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P57757

- CTNS_MOUSE

UniProt

P57757 - CTNS_MOUSE

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Protein

Cystinosin

Gene

Ctns

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cystine/H+ symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR.1 Publication

GO - Molecular functioni

  1. L-cystine transmembrane transporter activity Source: MGI

GO - Biological processi

  1. adult walking behavior Source: MGI
  2. ATP metabolic process Source: Ensembl
  3. brain development Source: Ensembl
  4. glutathione metabolic process Source: Ensembl
  5. grooming behavior Source: MGI
  6. L-cystine transport Source: MGI
  7. lens development in camera-type eye Source: MGI
  8. long-term memory Source: MGI
  9. visual learning Source: MGI
Complete GO annotation...

Keywords - Biological processi

Melanin biosynthesis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cystinosin
Gene namesi
Name:Ctns
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1932872. Ctns.

Subcellular locationi

Lysosome membrane By similarity; Multi-pass membrane protein. Melanosome 1 Publication

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. intermediate filament cytoskeleton Source: Ensembl
  4. late endosome Source: Ensembl
  5. lysosomal membrane Source: Ensembl
  6. lysosome Source: MGI
  7. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367CystinosinPRO_0000205515Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi66 – 661N-linked (GlcNAc...)1 Publication
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP57757.

Expressioni

Gene expression databases

BgeeiP57757.
CleanExiMM_CTNS.
ExpressionAtlasiP57757. baseline.
GenevestigatoriP57757.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 121121LumenalSequence AnalysisAdd
BLAST
Topological domaini143 – 16119CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini183 – 20523LumenalSequence AnalysisAdd
BLAST
Topological domaini227 – 23711CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini259 – 2613LumenalSequence Analysis
Topological domaini283 – 29715CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini319 – 33517LumenalSequence AnalysisAdd
BLAST
Topological domaini357 – 36711CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei122 – 14221HelicalSequence AnalysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence AnalysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence AnalysisAdd
BLAST
Transmembranei262 – 28221HelicalSequence AnalysisAdd
BLAST
Transmembranei298 – 31821HelicalSequence AnalysisAdd
BLAST
Transmembranei336 – 35621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini123 – 18967PQ-loop 1Add
BLAST
Domaini263 – 32866PQ-loop 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi362 – 3665Lysosomal targeting motifSequence Analysis

Sequence similaritiesi

Belongs to the cystinosin family.Curated
Contains 2 PQ-loop domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG266153.
HOGENOMiHOG000192503.
HOVERGENiHBG003083.
InParanoidiP57757.
KOiK12386.
OMAiFQVTSQN.
OrthoDBiEOG7T1RBM.
PhylomeDBiP57757.
TreeFamiTF313589.

Family and domain databases

InterProiIPR005282. LC_transporter.
IPR006603. PQ-loop_rpt.
[Graphical view]
PANTHERiPTHR13131. PTHR13131. 1 hit.
PfamiPF04193. PQ-loop. 2 hits.
[Graphical view]
SMARTiSM00679. CTNS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00951. 2A43. 1 hit.

Sequencei

Sequence statusi: Complete.

P57757-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRNWLLILT LFLLMFIEKY ESTVSLTAPP TVKLENGSST NVDITLGHPL
60 70 80 90 100
NSTLVITFEV TFRSKNLTIV ELPDEVIVPR GEKNASFQVT SQNIGQVTVF
110 120 130 140 150
LHGNHSNQTC PRIRFLVIHS RIVSIINQVI GWIYFMAWSV SFYPQVIQNW
160 170 180 190 200
RRKSVIGLSF DFLALNLTGF VAYSVFNIGL LWVPYIQEEF LLKYPNGVNP
210 220 230 240 250
VDSNDAFFSL HAVALTLIVI LQCCLYERGN QRVSWPSIGF LVLAWLFVLV
260 270 280 290 300
TMIVAAVGIT TWLQFLFCFS YIKLIITLIK YFPQAYMNFY YKSTKGWSIG
310 320 330 340 350
GVLLDFTGGS FSLLQMFLQS YNNDQWTLIF GDPTKFGLGV FTIFFDVVFF
360
IQHFYLYRKK PGYDQLN
Length:367
Mass (Da):42,203
Last modified:February 21, 2001 - v1
Checksum:i651DF351189C419E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ250670 mRNA. Translation: CAC19455.1.
AK078511 mRNA. Translation: BAC37316.1.
BC005479 mRNA. Translation: AAH05479.1.
CCDSiCCDS25001.1.
RefSeqiNP_112541.1. NM_031251.4.
XP_006534596.1. XM_006534533.1.
XP_006534597.1. XM_006534534.1.
XP_006536368.1. XM_006536305.1.
XP_006536369.1. XM_006536306.1.
UniGeneiMm.259852.

Genome annotation databases

EnsembliENSMUST00000006103; ENSMUSP00000006103; ENSMUSG00000005949.
ENSMUST00000108476; ENSMUSP00000104116; ENSMUSG00000005949.
GeneIDi83429.
KEGGimmu:83429.
UCSCiuc007kae.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ250670 mRNA. Translation: CAC19455.1 .
AK078511 mRNA. Translation: BAC37316.1 .
BC005479 mRNA. Translation: AAH05479.1 .
CCDSi CCDS25001.1.
RefSeqi NP_112541.1. NM_031251.4.
XP_006534596.1. XM_006534533.1.
XP_006534597.1. XM_006534534.1.
XP_006536368.1. XM_006536305.1.
XP_006536369.1. XM_006536306.1.
UniGenei Mm.259852.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P57757.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006103 ; ENSMUSP00000006103 ; ENSMUSG00000005949 .
ENSMUST00000108476 ; ENSMUSP00000104116 ; ENSMUSG00000005949 .
GeneIDi 83429.
KEGGi mmu:83429.
UCSCi uc007kae.1. mouse.

Organism-specific databases

CTDi 1497.
MGIi MGI:1932872. Ctns.

Phylogenomic databases

eggNOGi NOG266153.
HOGENOMi HOG000192503.
HOVERGENi HBG003083.
InParanoidi P57757.
KOi K12386.
OMAi FQVTSQN.
OrthoDBi EOG7T1RBM.
PhylomeDBi P57757.
TreeFami TF313589.

Miscellaneous databases

NextBioi 350546.
PROi P57757.
SOURCEi Search...

Gene expression databases

Bgeei P57757.
CleanExi MM_CTNS.
ExpressionAtlasi P57757. baseline.
Genevestigatori P57757.

Family and domain databases

InterProi IPR005282. LC_transporter.
IPR006603. PQ-loop_rpt.
[Graphical view ]
PANTHERi PTHR13131. PTHR13131. 1 hit.
Pfami PF04193. PQ-loop. 2 hits.
[Graphical view ]
SMARTi SM00679. CTNS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00951. 2A43. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterisation of the murine homologue of the gene responsible for cystinosis, Ctns."
    Cherqui S., Kalatzis V., Forestier L., Poras I., Antignac C.
    BMC Genomics 1:2-2(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-66.
  5. Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCTNS_MOUSE
AccessioniPrimary (citable) accession number: P57757
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3