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Protein

Cystinosin

Gene

Ctns

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cystine/H+ symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR.1 Publication

GO - Molecular functioni

  • L-cystine transmembrane transporter activity Source: MGI

GO - Biological processi

  • adult walking behavior Source: MGI
  • ATP metabolic process Source: MGI
  • brain development Source: MGI
  • cognition Source: MGI
  • glutathione metabolic process Source: MGI
  • grooming behavior Source: MGI
  • L-cystine transport Source: MGI
  • lens development in camera-type eye Source: MGI
  • long-term memory Source: MGI
  • melanin biosynthetic process Source: UniProtKB-KW
  • visual learning Source: MGI
Complete GO annotation...

Keywords - Biological processi

Melanin biosynthesis, Transport

Enzyme and pathway databases

ReactomeiR-MMU-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.
R-MMU-5223345. Miscellaneous transport and binding events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystinosin
Gene namesi
Name:Ctns
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1932872. Ctns.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 121LumenalSequence analysisAdd BLAST121
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 161CytoplasmicSequence analysisAdd BLAST19
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 205LumenalSequence analysisAdd BLAST23
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 237CytoplasmicSequence analysisAdd BLAST11
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 261LumenalSequence analysis3
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 297CytoplasmicSequence analysisAdd BLAST15
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 335LumenalSequence analysisAdd BLAST17
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Topological domaini357 – 367CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002055151 – 367CystinosinAdd BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...)Sequence analysis1
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Glycosylationi66N-linked (GlcNAc...)1 Publication1
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi107N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP57757.
PRIDEiP57757.

PTM databases

PhosphoSitePlusiP57757.

Expressioni

Gene expression databases

BgeeiENSMUSG00000005949.
CleanExiMM_CTNS.
ExpressionAtlasiP57757. baseline and differential.
GenevisibleiP57757. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006103.

Structurei

3D structure databases

ProteinModelPortaliP57757.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 189PQ-loop 1Add BLAST67
Domaini263 – 328PQ-loop 2Add BLAST66

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi362 – 366Lysosomal targeting motifSequence analysis5

Sequence similaritiesi

Belongs to the cystinosin family.Curated
Contains 2 PQ-loop domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3145. Eukaryota.
ENOG410XQSD. LUCA.
GeneTreeiENSGT00390000005338.
HOGENOMiHOG000192503.
HOVERGENiHBG003083.
InParanoidiP57757.
KOiK12386.
OMAiFFIQHFC.
OrthoDBiEOG091G0BG6.
PhylomeDBiP57757.
TreeFamiTF313589.

Family and domain databases

InterProiIPR005282. LC_transporter.
IPR006603. PQ-loop_rpt.
[Graphical view]
PANTHERiPTHR13131. PTHR13131. 1 hit.
PfamiPF04193. PQ-loop. 2 hits.
[Graphical view]
SMARTiSM00679. CTNS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00951. 2A43. 1 hit.

Sequencei

Sequence statusi: Complete.

P57757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRNWLLILT LFLLMFIEKY ESTVSLTAPP TVKLENGSST NVDITLGHPL
60 70 80 90 100
NSTLVITFEV TFRSKNLTIV ELPDEVIVPR GEKNASFQVT SQNIGQVTVF
110 120 130 140 150
LHGNHSNQTC PRIRFLVIHS RIVSIINQVI GWIYFMAWSV SFYPQVIQNW
160 170 180 190 200
RRKSVIGLSF DFLALNLTGF VAYSVFNIGL LWVPYIQEEF LLKYPNGVNP
210 220 230 240 250
VDSNDAFFSL HAVALTLIVI LQCCLYERGN QRVSWPSIGF LVLAWLFVLV
260 270 280 290 300
TMIVAAVGIT TWLQFLFCFS YIKLIITLIK YFPQAYMNFY YKSTKGWSIG
310 320 330 340 350
GVLLDFTGGS FSLLQMFLQS YNNDQWTLIF GDPTKFGLGV FTIFFDVVFF
360
IQHFYLYRKK PGYDQLN
Length:367
Mass (Da):42,203
Last modified:February 21, 2001 - v1
Checksum:i651DF351189C419E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250670 mRNA. Translation: CAC19455.1.
AK078511 mRNA. Translation: BAC37316.1.
BC005479 mRNA. Translation: AAH05479.1.
CCDSiCCDS25001.1.
RefSeqiNP_112541.1. NM_031251.4.
XP_006534596.1. XM_006534533.3.
XP_006534597.1. XM_006534534.3.
UniGeneiMm.259852.

Genome annotation databases

EnsembliENSMUST00000006103; ENSMUSP00000006103; ENSMUSG00000005949.
ENSMUST00000108476; ENSMUSP00000104116; ENSMUSG00000005949.
GeneIDi83429.
KEGGimmu:83429.
UCSCiuc007kae.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250670 mRNA. Translation: CAC19455.1.
AK078511 mRNA. Translation: BAC37316.1.
BC005479 mRNA. Translation: AAH05479.1.
CCDSiCCDS25001.1.
RefSeqiNP_112541.1. NM_031251.4.
XP_006534596.1. XM_006534533.3.
XP_006534597.1. XM_006534534.3.
UniGeneiMm.259852.

3D structure databases

ProteinModelPortaliP57757.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006103.

PTM databases

PhosphoSitePlusiP57757.

Proteomic databases

PaxDbiP57757.
PRIDEiP57757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006103; ENSMUSP00000006103; ENSMUSG00000005949.
ENSMUST00000108476; ENSMUSP00000104116; ENSMUSG00000005949.
GeneIDi83429.
KEGGimmu:83429.
UCSCiuc007kae.1. mouse.

Organism-specific databases

CTDi1497.
MGIiMGI:1932872. Ctns.

Phylogenomic databases

eggNOGiKOG3145. Eukaryota.
ENOG410XQSD. LUCA.
GeneTreeiENSGT00390000005338.
HOGENOMiHOG000192503.
HOVERGENiHBG003083.
InParanoidiP57757.
KOiK12386.
OMAiFFIQHFC.
OrthoDBiEOG091G0BG6.
PhylomeDBiP57757.
TreeFamiTF313589.

Enzyme and pathway databases

ReactomeiR-MMU-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.
R-MMU-5223345. Miscellaneous transport and binding events.

Miscellaneous databases

PROiP57757.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005949.
CleanExiMM_CTNS.
ExpressionAtlasiP57757. baseline and differential.
GenevisibleiP57757. MM.

Family and domain databases

InterProiIPR005282. LC_transporter.
IPR006603. PQ-loop_rpt.
[Graphical view]
PANTHERiPTHR13131. PTHR13131. 1 hit.
PfamiPF04193. PQ-loop. 2 hits.
[Graphical view]
SMARTiSM00679. CTNS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00951. 2A43. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCTNS_MOUSE
AccessioniPrimary (citable) accession number: P57757
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.