Reviewed, UniProtKB/Swiss-Prot P57749 (PGM_ASPOR)

Names and origin

Protein names

Recommended name:
    Phosphoglucomutase
      Short name=PGM
    EC=5.4.2.2
Alternative name(s):
    Glucose phosphomutase

Gene names

Name:	pgmA
ORF Names:	AO090003000746

Organism

Aspergillus oryzae [Complete proteome]

Taxonomic identifier

5062 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This enzyme participates in both the breakdown and synthesis of glucose By similarity.
Catalytic activity	Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglucomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 555	555	Phosphoglucomutase		PRO_0000147793
Sites
	Active site	114	1	Phosphoserine intermediate By similarity
	Metal binding	114	1	Magnesium; via phosphate group By similarity
	Metal binding	279	1	Magnesium By similarity
	Metal binding	281	1	Magnesium By similarity
	Metal binding	283	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	P57749-1 [UniParc]. Last modified January 24, 2001. Version 1. Checksum: 6AA1DB84878C6DF1	FASTA	555	60,357
	10 20 30 40 50 60 MSIQTVSFQS FTDQKPGTSG LRKKVKVFQQ PNYSESFITS ILLSIPEGAK DAFLVIGGDG 70 80 90 100 110 120 RYYNPEAIQK IAKISAAYGV KKLLVGQNGI LSTPAASNLI RVRKATGGIL LTASHNPGGP 130 140 150 160 170 180 NADFGIKYNL SNGAPAPETV TNKIYETSKT LTSYNYAEIP ELDLSSIGSK TYGPLEVEVV 190 200 210 220 230 240 HSTSDYVKMM KEIFDFDLIK EFLNTHKDFK VLFDGMHGVT GPYGVDIFVN ELGLPSSSTM 250 260 270 280 290 300 NCVPSPDFNG GHPDPNLVYA HELVEAVDKN GIHFGAASDG DGDRNMIYGA NTFVSPGDSL 310 320 330 340 350 360 AIISHHAKLI PYFQKQGVYG LARSMPTSGA VDLVAKAQGL QSYEVPTGWK FFCNLFDNKK 370 380 390 400 410 420 ISICGEESFG TGSNHIREKD GLWAIVAWLN IIAGVAKEKP DQTPSIASIQ NDFWQAYGRT 430 440 450 460 470 480 FFTRYDYENV DSDGANKVIA ILSDKVANKD SFVGSTVSGR KVTDVGNFSY TDLDGSVSKN 490 500 510 520 530 540 QGLYAKFDDG SRIIVRLSGT GSSGATIRLY IEKYESDKSK FGLTASEYLK DNVALALSLL 550 NFKEFIGREE PDVRT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of phosphoglucomutase from Aspergillus oryzae." Nakajima K., Kunihiro S., Sano M., Eto S., Machida M. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC 42149 / RIB 40.
[2]	"Genome sequencing and analysis of Aspergillus oryzae." Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K., Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H., Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E. , Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D., Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A., Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y., Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H., Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T., Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O., Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y., Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N., Kikuchi H. Nature 438:1157-1161(2005) [PubMed: 16372010] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 42149 / RIB 40.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB032275 mRNA. Translation: BAB12235.1. AP007155 Genomic DNA. Translation: BAE57887.1.
RefSeq	XP_001819889.1.
3D structure databases
HSSP	HSSP built from PDB template 3PMG based on UniProtKB P00949.
ModBase	Search...
Genome annotation databases
GeneID	5991872.
GenomeReviews	Gene locus pgmA in contig AP007155_GR.
KEGG	aor:AO090003000746.
Enzyme and pathway databases
BRENDA	5.4.2.2. 2240.
Family and domain databases
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. A-D-PHexomutase_N. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGM_ASPOR

Accession

Primary (citable) accession number: P57749
Secondary accession number(s): Q2UKM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	January 24, 2001
Last modified:	September 22, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)