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Protein

Phosphoacetylglucosamine mutase

Gene

DRT101

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Interconverts GlcNAc-6-P and GlcNAc-1-P.By similarity

Catalytic activityi

N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Pathwayi: UDP-N-acetyl-alpha-D-glucosamine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glucosamine 6-phosphate N-acetyltransferase (GNA1)
  2. Phosphoacetylglucosamine mutase (DRT101)
This subpathway is part of the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I), the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Phosphoserine intermediateBy similarity1
Metal bindingi68Magnesium; via phosphate groupBy similarity1
Metal bindingi286MagnesiumBy similarity1
Metal bindingi288MagnesiumBy similarity1
Metal bindingi290MagnesiumBy similarity1
Binding sitei527SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G18070-MONOMER.
ReactomeiR-ATH-446210. Synthesis of UDP-N-acetyl-glucosamine.
UniPathwayiUPA00113; UER00530.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoacetylglucosamine mutase (EC:5.4.2.3)
Short name:
PAGM
Alternative name(s):
Acetylglucosamine phosphomutase
DNA-damage-repair/toleration protein DRT101
N-acetylglucosamine-phosphate mutase
Gene namesi
Name:DRT101
Ordered Locus Names:At5g18070
ORF Names:MRG7.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G18070.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • mitochondrion Source: TAIR
  • plasmodesma Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001480151 – 556Phosphoacetylglucosamine mutaseAdd BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP57750.

PTM databases

iPTMnetiP57750.

Expressioni

Gene expression databases

GenevisibleiP57750. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G18070.1.

Structurei

3D structure databases

ProteinModelPortaliP57750.
SMRiP57750.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni386 – 388Substrate bindingBy similarity3
Regioni518 – 522Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiKOG2537. Eukaryota.
COG1109. LUCA.
HOGENOMiHOG000210027.
InParanoidiP57750.
KOiK01836.
OMAiEPFTRCV.
OrthoDBiEOG093606S1.
PhylomeDBiP57750.

Family and domain databases

CDDicd03086. PGM3. 1 hit.
Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016657. PAGM.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PIRSFiPIRSF016408. PAGM. 1 hit.
SUPFAMiSSF53738. SSF53738. 4 hits.
SSF55957. SSF55957. 1 hit.

Sequencei

Sequence statusi: Complete.

P57750-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEIQIASIL KSSELFPIPQ GVKLSYGTAG FRGDAKLLES TVYRVGILSA
60 70 80 90 100
LRSLKLGSAT VGLMITASHN KVSDNGIKVS DPSGFMLSQE WEPFADQIAN
110 120 130 140 150
ASSPEELVSL IRKFMEKEEI AIGENNKGAE VWLGRDTRPS GESLLRAGEI
160 170 180 190 200
GVGSILGSVA IDIGILTTPQ LHWMVRAKNK GLKATENDYF ENLSTSFRCL
210 220 230 240 250
IDLIPSSGND KLEISKLLVD GANGVGGQKI EKLRGSLSNL DVEIRNTGRD
260 270 280 290 300
GGVLNEGVGA DFVQKEKVLP VGFGFKDVGM RCASLDGDAD RLVYFYIPSD
310 320 330 340 350
SSEKVELLDG DKILSLFALF IKEQLNALED DEERKQSRLG VVQTAYANGA
360 370 380 390 400
STDYLKHLGL DVVFAKTGVK HLHEKAAEFD IGIYFEANGH GTILFSESFL
410 420 430 440 450
SWLVSKQKDL TAKGQGGSEE HKAVSRLMAV SNLINQAVGD ALSGVLLVEV
460 470 480 490 500
ILQHLGWSIE KWNELYKDLP SRQIKVEVPD RTAVVTTSEE TEALRPMGIQ
510 520 530 540 550
DAINSEIKKY SRGRAFIRPS GTEDVVRVYA EASTQEDADS LANSVAQLVK

SFLGSS
Length:556
Mass (Da):60,391
Last modified:January 24, 2001 - v1
Checksum:iBCADE44F14DDC3D0
GO

Sequence cautioni

The sequence AAA72352 differs from that shown. Sequencing errors.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012246 Genomic DNA. Translation: BAB09465.1.
CP002688 Genomic DNA. Translation: AED92503.1.
AY075620 mRNA. Translation: AAL91631.1.
L11367 mRNA. Translation: AAA72352.1. Sequence problems.
PIRiS35270.
RefSeqiNP_568359.2. NM_121812.3.
UniGeneiAt.466.

Genome annotation databases

EnsemblPlantsiAT5G18070.1; AT5G18070.1; AT5G18070.
GeneIDi831926.
GrameneiAT5G18070.1; AT5G18070.1; AT5G18070.
KEGGiath:AT5G18070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012246 Genomic DNA. Translation: BAB09465.1.
CP002688 Genomic DNA. Translation: AED92503.1.
AY075620 mRNA. Translation: AAL91631.1.
L11367 mRNA. Translation: AAA72352.1. Sequence problems.
PIRiS35270.
RefSeqiNP_568359.2. NM_121812.3.
UniGeneiAt.466.

3D structure databases

ProteinModelPortaliP57750.
SMRiP57750.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G18070.1.

PTM databases

iPTMnetiP57750.

Proteomic databases

PaxDbiP57750.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G18070.1; AT5G18070.1; AT5G18070.
GeneIDi831926.
GrameneiAT5G18070.1; AT5G18070.1; AT5G18070.
KEGGiath:AT5G18070.

Organism-specific databases

TAIRiAT5G18070.

Phylogenomic databases

eggNOGiKOG2537. Eukaryota.
COG1109. LUCA.
HOGENOMiHOG000210027.
InParanoidiP57750.
KOiK01836.
OMAiEPFTRCV.
OrthoDBiEOG093606S1.
PhylomeDBiP57750.

Enzyme and pathway databases

UniPathwayiUPA00113; UER00530.
BioCyciARA:AT5G18070-MONOMER.
ReactomeiR-ATH-446210. Synthesis of UDP-N-acetyl-glucosamine.

Miscellaneous databases

PROiP57750.

Gene expression databases

GenevisibleiP57750. AT.

Family and domain databases

CDDicd03086. PGM3. 1 hit.
Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016657. PAGM.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PIRSFiPIRSF016408. PAGM. 1 hit.
SUPFAMiSSF53738. SSF53738. 4 hits.
SSF55957. SSF55957. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAGM1_ARATH
AccessioniPrimary (citable) accession number: P57750
Secondary accession number(s): Q05211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.