosis, Ctns."
      Cherqui S., Kalatzis V., Forestier L., Poras I., Antignac C.
      BMC Genomics 1:2-2(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-66.

    Entry informationi

    Entry nameiCTNS_MOUSE
    AccessioniPrimary (citable) accession number: P57757
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: February 21, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3