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P57757

- CTNS_MOUSE

UniProt

P57757 - CTNS_MOUSE

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Protein

Cystinosin

Gene
Ctns
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Thought to transport cystine out of lysosomes.

GO - Molecular functioni

  1. L-cystine transmembrane transporter activity Source: MGI

GO - Biological processi

  1. adult walking behavior Source: MGI
  2. ATP metabolic process Source: Ensembl
  3. brain development Source: Ensembl
  4. glutathione metabolic process Source: Ensembl
  5. grooming behavior Source: MGI
  6. L-cystine transport Source: MGI
  7. lens development in camera-type eye Source: MGI
  8. long-term memory Source: MGI
  9. visual learning Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cystinosin
Gene namesi
Name:Ctns
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1932872. Ctns.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 121121Lumenal Reviewed predictionAdd
BLAST
Transmembranei122 – 14221Helical; Reviewed predictionAdd
BLAST
Topological domaini143 – 16119Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei162 – 18221Helical; Reviewed predictionAdd
BLAST
Topological domaini183 – 20523Lumenal Reviewed predictionAdd
BLAST
Transmembranei206 – 22621Helical; Reviewed predictionAdd
BLAST
Topological domaini227 – 23711Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei238 – 25821Helical; Reviewed predictionAdd
BLAST
Topological domaini259 – 2613Lumenal Reviewed prediction
Transmembranei262 – 28221Helical; Reviewed predictionAdd
BLAST
Topological domaini283 – 29715Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei298 – 31821Helical; Reviewed predictionAdd
BLAST
Topological domaini319 – 33517Lumenal Reviewed predictionAdd
BLAST
Transmembranei336 – 35621Helical; Reviewed predictionAdd
BLAST
Topological domaini357 – 36711Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. late endosome Source: Ensembl
  3. lysosomal membrane Source: UniProtKB-SubCell
  4. lysosome Source: MGI
  5. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367CystinosinPRO_0000205515Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi51 – 511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi66 – 661N-linked (GlcNAc...)1 Publication
Glycosylationi84 – 841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi104 – 1041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi107 – 1071N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP57757.

Expressioni

Gene expression databases

ArrayExpressiP57757.
BgeeiP57757.
CleanExiMM_CTNS.
GenevestigatoriP57757.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini123 – 18967PQ-loop 1Add
BLAST
Domaini263 – 32866PQ-loop 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi362 – 3665Lysosomal targeting motif Reviewed prediction

Sequence similaritiesi

Belongs to the cystinosin family.
Contains 2 PQ-loop domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG266153.
HOGENOMiHOG000192503.
HOVERGENiHBG003083.
InParanoidiP57757.
KOiK12386.
OMAiFQVTSQN.
OrthoDBiEOG7T1RBM.
PhylomeDBiP57757.
TreeFamiTF313589.

Family and domain databases

InterProiIPR005282. LC_transporter.
IPR006603. PQ-loop_rpt.
[Graphical view]
PANTHERiPTHR13131. PTHR13131. 1 hit.
PfamiPF04193. PQ-loop. 2 hits.
[Graphical view]
SMARTiSM00679. CTNS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00951. 2A43. 1 hit.

Sequencei

Sequence statusi: Complete.

P57757-1 [UniParc]FASTAAdd to Basket

« Hide

MRRNWLLILT LFLLMFIEKY ESTVSLTAPP TVKLENGSST NVDITLGHPL    50
NSTLVITFEV TFRSKNLTIV ELPDEVIVPR GEKNASFQVT SQNIGQVTVF 100
LHGNHSNQTC PRIRFLVIHS RIVSIINQVI GWIYFMAWSV SFYPQVIQNW 150
RRKSVIGLSF DFLALNLTGF VAYSVFNIGL LWVPYIQEEF LLKYPNGVNP 200
VDSNDAFFSL HAVALTLIVI LQCCLYERGN QRVSWPSIGF LVLAWLFVLV 250
TMIVAAVGIT TWLQFLFCFS YIKLIITLIK YFPQAYMNFY YKSTKGWSIG 300
GVLLDFTGGS FSLLQMFLQS YNNDQWTLIF GDPTKFGLGV FTIFFDVVFF 350
IQHFYLYRKK PGYDQLN 367
Length:367
Mass (Da):42,203
Last modified:February 21, 2001 - v1
Checksum:i651DF351189C419E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ250670 mRNA. Translation: CAC19455.1.
AK078511 mRNA. Translation: BAC37316.1.
BC005479 mRNA. Translation: AAH05479.1.
CCDSiCCDS25001.1.
RefSeqiNP_112541.1. NM_031251.4.
XP_006534596.1. XM_006534533.1.
XP_006534597.1. XM_006534534.1.
XP_006536368.1. XM_006536305.1.
XP_006536369.1. XM_006536306.1.
UniGeneiMm.259852.

Genome annotation databases

EnsembliENSMUST00000006103; ENSMUSP00000006103; ENSMUSG00000005949.
ENSMUST00000108476; ENSMUSP00000104116; ENSMUSG00000005949.
GeneIDi83429.
KEGGimmu:83429.
UCSCiuc007kae.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ250670 mRNA. Translation: CAC19455.1 .
AK078511 mRNA. Translation: BAC37316.1 .
BC005479 mRNA. Translation: AAH05479.1 .
CCDSi CCDS25001.1.
RefSeqi NP_112541.1. NM_031251.4.
XP_006534596.1. XM_006534533.1.
XP_006534597.1. XM_006534534.1.
XP_006536368.1. XM_006536305.1.
XP_006536369.1. XM_006536306.1.
UniGenei Mm.259852.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P57757.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006103 ; ENSMUSP00000006103 ; ENSMUSG00000005949 .
ENSMUST00000108476 ; ENSMUSP00000104116 ; ENSMUSG00000005949 .
GeneIDi 83429.
KEGGi mmu:83429.
UCSCi uc007kae.1. mouse.

Organism-specific databases

CTDi 1497.
MGIi MGI:1932872. Ctns.

Phylogenomic databases

eggNOGi NOG266153.
HOGENOMi HOG000192503.
HOVERGENi HBG003083.
InParanoidi P57757.
KOi K12386.
OMAi FQVTSQN.
OrthoDBi EOG7T1RBM.
PhylomeDBi P57757.
TreeFami TF313589.

Miscellaneous databases

NextBioi 350546.
PROi P57757.
SOURCEi Search...

Gene expression databases

ArrayExpressi P57757.
Bgeei P57757.
CleanExi MM_CTNS.
Genevestigatori P57757.

Family and domain databases

InterProi IPR005282. LC_transporter.
IPR006603. PQ-loop_rpt.
[Graphical view ]
PANTHERi PTHR13131. PTHR13131. 1 hit.
Pfami PF04193. PQ-loop. 2 hits.
[Graphical view ]
SMARTi SM00679. CTNS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00951. 2A43. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterisation of the murine homologue of the gene responsible for cystinosis, Ctns."
    Cherqui S., Kalatzis V., Forestier L., Poras I., Antignac C.
    BMC Genomics 1:2-2(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-66.

Entry informationi

Entry nameiCTNS_MOUSE
AccessioniPrimary (citable) accession number: P57757
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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