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Protein

Phosphoacetylglucosamine mutase

Gene

DRT101

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interconverts GlcNAc-6-P and GlcNAc-1-P.By similarity

Catalytic activityi

N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Pathwayi: UDP-N-acetyl-alpha-D-glucosamine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glucosamine 6-phosphate N-acetyltransferase (GNA1)
  2. Phosphoacetylglucosamine mutase (DRT101), Phosphoacetylglucosamine mutase (AXX17_At5g17810)
This subpathway is part of the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I), the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Phosphoserine intermediateBy similarity1
Metal bindingi68Magnesium; via phosphate groupBy similarity1
Metal bindingi286MagnesiumBy similarity1
Metal bindingi288MagnesiumBy similarity1
Metal bindingi290MagnesiumBy similarity1
Binding sitei527SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processDNA damage, DNA repair
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G18070-MONOMER
ReactomeiR-ATH-446210 Synthesis of UDP-N-acetyl-glucosamine
UniPathwayiUPA00113; UER00530

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoacetylglucosamine mutase (EC:5.4.2.3)
Short name:
PAGM
Alternative name(s):
Acetylglucosamine phosphomutase
DNA-damage-repair/toleration protein DRT101
N-acetylglucosamine-phosphate mutase
Gene namesi
Name:DRT101
Ordered Locus Names:At5g18070
ORF Names:MRG7.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G18070
TAIRilocus:2172294 AT5G18070

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001480151 – 556Phosphoacetylglucosamine mutaseAdd BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP57750

PTM databases

iPTMnetiP57750

Expressioni

Gene expression databases

ExpressionAtlasiP57750 baseline and differential
GenevisibleiP57750 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G18070.1

Structurei

3D structure databases

ProteinModelPortaliP57750
SMRiP57750
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni386 – 388Substrate bindingBy similarity3
Regioni518 – 522Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiKOG2537 Eukaryota
COG1109 LUCA
HOGENOMiHOG000210027
InParanoidiP57750
KOiK01836
OMAiLHYMVCC
OrthoDBiEOG093606S1
PhylomeDBiP57750

Family and domain databases

CDDicd03086 PGM3, 1 hit
InterProiView protein in InterPro
IPR005844 A-D-PHexomutase_a/b/a-I
IPR016055 A-D-PHexomutase_a/b/a-I/II/III
IPR005846 A-D-PHexomutase_a/b/a-III
IPR005843 A-D-PHexomutase_C
IPR036900 A-D-PHexomutase_C_sf
IPR016657 PAGM
PfamiView protein in Pfam
PF02878 PGM_PMM_I, 1 hit
PF02880 PGM_PMM_III, 1 hit
PF00408 PGM_PMM_IV, 1 hit
PIRSFiPIRSF016408 PAGM, 1 hit
SUPFAMiSSF53738 SSF53738, 4 hits
SSF55957 SSF55957, 1 hit

Sequencei

Sequence statusi: Complete.

P57750-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEIQIASIL KSSELFPIPQ GVKLSYGTAG FRGDAKLLES TVYRVGILSA
60 70 80 90 100
LRSLKLGSAT VGLMITASHN KVSDNGIKVS DPSGFMLSQE WEPFADQIAN
110 120 130 140 150
ASSPEELVSL IRKFMEKEEI AIGENNKGAE VWLGRDTRPS GESLLRAGEI
160 170 180 190 200
GVGSILGSVA IDIGILTTPQ LHWMVRAKNK GLKATENDYF ENLSTSFRCL
210 220 230 240 250
IDLIPSSGND KLEISKLLVD GANGVGGQKI EKLRGSLSNL DVEIRNTGRD
260 270 280 290 300
GGVLNEGVGA DFVQKEKVLP VGFGFKDVGM RCASLDGDAD RLVYFYIPSD
310 320 330 340 350
SSEKVELLDG DKILSLFALF IKEQLNALED DEERKQSRLG VVQTAYANGA
360 370 380 390 400
STDYLKHLGL DVVFAKTGVK HLHEKAAEFD IGIYFEANGH GTILFSESFL
410 420 430 440 450
SWLVSKQKDL TAKGQGGSEE HKAVSRLMAV SNLINQAVGD ALSGVLLVEV
460 470 480 490 500
ILQHLGWSIE KWNELYKDLP SRQIKVEVPD RTAVVTTSEE TEALRPMGIQ
510 520 530 540 550
DAINSEIKKY SRGRAFIRPS GTEDVVRVYA EASTQEDADS LANSVAQLVK

SFLGSS
Length:556
Mass (Da):60,391
Last modified:January 24, 2001 - v1
Checksum:iBCADE44F14DDC3D0
GO

Sequence cautioni

The sequence AAA72352 differs from that shown. Sequencing errors.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012246 Genomic DNA Translation: BAB09465.1
CP002688 Genomic DNA Translation: AED92503.1
AY075620 mRNA Translation: AAL91631.1
L11367 mRNA Translation: AAA72352.1 Sequence problems.
PIRiS35270
RefSeqiNP_568359.2, NM_121812.3
UniGeneiAt.466

Genome annotation databases

EnsemblPlantsiAT5G18070.1; AT5G18070.1; AT5G18070
GeneIDi831926
GrameneiAT5G18070.1; AT5G18070.1; AT5G18070
KEGGiath:AT5G18070

Similar proteinsi

Entry informationi

Entry nameiAGM1_ARATH
AccessioniPrimary (citable) accession number: P57750
Secondary accession number(s): Q05211
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: April 25, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health