P57751 (UGPA1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UTP--glucose-1-phosphate uridylyltransferase 1
EC=2.7.7.9

Alternative name(s):
UDP-glucose pyrophosphorylase 1
Short name=UDPGP 1
Short name=UGPase 1

Gene names

Ordered Locus Names:	At5g17310
ORF Names:	MKP11.16

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a central role as a glucosyl donor in cellular metabolic pathways By similarity.
Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the UDPGP type 1 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	callose deposition in cell wall Inferred from genetic interaction PubMed 20435647. Source: TAIR pollen development Inferred from genetic interaction PubMed 20435647. Source: TAIR response to cadmium ion Inferred from expression pattern PubMed 16502469. Source: TAIR response to salt stress Inferred from expression pattern PubMed 17916636. Source: TAIR
Cellular_component	cytosol Inferred from direct assay PubMed 21166475. Source: TAIR plasma membrane Inferred from direct assay PubMed 17644812. Source: TAIR
Molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: P57751-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 470	470	UTP--glucose-1-phosphate uridylyltransferase 1		PRO_0000185756

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 24, 2001. Version 1. Checksum: 488C4A034DC73AE8	FASTA	470	51,920
	10 20 30 40 50 60 MAATATEKLP QLKSAVDGLT EMSENEKSGF INLVSRYLSG EAQHIEWSKI QTPTDEIVVP 70 80 90 100 110 120 YDKMANVSED ASETKYLLDK LVVLKLNGGL GTTMGCTGPK SVIEVRDGLT FLDLIVIQIE 130 140 150 160 170 180 NLNNKYNCKV PLVLMNSFNT HDDTQKIVEK YTKSNVDIHT FNQSKYPRVV ADEFVPWPSK 190 200 210 220 230 240 GKTDKDGWYP PGHGDVFPSL MNSGKLDAFL SQGKEYVFIA NSDNLGAIVD LKILKHLIQN 250 260 270 280 290 300 KNEYCMEVTP KTLADVKGGT LISYEGKVQL LEIAQVPDEH VNEFKSIEKF KIFNTNNLWV 310 320 330 340 350 360 NLKAIKKLVE ADALKMEIIP NPKEVDGVKV LQLETAAGAA IRFFDNAIGV NVPRSRFLPV 370 380 390 400 410 420 KATSDLLLVQ SDLYTLVDGF VTRNKARTNP TNPAIELGPE FKKVASFLSR FKSIPSIVEL 430 440 450 460 470 DSLKVSGDVW FGSGVVLKGK VTVKANAGTK LEIPDNAVLE NKDINGPEDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence features of the 1.6 Mb regions covered by twenty physically assigned P1 clones." Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M., Miyajima N., Tabata S. DNA Res. 4:215-230(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB005238 Genomic DNA. Translation: BAB10518.1. CP002688 Genomic DNA. Translation: AED92412.1. AF360244 mRNA. Translation: AAK25954.1. AY040042 mRNA. Translation: AAK64100.1. AF361816 mRNA. Translation: AAK32829.1.
IPI	IPI00537899.
RefSeq	NP_197233.1. NM_121737.3.
UniGene	At.20807.
3D structure databases
ProteinModelPortal	P57751.
SMR	P57751. Positions 9-470.
ModBase	Search...
Protein-protein interaction databases
STRING	3702.AT5G17310.2-P.
Proteomic databases
PaxDb	P57751.
PRIDE	P57751.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT5G17310.2; AT5G17310.2; AT5G17310.
GeneID	831596.
KEGG	ath:AT5G17310.
Organism-specific databases
TAIR	At5g17310.
Phylogenomic databases
eggNOG	COG4284.
HOGENOM	HOG000113618.
InParanoid	P57751.
KO	K00963.
OMA	VWFGSGV.
PhylomeDB	P57751.
ProtClustDB	PLN02474.
Gene expression databases
ArrayExpress	P57751.
Genevestigator	P57751.
GermOnline	AT5G17310. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR002618. UDPGP_trans. IPR016267. UDPGP_trans_subgr. [Graphical view]
PANTHER	PTHR11952. PTHR11952. 1 hit. PTHR11952:SF1. PTHR11952:SF1. 1 hit.
Pfam	PF01704. UDPGP. 1 hit. [Graphical view]
PIRSF	PIRSF000806. UDPGP. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UGPA1_ARATH

Accession

Primary (citable) accession number: P57751
Secondary accession number(s): Q3E9G5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	January 24, 2001
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program