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P57757 (CTNS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cystinosin
Gene names
Name:Ctns
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Thought to transport cystine out of lysosomes.

Subcellular location

Lysosome membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cystinosin family.

Contains 2 PQ-loop domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Cystinosin
PRO_0000205515

Regions

Topological domain1 – 121121Lumenal Potential
Transmembrane122 – 14221Helical; Potential
Topological domain143 – 16119Cytoplasmic Potential
Transmembrane162 – 18221Helical; Potential
Topological domain183 – 20523Lumenal Potential
Transmembrane206 – 22621Helical; Potential
Topological domain227 – 23711Cytoplasmic Potential
Transmembrane238 – 25821Helical; Potential
Topological domain259 – 2613Lumenal Potential
Transmembrane262 – 28221Helical; Potential
Topological domain283 – 29715Cytoplasmic Potential
Transmembrane298 – 31821Helical; Potential
Topological domain319 – 33517Lumenal Potential
Transmembrane336 – 35621Helical; Potential
Topological domain357 – 36711Cytoplasmic Potential
Domain123 – 18967PQ-loop 1
Domain263 – 32866PQ-loop 2
Motif362 – 3665Lysosomal targeting motif Potential

Amino acid modifications

Glycosylation361N-linked (GlcNAc...) Potential
Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation661N-linked (GlcNAc...) Ref.4
Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1071N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P57757 [UniParc].

Last modified February 21, 2001. Version 1.
Checksum: 651DF351189C419E

FASTA36742,203
        10         20         30         40         50         60 
MRRNWLLILT LFLLMFIEKY ESTVSLTAPP TVKLENGSST NVDITLGHPL NSTLVITFEV 

        70         80         90        100        110        120 
TFRSKNLTIV ELPDEVIVPR GEKNASFQVT SQNIGQVTVF LHGNHSNQTC PRIRFLVIHS 

       130        140        150        160        170        180 
RIVSIINQVI GWIYFMAWSV SFYPQVIQNW RRKSVIGLSF DFLALNLTGF VAYSVFNIGL 

       190        200        210        220        230        240 
LWVPYIQEEF LLKYPNGVNP VDSNDAFFSL HAVALTLIVI LQCCLYERGN QRVSWPSIGF 

       250        260        270        280        290        300 
LVLAWLFVLV TMIVAAVGIT TWLQFLFCFS YIKLIITLIK YFPQAYMNFY YKSTKGWSIG 

       310        320        330        340        350        360 
GVLLDFTGGS FSLLQMFLQS YNNDQWTLIF GDPTKFGLGV FTIFFDVVFF IQHFYLYRKK 


PGYDQLN 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterisation of the murine homologue of the gene responsible for cystinosis, Ctns."
Cherqui S., Kalatzis V., Forestier L., Poras I., Antignac C.
BMC Genomics 1:2-2(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
[4]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-66.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ250670 mRNA. Translation: CAC19455.1.
AK078511 mRNA. Translation: BAC37316.1.
BC005479 mRNA. Translation: AAH05479.1.
RefSeqNP_112541.1. NM_031251.4.
XP_006534596.1. XM_006534533.1.
XP_006534597.1. XM_006534534.1.
XP_006536368.1. XM_006536305.1.
XP_006536369.1. XM_006536306.1.
UniGeneMm.259852.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP57757.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000006103; ENSMUSP00000006103; ENSMUSG00000005949.
ENSMUST00000108476; ENSMUSP00000104116; ENSMUSG00000005949.
GeneID83429.
KEGGmmu:83429.
UCSCuc007kae.1. mouse.

Organism-specific databases

CTD1497.
MGIMGI:1932872. Ctns.

Phylogenomic databases

eggNOGNOG266153.
HOGENOMHOG000192503.
HOVERGENHBG003083.
InParanoidP57757.
KOK12386.
OMAFQVTSQN.
OrthoDBEOG7T1RBM.
PhylomeDBP57757.
TreeFamTF313589.

Gene expression databases

ArrayExpressP57757.
BgeeP57757.
CleanExMM_CTNS.
GenevestigatorP57757.

Family and domain databases

InterProIPR005282. LC_transporter.
IPR006603. PQ-loop_rpt.
[Graphical view]
PANTHERPTHR13131. PTHR13131. 1 hit.
PfamPF04193. PQ-loop. 2 hits.
[Graphical view]
SMARTSM00679. CTNS. 2 hits.
[Graphical view]
TIGRFAMsTIGR00951. 2A43. 1 hit.
ProtoNetSearch...

Other

NextBio350546.
PROP57757.
SOURCESearch...

Entry information

Entry nameCTNS_MOUSE
AccessionPrimary (citable) accession number: P57757
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot